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Study of Objective Methods for Evaluating and Supporting Attachiment Disorders

Research Project

Project/Area Number 19H00617
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 9:Education and related fields
Research InstitutionUniversity of Fukui

Principal Investigator

Tomoda Akemi  福井大学, 子どものこころの発達研究センター, 教授 (80244135)

Co-Investigator(Kenkyū-buntansha) 水野 賀史  福井大学, 子どものこころの発達研究センター, 准教授 (50756814)
藤澤 隆史  福井大学, 子どものこころの発達研究センター, 准教授 (90434894)
島田 浩二  福井大学, 子どものこころの発達研究センター, 助教 (00711128)
牧田 快  福井大学, 子どものこころの発達研究センター, 特命助教 (10726607)
滝口 慎一郎  福井大学, 学術研究院医学系部門(附属病院部), 特命助教 (70382926)
松崎 秀夫  福井大学, 子どものこころの発達研究センター, 教授 (00334970)
Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥42,900,000 (Direct Cost: ¥33,000,000、Indirect Cost: ¥9,900,000)
Fiscal Year 2022: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2021: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2020: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2019: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Keywords愛着障害 / アタッチメント / マルトリートメント / 脳MR画像 / エピゲノム / オキシトシン点鼻 / 子ども虐待 / 養育者支援 / アタッチメント障害 / マルトリートメント(虐待) / 脳MR画像解析 / エピゲノム研究 / RMET課題 / 表情認知 / 脳MR画像 / 感受性期 / 脳画像解析 / エピゲノム解析 / トラウマ関連障害 / 中間表現型 / マルトリートメント(不適切な養育) / 拡散テンソル画像 / オキシトシン / マルトリートメント(不適切な養育) / 視線計測評価 / ADHD
Outline of Research at the Start

子どもの愛着障害リスク因子である不適切養育(虐待・ネグレクト)は、危機状況にある子育て困難な親子・家族を見極めるための目安として重要である。近年、少子化・核家族化やコミュニティ崩壊に経済不況等の世相が加わっての生き辛さの現れとして語られており、特別な家族の問題ではなく、どの家庭にも起こりうるものとして捉えられるようになった。愛着障害リスクに関する客観的指標の創生を目指す本研究は、保育や学校現場での同障害児に対する早期発達支援につながり、今後の教育学(子ども学)領域の発展に寄与するものである。

Outline of Final Research Achievements

A brain imaging study conducted on children who developed Reactive Attachment Disorder as a result of abuse or other inappropriate nurturing "maltreatment" revealed the effects of intranasal oxytocin administration on neural reward processing for the first time in the world. The findings were published in Front Child Adolesc Psychiatry. The study contributed to the elucidation of the pathophysiology of this disorder and to the development of clinical applications, including the development of therapeutic drugs based on the pathophysiological characteristics of the disorder. We are promoting brain imaging genetics research by accumulating new genome data and combining them with brain imaging data. As an existing resource for biological samples and data on rare diseases, we have registered genetic data in the CIN registry and released them to the public database (AMAZE).

Academic Significance and Societal Importance of the Research Achievements

子どもの愛着障害リスク因子であるマルトリートメントは、危機状況にある子育て困難な親子・家族を見極めるための目安として重要である。近年、少子化・核家族化やコミュニティ崩壊に経済不況等の世相が加わり、特別な家族の問題ではなく、どの家庭にも起こりうるものとして捉えられるようになった。生物学的エビデンスを有する新規診断・個別化支援法の研究開発を目指した本研究は、保育や学校現場での同障害児に対する早期発達支援につながり、今後の教育学(子ども学)領域の発展に寄与するものである。更に、これまでにない世界初となるデータベースの開発を通じ、“画像医学研究分野の成果を、未開の研究分野へと展開する”ことに貢献した。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Comments on the Screening Results   Annual Research Report
  • Research Products

    (99 results)

All 2023 2022 2021 2020 2019 Other

All Int'l Joint Research (2 results) Journal Article (76 results) (of which Int'l Joint Research: 15 results,  Peer Reviewed: 43 results,  Open Access: 61 results) Presentation (4 results) (of which Int'l Joint Research: 1 results,  Invited: 2 results) Book (13 results) Remarks (1 results) Patent(Industrial Property Rights) (3 results)

  • [Int'l Joint Research] ハーバード大学精神神経科学教室/エモリー大学医学部/スタンフォード大学医学部(米国)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] コロンビア大学(コロンビア)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Impact of stable environments on maltreated children2023

    • Author(s)
      Koizumi Michiko、Tomoda Akemi、Takiguchi Shinichiro、Kosaka Hirotaka
    • Journal Title

      Pediatrics International

      Volume: 65 Issue: 1

    • DOI

      10.1111/ped.15443

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of intranasal oxytocin on neural reward processing in children and adolescents with reactive attachment disorder: A randomized controlled trial2023

