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Quality control mechanism of misfolded proteins

Research Project

Project/Area Number 19GS0314
Research Category

Grant-in-Aid for Creative Scientific Research

Allocation TypeSingle-year Grants
Research InstitutionKyoto Sangyo University (2011)
Kyoto University (2007-2010)

Principal Investigator

NAGATA Kazuhiro  京都産業大学, 総合生命科学部, 教授 (50127114)

Co-Investigator(Kenkyū-buntansha) INABA Kenji  九州大学, 生体防御医学研究所, 准教授 (10423039)
HOSOKAWA Nobuko  京都大学, 再生医科学研究所, 准教授 (00263153)
HOSEKI Jun  京都大学, 生理化学研究ユニット, 特定准教授 (40423058)
Project Period (FY) 2007 – 2011
Project Status Completed (Fiscal Year 2011)
Budget Amount *help
¥576,680,000 (Direct Cost: ¥443,600,000、Indirect Cost: ¥133,080,000)
Fiscal Year 2011: ¥116,350,000 (Direct Cost: ¥89,500,000、Indirect Cost: ¥26,850,000)
Fiscal Year 2010: ¥116,350,000 (Direct Cost: ¥89,500,000、Indirect Cost: ¥26,850,000)
Fiscal Year 2009: ¥116,350,000 (Direct Cost: ¥89,500,000、Indirect Cost: ¥26,850,000)
Fiscal Year 2008: ¥111,280,000 (Direct Cost: ¥85,600,000、Indirect Cost: ¥25,680,000)
Fiscal Year 2007: ¥116,350,000 (Direct Cost: ¥89,500,000、Indirect Cost: ¥26,850,000)
Keywords品質管理 / フォールディング / レドックス / 小胞体 / 小胞体品質管理 / ジスルフィド結合 / EDEM / ERdj5 / 分子シャペロン
Research Abstract

Our study was performed by focusing two issues in protein quality control in the endoplasmic reticulum (ER). The first one was on the productive folding of nascent polypeptides by molecular chaperones and oxidoredcutases in the ER. The second one was to reveal the quality control mechanism of ER-associated degradation (ERAD) system that eliminates the misfolded proteins from the ER. We found two novel factors involved in the ERAD, EDEM1 and ERdj5. In this term, mainly three issues on this proposal was addressed: 1) we succeeded to solve the crystal structure of ERdj5 that reduces the disulfide bonds in the misfolded proteins to be degraded and proposed the substrate transfer pathway in the ERAD system for glycoproteins, 2) we revealed the novel ERAD pathway for misfolded non-glycosylated proteins, and 3) we showed the electron transfer pathway in the process of oxidation including Ero1a, PDI and ERp46.

Assessment Rating
Verification Result (Rating)

A

Report

(7 results)
  • 2013 Research Progress Assessment (Verification Result) ( PDF )
  • 2011 Annual Research Report   Final Research Report ( PDF )
  • 2009 Annual Research Report   Self-evaluation Report ( PDF )
  • 2008 Annual Research Report
  • 2007 Annual Research Report
  • Research Products

    (68 results)

All 2013 2012 2011 2010 2009 2008 2007 Other

All Journal Article (35 results) (of which Peer Reviewed: 27 results) Presentation (21 results) Book (9 results) Remarks (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] A pH-Regulated Quality Control Cycle forSurveillance of Secretory Protein Assembly2013

    • Author(s)
      S.Vavassori, M. Cortini, S. Masui, S.Sannino,T.Anelli, I. R.Caserta, C.Fagioli, A.Fornili, M.F.Mossuto, M .Degano, K.Inaba, & R.Sitia
    • Journal Title

      Molecular Cell

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Endoplasmic reticulum lectinXTP3-B inhibits endoplasmic reticulum-associated degradation of a misfolded α1-antitrypsinvariant2013

    • Author(s)
      T. Fujimori, Y. Kamiya, K. Nagata, K. Kato &N. Hosokawa
    • Journal Title

      FEBS J

      Volume: (in press)

