| Budget Amount *help |
¥45,110,000 (Direct Cost: ¥34,700,000、Indirect Cost: ¥10,410,000)
Fiscal Year 2023: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2022: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2021: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2020: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2019: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Outline of Final Research Achievements |
We have investigated the mechanisms by which tubular epithelial tissues achieve stable morphogenesis under the influence of cellular and external environmental noise. In the tracheal tissue of Drosophila embryos, the expansion of the lumen is characterized by an uneven distribution of expansion materials, leading to non-uniform lumen expansion. We discovered that actin nanoclusters, which accumulate just beneath the cell membrane facing the lumen, autonomously undergo rapid aggregation and disaggregation. These actin nanoclusters sense the tension of the cell membrane and align in the direction of tube expansion, constructing actin cables that counteract the expansion force. By replicating this dynamic through mathematical simulation, we demonstrated that the simple operational principles of actin can facilitate higher-order morphogenesis.
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