    • Author(s)
      Takiguchi Shinichiro、Makita Kai、Fujisawa Takashi X.、Nishitani Shota、Tomoda Akemi
    • Journal Title

      Frontiers in Child and Adolescent Psychiatry

      Volume: 1 Pages: 1-16

    • DOI

      10.3389/frcha.2022.1056115

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of prenatal cannabis exposure on developmental trajectory of cognitive ability and brain volumes in the adolescent brain cognitive development (ABCD) study2023

    • Author(s)
      Hiraoka Daiki、Makita Kai、Hamatani Sayo、Tomoda Akemi、Mizuno Yoshifumi
    • Journal Title

      Developmental Cognitive Neuroscience

      Volume: 60 Pages: 101209-101209

    • DOI

      10.1016/j.dcn.2023.101209

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cross-tissue correlations of genome-wide DNA methylation in Japanese live human brain and blood, saliva, and buccal epithelial tissues.2023

    • Author(s)
      Nishitani S, Isozaki M, Yao A, Higashino Y, Yamauchi T, Kidoguchi M, Kawajiri S, Tsunetoshi K, Neish H, Imoto H, Arishima H, Kodera T, Fujisawa TX, Nomura S, Kikuta K, Shinozaki G, Tomoda A.
    • Journal Title

      Transl Psychiatry

      Volume: 13 Issue: 1 Pages: 72-72

    • DOI

      10.1038/s41398-023-02370-0

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Methylphenidate Enhances Spontaneous Fluctuations in Reward and Cognitive Control Networks in Children With Attention-Deficit/Hyperactivity Disorder2023

    • Author(s)
      Mizuno Yoshifumi、Cai Weidong、Supekar Kaustubh、Makita Kai、Takiguchi Shinichiro、Silk Timothy J.、Tomoda Akemi、Menon Vinod
    • Journal Title

      Biological Psychiatry: Cognitive Neuroscience and Neuroimaging

      Volume: 8 Issue: 3 Pages: 271-280

    • DOI

      10.1016/j.bpsc.2022.10.001

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Neural and behavioral effects of parent training on emotion recognition in mothers rearing children with attention-deficit/hyperactivity disorder2023

    • Author(s)
      Makita Kai、Yao Akiko、Shimada Koji、Kasaba Ryoko、Fujisawa Takashi X.、Mizuno Yoshifumi、Tomoda Akemi
    • Journal Title

      Brain Imaging and Behavior

      Volume: - Issue: 4 Pages: 436-449

    • DOI

      10.1007/s11682-023-00771-9

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Triadic therapy based on somatic eye movement desensitization and reprocessing for posttraumatic stress disorder: A pilot randomized controlled study.2023

    • Author(s)
      Wakusawa K*, Sugiyama T, Hotta H, Wada K, Suzuki F, Morimoto T, Shiino T, Tomoda A.
    • Journal Title

      J. EMDR Pract. Res

      Volume: -

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The effectiveness and cost-effectiveness of Well Parent Japan for Japanese mothers of children with ADHD: Protocol for a randomized controlled trial2022

    • Author(s)
      Shizuka Shimabukuro, David Daley, Takahiro Endo, Satoshi Harada, Akemi Tomoda, Yushiro Yamashita, Takashi Oshio, et al.
    • Journal Title

      JMIR Research Protocols

      Volume: 11 Issue: 4 Pages: e32693-e32693

    • DOI

      10.2196/32693

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Beneficial Effects of Behavioral Parent Training on Inhibitory Control in Children With Attention-Deficit/Hyperactivity Disorder: A Small-Scale Randomized Controlled Trial2022

    • Author(s)
      Yao Akiko、Shimada Koji、Kasaba Ryoko、Tomoda Akemi
    • Journal Title

      Frontiers in Psychiatry

      Volume: 13 Pages: 1-10

    • DOI

      10.3389/fpsyt.2022.859249

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Methylphenidate remediates aberrant brain network dynamics in children with attention‐deficit/hyperactivity disorder: A randomized controlled trial2022

    • Author(s)
      Mizuno Yoshifumi、Cai Weidong、Supekar Kaustubh、Makita Kai、Takiguchi Shinichiro、Tomoda Akemi、Menon Vinod
    • Journal Title

      NeuroImage

      Volume: 257 Pages: 119332-119332

    • DOI

      10.1016/j.neuroimage.2022.119332

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Longitudinal impact of COVID-19 pandemic on mental health of children in the ABCD study cohort2022

    • Author(s)
      Hamatani Sayo、Hiraoka Daiki、Makita Kai、Tomoda Akemi、Mizuno Yoshifumi
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 19601-19601

