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Elucidation of the functional mechanisms associated with structural dynamics of antibodies by integration of cutting-edge measurement approaches

Research Project

Project/Area Number 19H01017
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 47:Pharmaceutical sciences and related fields
Research InstitutionNagoya City University

Principal Investigator

Kato Koichi  名古屋市立大学, 大学院薬学研究科, 教授 (20211849)

Co-Investigator(Kenkyū-buntansha) 矢木 真穂  大学共同利用機関法人自然科学研究機構(新分野創成センター、アストロバイオロジーセンター、生命創成探究, 生命創成探究センター, 准教授(兼任) (40608999)
谷中 冴子  分子科学研究所, 生命・錯体分子科学研究領域, 准教授(兼任) (80722777)
Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥45,240,000 (Direct Cost: ¥34,800,000、Indirect Cost: ¥10,440,000)
Fiscal Year 2022: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2021: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2020: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2019: ¥13,520,000 (Direct Cost: ¥10,400,000、Indirect Cost: ¥3,120,000)
Keywords抗体 / 動的立体構造 / 相互作用 / Fc受容体 / 補体
Outline of Research at the Start

抗体の分子中には、抗原、補体、受容体など様々な分子との相互作用部位が配置されており、しかも、それらの部位の間の働きを連関させる仕組みが存在する。本研究は、3次元構造のダイナミクスの観点から抗体分子の機能連関の仕組みを明らかにすることを目的とする。さらに、抗体が本来機能する場である膜表面や血液中における分子間相互作用の実態解明に挑む。そのために、先端計測と理論的アプローチを駆使して、抗体の立体構造動態と相互作用の連関の詳細を明らかにする。得られた成果に基づいて抗体の機能連関とin situにおける動作を最適化するように分子構造を改変し、機能向上をはかる。

Outline of Final Research Achievements

By integrating experimental and computational approaches, we thoroughly investigated the relationship between the conformational dynamics of antibody molecules and their effector functions. This comprehensive exploration provided a profound understanding of how glycans, which modify the Fc region of immunoglobulin G (IgG), govern the conformational dynamics of the binding site with the Fcγ receptor (FcγR), ultimately impacting effector functions. Additionally, we made a significant discovery of a previously unidentified binding site for FcγRIII in the Fab region of IgG, which becomes activated upon antigen recognition. Moreover, we demonstrated that IgG molecules recognizing antigens on lipid membranes spontaneously form a hexameric ring structure, facilitating their interaction with the complement component C1q. Conversely, our experimental evidence conclusively showed that serum proteins hinder the interaction between IgG and FcγRIII, leading to a decrease in effector activity.

Academic Significance and Societal Importance of the Research Achievements

本研究で得られた成果は、薬学的応用を視野に入れた抗体の分子構造の設計・改変に重要な指針を与えるものである。すなわち、抗体分子内に張り巡らされたアロステリックネットワークを読み解くことにより、抗体分子に与えた摂動が分子構造の動態に及ぼす影響を予測することができるようになり、抗体の分子改変を効率的に行うことが可能となるものと期待される。さらに本研究の結果は、有効性と安全性を向上させた抗体医薬の設計と応用において、血清タンパク質の相互作用を考慮することの重要性も示している。このように、本研究を通じて、次世代の抗体医薬を開発するうえで重要な知見を数多く得ることができた。

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Comments on the Screening Results   Annual Research Report
  • Research Products

    (65 results)

All 2023 2022 2021 2020 2019 2018 Other

All Int'l Joint Research (7 results) Journal Article (18 results) (of which Int'l Joint Research: 7 results,  Peer Reviewed: 17 results,  Open Access: 12 results) Presentation (35 results) (of which Int'l Joint Research: 11 results,  Invited: 16 results) Book (3 results) Remarks (2 results)

  • [Int'l Joint Research] Institut Laue-Langevin(フランス)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] NIST/Boston University School of Medicine/University of Georgia(米国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Max Planck Institute/University of Hamburg/University of Tuebingen(ドイツ)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] NIBSC/Ludger Limited/AstraZeneca(英国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Centre d'Immunologie Pierre Fabre/Proteodynamics/University of Strasbo(フランス)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] Institute of Computing Technology/Institute of Biophysics(中国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research]

