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Analysis of homeostasis mechanisms using a human in vitro multi organ model

Research Project

Project/Area Number 19H01050
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 53:Organ-based internal medicine and related fields
Research InstitutionTokyo Medical and Dental University

Principal Investigator

Watanabe Mamoru  東京医科歯科大学, 高等研究院, 特別栄誉教授 (10175127)

Co-Investigator(Kenkyū-buntansha) 油井 史郎  東京医科歯科大学, 統合研究機構, 准教授 (00383886)
柿沼 晴  東京医科歯科大学, 大学院医歯学総合研究科, 教授 (30372444)
鬼澤 道夫  福島県立医科大学, 医学部, 助教 (30783352)
土屋 輝一郎  筑波大学, 医学医療系, 教授 (40376786)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥45,760,000 (Direct Cost: ¥35,200,000、Indirect Cost: ¥10,560,000)
Fiscal Year 2021: ¥8,840,000 (Direct Cost: ¥6,800,000、Indirect Cost: ¥2,040,000)
Fiscal Year 2020: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2019: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
Keywordsヒトオルガノイド / 臓器間制御機構 / 臓器共培養 / 炎症性腸疾患 / 臓器間制御 / iPS細胞複合臓器体外モデル / iPS細胞 / 複合臓器体外モデル
Outline of Research at the Start

炎症性腸疾患の病態は炎症ではなく、上皮細胞機能不全による粘膜障害が原因であることを上皮細胞のみを単離して解析することで明らかとしてきました。しかし病態の大元である上皮細胞の変化は生体の環境と密接に関わることを発見し、生体環境と腸管との相互作用を明らかにすることが新たに必要であることがわかってきました。そこで本研究ではヒト細胞を用いて臓器体外モデルを作成し、新規の原因を探索すること目的としています。

Outline of Final Research Achievements

Culture system of human colon cells and human iPS-derived liver cells was established respectively. We are examining whether colon cells and liver cells can be cultured in the same culture medium. After examining various culture conditions, we confirmed that colon cells and liver cells can be co-cultured, and constructed a system in which the interaction can be analyzed. We have also constructed disease models for both liver and colon cells, and have established a system that can analyze the effects between organs in disease by co-culturing normal colon and diseased liver, or diseased colon and normal liver. Furthermore, by transplanting human cells into mice, we have constructed chimeric mice with diseased human cell organs. These results are expected to advance our understanding of the pathophysiology of inter-organ regulatory mechanisms in human diseases.

Academic Significance and Societal Importance of the Research Achievements

ヒト疾患において臓器間制御機構の関与が注目されているが、多くの研究は実験動物を用いたin vivoモデルにより得られた結果である。ヒト細胞を用いた臓器間制御機構の解析は困難であるが、我々はその擬似モデルとして多臓器共培養システムやヒト多臓器保持マウスを構築し、臓器間制御機構を明らかにすることは学術的に意義が高いと考える。より、ヒトに近い実験系を作成することがヒト疾患の病態解明に有用な手法であり、疾患の全身的な理解が進むことは社会的にも意義が高い。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Comments on the Screening Results   Annual Research Report
  • Research Products

    (56 results)

All 2022 2021 2020 2019

All Journal Article (32 results) (of which Int'l Joint Research: 11 results,  Peer Reviewed: 32 results,  Open Access: 22 results) Presentation (24 results) (of which Int'l Joint Research: 13 results,  Invited: 12 results)

  • [Journal Article] Higher vs Standard Adalimumab Induction and Maintenance Dosing Regimens for Treatment of Ulcerative Colitis: SERENE UC Trial Results.2022

    • Author(s)
      Panes J,Colombel JF,D’Hanes GR,Schreiber S,Panaccione R,Peyrin-Biroulet L,Loftus EV Jr,Danese S,Tanida S,Okuyama Y,Louis E,Armuzzi A,Ferrante M,Vogelsang H,Hibi T,Watanabe M,Lefebve J,Finney-Hayward T,Gonzalez YS,Doan TT,Mostafa NM,Ikeda K,Xie W,Huang B,Petersson J,Kalabic J,Robinson AM,Sandborn WJ
    • Journal Title