    • DOI

      10.1038/s41598-022-22694-z

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 小児腎移植に関連するPTSDに対してEMDRか奏功した症例2022

    • Author(s)
      篠崎志美, 友田明美
    • Journal Title

      EMDR研究

      Volume: 14(1) Pages: 66-75

    • Related Report
      2022 Annual Research Report
    • Open Access
  • [Journal Article] 新たな簡易型トラウマ処理フロトコールによる複雑性患者へのランタム化比較試験による治療研究2022

    • Author(s)
      杉山登志郎, 堀田 洋, 涌澤圭介, 和田浩平, 鈴木 太, 森本武志, 椎野智子, 友田明美
    • Journal Title

      EMDR研究

      Volume: 14(1) Pages: 56-65

    • Related Report
      2022 Annual Research Report
    • Open Access
  • [Journal Article] TSプロトコールによる複雑性PTSD患者へのRCTによる治療研究2022

    • Author(s)
      杉山登志郎, 堀田 洋, 涌澤圭介, 和田浩平, 鈴木 太, 森本武志, 椎野智子, 友田明美
    • Journal Title

      明治安田こころの健康財団研究助成論文集

      Volume: 56 Pages: 38-48

    • Related Report
      2022 Annual Research Report
    • Open Access
  • [Journal Article] コロナ禍における神経発達症児の養育者支援について2022

    • Author(s)
      松村菜々子, 伊達岡五月, Kawata NYS, 友田明美
    • Journal Title

      外来小児科

      Volume: 25(4) Pages: 480-485

    • Related Report
      2022 Annual Research Report
    • Open Access
  • [Journal Article] Association of Epigenetic Differences Screened in a Few Cases of Monozygotic Twins Discordant for Attention-Deficit Hyperactivity Disorder With Brain Structures2022

    • Author(s)
      Fujisawa Takashi X.、Nishitani Shota、Makita Kai、Yao Akiko、Takiguchi Shinichiro、Hamamura Shoko、Shimada Koji、Okazawa Hidehiko、Matsuzaki Hideo、Tomoda Akemi
    • Journal Title

      Frontiers in Neuroscience

      Volume: 15 Pages: 1-12

    • DOI

      10.3389/fnins.2021.799761

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The effects of epigenetic age and its acceleration on surface area, cortical thickness and volume in young adults.2022

    • Author(s)
      Cheong Y, Nishitani S, Yu J, Habata K, Kamiya T, Shiotsu D, Omori IM, Okazawa H, Tomoda A, Kosaka H, Jung M.
    • Journal Title

      Cereb Corte

      Volume: in press Issue: 24 Pages: 043-043

    • DOI

      10.1093/cercor/bhac043

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Epigenetic Clock Deceleration and Maternal Reproductive Efforts: Associations With Increasing Gray Matter Volume of the Precuneus.2022

    • Author(s)
      Nishitani S, Kasaba R, Hiraoka D, Shimada K, Fujisawa TX, Okazawa H, Tomoda A.
    • Journal Title

      Front Genet.

      Volume: 12 Pages: 803584-803584

    • DOI

      10.3389/fgene.2022.803584

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Guided internet-based cognitive behavioral therapy for obsessive-compulsive disorder: A multicenter randomized controlled trial in Japan2022

    • Author(s)
      Matsumoto Kazuki、Hamatani Sayo、Makino Takuya、Takahashi Jumpei、Suzuki Futoshi、Ida Tomoko、Hamamura Shoko、Takiguchi Shinichiro、Tomoda Akemi、Omori Ichiro M.、Kosaka Hirotaka、Shinno Seina、Ikai Tomoki、Hayashi Hiroyuki、Katayama Hiroto、Shiko Yuki、Ozawa Yoshihito、Kawasaki Yohei、Sutoh Chihiro、Shimizu Eiji
    • Journal Title

      Internet Interventions

      Volume: 28 Pages: 100515-100515

    • DOI

      10.1016/j.invent.2022.100515

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of attentional networks during childhood and adolescence: A functional MRI study2022

    • Author(s)
      Saito DN, Fujisawa TX, Yanaka HT, Fujii T, Kochiyama T, Makita K, Tomoda A, Okazawa H.
    • Journal Title

      Neuropsychopharmacol Rep.

