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Development of Comprehensive Analysis Method of Single-Molecule Chemical Reactions

Research Project

Project/Area Number 19H00852
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 28:Nano/micro science and related fields
Research InstitutionOsaka University

Principal Investigator

Taniguchi Masateru  大阪大学, 産業科学研究所, 教授 (40362628)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥44,460,000 (Direct Cost: ¥34,200,000、Indirect Cost: ¥10,260,000)
Fiscal Year 2021: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
Fiscal Year 2020: ¥13,780,000 (Direct Cost: ¥10,600,000、Indirect Cost: ¥3,180,000)
Fiscal Year 2019: ¥16,900,000 (Direct Cost: ¥13,000,000、Indirect Cost: ¥3,900,000)
Keywords1分子化学反応 / 1分子科学 / 1分子解析法 / 機械学習 / マルチフィジックス / 1分子化学反応 / 1分子科学 / 1分子解析法
Outline of Research at the Start

モル数程度の分子を扱うフラスコの化学では、少量しか生成されない分子を検出して調べる方法が無く、これらの分子は見逃されている。しかし、思いがけない分子の発見が、革新的な材料や薬を生み出し、社会を変革してきた。本研究では、少量しか生成されない分子を全て調べ上げる1分子化学反応の網羅的解析法を開発することで、1分子化学反応の学理を構築する。これにより、革新的な材料や薬を生み出す化学反応の新手法へと発展させる。

Outline of Final Research Achievements

In this study, we investigate the molecular species produced in single-molecule chemical reactions, occurring among single molecules in a solution. To precisely identify the reactants and products, a single molecule identification method was developed by combining measurements using quantum mechanical currents that read out the electronic state of a single molecule and machine learning. Using this identification method, we successfully identified multiple and target molecular species in solution and impurities, respectively, with high precision. Furthermore, quantitative analysis was demonstrated through the determination of the molecular species and existence ratio of the molecular species in solutions with two types of molecules that were mixed at different ratios. In addition, the existence of multiple intermolecular interactions was shown via the measurement of bimolecular aggregates.

Academic Significance and Societal Importance of the Research Achievements

予測しなかった分子が、世の中を変える材料になることがある。1分子化学反応で生じる分子種を調べることで、予測できない分子種を発見できる可能性がある。本研究では、事前予測できない革新的な機能を持つ分子種を効率的に探索する手法として、1分子の抵抗を電流で計測する1分子計測法と機械学習が融合した1分子識別法を開発した。本手法は、溶液中の1分子間の化学反応における反応物と生成物を調べることが可能である。フラスコの化学では生成率が低く見出せなかった分子種の発見は、新たな化学反応経路の発見が期待される。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Comments on the Screening Results   Annual Research Report
  • Research Products

    (63 results)

All 2022 2021 2020 2019 Other

All Int'l Joint Research (1 results) Journal Article (39 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 39 results,  Open Access: 16 results) Presentation (19 results) (of which Int'l Joint Research: 3 results,  Invited: 5 results) Book (2 results) Remarks (2 results)

  • [Int'l Joint Research] マサチューセッツ工科大学/ハーバードメディカルスクール(米国)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 3D designing of resist membrane pores via direct electron beam lithography2022

    • Author(s)
      Kishimoto Shohei、Leong Iat Wai、Murayama Sanae、Nakada Tomoko、Komoto Yuki、Tsutsui Makusu、Taniguchi Masateru
    • Journal Title

      Sensors and Actuators B: Chemical

      Volume: 357 Pages: 131380-131380

    • DOI

      10.1016/j.snb.2022.131380

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Length Discrimination of Homo-oligomeric Nucleic Acids with Single-molecule Measurement2021

    • Author(s)
      KOMOTO Yuki、OHSHIRO Takahito、TANIGUCHI Masateru
    • Journal Title

      Analytical Sciences

      Volume: 37 Issue: 3 Pages: 513-518

    • DOI

      10.2116/analsci.20SCP13

    • NAID

      130007996240

    • ISSN
      0910-6340, 1348-2246
    • Year and Date
      2021-03-10
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Salt Gradient Control of Translocation Dynamics in a Solid-State Nanopore2021