      Gastroenterology

      Volume: - Issue: 7 Pages: 1891-1910

    • DOI

      10.1053/j.gastro.2022.02.033

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] AJM300(carotegrast methyl), an oral antagonist of α4-integrin, as induction therapy for patients with moderately active ulcerative colitis: a multicentre, randomised, double-blind, placebo-controlled phase 3 study.2022

    • Author(s)
      Matsuoka K, Watanabe M, Ohmori T, Nakajima K, Ishida T, Ishiguro Y, Kanke K, Kobayashi K, Hirai F, Watanabe K, Mizusawa H, Kishida S, Miura Y, Ohta A, Kajioka T, Hibi T
    • Journal Title

      Lancet Gastroenterol Hepatol

      Volume: - Issue: 7 Pages: 648-657

    • DOI

      10.1016/s2468-1253(22)00022-x

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Nickel particles are present in Crohn's disease tissue and exacerbate intestinal inflammation in IBD susceptible mice.2022

    • Author(s)
      Hiroki Matsuda, Yoichi Nibe-Shirakihara, Akiko Tamura, Emi Aonuma, Satoko Arakawa, Kana Otsubo, Yasuhiro Nemoto, Takashi Nagaishi, Kiichiro Tsuchiya, Shigeomi Shimizu, Averil Ma, Mamoru Watanabe, Motohiro Uo, Ryuichi Okamoto, Shigeru Oshima.
    • Journal Title

      Biochemical and Biophysical Research Communications.

      Volume: 592 Pages: 74-80

    • DOI

      10.1016/j.bbrc.2021.12.111

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Transplantation of intestinal organoids into a mouse model of colitis2022

    • Author(s)
      Watanabe Satoshi、Kobayashi Sakurako、Ogasawara Nobuhiko、Okamoto Ryuichi、Nakamura Tetsuya、Watanabe Mamoru、Jensen Kim B.、Yui Shiro
    • Journal Title

      Nature Protocols

      Volume: 17 Issue: 3 Pages: 649-671

    • DOI

      10.1038/s41596-021-00658-3

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Deep neural network for video colonoscopy of ulcerative colitis: a cross-sectional study2022

    • Author(s)
      Kento Takenaka, Toshimitsu Fujii, Ami Kawamoto, Kohei Suzuki, Hiromichi Shimizu, Chiaki Maeyashiki, Osamu Yamaji, Maiko Motobayashi, Akira Igarashi, Ryoichi Hanazawa, Shuji Hibiya, Masakazu Nagahori, Eiko Saito, Ryuichi Okamoto, Kazuo Ohtsuka, Mamoru Watanabe
    • Journal Title

      Lancet Gastroenterol Hepatol

      Volume: 7 Issue: 3 Pages: 230-237

    • DOI

      10.1016/s2468-1253(21)00372-1

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Activated mucosal-associated invariant T cells have a pathogenic role in a murine model of inflammatory bowel disease.2022

    • Author(s)
      usuke Yasutomi, Asako Chiba, Keiichi Haga, Goh Murayama, Ayako Makiyama, Taiga Kuga, Mamoru Watanabe, Ryuichi Okamoto, Akihito Nagahara, Takashi Nagaishi, Saichiko Miyake.
    • Journal Title

      Cellular and Molecular Gastroenterology and Hepatology.

      Volume: 13 Issue: 1 Pages: 81-93

    • DOI

      10.1016/j.jcmgh.2021.08.018

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Immunoglobulin A-specific deficiency induces spontaneous inflammation specifically in the ileum2021

    • Author(s)
      Nagaishi Takashi、Watabe Taro、Kotake Kunihiko、Kumazawa Toshihiko、Aida Tomomi、et al.
    • Journal Title

      Gut

      Volume: 71 Issue: 3 Pages: 487-496

    • DOI

      10.1136/gutjnl-2020-322873

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Importance of Telomere Shortening in the Pathogenesis of Ulcerative Colitis: A New Treatment From the Aspect of Telomeres in Intestinal Epithelial Cells2021

    • Author(s)
      Watanabe Sho、Hibiya Shuji、Katsukura Nobuhiro、Kitagawa Sayuki、Sato Ayako、Okamoto Ryuichi、Watanabe Mamoru、Tsuchiya Kiichiro
    • Journal Title