      Volume: N/A Issue: 2 Pages: 191-198

    • DOI

      10.1002/npr2.12246

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The influence of intelligence and cognitive abilities on the reading ability of Japanese students with developmental disorders2022

    • Author(s)
      Yamaguchi Daisuke、Hiratani Michio、Matsuura Naomi、Fujisawa Takashi X.、Takiguchi Shinichiro、Fujioka Toru、Kono Toshihiro、Ishizaka Ikuyo、Tomoda Akemi
    • Journal Title

      Brain and Development

      Volume: 44 Issue: 6 Pages: 361-371

    • DOI

      10.1016/j.braindev.2022.02.006

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Aripiprazole in the real-world treatment for irritability associated with autism spectrum disorder in children and adolescents in Japan: 52-week post-marketing surveillance2021

    • Author(s)
      Sugimoto Yuna、Yamamura Kayo、Takayama Tomoyo、Fukuta Yasuhiko、Aoki Kazuo、Mikami Katsunaka、Tomoda Akemi
    • Journal Title

      BMC Psychiatry

      Volume: 21 Issue: 1

    • DOI

      10.1186/s12888-021-03201-6

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A multi-modal MRI analysis of brain structure and function in relation to OXT methylation in maltreated children and adolescents2021

    • Author(s)
      Nishitani S, Fujisawa TX, Hiraoka D, Makita K, Takiguchi S, Hamamura S, Yao A, Shimada K, Smith A, Tomoda A*
    • Journal Title

      Transl Psychiatry

      Volume: 11 Pages: 589-589

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influence of the COVID-19 Pandemic on Parenting Stress Across Asian Countries: A Cross-National Study.2021

    • Author(s)
      Kurata S, Hiraoka D, Ahmad Adlan AS, Jayanath S, Hamzah N, Ahmad-Fauzi A, Fujisawa TX, Nishitani S, Tomoda A.
    • Journal Title

      Front Psychol.

      Volume: 12 Pages: 782298-782298

    • DOI

      10.3389/fpsyg.2021.782298

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Shared neural basis for the exposure to child maltreatment and eating disorders2021

    • Author(s)
      Tomoda Akemi、Fujisawa Takashi X.
    • Journal Title

      Academia Letters

      Volume: -

    • DOI

      10.20935/al4108

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 子どもに「早く!」と言ってはいけないのはなぜ?2021

    • Author(s)
      友田明美
    • Journal Title

      PHPのびのび子育て

      Volume: 415 Pages: 50-55

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 養育ストレスの脳内機構2021

    • Author(s)
      藤澤隆史, 島田浩二, 友田明美.
    • Journal Title

      月刊臨床神経科学

      Volume: 95 Pages: 762-765

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 子ども虐待と脳科学-マルトリートメントによる脳への影響と回復へのアプローチ-2021

    • Author(s)
      友田明美
    • Journal Title

      女性心身医学

      Volume: 26(1) Pages: 49-50

    • Related Report
      2021 Annual Research Report
  • [Journal Article] アタッチメント障害に関する脳科学の関連から2021

    • Author(s)
      友田明美
    • Journal Title

      心理学ワールド

      Volume: 95 Pages: 9-12

    • Related Report
      2021 Annual Research Report
  • [Journal Article] マルトリーメントが子どもの脳の発達に与える影響について2021

    • Author(s)
      友田明美
    • Journal Title

      CAPニューズ

      Volume: 119 Pages: 1-5

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 過度なメディア視聴も含めたマルトリートメント(避けたい子育て)2021

    • Author(s)
      友田明美
    • Journal Title

      Growth Ring

      Volume: -

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 『マルトリ予防』と『とも育て』の重要性ー子どもの脳を傷つけないために2021

    • Author(s)
      友田明美
    • Journal Title

      保育通信

      Volume: 796

    • Related Report
      2021 Annual Research Report
  • [Journal Article] めをみてはなしをきいて2021

    • Author(s)
      友田明美
    • Journal Title

      ほけんニュース

      Volume: 453

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 脳科学の知見を生かし虐待防止 地域ぐるみで「とも育て」に挑む2021

    • Author(s)
      友田明美
    • Journal Title

      JUT News

      Volume: - Pages: 8-11

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 虐待と脳、回復へのアプローチ2021

    • Author(s)
      牧野拓也, 友田明美
    • Journal Title

      精神科

      Volume: 39(5) Pages: 565-571

    • Related Report
      2021 Annual Research Report
  • [Journal Article] COVID-19 流行下の生活と子どものこころー小児・思春期のうつ・気分障害を考えるー2021

    • Author(s)
      友田明美
    • Journal Title

      PROGRESS IN MEDICINE 2021

      Volume: 41(10) Pages: 7-8

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 脳科学から見たマルトリートメント(児童虐待)2021

    • Author(s)
      友田明美
    • Journal Title

      指導と評価

      Volume: 68(806) Pages: 36-38

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 神経生物学的観点からみたマルトリートメントに起因するアタッチメント障害2021

    • Author(s)
      友田明美
    • Journal Title

      日本乳幼児精神保健学会誌,

      Volume: 14 Pages: 26-31

    • Related Report
      2021 Annual Research Report
  • [Journal Article] ヒト親性の脳機能と機能不全への介入2021

    • Author(s)
      藤澤隆史, 島田浩二, 友田明美
    • Journal Title

      発達心理学研究

      Volume: 32(4)