    • Author(s)
      Leong Iat Wai、Tsutsui Makusu、Yokota Kazumichi、Taniguchi Masateru
    • Journal Title

      Analytical Chemistry

      Volume: 93 Issue: 49 Pages: 16700-16708

    • DOI

      10.1021/acs.analchem.1c04342

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Single-molecule RNA sequencing for simultaneous detection of m6A and 5mC2021

    • Author(s)
      Ohshiro Takahito、Konno Masamitsu、Asai Ayumu、Komoto Yuki、Yamagata Akira、Doki Yuichiro、Eguchi Hidetoshi、Ofusa Ken、Taniguchi Masateru、Ishii Hideshi
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 19304-19304

    • DOI

      10.1038/s41598-021-98805-z

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Inertial focusing and zeta potential measurements of single-nanoparticles using octet-nanochannels2021

    • Author(s)
      Kishimoto Shohei、Tsutsui Makusu、Yokota Kazumichi、Taniguchi Masateru
    • Journal Title

      Lab on a Chip

      Volume: 21 Issue: 16 Pages: 3076-3085

    • DOI

      10.1039/d1lc00239b

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Direct Observation of Distinctive Electronic States of Ferrocene Moieties in Ferrocene-Bridged Trisporphyrin on Au(111) Using Scanning Tunneling Microscopy/Spectroscopy2021

    • Author(s)
      Tanaka Hiroyuki、Satake Akiharu、Taniguchi Masateru
    • Journal Title

      Langmuir

      Volume: 37 Issue: 21 Pages: 6468-6474

    • DOI

      10.1021/acs.langmuir.1c00602

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dielectric Coatings for Resistive Pulse Sensing Using Solid-State Pores2021

    • Author(s)
      Hayashida Tomoki、Tsutsui Makusu、Murayama Sanae、Nakada Tomoko、Taniguchi Masateru
    • Journal Title

      ACS Applied Materials & Interfaces

      Volume: 13 Issue: 8 Pages: 10632-10638

    • DOI

      10.1021/acsami.0c22548

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Development of Single-Molecule Electrical Identification Method for Cyclic Adenosine Monophosphate Signaling Pathway2021

    • Author(s)
      Komoto Yuki、Ohshiro Takahito、Taniguchi Masateru
    • Journal Title

      Nanomaterials

      Volume: 11 Issue: 3 Pages: 784-784

    • DOI

      10.3390/nano11030784

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Classification from Positive and Unlabeled Data Based on Likelihood Invariance for Measurement2021

    • Author(s)
      Takeshi Yoshida, Takashi Washio, Takahito Ohshiro, Masateru Taniguchi
    • Journal Title

      Intelligent Data Analysis

      Volume: 25 Issue: 1 Pages: 57-79

    • DOI

      10.3233/ida-194980

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Epitranscriptome Analysis Using Single-Molecule Quantum Sequencer2021

    • Author(s)
      Masateru Taniguchi
    • Journal Title

      Cancer science

      Volume: 112 Pages: 181-181

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Analysis Method of the Ion Current–Time Waveform Obtained from Low Aspect Ratio Solid-state Nanopores2020

    • Author(s)
      TANIGUCHI Masateru
    • Journal Title

      Analytical Sciences

      Volume: 36 Issue: 2 Pages: 161-175

    • DOI

      10.2116/analsci.19R009

    • NAID

      130007796148

    • ISSN
      0910-6340, 1348-2246
    • Year and Date
      2020-02-10
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] COVID-19 Drug Discovery Using Intensive Approaches2020

    • Author(s)
      Asai Ayumu、Konno Masamitsu、Ozaki Miyuki、Otsuka Chihiro、Vecchione Andrea、Arai Takahiro、Kitagawa Toru、Ofusa Ken、Yabumoto Masami、Hirotsu Takaaki、Taniguchi Masateru、Eguchi Hidetoshi、Doki Yuichiro、Ishii Hideshi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Issue: 8 Pages: 2839-2839

    • DOI

      10.3390/ijms21082839

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Thermally activated charge transport in carbon atom chains2020

    • Author(s)
      Liu Bo、Yokota Kazumichi、Komoto Yuki、Tsutsui Makusu、Taniguchi Masateru
    • Journal Title

