| Budget Amount *help |
¥45,110,000 (Direct Cost: ¥34,700,000、Indirect Cost: ¥10,410,000)
Fiscal Year 2022: ¥10,790,000 (Direct Cost: ¥8,300,000、Indirect Cost: ¥2,490,000)
Fiscal Year 2021: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2020: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Fiscal Year 2019: ¥12,090,000 (Direct Cost: ¥9,300,000、Indirect Cost: ¥2,790,000)
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| Outline of Final Research Achievements |
In this study, we aimed to identify metabolic pathways and metabolites that contribute to tumorigenesis and regulate therapeutic resistance and stemness. We found that metabolic regulation by lysosomes plays an important role in malignant properties in leukemia and brain tumors. We found that lysosome activity was closely linked to chromatin regulation, suggesting that it contributes to fate determination. The findings also contribute to the development of novel therapeutic strategies targeting lysosomes. Further investigation based on this study will provide an effective opening for elucidating the true nature of cancer.
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