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Tip-enhanced Nano-Raman measurement techniques for biological applications

Research Project

Project/Area Number 19H00870
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 30:Applied physics and engineering and related fields
Research InstitutionOsaka University

Principal Investigator

Verma Prabhat  大阪大学, 大学院工学研究科, 教授 (60362662)

Co-Investigator(Kenkyū-buntansha) 馬越 貴之  大阪大学, 大学院工学研究科, 講師 (00793192)
Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥46,020,000 (Direct Cost: ¥35,400,000、Indirect Cost: ¥10,620,000)
Fiscal Year 2022: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2021: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2020: ¥11,960,000 (Direct Cost: ¥9,200,000、Indirect Cost: ¥2,760,000)
Fiscal Year 2019: ¥22,100,000 (Direct Cost: ¥17,000,000、Indirect Cost: ¥5,100,000)
Keywords先端増強ラマン顕微鏡 / 近接場光学 / プラズモニクス / 超解像光学顕微鏡 / 先端増強ラマン散乱顕微鏡 / バイオイメージング
Outline of Research at the Start

生きた生体試料のありのままの姿を非染色かつナノスケールの空間分解能で観察できる技術は、ライフサイエンスに多くの新たな知見をもたらし得る。先端増強ラマン散乱顕微鏡は、これらの要件を満たし得る強力な顕微法であるが、これまで静的な材料等の観察に応用が限られていた。本研究では、先端増強ラマン顕微鏡を生体試料観察に特化することによって、生命科学を観察する新たな基盤技術を生み出す。

Outline of Final Research Achievements

This research aims to achieve operation in a liquid environment and nanoscale stability using Tip-Enhanced Raman Scattering (TERS) microscopy. We developed a new AFM head for the operation of the TERS system in a liquid environment, and additionally, we created two feedback systems to compensate for vertical and horizontal drifts. As a result, this enhanced system enables long-duration TERS imaging at the nanoscale, bringing new possibilities for the study of biological samples.

Academic Significance and Societal Importance of the Research Achievements

先端増強ラマン散乱顕微鏡は、回折限界を超えたナノスケールの空間分解能でラマンイメージングが可能な非常に強力な顕微法である。しかしながら、技術的な問題で、生命科学への応用例は限られていた。本研究では、液中環境下で動作する先端増強ラマン散乱顕微鏡を構築した。さらに、高い安定性を実現することによって、ラマン信号の弱い生体試料でも長時間にわたってイメージングできるようにした。生きた生体試料をナノレベルの空間分解能でラマン観察できるようにする上で非常に重要な成果であり、学術的にも社会的にも非常に大きな意義を有する。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Comments on the Screening Results   Annual Research Report
  • Research Products

    (21 results)

All 2023 2022 2021 2020 2019

All Journal Article (16 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 16 results,  Open Access: 9 results) Presentation (5 results) (of which Int'l Joint Research: 5 results,  Invited: 4 results)

  • [Journal Article] Raman Spectroscopic and DFT Study of COA-Cl and Its Analogues2023

    • Author(s)
      Umakoshi Takayuki、Urakami Takumi、Kidoguchi Haruki、Yang Keishi、Verma Prabhat、Sato Hirofumi、Higashi Masahiro、Tsukamoto Ikuko
    • Journal Title

      The Journal of Physical Chemistry A

      Volume: 127 Issue: 8 Pages: 1849-1856

    • DOI

      10.1021/acs.jpca.2c08382

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ultrastable tip-enhanced hyperspectral optical nanoimaging for defect analysis of large-sized WS2 layers2022

    • Author(s)
      Kato Ryo、Moriyama Toki、Umakoshi Takayuki、Yano Taka-aki、Verma Prabhat
    • Journal Title

      Science Advances

      Volume: 8 Issue: 28

    • DOI

      10.1126/sciadv.abo4021

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tip-enhanced Raman spectroscopy with amplitude-controlled tapping-mode AFM2022

    • Author(s)
      Umakoshi Takayuki、Kawashima Koji、Moriyama Toki、Kato Ryo、Verma Prabhat
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 12776-12776

    • DOI

      10.1038/s41598-022-17170-7

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Numerical characterization of optical properties of tapered plasmonic structure on a cantilever pyramidal tip for plasmon nanofocusing2022

    • Author(s)
      Yadav Ravi、Umakoshi Takayuki、Verma Prabhat
    • Journal Title

      AIP Advances

      Volume: 12 Issue: 8 Pages: 085216-085216

    • DOI

      10.1063/5.0106066

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Raman Spectroscopic Nanoimaging of Optical Fields of Metal Nanostructures with a Chemically Modified Metallic Tip2021

    • Author(s)
      Kato Ryo、Umakoshi Takayuki、Verma Prabhat
    • Journal Title

      The Journal of Physical Chemistry C

      Volume: 125 Issue: 37 Pages: 20397-20404

    • DOI

      10.1021/acs.jpcc.1c04823

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polarization Raman Imaging of Organic Monolayer Islands for Crystal Orientation Analysis2021

    • Author(s)
      Moriyama Toki、Umakoshi Takayuki、Hattori Yoshiaki、Taguchi Koki、Verma Prabhat、Kitamura Masatoshi
    • Journal Title

