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Investigations and control of functional nanocomplexes in tumor environment

Research Project

Project/Area Number 19H00857
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 28:Nano/micro science and related fields
Research InstitutionJapan Advanced Institute of Science and Technology

Principal Investigator

Miyako Eijiro  北陸先端科学技術大学院大学, 先端科学技術研究科, 准教授 (70443231)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥46,020,000 (Direct Cost: ¥35,400,000、Indirect Cost: ¥10,620,000)
Fiscal Year 2021: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
Fiscal Year 2020: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2019: ¥24,050,000 (Direct Cost: ¥18,500,000、Indirect Cost: ¥5,550,000)
Keywordsナノ粒子 / がん / ドラッグデリバリー / レーザー / ナノテクノロジー / ガン / ナノ材料 / ナノチューブ・フラーレン / ナノバイオ / 細胞・組織
Outline of Research at the Start

ガンは世界の死因のトップクラスである。本研究では、申請者が独自開発した機能性ナノ粒子を駆使し、マウス生体内腫瘍環境の高度制御技術を開発する。本研究は、ガンに対する新しい分子標的医薬や先進医療技術のための普遍的な技術となる。

Outline of Final Research Achievements

Due to their unique characteristics, gallium-based liquid metal (LM) nanoparticles have been applied in various research fields. LM nanoparticle surface-modification design is essential for enhancing the original LM properties and physicochemical multifunctionalization. Besides, standard cancer treatments are currently limited to surgery, radiation, and chemotherapy. Unfortunately, all three methods risk damage to normal tissues or incomplete eradication of the cancer. Development of LM-based nanomedicinal technology is challenging area for exploring new and innovative applications in the advanced cancer treatments. We have created a cancer optotheranostics using functional eutectic gallium-indium (EGaIn)-based LM nanoparticles that were successfully synthesized by various biomolecules (gelatin, DNA, lecithin, and bovine serum albumin), sonication, and quantum beam (γ-ray) radiation (Figure 1).

Academic Significance and Societal Importance of the Research Achievements

これらの成果は、本研究の最終目標に掲げた腫瘍血管内部観察用のナノ粒子として充分に機能を発現できると期待している。また、今回開発した生体高分子のナノ粒子コーティング技術が、革新的がん診断・治療法の基礎に成り得ることを示すだけでなく、ナノテクノロジー、光学、量子ビーム工学といった幅広い研究領域における材料設計の技術基盤として貢献することを十分期待させるものである。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Comments on the Screening Results   Annual Research Report
  • Research Products

    (15 results)

All 2022 2021 2020 2019

All Journal Article (12 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 12 results,  Open Access: 2 results) Presentation (2 results) (of which Invited: 2 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Sonication- and γ-ray-mediated biomolecule-liquid metal nanoparticlization in cancer optotheranostics2022

    • Author(s)
      Qi Yun, Atsushi Kimura, Mitsumasa Taguchi, Eijiro Miyako
    • Journal Title

      Applied Materials Today

      Volume: 26 Pages: 101302-101302

    • DOI

      10.1016/j.apmt.2021.101302

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nanoengineered Bifidobacterium bifidum with optical activity for photothermal cancer immunotheranostics2022

    • Author(s)
      Sheethal Reghu, Eijiro Miyako
    • Journal Title

      Nano Letters

      Volume: 22 Issue: 5 Pages: 1880-1888

    • DOI

      10.1021/acs.nanolett.1c04037

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Convergence of liquid metal biotechnologies for our health2021

    • Author(s)
      Eijiro Miyako
    • Journal Title

      Accounts of Materials Research

      Volume: 2 Issue: 10 Pages: 858-862

    • DOI

      10.1021/accountsmr.1c00126

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Optically activatable photosynthetic bacteria-based highly tumor specific immunotheranostics2021

    • Author(s)
      Xi Yang, Satoru Komatsu, Sheethal Reghu, Eijiro Miyako
    • Journal Title