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Negative interference with antibody-dependent cellular cytotoxicity mediated by rituximab from its interactions with human serum proteins2023

    • Author(s)
      Yanaka Saeko、Yogo Rina、Yagi Hirokazu、Onitsuka Masayoshi、Wakaizumi Natsumi、Yamaguchi Yuki、Uchiyama Susumu、Kato Koichi
    • Journal Title

      Frontiers in Immunology

      Volume: 14 Pages: 1090898-1090898

    • DOI

      10.3389/fimmu.2023.1090898

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Glutamine-free mammalian expression of recombinant glycoproteins with uniform isotope labeling: an application for NMR analysis of pharmaceutically relevant Fc glycoforms of human immunoglobulin G12022

    • Author(s)
      Yanaka Saeko、Yagi Hirokazu、Yogo Rina、Onitsuka Masayoshi、Kato Koichi
    • Journal Title

      Journal of Biomolecular NMR

      Volume: なし Issue: 1-2 Pages: 17-22

    • DOI

      10.1007/s10858-021-00387-5

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Fab portion of immunoglobulin G has sites in the CL domain that interact with Fc gamma receptor IIIa2022

    • Author(s)
      Yamaguchi Yuki、Wakaizumi Natsumi、Irisa Mine、Maruno Takahiro、Shimada Mari、Shintani Koya、Nishiumi Haruka、Yogo Rina、Yanaka Saeko、Higo Daisuke、Torisu Tetsuo、Kato Koichi、Uchiyama Susumu
    • Journal Title

      mAbs

      Volume: 14 Issue: 1

    • DOI

      10.1080/19420862.2022.2038531

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Experimental and computational characterization of dynamic biomolecular interaction systems involving glycolipid glycans2022

    • Author(s)
      Kato Koichi、Yamaguchi Takumi、Yagi-Utsumi Maho
    • Journal Title

      Glycoconjugate Journal

      Volume: 39 Issue: 2 Pages: 219-228

    • DOI

      10.1007/s10719-022-10056-w

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Quantitative Visualization of the Interaction between Complement Component C1 and Immunoglobulin G: The Effect of CH1 Domain Deletion2022

    • Author(s)
      Yanaka Saeko、Nishiguchi Shigetaka、Yogo Rina、Watanabe Hiroki、Shen Jiana、Yagi Hirokazu、Uchihashi Takayuki、Kato Koichi
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 23 Issue: 4 Pages: 2090-2090

    • DOI

      10.3390/ijms23042090

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comprehensive characterization of oligosaccharide conformational ensembles with conformer classification by free-energy landscape via reproductive kernel Hilbert space2021

    • Author(s)
      Watanabe Tokio、Yagi Hirokazu、Yanaka Saeko、Yamaguchi Takumi、Kato Koichi
    • Journal Title

      Physical Chemistry Chemical Physics

      Volume: - Issue: 16 Pages: 9753-9760

    • DOI

      10.1039/d0cp06448c

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NMR assignments of the N-glycans of the Fc fragment of mouse immunoglobulin G2b glycoprotein2021

    • Author(s)
      Yanaka Saeko、Yamaguchi Yoshiki、Takizawa Takeshi、Miyanoiri Yohei、Yogo Rina、Shimada Ichio、Kato Koichi
    • Journal Title

      Biomolecular NMR Assignments

      Volume: 15 Issue: 1 Pages: 187-192

    • DOI

      10.1007/s12104-020-10004-5

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A feasibility study of inverse contrast-matching small-angle neutron scattering method combined with size exclusion chromatography using antibody interactions as model systems2021

    • Author(s)
      Sato Nobuhiro、Yogo Rina、Yanaka Saeko、Martel Anne、Porcar Lionel、Morishima Ken、Inoue Rintaro、Tominaga Taiki、Arimori Takao、Takagi Junichi、Sugiyama Masaaki、Kato Koichi
    • Journal Title