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 孤立とストレスは親の脳に何を引き起こす?2021

    • Author(s)
      友田明美
    • Journal Title

      季刊 ビィ

      Volume: 38(1) Pages: 46-53

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Low threshold to Vestibular and Oral Sensory stimuli might affect quality of sleep among children with autism spectrum disorder2021

    • Author(s)
      Kosaka Takuya、Kawatani Masao、Ohta Genrei、Mizuno Yoshifumi、Takiguchi Shinichiro、Kumano Asami、Hayashi Hisako、Fujine Akio、Tsuda Akemi、Fujisawa Takashi X.、Tomoda Akemi、Ohshima Yusei
    • Journal Title

      Brain and Development

      Volume: 43 Issue: 1 Pages: 55-62

    • DOI

      10.1016/j.braindev.2020.07.010

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Epigenetic modification of the oxytocin gene is associated with gray matter volume and trait empathy in mothers2021

    • Author(s)
      Hiraoka D, Nishitani S, Shimada K, Kasaba R, Fujisawa TX, Tomoda A.
    • Journal Title

      Psychoneuroendocrinology.

      Volume: 123 Pages: 105026-105026

    • DOI

      10.1016/j.psyneuen.2020.105026

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Altered epigenetic clock in children exposed to maltreatment.2021

    • Author(s)
      Nishitani S, Suzuki S, Ochiai K, Yao A, Fujioka T, Fujisawa TX, Tomoda A.
    • Journal Title

      Psychiatry Clin Neurosci.

      Volume: 75 Issue: 3 Pages: 110-112

    • DOI

      10.1111/pcn.13183

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neural Mechanisms of Parental Communicative Adjustments in Spoken Language2021

    • Author(s)
      Kasaba Ryoko、Shimada Koji、Tomoda Akemi
    • Journal Title

      Neuroscience

      Volume: 457 Pages: 206-217

    • DOI

      10.1016/j.neuroscience.2020.12.002

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mismatch negativity of preschool children at risk of developing mental health problems2021

    • Author(s)
      Aoi T, Fujisawa TX, Nishitani S, Tomoda A.
    • Journal Title

      Neuropsychopharmacol Rep.

      Volume: - Issue: 2 Pages: 1-7

    • DOI

      10.1002/npr2.12168

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Sleep and the General Behavior of Infants and Parents during the Closure of Schools as a Result of the COVID-19 Pandemic: Comparison with 2019 Data2021

    • Author(s)
      Shinomiya Yasuaki、Yoshizaki Arika、Murata Emi、Fujisawa Takashi、Taniike Masako、Mohri Ikuko
    • Journal Title

      Children

      Volume: 8 Issue: 2 Pages: 168-168

    • DOI

      10.3390/children8020168

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] マルトリートメントの理解に関する研修効果の検討2021

    • Author(s)
      椎野智子, 榊原信子, 友田明美
    • Journal Title

      小児の精神と神経

      Volume: 60(4) Pages: 337-343

    • Related Report
      2020 Annual Research Report
    • Open Access
  • [Journal Article] 子どものマルトリートメントに関する最近の神経性物学的知見2021

    • Author(s)
      友田明美
    • Journal Title

      精神科治療学

      Volume: 36(1) Pages: 11-15

    • Related Report
      2020 Annual Research Report
    • Open Access
  • [Journal Article] Developmental changes in attention to social information from childhood to adolescence in autism spectrum disorders: a comparative study.2020

    • Author(s)
      Fujioka T, Tsuchiya KJ, Saito M, Hirano Y, Matsuo M, Kikuchi M, Maegaki Y, Choi D, Kato S, Yoshida T, Yoshimura Y, Ooba S, Mizuno Y, Takiguchi S, Matsuzaki H, Tomoda A, Shudo K, Ninomiya M, Katayama T, Kosaka H.
    • Journal Title

      Molecular Autism

      Volume: 11 Issue: 1 Pages: 24-24

    • DOI

      10.1186/s13229-020-00321-w

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Development of Social Attention and Oxytocin Levels in Maltreated Children2020

    • Author(s)
      Suzuki S, Fujisawa TX, Sakakibara N, Fujioka T, Takiguchi S, Tomoda A.
    • Journal Title

      Sci Rep.

      Volume: 10 Issue: 1 Pages: 7407-7407

    • DOI

      10.1038/s41598-020-64297-6

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Attenuated relationship between salivary oxytocin levels and attention to social information in adolescents and adults with autism spectrum disorder: a comparative study2020

    • Author(s)
      Fujioka T, Fujisawa TX, Inohara K, Okamoto Y, Matsumura Y, Tsuchiya KJ, Katayama T, Munesue T, Tomoda A, Wada Y, Kosaka H.
    • Journal Title

      Ann Gen Psychiatry.