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The mutation incyclophilin B that causes hyperelastosis cutis in the American Quarter Horse does not affectpeptidyl-prolyl cis-trans isomerase activity, butshows altered cyclophilin B-protein interactionsand affects collagen folding2012

    • Author(s)
      Y. Ishikawa, J. A. Vranka, S. P. Boudko, E.Pokidysheva, K. Mizuno, K. Zientek, D. R.Keene, A. M. Rashmir-Raven, K. Nagata, N. J.Winand and H. P. Bachinger
    • Journal Title

      J. Biol. Chem

      Volume: 287(26) Issue: 26 Pages: 22253-22265

    • DOI

      10.1074/jbc.m111.333336

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Direct in vitro and in vivo evidence for interaction between Hsp47 protein and collagen triple helix2012

    • Author(s)
      T. Ono, T. Miyazaki, Y. Ishida, M. Uehata and K. Nagata
    • Journal Title

      J. Biol. Chem.

      Volume: 287(9) Issue: 9 Pages: 6810-6818

    • DOI

      10.1074/jbc.m111.280248

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Molecular chaperone Hsp47 is essential for cartilage and endochondral bone formation2012

    • Author(s)
      Y. Masago, A. Hosoya, S. Kawano, A. Nasu, J. Toguchida, K. Fujita, H. Nakamura, G. Kondoh and K. Nagata
    • Journal Title

      J. Cell Sci.

      Volume: 125(5) Issue: 5 Pages: 1118-1128

    • DOI

      10.1242/jcs.089748

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Functional in vitro analysis of ERO1 and protein-disulfide isomerase (PDI) pathway2011

    • Author(s)
      K. Araki and K. Nagata
    • Journal Title

      J. Biol. Chem.

      Volume: 286(37) Issue: 37 Pages: 32705-32712

    • DOI

      10.1074/jbc.m111.227181

    • Related Report
      2011 Annual Research Report 2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Structural basis of an ERAD pathway mediated by the ER-resident protein disulfide reductase ERdj52011

    • Author(s)
      M. Hagiwara, K. Maegawa, M. Suzuki, R. Ushioda, K. Araki, Y. Matsumoto, J. Hoseki, K. Nagata and K. Inaba
    • Journal Title

      Mol. Cell

      Volume: 41(4) Issue: 4 Pages: 432-444

    • DOI

      10.1016/j.molcel.2011.01.021

    • NAID

      120003836694

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Identification of RNF213 as a Susceptibility Gene for Moyamoya Disease and Its Possible Role in Vascular Development2011

    • Author(s)
      Wanyang Liu, et al
    • Journal Title

      PLoS ONE

      Volume: 6(7) Issue: 7 Pages: e22542-e22542

    • DOI

      10.1371/journal.pone.0022542

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Solution structure and dynamics of mouse ARMET2010

    • Author(s)
      J. Hoseki, H.Sasakawa, Y. Yamaguchi, M. Maeda, H. Kubota, K. Kato and K. Nagata
    • Journal Title

      FEBS. Letters

      Volume: 584 Issue: 8 Pages: 1536-1542

    • DOI

      10.1016/j.febslet.2010.03.008

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The novel thioredoxin-related transmembrane protein TMX4 has reductase activity2010

    • Author(s)
      Y. Sugiura, K. Araki, S. Iemura, T. Natsume, J. Hoseki1 and K. Nagata
    • Journal Title

      J. Biol. Chem.

      Volume: 285(10) Issue: 10 Pages: 7135-7142

    • DOI

      10.1074/jbc.m109.082545

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] The novel thioredoxin-related transmembrane protein TMX4 has reductase activity2010

    • Author(s)
      Y. Sugiura, K. Araki, 1 S. Iemura, T. Natsume,. J. Hoseki., K. Nagata
    • Journal Title

      J. Biol. Chem 285(10)

      Pages: 7135-7142

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] The novel thioredoxin-related transmembrane protein TMX4 has reductase activity2010

    • Author(s)
      Y.Sugiura, et al.
    • Journal Title

      J.Biol.Chem. 285(10)