      The Journal of Biochemistry

      Volume: 0 Issue: 6 Pages: 1-8

    • DOI

      10.1093/jb/mvab012

    • NAID

      40022687772

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Silkworm Pupae Function as Efficient Producers of Recombinant Glycoproteins with Stable-Isotope Labeling2020

    • Author(s)
      Yagi Hirokazu、Yanaka Saeko、Yogo Rina、Ikeda Akari、Onitsuka Masayoshi、Yamazaki Toshio、Kato Tatsuya、Park Enoch Y.、Yokoyama Jun、Kato Koichi
    • Journal Title

      Biomolecules

      Volume: 10 Issue: 11 Pages: 1482-1482

    • DOI

      10.3390/biom10111482

    • NAID

      120007045052

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Biophysical characterization of dynamic structures of immunoglobulin G2020

    • Author(s)
      Yanaka Saeko、Yogo Rina、Kato Koichi
    • Journal Title

      Biophysical Reviews

      Volume: 12 Issue: 3 Pages: 637-645

    • DOI

      10.1007/s12551-020-00698-1

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] 複雑な糖鎖のコンフォメーション空間の探査と改変―計算と実験の統合によるアプローチ2020

    • Author(s)
      谷中冴子,、加藤晃一
    • Journal Title

      化学

      Volume: 75 Pages: 30-71

    • Related Report
      2020 Annual Research Report
  • [Journal Article] 抗体に秘められた結合部位の発見 ― 免疫分子の働く姿をリアルタイムで観測!2020

    • Author(s)
      加藤晃一, 與語理那
    • Journal Title

      academist Journal

      Volume: -

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] On-Membrane Dynamic Interplay between Anti-GM1 IgG Antibodies and Complement Component C1q.2019

    • Author(s)
      Saeko Yanaka,Rina Yogo,Hiroki Watanabe,Yuki Taniguchi,Tadashi Satoh,Naoko Komura,Hiromune Ando,Hirokazu Yagi,Nobuhiro Yuki,Takayuki Uchihashi,Koichi Kato
    • Journal Title

      International Journal of Molecular Sciences

      Volume: 21 Issue: 1 Pages: 147-147

    • DOI

      10.3390/ijms21010147

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Dynamic Views of the Fc Region of Immunoglobulin G Provided by Experimental and Computational Observations2019

    • Author(s)
      Yanaka Saeko、Yogo Rina、Inoue Rintaro、Sugiyama Masaaki、Itoh Satoru G.、Okumura Hisashi、Miyanoiri Yohei、Yagi Hirokazu、Satoh Tadashi、Yamaguchi Takumi、Kato Koichi
    • Journal Title

      Antibodies

      Volume: 8 Issue: 3 Pages: 39-39

    • DOI

      10.3390/antib8030039

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Fab portion of immunoglobulin G contributes to its binding to Fcγ receptor III.2019

    • Author(s)
      [Rina Yogo,Yuki Yamaguchi,Hiroki Watanabe,Hirokazu Yagi,Tadashi Satoh,Mahito Nakanishi,Masayoshi Onitsuka,Takeshi Omasa,Mari Shimada,Takahiro Maruno,Tetsuo Torisu,Shio Watanabe,Daisuke Higo,Takayuki Uchihashi,Saeko Yanaka,Susumu Uchiyama,Koichi Kato]
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 11957-11957

    • DOI

      10.1038/s41598-019-48323-w

    • NAID

      120006875664

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Newly developed Laboratory-based Size exclusion chromatography Small-angle x-ray scattering System (La-SSS)2019

    • Author(s)
      R. Inoue, T. Nakagawa, K. Morishima, N. Sato, A. Okuda, R. Urade, R. Yogo, S. Yanaka, M. Yagi-Utsumi, K. Kato, K. Omoto, K. Ito, M. Sugiyama
    • Journal Title

      Scientific Reports

      Volume: 9 Issue: 1 Pages: 1-12

    • DOI

      10.1038/s41598-019-48911-w

    • NAID

      120006799252

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] NIST Interlaboratory Study on Glycosylation Analysis of Monoclonal Antibodies: Comparison of Results from Diverse Analytical Methods2019