      Volume: 19 Issue: 1 Pages: 38-38

    • DOI

      10.1186/s12991-020-00287-2

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] White matter changes in children and adolescents with reactive attachment disorder: A diffusion tensor imaging study2020

    • Author(s)
      Makita K, Takiguchi S, Naruse H, Shimada K, Morioka S, Fujisawa TX, Shimoji K, Tomoda A.
    • Journal Title

      Psychiatry Res Neuroimaging.

      Volume: 303 Pages: 111129-111129

    • DOI

      10.1016/j.pscychresns.2020.111129

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Relationship between parenting stress and school closures due to the COVID ‐19 pandemic2020

    • Author(s)
      Hiraoka Daiki、Tomoda Akemi
    • Journal Title

      Psychiatry and Clinical Neurosciences

      Volume: 74 Issue: 9 Pages: 497-498

    • DOI

      10.1111/pcn.13088

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An investigation of the effect of social reciprocity, social anxiety, and letter fluency on communicative behaviors in adults with autism spectrum disorder2020

    • Author(s)
      Kimura Y, Fujioka T, Jung M, Fujisawa TX, Tomoda A, Kosaka H.
    • Journal Title

      Psychiatry Res.

      Volume: 294 Pages: 113503-113503

    • DOI

      10.1016/j.psychres.2020.113503

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Using the drug repositioning approach to develop a novel therapy, tipepidine hibenzate sustained-release tablet (TS-141), for children and adolescents with attention-deficit/hyperactivity disorder2020

    • Author(s)
      Saito Takuya、Yamashita Yushiro、Tomoda Akemi、Okada Takashi、Umeuchi Hideo、Iwamori Saki、Shinoda Satoru、Mizuno-Yasuhira Akiko、Urano Hidetoshi、Nishino Izumi、Saito Kazuhiko
    • Journal Title

      BMC Psychiatry

      Volume: 20 Issue: 1 Pages: 530-530

    • DOI

      10.1186/s12888-020-02932-2

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intrinsic brain activity associated with eye gaze during mother-child interaction2020

    • Author(s)
      Kuboshita R, Fujisawa TX, Makita K, Kasaba R, Okazawa H, Tomoda A.
    • Journal Title

      Sci Rep.

      Volume: 10 Issue: 1 Pages: 18903-18903

    • DOI

      10.1038/s41598-020-76044-y

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] インターネット・スマホが子どものこころと脳に及ぼす影響2020

    • Author(s)
      椎野智子, 友田明美.
    • Journal Title

      こころの科学

      Volume: 211 Pages: 26-29

    • Related Report
      2020 Annual Research Report
    • Open Access
  • [Journal Article] 医療最前線 子ども虐待(マルトリートメント)は脳にどのようなダメージを与えるのか-虐待の脳科学から視えてきた「とも育て」の重要性-2020

    • Author(s)
      友田明美
    • Journal Title

      手話通訳 問題研究

      Volume: 152 Pages: 56-57

    • Related Report
      2020 Annual Research Report
    • Open Access
  • [Journal Article] 子ども虐待と脳科学2020

    • Author(s)
      友田明美
    • Journal Title

      小児科

      Volume: 61(6) Pages: 871-877

    • NAID

      10029413836

    • Related Report
      2020 Annual Research Report
    • Open Access
  • [Journal Article] ADHD児の母親に対するペアレント・トレーニングの効果が子どもの実行機能改善の及ぼす影響の予備的検討2020

    • Author(s)
      矢尾明子, 島田浩二, 笠羽涼子, 牧田 快, 友田明美
    • Journal Title

      発達研究

      Volume: 34 Pages: 137-146

    • Related Report
      2020 Annual Research Report
    • Open Access
  • [Journal Article] 子どもの健やかな育ちのためのマルトリートメント予防と養育者支援2020

    • Author(s)
      友田明美
    • Journal Title

      小児の精神と神経

      Volume: 60(2) Pages: 111-115

    • NAID

      130007867875

    • Related Report
      2020 Annual Research Report
    • Open Access
  • [Journal Article] マルトリートメント予防モデル 大阪の取り組み2020

    • Author(s)
      友田明美
    • Journal Title

      地域保健

      Volume: 51(4) Pages: 32-35

    • Related Report
      2020 Annual Research Report
    • Open Access
  • [Journal Article] マルトリートメント(子ども虐待)は脳にどのようなダメージを与えるのか-子ども虐待の脳科学から視えてきた「とも育て」の重要性-2020

    • Author(s)
      友田明美
    • Journal Title

      幼児教育じほう

      Volume: 48(6) Pages: 12-18

    • Related Report
      2020 Annual Research Report
    • Open Access
  • [Journal Article] 虐待などのマルトリーメントが子どもに与えるダメージ2020

