| Budget Amount *help |
¥44,850,000 (Direct Cost: ¥34,500,000、Indirect Cost: ¥10,350,000)
Fiscal Year 2022: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
Fiscal Year 2021: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2020: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Fiscal Year 2019: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
|
|---|
| Outline of Final Research Achievements |
(1)Arabidopsis mutations in H3K9 demethylase IBM1 induces genic accumulation of H3K9me and developmental defects. This defect is suppressed by mutations of H3K4me1 demethylase LDL2. In addition, another H3K4me1 demethylase FLD control transcriptional elongation negatively. On the other hand, H3K4me2 is removed from transcribed genes by another demethylase LDL3. (2)Importance of CG methylation for establishment of H3K9me is shown. (3) Mode of interaction between a transposon-encoded anti-silenicng factor VANC and the target DNA was shown by AFM and structural analysis. It is shown that target sequence of VANC are subject of RNAi-based silencing by host.
|