    • Author(s)
      De Leoz MLA, Duewer DL, Fung A, Liu L, Yau HK, Potter O, Staples GO, Furuki K, Frenkel R, Hu Y, Sosic Z, Zhang P, Altmann F, Gru Nwald-Grube C, Shao C, Zaia J, Evers W, Pengelley S, Suckau D, Wiechmann A, NakanoM, その他141名
    • Journal Title

      Mol Cell Proteomics

      Volume: 19(1) Issue: 1 Pages: 11-30

    • DOI

      10.1074/mcp.ra119.001677

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Enabling adoption of 2D-NMR for the higher order structure assessment of monoclonal antibody therapeutics2018

    • Author(s)
      Brinson RG.、Marino JP.、Delaglio F、Arbogast LW.、Evans RM.、Kearsley A、Gingras G、Ghasriani H、Aubin Y、Pierens GK.、Jia X、Mobli M、Grant HG.、Keizer DW.、Schweimer K、Sthle J、Widmalm G、Zartler ER.、Lawrence CW.、Reardon PN.、Cort JR.、Xu P、Ni F、Yanaka S、Kato K、et al.
    • Journal Title

      mAbs

      Volume: 11 Issue: 1 Pages: 94-105

    • DOI

      10.1080/19420862.2018.1544454

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Exploring the Structural Dynamics and Interactions of Antibodies: A Multidisciplinary Approach2023

    • Author(s)
      Saeko Yanaka, Rina Yogo, Hirokazu Yagi, and Koichi Kato
    • Organizer
      Symposium on Frontier Research for Disease-related Proteins and 2023 Korea-Japan Joint Meeting for Molecular Sciences
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Investigation of conformational dynamics and interactions of antibodies towards their functional improvement2023

    • Author(s)
      Saeko Yanaka, Koichi Kato
    • Organizer
      日本薬学会 第143年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Multifaceted observation of conformational dynamics and interactions of antibodies2022

    • Author(s)
      Saeko Yanaka, Rina Yogo, Hirokazu Yagi, Koichi Kato
    • Organizer
      ABA APPA & TBS Join Congress
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] NMR approaches for the evaluation and advancement of antibody therapeutics2022

    • Author(s)
      Koichi Kato, Rina Yogo, Hirokazu Yagi, and Saeko Yanaka
    • Organizer
      29th ICMRBS
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Integrative approach for the observation of conformational dynamics and interactions of antibodies2022

    • Author(s)
      Saeko Yanaka, Koichi Kato
    • Organizer
      The 7th International Symposium on Drug Discovery and Design by NMR
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 抗体の高次構造と相互作用のダイナミクス2022

    • Author(s)
      加藤晃一,谷中冴子
    • Organizer
      第1回 日本抗体学会設立記念学術大会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Subsequent developments of the project on dynamical ordering of biomolecular systems for creation of integrated functions2022

    • Author(s)
      Koichi Kato
    • Organizer
      iNANO-IMS-ExCELLS Interdisciplinary Nanoscience Joint Meeting
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] From Antibody NMR to Integrative Glycoscience2022

    • Author(s)
      Koichi Kato
    • Organizer
      20th IPR Retreat
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 抗体分子に隠された補体第一成分の相互作用部位の探査2022

    • Author(s)
      沈佳娜、谷中冴子、西口茂孝、内橋貴之、加藤晃一
    • Organizer
      令和3年度 生物物理学会中部支部講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Dynamic Views of Oligosaccharides and Glycoproteins Provided by Experimental and Computational Observations2021

    • Author(s)
      Koichi Kato、Saeko Yanaka、Tokio Watanabe、Tatsuya Suzuki、Rina Yogo、Tadashi Satoh、Takumi Yamaguchi、Hirokazu Yagi
    • Organizer
      3rd Australasian Glycoscience Symposium (3rd AGS)
    • Related Report
      2021 Annual Research Report
  • [Presentation] Stable isotope-assisted NMR analysis of dynamics and interactions of the Fc region of immunoglobulin G as glycoprotein2021