      Pages: 7135-7142

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-Glycans2009

    • Author(s)
      N. Hosokawa, Y. Kamiya, D. Kamiya, K. Kato & K. Nagata
    • Journal Title

      J. Biol. Chem.

      Volume: 284(25) Issue: 25 Pages: 17061-17068

    • DOI

      10.1074/jbc.m809725200

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Autophagic elimination of misfolded procollagen aggregates in the endoplasmic reticulum as a means of cell protection2009

    • Author(s)
      Y.Ishida, A.Yamamoto, A.Kitamura,S.R.Lamande, T.YoshimorI, F.B.John, H.Kubota and K.Nagata
    • Journal Title

      Mol. Biol. Cell.

      Volume: 20 Issue: 11 Pages: 2744-2754

    • DOI

      10.1091/mbc.e08-11-1092

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Dynamicnature of disulfide bond formation catalystsrevealed by crystal structures of DsbB2009

    • Author(s)
      Inaba, K., Murakami, S., Nakagawa, A., Iida,H., Kinjo, M., Ito, K. and Suzuki, M.
    • Journal Title

      EMBO J

      Volume: 28 Issue: 6 Pages: 779-791

    • DOI

      10.1038/emboj.2009.21

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human 0S-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-Glycans2009

    • Author(s)
      N. Hosokawa, Y. Kamiya, D. Kamiya, K. Kato, K. Nagata
    • Journal Title

      J. Biol. Chem. 284(25)

      Pages: 17061-17068

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Autophagic elimination of misfolded procollagen aggregates in the endoplasmic reticulum as a means of cell protection2009

    • Author(s)
      Y. Ishida, A. Yamamoto, A. Kitamura, S. R. Lamande, T. YoshimorI, F. B. John, H. Kubota, K. Nagata
    • Journal Title

      Mol. Biol. Cell. 20

      Pages: 2744-2754

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Dynamic nature of disulfide bond formation catalysts revealed by crystal structures of DsbB2009

    • Author(s)
      Inaba, K., Murakami, S., Nakagawa, A., Iida, H., Kinjo, M., Ito, K., Suzuki, M.
    • Journal Title

      EMBO J 28

      Pages: 779-791

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Autophagic elimination of misfolded procollagen aggregates in the endoplasmic reticulum as a means of cell protection2009

    • Author(s)
      Y.Ishida, et al.
    • Journal Title

      Mol.Biol.Cell. 20

      Pages: 2744-2754

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human OS-9, a lectin required for glycoprotein endoplasmic reticulum-associated degradation, recognizes mannose-trimmed N-Glycans2009

    • Author(s)
      N.Hosokawa, et al.
    • Journal Title

      J.Biol.Chem. 284(25)

      Pages: 17061-17068

    • Related Report
      2009 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ERdj5 is required as a disulfide reductase for degradation of misfolded proteins in the ER2008

    • Author(s)
      R.Ushioda, J.Hoseki, K.Araki, G.Jansen, D.Y.Thomas and K.Nagata
    • Journal Title

      Science

      Volume: 321(5888) Issue: 5888 Pages: 569-572

    • DOI

      10.1126/science.1159293

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Human XTP3-B Forms an Endoplasmic Reticulum Quality Control Scaffold with the HRD1-SEL1L Ubiquitin Ligase Complex and BiP2008

    • Author(s)
      N.Hosokawa, I.Wada, K.Nagasawa, T.Moriyama, K.Okawa, and K.Nagata
    • Journal Title

      J. Biol. Chem.

      Volume: 283(30) Issue: 30 Pages: 20914-20924

    • DOI

      10.1074/jbc.m709336200

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gp78 cooperates with RMA1 in ER-associated degradation of CFTRΔF5082008

    • Author(s)
      D. Morito, K. Hirao, F. Tokunaga, N. Hosokawa, D. M. Cyr, K. Tanaka, K. Iwai and K. Nagata
    • Journal Title

      Mol. Biol. Cell.