      ACS Omega

      Volume: 6 Issue: 14 Pages: 9520-9527

    • DOI

      10.1021/acsomega.0c06313

    • NAID

      120007159894

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Broadband Plasmon Nanofocusing: Comprehensive Study of Broadband Nanoscale Light Source2021

    • Author(s)
      Taguchi Koki、Umakoshi Takayuki、Inoue Shota、Verma Prabhat
    • Journal Title

      The Journal of Physical Chemistry C

      Volume: 125 Issue: 11 Pages: 6378-6386

    • DOI

      10.1021/acs.jpcc.0c11541

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Probing stacking configurations in a few layered MoS2 by low frequency Raman spectroscopy2020

    • Author(s)
      Sam Rhea Thankam、Umakoshi Takayuki、Verma Prabhat
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 21227-21227

    • DOI

      10.1038/s41598-020-78238-w

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Defect-related anomalous low-frequency Raman scattering in a few-layered MoS22020

    • Author(s)
      Sam Rhea Thankam、Umakoshi Takayuki、Verma Prabhat
    • Journal Title

      Applied Physics Express

      Volume: 13 Issue: 7 Pages: 072003-072003

    • DOI

      10.35848/1882-0786/ab9a91

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] One-side metal-coated pyramidal cantilever tips for highly reproducible tip-enhanced Raman spectroscopy2020

    • Author(s)
      Kato Ryo、Taguchi Koki、Yadav Ravi、Umakoshi Takayuki、Verma Prabhat
    • Journal Title

      Nanotechnology

      Volume: 31 Issue: 33 Pages: 335207-335207

    • DOI

      10.1088/1361-6528/ab90b6

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] White nanolight source for optical nanoimaging2020

    • Author(s)
      Umakoshi Takayuki、Tanaka Misaki、Saito Yuika、Verma Prabhat
    • Journal Title

      Science Advances

      Volume: 6 Issue: 23

    • DOI

      10.1126/sciadv.aba4179

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tip-Enhanced Raman Spectroscopy of Multiwalled Carbon Nanotubes through D-Band Imaging: Implications for Nanoscale Analysis of Interwall Interactions2020

    • Author(s)
      Kato Ryo、Igarashi Shun、Umakoshi Takayuki、Verma Prabhat
    • Journal Title

      ACS Applied Nano Materials

      Volume: 3 Issue: 6 Pages: 6001-6008

    • DOI

      10.1021/acsanm.0c01188

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anharmonic effects in single-walled carbon nanotubes analyzed through low-temperature Raman imaging2020

    • Author(s)
      Takayuki Umakoshi, Masaki Taniguchi, Prabhat Verma
    • Journal Title

      The Journal of Physical Chemistry C

      Volume: 124 Issue: 12 Pages: 6922-6928

    • DOI

      10.1021/acs.jpcc.0c00416

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Probing inter-molecular interactions of dinaphthothienothiophene (DNTT) molecules in a transistor device using low-frequency Raman spectroscopy2020

    • Author(s)
      Bishwajeet Singh Bhardwaj, Rhea Thankam Sam, Takayuki Umakoshi, Naoko Namba, Takafumi Uemura, Tsuyoshi Sekitani, Prabhat Verma
    • Journal Title

      Applied Physics Express

      Volume: 13 Issue: 2 Pages: 22010-22010

    • DOI

      10.35848/1882-0786/ab6e0d

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Orientation analysis of pentacene molecules in organic field-effect transistor devices using polarization-dependent Raman spectroscopy2019

    • Author(s)
      Bishwajeet Singh Bhardwaj, Takeshi Sugiyama, Naoko Namba, Takayuki Umakoshi, Takafumi Uemura, Tsuyoshi Sekitani, and Prabhat Verma
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 15149-15149

    • DOI

      10.1038/s41598-019-51647-2

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Raman spectroscopic studies of Dinaphthothienothiophene (DNTT)2019

    • Author(s)
      Bishwajeet Singh Bhardwaj, Takeshi Sugiyama, Naoko Namba, Takayuki Umakoshi, Takafumi Uemura, Tsuyoshi Sekitani, Prabhat Verma
    • Journal Title

      Materials

      Volume: 12 Issue: 4 Pages: 615-615

    • DOI

      10.3390/ma12040615

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Plasmonically Enhanced Spectroscopies for Optical Nanoimaging and Sensing2023

    • Author(s)
      Prabhat Verma
    • Organizer
      7th IEEE-EDTM Conference 2023 in Seoul
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] White-nanolight-source for background-free nano-optical investigation2022

    • Author(s)
      Prabhat Verma
    • Organizer
      MRS Fall Meeting 2022 in Boston
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Large-area Raman spectral nano-analysis of 2D materials by long-term TERS imaging2021

    • Author(s)
      Toki Moriyama, Ryo Kato, Takayuki Umakoshi, and Prabhat Verma
    • Organizer
      JSAP-OSA joint symposia 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Plasmon nanofocusing for near-field optical imaging2019

    • Author(s)
      Takayuki Umakoshi and Prabhat Verma
    • Organizer
      Global Nanophotonics 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Tunable Plasmonics for Sensing and Nano-Raman-Imaging2019

    • Author(s)
      Takayuki Umakoshi, Ryo Kato, Bikas Ranjan and Prabhat Verma
    • Organizer
      Optics & Photonics Congress
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited

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Published: 2019-04-18   Modified: 2024-01-30  

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