      Nano Today

      Volume: 37 Pages: 101100-101100

    • DOI

      10.1016/j.nantod.2021.101100

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rational chemical multifunctionalization of graphene interface enhances targeting cancer therapy2020

    • Author(s)
      Matteo Andrea Lucherelli, Yue Yu, Giacomo Reina, Gonzalo Abellan, Eijiro Miyako, Alberto Bianco
    • Journal Title

      Angewandte Chemie International Edition

      Volume: - Issue: 33 Pages: 14034-14039

    • DOI

      10.1002/anie.201916112

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Design and control of bioinspired millibots2020

    • Author(s)
      Sheethal Reghu, Hui You, Kalaivani Seenivasan, Shun Nishimura, Toshiaki Taniike, Eijiro Miyako
    • Journal Title

      Advanced Intelligent Systems

      Volume: 2 Issue: 7 Pages: 2000059-2000059

    • DOI

      10.1002/aisy.202000059

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Soap bubble pollination2020

    • Author(s)
      Xi Yang, Eijiro Miyako
    • Journal Title

      iScience

      Volume: 23 Issue: 6 Pages: 101188-101188

    • DOI

      10.1016/j.isci.2020.101188

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Photothermogenetic inhibition of cancer stemness by near-infrared-light-activatable nanocomplexes2020

    • Author(s)
      Yue Yu, Xi Yang, Sheethal Reghu, Sunil C. Kaul, Renu Wadhwa, Eijiro Miyako
    • Journal Title

      Nature Communications

      Volume: 11 Issue: 1 Pages: 4117-4117

    • DOI

      10.1038/s41467-020-17768-3

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Amphipathic nanodiamond supraparticles for anticancer drug loading and delivery2019

    • Author(s)
      Yue Yu, Xi Yang, Ming Liu, Masahiro Nishikawa, Takahiro Tei, Eijiro Miyako
    • Journal Title

      ACS Applied Materials & Interfaces

      Volume: 11 Issue: 21 Pages: 18978-18987

    • DOI

      10.1021/acsami.9b04792

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Folic acid receptor-mediated targeting enhances the cytotoxicity, efficacy and selectivity of Withania somnifera leaf extract: In vitro and in vivo evidence2019

    • Author(s)
      Yue Yu, Jia Wang, Sunil Kaul, Renu Wadhwa, Eijiro Miyako
    • Journal Title

      Frontiers in Oncology

      Volume: 9 Pages: 602-602

    • DOI

      10.3389/fonc.2019.00602

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Multifunctional cancer phototherapy using fluorophore-functionalized nanodiamond supraparticles2019

    • Author(s)
      Yue Yu, Xi Yang, Ming Liu, Masahiro Nishikawa, Takahiro Tei, Eijiro Miyako
    • Journal Title

      ACS Applied Bio Materials

      Volume: 2 Issue: 8 Pages: 3693-3705

    • DOI

      10.1021/acsabm.9b00603

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anticancer drug delivery to cancer cells using alkyl amine-functionalized nanodiamond supraparticles2019

    • Author(s)
      Yue Yu, Xi Yang, Ming Liu, Masahiro Nishikawa, Takahiro Tei, Eijiro Miyako
    • Journal Title

      Nanoscale Advances

      Volume: 1 Issue: 9 Pages: 3406-3412

    • DOI

      10.1039/c9na00453j

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 光合成細菌の光機能を活用する癌診断・治療法の創出2022

    • Author(s)
      都英次郎
    • Organizer
      日本化学会 第102春季年会 (2022)
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Bio Symphonic System Using Functional Materials2021

    • Author(s)
      Eijiro Miyako
    • Organizer
      第11回ナノカーボンバイオシンポジウム
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Patent(Industrial Property Rights)] がんの治療薬又は診断薬2020

    • Inventor(s)
      都英次郎
    • Industrial Property Rights Holder
      国立大学法人北陸先端科学技術大学院大学
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2020-128089
    • Filing Date
      2020
    • Related Report
      2020 Annual Research Report

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Published: 2019-04-18   Modified: 2023-01-30  

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