      Volume: 19 Issue: 4 Pages: 1328-1336

    • DOI

      10.1091/mbc.e07-06-0601

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] MKKS is a centrosome-shuttling protein degraded by disease-causing mutations via CHIP-mediated ubiquitination2008

    • Author(s)
      S. Hirayama, Y. Yamazaki, A. Kitamura, Y. Oda, D. Morito, K. Okawa, H. Kimura, D. M. Cyr, H. Kubota and K. Nagata
    • Journal Title

      Mol. Biol. Cell.

      Volume: 19 Issue: 3 Pages: 899-911

    • DOI

      10.1091/mbc.e07-07-0631

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] A pair of circularlypermutated PDZ domains control RseP, the S2Pfamily intramembrane protease of E. coli2008

    • Author(s)
      Inaba, K., Suzuki, M., Maegawa, K., Akiyama,S., Ito, K. and Akiyama, Y.
    • Journal Title

      J. Biol. Chem.

      Volume: 283 Issue: 50 Pages: 35042-52

    • DOI

      10.1074/jbc.m806603200

    • Related Report
      2011 Final Research Report
    • Peer Reviewed
  • [Journal Article] ERdj5 is required as a disulfide reductase for degradation of misfolded proteins in the ER.2008

    • Author(s)
      R. Ushioda, J. Hoseki, K. Araki, G. Jansen, D. Y. Thomas, K. Nagata
    • Journal Title

      Science 321(5888)

      Pages: 569-572

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] Gp78 cooperates with RMA1 in ER-associated degradation of CFTRΔF5082008

    • Author(s)
      D. Morito, K. Hirao, F. Tokunaga, N. Hosokawa, D. M. Cyr, K. Tanaka, K. Iwai, K. Nagata
    • Journal Title

      Mol. Biol. Cell. 19

      Pages: 1328-1336

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] MKKS is a centrosome-shuttling protein degraded by disease-causing mutations via CHIP-mediated ubiquitination2008

    • Author(s)
      S. Hirayama, Y. Yamazaki, A. Kitamura, Y. Oda, D. Morito, K. Okawa, H. Kimura, D. M. Cyr, H. Kubota, K. Nagata
    • Journal Title

      Mol. Biol. Cell. 19

      Pages: 899-911

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] A pair of circularly permutated PDZ domains control RseP, the S2P family intramembrane protease of E. coli2008

    • Author(s)
      Inaba, K., Suzuki, M., Maegawa, K., Akiyama, S., Ito, K., Akiyama, Y.
    • Journal Title

      J. Biol. Chem. 283

      Pages: 35042-35052

    • Related Report
      2009 Self-evaluation Report
  • [Journal Article] ERdj5 is required as a disulfide reductase for degradation of misfolded proteins in the ER2008

    • Author(s)
      R.Ushioda, et al.
    • Journal Title

      Science 321(5888)

      Pages: 569-572

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gp78 cooperates with RMA1 in ER-associated degradation of CFTR△F5082008

    • Author(s)
      D.Morito, et al.
    • Journal Title

      Mol.Biol.Cell. 19

      Pages: 1328-1336

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] MKKS is a centrosome-shuttling protein degraded by disease-causing mutations via CHIP-mediated ubiquitination2008

    • Author(s)
      S.Hirayama, et al.
    • Journal Title

      Mol.Biol.Cell. 19

      Pages: 899-911

    • Related Report
      2008 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ERdj5 is required as a disulfide reductase for degradation of misfolded proteins in the ER.2008

    • Author(s)
      R. USHIODA, et al.
    • Journal Title

      Science 321(5888)

      Pages: 569-572

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human XTP3-B Forms an Endoplasmic Reticulum Quality Control Scaffold with the HRD1-SEL1L Ubiquitin Ligase Complex and BiP.2008

    • Author(s)
      N. HOSOKAWA, et al.
    • Journal Title

      Biol J. Chem. 283(30)

      Pages: 20914-20924

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gp78 cooperates with RMA1 in ER-associated degradation of CFTR ΔF5082008