    • Author(s)
      Saeko Yanaka、Rina Yogo、Hirokazu Yagi、Koichi Kato
    • Organizer
      ISMAR-APNMR-NMRSJ-SEST 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 抗体の3次元構造ダイナミクスと相互作用のダイナミクスをみる2021

    • Author(s)
      谷中冴子
    • Organizer
      PPF2020/2021 第18回次世代を担う若手のためのフィジカル・ファーマフォーラム
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 真核生物における安定同位体標識法2021

    • Author(s)
      谷中冴子
    • Organizer
      第21回若手NMR研究会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Comprehensive characterization of oligosaccharide dynamical conformations by a kernel method in conjunction with graph theoretical techniques2021

    • Author(s)
      Takumi Yamaguchi、Tokio Watanabe、Hirokazu Yagi、Saeko Yanaka、Koichi Kato
    • Organizer
      The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem 2021)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] SEC-iCM-SANSによる抗体分子の精密構造解析2021

    • Author(s)
      佐藤信浩,與語理那,谷中冴子,Anne Martel,Lionel Porcar,守島 健,井上倫太郎,富永大輝,有森貴夫,高木淳一,杉山正明,加藤晃一
    • Organizer
      2020年度量子ビームサイエンスフェスタ 第12回MLFシンポジウム、第38回PFシンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] 抗体の3次元構造と相互作用のダイナミクスを解明する方法の開発と抗体の高機能化への展開2021

    • Author(s)
      谷中冴子
    • Organizer
      日本薬学会 第141年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 血清環境における抗体の分子間相互作用と機能の解明2021

    • Author(s)
      與語理那,谷中冴子,矢木宏和,加藤晃一
    • Organizer
      日本薬学会 第141年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Impacts of the N-glycan variation of antibodies on their dynamic structures of functional relevance2020

    • Author(s)
      Saeko Yanaka, Rina Yogo, Hirokazu Yagi, and Koichi Kato
    • Organizer
      第58回 日本生物物理学会年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Investigation of possible alteration in protein glycosylation during estrous cycle2020

    • Author(s)
      Saeko Yanaka
    • Organizer
      第3回 ExCELLSシンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] IgG のフコシル化による Fc のタイナミクスの変化か Fcγ受容体との相互 作用に及ほす影響2019

    • Author(s)
      谷中冴子,與語理那,矢木宏和,伊藤 暁,奥村久士,山口拓実,加藤晃一
    • Organizer
      第19回日本蛋白質科学会年会、第71回日本細胞生物学会大会 合同年次大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Experimental and Computational Approaches for Elucidating Glycofunctional Mechanisms2019

    • Author(s)
      Koichi Kato
    • Organizer
      The 23rd International Annual Symposium on Computational Science and Engineering: Expanding Your Mind
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] NMR characterization of dynamic conformations and interactions of functional oligosaccharides and antibody glycoproteins2019

    • Author(s)
      Koichi Kato, Tatsuya Suzuki, Rina Yogo, Maho Yagi-Utsumi, Hirokazu Yagi, Tadashi Satoh, Takumi Yamaguchi, and Saeko Yanaka
    • Organizer
      8th Asia-Pacific NMR Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Dynamic Views of the Fc Portion of Immunoglobulin G Provided by Experimental and Computational Observations2019

    • Author(s)
      Saeko Yanaka, Rina Yogo, Rintaro Inoue, Masaaki Sugiyama, Satoru G. Itoh, Hisashi Okumura, Yohei Miyanoiri, Hirokazu Yagi, Tadashi Satoh, Takumi Yamaguchi and Koichi Kato
    • Organizer
      Frontier Bioorganization Forum 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 安定同位体標識を利用したNMRによる抗体の動的構造解析2019

    • Author(s)
      與語理那,谷中冴子,矢木宏和,加藤晃一
    • Organizer
      第20回 若手NMR研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 令和初めての夏に想う、抗体のNMRから学んだこと2019

    • Author(s)
      加藤晃一
    • Organizer
      第20回若手NMR研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 構造学的なアプローチによる 細胞外O-GlcNAc 修飾の分子機能解析2019