    • Author(s)
      友田明美
    • Journal Title

      臨床心理学

      Volume: 20(5) Pages: 530-534

    • Related Report
      2020 Annual Research Report
    • Open Access
  • [Journal Article] 「マルトリ予防」と「とも育て」の重要性.2020

    • Author(s)
      友田明美
    • Journal Title

      ほけんニュース(少年写真新聞社)

      Volume: 441 Pages: 1-4

    • Related Report
      2020 Annual Research Report
    • Open Access
  • [Journal Article] マルトリートメントによる子どもの脳の変化と親の支援2020

    • Author(s)
      友田明美
    • Journal Title

      月刊保団連(全国保険医団体連合会)

      Volume: 1333 Pages: 4-9

    • Related Report
      2020 Annual Research Report
    • Open Access
  • [Journal Article] 幼少期のマルトリートメントストレスが脳発達に与える影響-脳科学とエピゲノム科学からの知見-2020

    • Author(s)
      友田明美
    • Journal Title

      医学のあゆみ

      Volume: 275(9) Pages: 957-962

    • Related Report
      2020 Annual Research Report
    • Open Access
  • [Journal Article] 脳科学的な診断技術の進歩2020

    • Author(s)
      友田明美
    • Journal Title

      児童青年精神医学とその領域

      Volume: 61(3) Pages: 44-48

    • Related Report
      2020 Annual Research Report
    • Open Access
  • [Journal Article] Thalamic Volume Is Related to Increased Anterior Thalamic Radiations in Children with Reactive Attachment Disorder2020

    • Author(s)
      Jung Minyoung、Takiguchi Shinichiro、Hamamura Shoko、Mizuno Yoshifumi、Kosaka Hirotaka、Tomoda Akemi
    • Journal Title

      Cerebral Cortex

      Volume: - Issue: 7 Pages: 4238-4245

    • DOI

      10.1093/cercor/bhaa051

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 児童期逆境体験(ACE)が脳発達におよぼす影響と養育者支援への展望2020

    • Author(s)
      藤澤隆史, 島田浩二, 滝口慎一郎, 友田明美
    • Journal Title

      精神神経学雑誌

      Volume: 122 Pages: 135-143

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between parental visitation and depressive symptoms among institutionalized children in Japan: a cross-sectional study2019

    • Author(s)
      Yazawa A, Takada S, Suzuki H, Fujisawa TX, Tomoda A.
    • Journal Title

      BMC Psychiatry

      Volume: 19 Issue: 1 Pages: 129-129

    • DOI

      10.1186/s12888-019-2111-x

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oxytocin receptor DNA methylation and alterations of brain volumes in maltreated children2019

    • Author(s)
      Fujisawa Takashi X.、Nishitani Shota、Takiguchi Shinichiro、Shimada Koji、Smith Alicia K.、Tomoda Akemi
    • Journal Title

      Neuropsychopharmacology

      Volume: - Issue: 12 Pages: 2045-2053

    • DOI

      10.1038/s41386-019-0414-8

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Less efficient detection of positive facial expressions in parents at risk of engaging in child physical abuse2019

    • Author(s)
      Shimada Koji、Kasaba Ryoko、Yao Akiko、Tomoda Akemi
    • Journal Title

      BMC Psychology

      Volume: 7 Issue: 1 Pages: 56-56

    • DOI

      10.1186/s40359-019-0333-9

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Structural brain abnormalities in children and adolescents with comorbid autism spectrum disorder and attention-deficit/hyperactivity disorder2019

    • Author(s)
      Mizuno Y, Kagitani-Shimono K, Jung M, Makita K, Takiguchi S, Fujisawa TX, Tachibana M, Nakanishi M, Mohri I, Taniike M, Tomoda A.
    • Journal Title

      Transl Psychiatry.

      Volume: 9 Issue: 1 Pages: 332-332

    • DOI

      10.1038/s41398-019-0679-z

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 不適切な養育(マルトリートメント)と脳2019

    • Author(s)
      矢澤亜季, 滝口慎一郎, 友田明美
    • Journal Title

      チャイルドヘルス

      Volume: 22 Pages: 19-22

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 子どもの虐待防止対策は今のままでよいのか ~マルトリートメント防止を基軸とする対策への転換~2019

    • Author(s)
      笹井康典, 友田明美, 松岡太郎, 白井千香
    • Journal Title

      公衆衛生情報 8月号

      Volume: 83 Pages: 24-25

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 本音で語る海外留学の実際 with and without コロナ2021

    • Author(s)
      水野 賀史
    • Organizer
      日本小児神経学会北陸地方会夏季セミナー(第11回白山セミナー)
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Effects of methylphenidate on aberrant brain network dynamics in children with ADHD2021