    • Author(s)
      D. MORITO, et al.
    • Journal Title

      Mol. Biol. Cell. 19

      Pages: 1328-1336

    • Related Report
      2007 Annual Research Report
    • Peer Reviewed
  • [Presentation] Regulation and structure of a novelAAA+/ubiquitin ligase protein2012

    • Author(s)
      K. Nagata
    • Organizer
      mysterin EMBO/EMBL Symposium"QualityControl-From Molesules to Organelles"
    • Place of Presentation
      Heiderberg(Germany)
    • Year and Date
      2012-09-21
    • Related Report
      2011 Final Research Report
  • [Presentation] Two distinct ERAD pathways formisfolded glycoproteins and non-glycoproteins SFB5942012

    • Author(s)
      K. Nagata
    • Organizer
      3^<rd>International Symposium on Molecular Machines in Protein Folding and Protein Transport
    • Place of Presentation
      Munich(Germany)
    • Year and Date
      2012-07-24
    • Related Report
      2011 Final Research Report
  • [Presentation] Regulation of redox homeostasisin the ER2012

    • Author(s)
      K. Nagata
    • Organizer
      Cold Spring Harbor Meeting,Molecular Chaperones & Stress Responses
    • Place of Presentation
      Cold Spring Harbor(USA)
    • Year and Date
      2012-05-02
    • Related Report
      2011 Final Research Report
  • [Presentation] Protein quality control andproteostasis in the ER2011

    • Author(s)
      K. Nagata
    • Organizer
      Cold Spring Harbor Asia Conference,"Protein Homeostasis in Health &Disease"
    • Place of Presentation
      Suzhou(China)
    • Year and Date
      2011-09-29
    • Related Report
      2011 Final Research Report
  • [Presentation] Regulation of redoxhomeostasis in the ER2011

    • Author(s)
      K. Nagata and R. Sitia
    • Organizer
      Conference on QualityControl: Folding and Degradation of Proteins inthe Endoplasmic Reticulum
    • Place of Presentation
      Ascona(Switzerland)
    • Year and Date
      2011-09-15
    • Related Report
      2011 Final Research Report
  • [Presentation] Protein quality control in the ER and the nucleus2011

    • Author(s)
      K. Nagata
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      Lucca (Italy)(招待講演)
    • Year and Date
      2011-07-19
    • Related Report
      2011 Annual Research Report
  • [Presentation] Two distinct ERAD pathways contribute for maintaining the protein homeostasis in the EREMBO Conference2011

    • Author(s)
      K. Nagata
    • Organizer
      The biology of Molecular Chaperones
    • Place of Presentation
      Grundlsee(Austria)
    • Year and Date
      2011-05-22
    • Related Report
      2011 Final Research Report
  • [Presentation] Regulation in the electron transfer cascade among the oxidoreductases in the endoplasmic reticulum2010

    • Author(s)
      K. Nagata
    • Organizer
      The 3^<rd> International Symposium on Protein Community
    • Place of Presentation
      Nara
    • Year and Date
      2010-09-14
    • Related Report
      2011 Final Research Report
  • [Presentation] Quality control & Redox regulatory network2010

    • Author(s)
      K. Araki,R. Ushioda,J. Hoseki and K.Nagata
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      Lucca (Italy)
    • Year and Date
      2010-05-11
    • Related Report
      2011 Final Research Report
  • [Presentation] Two distinct ERAD pathways for misfolded glycoprotein and non-glycoprotein2009

    • Author(s)
      K. Nagata
    • Organizer
      4^<th> International Congress on Stress Responses in Biology and Medicine
    • Place of Presentation
      Plenary lecture, Sapporo
    • Year and Date
      2009-10-06
    • Related Report
      2011 Final Research Report
  • [Presentation] Quality control of misfoldedproteins in the endoplasmic reticulum2009

    • Author(s)
      K. Nagata
    • Organizer
      21th IUBMB International Congress and 12th FAOBMB Congress of Biochemistry and Molecular Biology
    • Place of Presentation
      Shanghai(China)
    • Year and Date
      2009-08-05
    • Related Report
      2011 Final Research Report
  • [Presentation] Quality control of misfolded proteins in the endoplasmic reticulum.2009