      Nanoscale

      Volume: 12 Issue: 20 Pages: 11001-11007

    • DOI

      10.1039/d0nr01827a

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crucial Role of Out-of-Pore Resistance on Temporal Response of Ionic Current in Nanopore Sensors2020

    • Author(s)
      Kishimoto Shohei、Murayama Sanae、Tsutsui Makusu、Taniguchi Masateru
    • Journal Title

      ACS Sensors

      Volume: 5 Issue: 6 Pages: 1597-1603

    • DOI

      10.1021/acssensors.0c00014

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Finite-difference time-domain simulations of inverted cone-shaped plasmonic nanopore structures2020

    • Author(s)
      Matsuda Rintaro、Ryuzaki Sou、Okamoto Koichi、Arima Yusuke、Tsutsui Makusu、Taniguchi Masateru、Tamada Kaoru
    • Journal Title

      Journal of Applied Physics

      Volume: 127 Issue: 24 Pages: 243109-243109

    • DOI

      10.1063/5.0010418

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Immuno-Surgical Management of Pancreatic Cancer with Analysis of Cancer Exosomes2020

    • Author(s)
      Takeda Yu、Kobayashi Shogo、Kitakaze Masatoshi、Yamada Daisaku、Akita Hirofumi、Asai Ayumu、Konno Masamitsu、Arai Takahiro、Kitagawa Toru、Ofusa Ken、Yabumoto Masami、Hirotsu Takaaki、Vecchione Andrea、Taniguchi Masateru、Doki Yuichiro、Eguchi Hidetoshi、Ishii Hideshi
    • Journal Title

      Cells

      Volume: 9 Issue: 7 Pages: 1645-1645

    • DOI

      10.3390/cells9071645

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Time-resolved neurotransmitter detection in mouse brain tissue using an artificial intelligence-nanogap2020

    • Author(s)
      Komoto Yuki、Ohshiro Takahito、Yoshida Takeshi、Tarusawa Etsuko、Yagi Takeshi、Washio Takashi、Taniguchi Masateru
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 11244-11244

    • DOI

      10.1038/s41598-020-68236-3

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Electroosmosis-Driven Nanofluidic Diodes2020

    • Author(s)
      Leong Iat Wai、Tsutsui Makusu、Murayama Sanae、He Yuhui、Taniguchi Masateru
    • Journal Title

      The Journal of Physical Chemistry B

      Volume: 124 Issue: 32 Pages: 7086-7092

    • DOI

      10.1021/acs.jpcb.0c04677

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Dissecting Time-Evolved Conductance Behavior of Single Molecule Junctions by Nonparametric Machine Learning2020

    • Author(s)
      Liu Bo、Murayama Sanae、Komoto Yuki、Tsutsui Makusu、Taniguchi Masateru
    • Journal Title

      The Journal of Physical Chemistry Letters

      Volume: 11 Issue: 16 Pages: 6567-6572

    • DOI

      10.1021/acs.jpclett.0c01948

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The effect of a two-dimensional structure on the dielectric constant and photovoltaic characteristics2020

    • Author(s)
      K. Mishima, T. Sakai, K. Yokota, M. Taniguchi, Y. Aso, Y. Ie, K. Yamashita
    • Journal Title

      J. Photochem. Photobiol. A

      Volume: 401 Pages: 112756-112756

    • DOI

      10.1016/j.jphotochem.2020.112756

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pore Structures for High-Throughput Nanopore Devices2020

    • Author(s)
      Ryuzaki Sou、Matsuda Rintaro、Taniguchi Masateru
    • Journal Title

      Micromachines

      Volume: 11 Issue: 10 Pages: 893-893

    • DOI

      10.3390/mi11100893

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Key aurophilic motif for robust quantum-tunneling-based characterization of a nucleoside analogue marker2020

    • Author(s)
      Furuhata Takafumi、Komoto Yuki、Ohshiro Takahito、Taniguchi Masateru、Ueki Ryosuke、Sando Shinsuke
    • Journal Title

      Chemical Science

      Volume: 11 Issue: 37 Pages: 10135-10142

    • DOI

      10.1039/d0sc03946b

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Single-Molecule Counting of Nucleotide by Electrophoresis with Nanochannel-Integrated Nano-Gap Devices2020