    • Author(s)
      小川光貴,矢木宏和,田嶌優子,妹尾勇弥,池田和貴,加藤晃一,竹内英之,岡島徹也
    • Organizer
      第38回 日本糖質学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 抗体の構造研究から学ぶ、研究者ってどんな職業?2019

    • Author(s)
      谷中冴子
    • Organizer
      中高生のための未来教室‐ホンネで語るライフサイエンスの道!
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Dynamic Views of Structures and Interactions of Antibodies2019

    • Author(s)
      Koichi Kato, Rina Yogo, Hirokazu Yagi, and Saeko Yanaka
    • Organizer
      The 10th Toyota RIKEN International Workshop on Science of Life Phenomena Woven by Water and Biomolecules
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Experimental and computational observations of the dynamics of the Fc region of immunoglobulin G2019

    • Author(s)
      Saeko Yanaka
    • Organizer
      Satellite meeting for PF Workshop“Marriage of Computational and Experimental Techniques for Solution Small-angle Scattering”
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] IgGとFc受容体の相互作用におけるFab領域の新規結合部位の同定2019

    • Author(s)
      與語理那
    • Organizer
      第92回 日本生化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Dynamic structures and interactions of antibodies under physiologically relevant conditions2019

    • Author(s)
      Saeko Yanaka, Rina Yogo, Hirokazu Yagi, and Koichi Kato
    • Organizer
      第57回 日本生物物理学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Lessons Learned from Antibody NMR2019

    • Author(s)
      Koichi Kato
    • Organizer
      The 58th Annual Meeting of the Nuclear Magnetic Resonance Society of Japan
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Observation of dynamical orchestration of antibodies2019

    • Author(s)
      Saeko Yanaka, Rina Yogo, Hiroki Watanabe, Satoru G. Itoh, Hirokazu Yagi, Susumu Uchiyama, Hisashi Okumura, Takayuki Uchihashi, Koichi Kato
    • Organizer
      The 2nd ExCELLS symposium
    • Related Report
      2019 Annual Research Report
  • [Presentation] 安定同位体標識を利用したNMRによる抗体の「品質」の解析2019

    • Author(s)
      谷中冴子,與語理那,矢木宏和,加藤晃一
    • Organizer
      第42回 日本分子生物学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] HDX-MSによる抗体とFc受容体の相互作用解析2019

    • Author(s)
      山口祐希,與語理那,矢木宏和,佐藤匡史,中西真人,嶋田麻里,丸野孝浩,鳥巣哲生,渡邊史生, 肥後大輔,谷中冴子,加藤晃一,内山 進
    • Organizer
      第42回 日本分子物学会年会
    • Related Report
      2019 Annual Research Report
  • [Book] Comprehensive Glycoscience, 2nd edition (J. Barchi ed.)2021

    • Author(s)
      Hirokazu Yagi、Saeko Yanaka、Koichi Kato
    • Publisher
      Elsevier (Oxford)
    • Related Report
      2021 Annual Research Report
  • [Book] 糖鎖生物学2020

    • Author(s)
      北島 健、佐藤 ちひろ、門松 健治、加藤 晃一
    • Total Pages
      306
    • Publisher
      名古屋大学出版会
    • ISBN
      9784815809812
    • Related Report
      2019 Annual Research Report
  • [Book] 医薬品開発における創薬スクリーニング関連技術開発2019

    • Author(s)
      浅井章良 他
    • Total Pages
      278
    • Publisher
      情報機構
    • ISBN
      9784865021806
    • Related Report
      2019 Annual Research Report
  • [Remarks] EurekAlert!

    • URL

      https://www.eurekalert.org/pub_releases/2020-01/nion-aga010620.php

    • Related Report
      2019 Annual Research Report
  • [Remarks] 免疫学の常識を覆す!抗体と受容体の新たな結合部位の発見

    • URL

      http://www.excells.orion.ac.jp/pr/20190816pr.html

    • Related Report
      2019 Annual Research Report

URL: 

Published: 2019-04-18   Modified: 2024-01-30  

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