    • Author(s)
      Kazuhiro Nagata
    • Organizer
      21th IUBMB International Congress and 12^th FAOBMB Congress of Biochemistry and Molecular Biology
    • Place of Presentation
      Shanghai (China)
    • Year and Date
      2009-08-05
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Quality control of misfolded proteins in the endoplasmic reticulum2009

    • Author(s)
      Kazuhiro Nagata
    • Organizer
      21th IUBMB International Congress and 12th FAOBMB Congress of Biochemistry and Molecular Biology
    • Place of Presentation
      Shanghai(China)
    • Year and Date
      2009-08-05
    • Related Report
      2009 Annual Research Report
  • [Presentation] Revisiting of collagen-specificmolecular chaperone Hsp47:Fate of procollagenwith or without Hsp472009

    • Author(s)
      K. Nagata
    • Organizer
      Yokosuka Science Festa 2009 8th Pan-Pacific Connective Tissue Societies Symposium
    • Place of Presentation
      Opening Lecture, Shonan
    • Year and Date
      2009-06-04
    • Related Report
      2011 Final Research Report
  • [Presentation] Revisiting of collagen-specific molecular chaperone HSP47:Alternative degradation pathway of misfolded procollagen in the ER;ERAD andautophagy2008

    • Author(s)
      K. Nagata,Y. Masago, Y. Ishida
    • Organizer
      Cold Spring Harbor Meeting "Molecular Chaperones and stress Response"
    • Place of Presentation
      Cold SpringHarbor(USA)
    • Year and Date
      2008-05-01
    • Related Report
      2011 Final Research Report
  • [Presentation] Revisiting of collagen-specific molecular chaperone HSP47 : Alternative degradation pathway of misfolded procollagen in the ER ; ERAD and autophagy2008

    • Author(s)
      Kazuhiro Nagata, Yusaku Masago, Yoshihito Ishida
    • Organizer
      Cold Spring Harbor Meeting "Molecular Chaperones and stress Response"
    • Place of Presentation
      Cold Spring Harbor (USA)
    • Year and Date
      2008-05-01
    • Related Report
      2009 Self-evaluation Report
  • [Presentation] Revisiting of collagen-specific molecular chaperone HSP47 : Alternative degradation pathway of misfolded procollagen in the ER : ERAD and autophagy2008

    • Author(s)
      Kazuhiro Nagata, et al.
    • Organizer
      Cold Spring Harbor Meeting "Molecular Chaperones and stress Response"
    • Place of Presentation
      Cold Spring Harbor(USA)
    • Year and Date
      2008-05-01
    • Related Report
      2008 Annual Research Report
  • [Presentation] Revisiting of collagen-specific molecular chaperone HSP47: Alternative degradation pathway of misfolded procollagen in the ER; ERAD and autophagy2008

    • Author(s)
      Kazuhiro Nagata
    • Organizer
      Cold Spring Harbor Meeting
    • Place of Presentation
      Cold Spring Harbor (USA)
    • Year and Date
      2008-05-01
    • Related Report
      2007 Annual Research Report
  • [Presentation] Collagen-specific molecular chaperone HSP472007

    • Author(s)
      K.Nagata
    • Organizer
      7th Pan Pacific Connective Tissue Societies Symposium
    • Place of Presentation
      Cairns(Australia)
    • Year and Date
      2007-10-30
    • Related Report
      2011 Final Research Report
  • [Presentation] Thiol reductase ERdj5 accelerates the ER-associated degradation by cleaving intermolecular disulfide bonds of misfolded proteis2007

    • Author(s)
      K.Nagata
    • Organizer
      Gordon Research Conference, Stress Proteins in Growth
    • Place of Presentation
      Development & Desease, Oxford(UK)
    • Year and Date
      2007-08-21
    • Related Report
      2011 Final Research Report
  • [Presentation] A novel thiol reductase ERdj5 accelerates ER-associated degradation by cleaving the intermolecular disulfide bonds of misfolded proteins2007

