| Budget Amount *help |
¥563,030,000 (Direct Cost: ¥433,100,000、Indirect Cost: ¥129,930,000)
Fiscal Year 2011: ¥109,460,000 (Direct Cost: ¥84,200,000、Indirect Cost: ¥25,260,000)
Fiscal Year 2010: ¥111,020,000 (Direct Cost: ¥85,400,000、Indirect Cost: ¥25,620,000)
Fiscal Year 2009: ¥110,630,000 (Direct Cost: ¥85,100,000、Indirect Cost: ¥25,530,000)
Fiscal Year 2008: ¥106,860,000 (Direct Cost: ¥82,200,000、Indirect Cost: ¥24,660,000)
Fiscal Year 2007: ¥125,060,000 (Direct Cost: ¥96,200,000、Indirect Cost: ¥28,860,000)
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| Research Abstract |
Sodium (Na) concentration and osmolality in body fluids are continuously monitored in the brain to maintain their physiological levels. The Na-level sensor is Nax channels that populate glial cells in the circumventricular organs. In this study, we revealed that locally produced endothelin-3 enhances the Na sensitivity for the gating of Nax and the glial Nax activity controls neuronal activities involved in the salt aversion through lactate signaling, and that autoimmunity to Nax develops essential hypernatremia in humans. As for the osmosensor, we demonstrated that the full-length form of TRPV1 is sensitive to an osmotic increase exclusively at around body temperature
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