| Project/Area Number |
19F19801
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| Research Category |
Grant-in-Aid for JSPS Fellows
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| Allocation Type | Single-year Grants |
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| Section | 外国 |
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| Review Section |
Basic Section 28050:Nano/micro-systems-related
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| Research Institution | The University of Tokyo |
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Principal Investigator |
Kim SooHyeon (2021) 東京大学, 生産技術研究所, 講師 (80709189)
藤井 輝夫 (2019-2020) 東京大学, 生産技術研究所, 教授 (30251474)
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| Co-Investigator(Kenkyū-buntansha) |
LI SHUO 東京大学, 生産技術研究所, 外国人特別研究員
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| Project Period (FY) |
2019-11-08 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥2,200,000 (Direct Cost: ¥2,200,000)
Fiscal Year 2021: ¥400,000 (Direct Cost: ¥400,000)
Fiscal Year 2020: ¥700,000 (Direct Cost: ¥700,000)
Fiscal Year 2019: ¥1,100,000 (Direct Cost: ¥1,100,000)
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| Keywords | Nanodots array / Electrochemistry / Biosensor / Apatmer / Microfluidic device / Nanoarray / Micro/Nanofludics / Biomolecules / Apatmers |
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| Outline of Research at the Start |
In this project, micro-/nanofluidics over already available nanosensors will be implemented showing improved performance and the statistical degree of freedom for kinetics optimization should be exploited. In addition, a new generation of 10 nm-scale devices should have been developed with the goal to get a single DNA molecule per dot in a reproducible manner. The expected results in this project are the development and implementation of a new class of versatile, mass-fabrication-compatible and energy-efficient devices and sensors in the 10 nm range based on micro-/nanofluidic techniques.
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| Outline of Annual Research Achievements |
The collaborative research has been successfully carried out by detecting target cancer cells without labelling. Especially, redox labelled DNA aptamer sensor has been firstly utilized for the detection of target cells by sensing surface markers on target cells. The new platform can be utilized for the miniaturized liquid biopsy analysis system by detecting target cancer cells in a blood samples for diagnosis and prognosis of cancer.
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| Research Progress Status |
令和3年度が最終年度であるため、記入しない。
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| Strategy for Future Research Activity |
令和3年度が最終年度であるため、記入しない。
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