    • Author(s)
      Yoshifumi Mizuno, Weidong Cai, Kaustubh Supekar, Kai Makita Shinichiro Takiguchi, Akemi Tomoda, Vinod Menon
    • Organizer
      Society of Biological Psychiatry 2021 Virtual Meeting
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of methylphenidate on aberrant brain network dynamics in children with ADHD2021

    • Author(s)
      Yoshifumi Mizuno, Weidong Cai, Kaustubh Supekar, Kai Makita Shinichiro Takiguchi, Akemi Tomoda, Vinod Menon
    • Organizer
      第63回日本小児神経学会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 神経発達症の脳画像研究 コロナ禍でのアメリカの学校や神経発達症診療状況と共に2021

    • Author(s)
      水野 賀史
    • Organizer
      第19回日本小児心身医学会東海北陸地方会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Book] 発達障がい―病態から支援まで―2022

    • Author(s)
      友田明美
    • Total Pages
      5
    • Publisher
      朝倉書店
    • Related Report
      2022 Annual Research Report
  • [Book] 市町村における児童虐待防止と支援のあり方2022

    • Author(s)
      友田明美
    • Total Pages
      5
    • Publisher
      岩崎学術出版社
    • Related Report
      2022 Annual Research Report
  • [Book] 今日の治療指針2022年(第19)版 ―私はこう治療している(福井次矢他編)2022

    • Author(s)
      友田明美
    • Total Pages
      1
    • Publisher
      医学書院
    • Related Report
      2021 Annual Research Report
  • [Book] 子どものこころと脳:発達のつまずきを支援する(青木省三, 福田正人編)2022

    • Author(s)
      友田明美
    • Total Pages
      11
    • Publisher
      日本評論社
    • Related Report
      2021 Annual Research Report
  • [Book] 児童虐待における公認心理師の活動 (日本公認心理師協会編)2021

    • Author(s)
      友田明美
    • Total Pages
      7
    • Publisher
      金剛出版
    • Related Report
      2021 Annual Research Report
  • [Book] 未成年期に父母の離婚を経験した子どもの養育に関する全国実態調査とその分析 (日本加除出版編)2021

    • Author(s)
      友田明美
    • Total Pages
      9
    • Publisher
      日本加除出版
    • Related Report
      2021 Annual Research Report
  • [Book] 今日の治療指針2021年版(福井次矢他 編)2021

    • Author(s)
      友田明美
    • Publisher
      医学書院
    • Related Report
      2020 Annual Research Report
  • [Book] 講座 精神疾患の臨床(神庭重信 編)2021

    • Author(s)
      濱村尚子, 友田明美
    • Total Pages
      8
    • Publisher
      中山書店
    • Related Report
      2020 Annual Research Report
  • [Book] 今日の問診表/診断辞典(斎藤昭彦 監修)2020

    • Author(s)
      友田明美
    • Total Pages
      4
    • Publisher
      Current Decision Support
    • Related Report
      2020 Annual Research Report
  • [Book] ベースボール・マガジン社2020

    • Author(s)
      友田明美
    • Total Pages
      12
    • Publisher
      部活動学(神谷 拓 監修)
    • Related Report
      2020 Annual Research Report
  • [Book] 今日の小児治療指針 第17版(水口 雅, 市橋 光 編)2020

    • Author(s)
      友田明美
    • Total Pages
      2
    • Publisher
      医学書院
    • Related Report
      2020 Annual Research Report
  • [Book] 実は危ない!その育児が子どもの脳を変形させる2019

    • Author(s)
      友田 明美
    • Total Pages
      160
    • Publisher
      PHP研究所
    • Related Report
      2019 Annual Research Report
  • [Book] 親の脳を癒やせば子どもの脳は変わる2019

    • Author(s)
      友田 明美
    • Total Pages
      202
    • Publisher
      NHK 出版
    • Related Report
      2019 Annual Research Report
  • [Remarks] https://researchmap.jp/read0172993

    • Related Report
      2020 Annual Research Report
  • [Patent(Industrial Property Rights)] マルトリ予防2020

    • Inventor(s)
      友田 明美
    • Industrial Property Rights Holder
      友田 明美
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Acquisition Date
      2020
    • Related Report
      2020 Annual Research Report
  • [Patent(Industrial Property Rights)] マルトリ予防士2020

    • Inventor(s)
      友田 明美
    • Industrial Property Rights Holder
      友田 明美
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Acquisition Date
      2020
    • Related Report
      2020 Annual Research Report
  • [Patent(Industrial Property Rights)] とも育て2020

    • Inventor(s)
      友田 明美
    • Industrial Property Rights Holder
      友田 明美
    • Industrial Property Rights Type
      特許
    • Filing Date
      2020
    • Acquisition Date
      2020
    • Related Report
      2020 Annual Research Report

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Published: 2019-04-18   Modified: 2024-01-30  

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