| Budget Amount *help |
¥45,370,000 (Direct Cost: ¥34,900,000、Indirect Cost: ¥10,470,000)
Fiscal Year 2022: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
Fiscal Year 2021: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
Fiscal Year 2020: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2019: ¥15,080,000 (Direct Cost: ¥11,600,000、Indirect Cost: ¥3,480,000)
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| Outline of Final Research Achievements |
In this study, we found that during mouse motor learning, the survival rate of input axon terminals from M2 to M1 decreases, while the input axon terminals from the motor thalamus to M1 stabilize. We also found that L5 neurons in M1 that project to the striatum maintain stable memory of motor-related activity formed during motor learning even during periods of rest without performing the movements. Furthermore, we found that in the case of context-dependent movements, axons inputting from M2 to M1 and layer 2/3 cells of M1 come to show context-specific activity and movement becomes more skillful.
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