| Budget Amount *help |
¥45,500,000 (Direct Cost: ¥35,000,000、Indirect Cost: ¥10,500,000)
Fiscal Year 2023: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2022: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2021: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2020: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
Fiscal Year 2019: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
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| Outline of Final Research Achievements |
Primary cilia serve as cellular antennae. Defects in intraflagellar transport (IFT) machinery cause the ciliopathies with a variety of severe symptoms. In this study, we identified aberrant protein-protein interactions and abnormalities at the level of ciliary function, which had been a black box between ciliopathy-causing gene mutations (genotypes) and abnormal phenotypes at the individual level (symptoms). In particular, with regard to ciliopathies caused by mutations in protein complexes and motor proteins that mediate IFT, we were able to link these protein-level mutations to abnormalities in protein-protein interactions and at the level of cilia, thus clarifying the molecular basis of ciliopathies.
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