| Budget Amount *help |
¥42,380,000 (Direct Cost: ¥32,600,000、Indirect Cost: ¥9,780,000)
Fiscal Year 2022: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2021: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2020: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2019: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
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| Outline of Final Research Achievements |
Many azanucleosides have a basic structure in which oxygen atoms are replaced by nitrogen atoms in the natural nucleic acid structure, and exhibit superior functions and activities to those of conventional nucleic acid drug candidates. In this study, we developed a systematic synthesis method for various azanucleoside derivatives, which are difficult to achieve by conventional methods, by advancing the chemical synthesis of intermediate molecules based on the organic electrolytic reaction method and the reverse micellar liquid phase reaction. We have established an innovative manufacturing method to efficiently obtain oligomers composed of azanucleoside units in a very short process.
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