    • Author(s)
      Ohshiro Takahito、Komoto Yuki、Taniguchi Masateru
    • Journal Title

      Micromachines

      Volume: 11 Issue: 11 Pages: 982-982

    • DOI

      10.3390/mi11110982

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Quasi-Stable Salt Gradient and Resistive Switching in Solid-State Nanopores2020

    • Author(s)
      Leong Iat Wai、Tsutsui Makusu、Murayama Sanae、Hayashida Tomoki、He Yuhui、Taniguchi Masateru
    • Journal Title

      ACS Applied Materials & Interfaces

      Volume: 12 Issue: 46 Pages: 52175-52181

    • DOI

      10.1021/acsami.0c15538

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Detection of an alcohol-associated cancer marker by single-molecule quantum sequencing2020

    • Author(s)
      Komoto Yuki、Ohshiro Takahito、Taniguchi Masateru
    • Journal Title

      Chemical Communications

      Volume: 56 Issue: 91 Pages: 14299-14302

    • DOI

      10.1039/d0cc05914e

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electronic and spin structures of CaMn4Ox clusters in the S0 state of the oxygen evolving complex of photosystem II. Domain-based local pair natural orbital (DLPNO) coupled-cluster (CC) calculations using optimized geometries and natural orbitals (UNO) by hybrid density functional theory (HDFT) calculations2020

    • Author(s)
      Miyagawa K.、Yamanaka S.、Isobe H.、Shoji M.、Kawakami T.、Taniguchi M.、Okumura M.、Yamaguchi K.
    • Journal Title

      Physical Chemistry Chemical Physics

      Volume: 22 Issue: 46 Pages: 27191-27205

    • DOI

      10.1039/d0cp04762g

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crucial Role of Out-of-Pore Resistance on Temporal Response of Ionic Current in Nanopore Sensors2020

    • Author(s)
      Shohei Kishimoto, Sanae Murayama, Makusu Tsutsui, Masateru Taniguchi
    • Journal Title

      ACS Sensors

      Volume: - Issue: 3 Pages: 748-755

    • DOI

      10.1021/acssensors.9b00113

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] “Chemical Labeling-Assisted Detection of Nucleobase Modifications by Quantum Tunneling-Based Single Molecule Sensing2020

    • Author(s)
      Furuhata, T; Ohshiro, T.; Izuhara, Y.; Tomoaki, S.; Ueki, R.; Taniguchi, M.; Sando, S.
    • Journal Title

      ChemBioChem

      Volume: 21 Issue: 3 Pages: 335-339

    • DOI

      10.1002/cbic.201900422

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Electric field interference and bimodal particle translocation in nano-integrated multipores2019

    • Author(s)
      Makusu Tsutsui, Kazumichi Yokota, Tomoko Nakada, Akihide Arima, Wataru Tonomura, Masateru Taniguchi, Takashi Washio, and Tomoji Kawai
    • Journal Title

      Nanoscale

      Volume: 11 Issue: 16 Pages: 7547-7553

    • DOI

      10.1039/c8nr08632j

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Silicon substrate effects on ionic current blockade in solid-state nanopores2019

    • Author(s)
      Makusu Tsutsui, Kazumichi Yokota, Tomoko Nakada, Akihide Arima, Wataru Tonomura, Masateru Taniguchi, Takashi Washio, and Tomoji Kawai
    • Journal Title

      Nanoscale

      Volume: 11 Issue: 10 Pages: 4190-4197

    • DOI

      10.1039/c8nr09042d

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Highly Conductive Nucleotide Analogue Facilitates Base-Calling in Quantum-Tunneling-Based DNA Sequencing2019

    • Author(s)
      Furuhata Takafumi、Ohshiro Takahito、Akimoto Gaku、Ueki Ryosuke、Taniguchi Masateru、Sando Shinsuke
    • Journal Title

      ACS Nano

      Volume: 13 Issue: 5 Pages: 5028-5035

    • DOI

      10.1021/acsnano.9b01250

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-throughput single-particle detections using a dual-height-channel-integrated pore2019

    • Author(s)
      Tonomura Wataru、Tsutsui Makusu、Arima Akihide、Yokota Kazumichi、Taniguchi Masateru、Washio Takashi、Kawai Tomoji
    • Journal Title