    • Author(s)
      K. Nagata
    • Organizer
      FASEB Summer Research Conference, Proteins Folding in the Cell
    • Place of Presentation
      Palm Springs(USA)
    • Year and Date
      2007-07-30
    • Related Report
      2011 Final Research Report
  • [Book] ER stress proteins in autoimmune and inflammatory diseases2012

    • Author(s)
      D. Morito and K. Nagata
    • Total Pages
      48
    • Publisher
      Frontiers in Inflammation
    • Related Report
      2011 Final Research Report
  • [Book] Redox-dependent protein quality control in the ER : folding to degrasation2012

    • Author(s)
      M. Hagiwara and K. Nagata
    • Publisher
      Antioxidants & Redox Signaling
    • Related Report
      2011 Final Research Report
  • [Book] Protein Folding and Quality Control in the ER Cold Spring Harbor Perspectives inBiology"Protein Homeostasis"2011

    • Author(s)
      K. Araki and K. Nagata
    • Publisher
      Cold SpringHarbor Laboratory press
    • Related Report
      2011 Final Research Report
  • [Book] Cold Spring Harbor Perspectives in Biology "Protein Homeostasis"2011

    • Author(s)
      K. Araki, K. Nagata, 他 分担執筆
    • Total Pages
      349
    • Publisher
      Cold Spring Harbor Laboratory press(分担執筆)
    • Related Report
      2011 Annual Research Report
  • [Book] 医学のための細胞生物学、315ページ2009

    • Author(s)
      永田和宏, 塩田浩平, 編
    • Publisher
      南山堂
    • Related Report
      2009 Self-evaluation Report
  • [Book] 医学のための細胞生物学2009

    • Author(s)
      永田和宏、塩田浩平(編)
    • Total Pages
      315
    • Publisher
      南由堂
    • Related Report
      2009 Annual Research Report
  • [Book] ルーイン細胞生物学、681ページ2008

    • Author(s)
      永田和宏, 中野明彦, 米田悦啓, 須藤和夫, 室伏擴, 榎森康文, 伊藤維昭, 訳
    • Publisher
      東京化学同人
    • Related Report
      2009 Self-evaluation Report
  • [Book] ルーイン細胞生物学2008

    • Author(s)
      永田和宏, 他(訳)
    • Total Pages
      681
    • Publisher
      東京化学同人
    • Related Report
      2008 Annual Research Report
  • [Book] 蛋白質核酸酵素増刊 キーワード:蛋白質の一生2008

    • Author(s)
      遠藤斗志也, 小椋光, 永田和宏, 森和俊, 田口英樹, 吉田賢右(編)
    • Total Pages
      1114
    • Publisher
      共立出版
    • Related Report
      2007 Annual Research Report
  • [Remarks]

    • URL

      http://www.cc.kyoto-su.ac.jp/~nagata/index-j.html

    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] 2-ヒドロキシベンズアルデヒド化合物、これを含有するコラーゲン細胞外分泌阻害剤及び医薬品組成物2012

    • Inventor(s)
      夏目徹、永田和宏、伊藤進也、土井隆行、吉田将人
    • Industrial Property Rights Holder
      夏目徹、永田和宏、伊藤進也、土井隆行、吉田将人
    • Industrial Property Number
      2012-163835
    • Filing Date
      2012-07-24
    • Related Report
      2011 Final Research Report
  • [Patent(Industrial Property Rights)] カルシウムポンプ制御物質のスクリーニング方法、メラニン色素合成阻害物質のスクリーニング方法、ベクター、並びに、細胞2012

    • Inventor(s)
      潮田亮、永田和宏
    • Industrial Property Rights Holder
      潮田亮、永田和宏
    • Industrial Property Number
      2012-176344
    • Filing Date
      2012-08-08
    • Related Report
      2011 Final Research Report

URL: 

Published: 2007-04-01   Modified: 2017-10-19  

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