| Budget Amount *help |
¥45,110,000 (Direct Cost: ¥34,700,000、Indirect Cost: ¥10,410,000)
Fiscal Year 2022: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2021: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
Fiscal Year 2020: ¥11,830,000 (Direct Cost: ¥9,100,000、Indirect Cost: ¥2,730,000)
Fiscal Year 2019: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
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| Outline of Final Research Achievements |
We identified a long noncoding (lnc) RNA involved in the regulation of Wnt signaling that is important for stem cell replication. This lncRNA is a direct target of β-catenin, is involved in the accessibility of the transcriptional regulatory regions of a subset of CTNNB1 targets, such as LGR5 and ASCL2, where additional transcription factor seems to bind and co-operate with CTNNB1. On the other hand, single-cell transcriptome and chromatin analyzes of reproliferating cell populations after anticancer drug treatment identified pioneer factor candidates that bind to regulatory regions that are activated prior to proliferation.
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