      Lab on a Chip

      Volume: 19 Issue: 8 Pages: 1352-1358

    • DOI

      10.1039/c8lc01371c

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Volume discrimination of nanoparticles via electrical trapping using nanopores2019

    • Author(s)
      Akihide Arima, Makusu Tsutsui, Masateru Taniguchi
    • Journal Title

      Journal of Nanobiotechnology

      Volume: 17:40 Issue: 1 Pages: 1-6

    • DOI

      10.1186/s12951-019-0471-5

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Direct Analysis of Incorporation of an Anticancer Drug into DNA at Single-Molecule Resolution2019

    • Author(s)
      Ohshiro Takahito、Komoto Yuuki、Konno Masamitsu、Koseki Jun、Asai Ayumu、Ishii Hideshi、Taniguchi Masateru
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 3886-3886

    • DOI

      10.1038/s41598-019-40504-x

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Paving the way to single-molecule chemistry through molecular electronics2019

    • Author(s)
      Taniguchi Masateru
    • Journal Title

      Physical Chemistry Chemical Physics

      Volume: 21 Issue: 19 Pages: 9641-9650

    • DOI

      10.1039/c9cp00264b

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] High-Precision Single-Molecule Identification Based on Single-Molecule Information within a Noisy Matrix2019

    • Author(s)
      Taniguchi Masateru、Ohshiro Takahito、Komoto Yuki、Takaai Takayuki、Yoshida Takeshi、Washio Takashi
    • Journal Title

      The Journal of Physical Chemistry C

      Volume: 123 Issue: 25 Pages: 15867-15873

    • DOI

      10.1021/acs.jpcc.9b03908

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Back-Side Polymer-Coated Solid-State Nanopore Sensors2019

    • Author(s)
      Leong Iat Wai、Tsutsui Makusu、Nakada Tomoko、Taniguchi Masateru、Washio Takashi、Kawai Tomoji
    • Journal Title

      ACS Omega

      Volume: 4 Issue: 7 Pages: 12561-12566

    • DOI

      10.1021/acsomega.9b00946

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Atomically flat palladium films grown on synthetic mica2019

    • Author(s)
      Tanaka Hiroyuki、Taniguchi Masateru
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 58 Issue: 12 Pages: 128004-128004

    • DOI

      10.7567/1347-4065/ab5471

    • NAID

      210000157503

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tailoring Dielectric Surface Charge via Atomic Layer Thickness2019

    • Author(s)
      Hayashida Tomoki、Yokota Kazumichi、Murayama Sanae、Arima Akihide、Tsutsui Makusu、Taniguchi Masateru
    • Journal Title

      ACS Applied Materials & Interfaces

      Volume: 12 Issue: 4 Pages: 5025-5030

    • DOI

      10.1021/acsami.9b18444

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] メチル化修飾マイクロRNA解析のための単分子検出法の開発2022

    • Author(s)
      大城 敬人、小本 祐貴、浅井 歩、今野 雅允、石井 秀始、谷口 正輝
    • Organizer
      日本化学会 第102春季年会(2022)
    • Related Report
      2021 Annual Research Report
  • [Presentation] Single-Molecule Classification based on Intermolecular Hydrogen Bond by Modified Nano-Gap2022

    • Author(s)
      JIHO RYU, Yuki Komoto, Takahito Ohshiro, Masateru Taniguchi
    • Organizer
      2022年 第69回 応用物理学会春季学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ナノギャップデバイスによる1分子検出法によるアミノ酸解析法の開発2022

    • Author(s)
      大城 敬人, 小本 祐貴, 谷口 正輝
    • Organizer
      2022年 第69回 応用物理学会春季学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] トリアザトリアンギュレン-アンカー基を有する分子ワイヤーの単分子伝導特性計測2022

    • Author(s)
      小本 祐貴, 横山 創一, 大城 敬人, 家 裕隆, 谷口 正輝
    • Organizer
      2022年 第69回 応用物理学会春季学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 単分子量子計測法による細胞中RNAの核酸アナログ分子解析2021

    • Author(s)
      大城 敬人、小本 祐貴、今野 雅允、浅井 歩、石井 秀治、谷口 正輝
    • Organizer
      第82回 応用物理学会秋季学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 固体ナノポアにおけるイオン濃度勾配を伴う1粒子ダイナミクス2021

    • Author(s)
      梁 逸偉1、筒井 真楠、谷口 正輝
    • Organizer
      第82回 応用物理学会秋季学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 生体ナノポアの識別機能を超える2021

    • Author(s)
      谷口 正輝
    • Organizer
      第82回 応用物理学会秋季学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] マイクロRNAエピトーク単分子検出法の開発2021

    • Author(s)
      大城敬人、今野雅允、浅井歩、小本祐貴、石井秀治、谷口正輝
    • Organizer
      第69回日本分析化学会 第69年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 単分子計測における接合破断時ナノギャップ電極間距離変化の定量的評価2021

    • Author(s)
      神田拓人、小本祐貴、筒井真楠、谷口正輝
    • Organizer
      日本化学会 第101春季年会(2021)
    • Related Report
      2020 Annual Research Report
  • [Presentation] コールターカウンターのダイナミクス2021

    • Author(s)
      岸本匠平、筒井真楠、谷口正輝
    • Organizer
      2021年 第68回 応用物理学会春季学術講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 第79回日本癌学会学術総会International Sessions2020

    • Author(s)
      谷口 正輝
    • Organizer
      SAKURA SUMMIT 桜サミット
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] AIナノポアを用いた細菌・ウイルス検査法2020

    • Author(s)
      谷口 正輝
    • Organizer
      アカデミア臨床開発Update~感染症―永遠の戦い~
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 大腸がんマイクロRNA修飾塩基のエピトーク単分子検出2020

    • Author(s)
      大城敬人、小本祐貴、今野雅允、浅井歩、石井秀治、谷口正輝
    • Organizer
      第81回応用物理学会秋季学術講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 固体ナノポアにおける非対称イオン輸送2020

    • Author(s)
      梁逸偉、筒井真楠、谷口正輝
    • Organizer
      第81回応用物理学会秋季学術講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Single-Molecule Science, DNA Sequencing, Nanotechnology2019

    • Author(s)
      Masateru Taniguchi
    • Organizer
      SAKURA SUMMIT 桜サミット
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Single-molecule Quantum Sequencer for Healthy Life Expectancy2019

    • Author(s)
      Masateru Taniguchi
    • Organizer
      EM-NANO2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 「AI と物質・デバイスの融合を目指すアライアンス共同研究」2019

    • Author(s)
      谷口 正輝
    • Organizer
      第9 回 物質・デバイス領域共同研究拠点活動報告会 平成30 年度 ダイナミック・アライアンス成果報告会  ~進化し続ける共同研空拠点組織~
    • Related Report
      2019 Annual Research Report
  • [Presentation] AIと物質・デバイスの融合を目指すアライアンス共同研究2019

    • Author(s)
      谷口 正輝
    • Organizer
      物質・デバイス領域共同研究拠点活動報告会 ダイナミック・アライアンス成果報告会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Artificial Intelligence-Nanopore for Infection Control2019

    • Author(s)
      Masateru Taniguchi
    • Organizer
      MATERIALS RESEARCH MEETING 2019 Materials Innovation for Sustainable Development Goals
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] 構造有機化学 基礎から物性へのアプローチまで2020

    • Author(s)
      谷口正輝
    • Total Pages
      302
    • Publisher
      東京化学同人
    • ISBN
      9784807909575
    • Related Report
      2019 Annual Research Report
  • [Book] Applications of Microfluidic Systems in Biology and Medicine2019

    • Author(s)
      Masateru Taniguchi, Takahito Ohshiro (Editor Manabu Tokeshi)
    • Total Pages
      382
    • Publisher
      Springer, Singapore
    • ISBN
      9789811362286
    • Related Report
      2019 Annual Research Report
  • [Remarks] TANIGUCHI LABORATORY

    • URL

      http://www.bionano.sanken.osaka-u.ac.jp/

    • Related Report
      2021 Annual Research Report
  • [Remarks] 研究室ホームページ

    • URL

      http://www.bionano.sanken.osaka-u.ac.jp/

    • Related Report
      2019 Annual Research Report

URL: 

Published: 2019-04-18   Modified: 2023-01-30  

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