      Journal of Crohn's and Colitis

      Volume: 16 Issue: 1 Pages: 109-121

    • DOI

      10.1093/ecco-jcc/jjab115

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A potent endocytosis inhibitor Ikarugamycin up-regulates TNF production.2021

    • Author(s)
      Ai Minamidate, Michio Onizawa, Chikako Saito, Rie Hikichi, Tomoaki Mochimaru, Mai Murakami, Chiharu Sakuma, Takehito Asakawa, Yuichi Hiraoka, Shigeru Oshima, Takashi Nagaishi, Kiichiro Tsuchiya, Hiromasa Ohira, Ryuichi Okamoto, Mamoru Watanabe.
    • Journal Title

      Biochemistry and Biophysics Reports.

      Volume: 27 Pages: 101065-101065

    • DOI

      10.1016/j.bbrep.2021.101065

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Serum leucine-rich α-2 glycoprotein; a novel biomarker for small bowel mucosal activity in Crohn’s Disease.2021

    • Author(s)
      Kawamoto T, Takenaka K, Hibiya S, Ohtsuka K, Okamoto R, Watanabe M
    • Journal Title

      Clin Gastroenterol Hepatol.

      Volume: 20 Issue: 5 Pages: e1196-e1200

    • DOI

      10.1016/j.cgh.2021.06.036

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Oral administration of D-serine prevents the onset and progression of colitis in mice.2021

    • Author(s)
      Takehito Asakawa, Michio Onizawa, Chikako Saito, Rie Hikichi, Daiki Yamada, Ai Minamidate, Tomoaki Mochimaru, Shun-ichiro Asahara, Yoshiaki Kido, Shigeru Oshima, Takashi Nagaishi, Kiichiro Tsuchiya, Hiromasa Ohira, Ryuichi Okamoto, Mamoru Watanabe.
    • Journal Title

      Journal of Gastroenterolog.

      Volume: 56 Issue: 8 Pages: 732-745

    • DOI

      10.1007/s00535-021-01792-1

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Influence of chronic inflammation on the malignant phenotypes and the plasticity of colorectal cancer cells.2021

    • Author(s)
      Watanabe S, Hibiya S, Katsukura N, Kitagawa S, Sato A, Okamoto R, Watanabe M, Tsuchiya K
    • Journal Title

      Biochem Biophys Rep.

      Volume: - Pages: 101031-101031

    • DOI

      10.1016/j.bbrep.2021.101031

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Discontinuation of infliximab in patients with ulcerative colitis in remission (HAYABUSA): a multicentre, open-label, randomised controlled trial.2021

    • Author(s)
      Kobayashi T, Motoya S, Nakamura S, Yamamoto T, Nagahori M, Tanaka S, Hisamatsu T, Hirai F, Nakase H, Watanabe K, Matsumoto T, Tanaka M, Abe T, Suzuki Y, Watanabe M, Hibi T; HAYABUSA Study Group
    • Journal Title

      Lancet Gastroenterol Hepatol.

      Volume: 6 Issue: 6 Pages: 429-437

    • DOI

      10.1016/s2468-1253(21)00062-5

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Filgotinib as induction and maintenance therapy for ulcerative colitis(SELECTION) t: a phase 2b/3 double-blind, randomised, placebo-controlled trial.2021

    • Author(s)
      Feagan BG,Danese S,Loftus EV Jr,Vermeire S,Schreiber S,Ritter T,Fogel R,Mehta R,Nijhawan S,Kempinski R,Filip R,Hospodarskyy I,Seidler U,Seibold F,Beales ILP,Kim HJ,McNally J,Yun C,Zhao S,Liu X,Hsueh CH,Tasset C,Besuyen R,Watanabe M,Sandborn WJ,Rogler G,Hibi T,Peyrin-Biroulet L
    • Journal Title

      Lancet

      Volume: 397 Issue: 10292 Pages: 2372-2384

    • DOI

      10.1016/s0140-6736(21)00666-8

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Schlafen 11 Is a Novel Target for Mucosal Regeneration in Ulcerative Colitis2021

    • Author(s)
      Watanabe Sho、Nishimura Ryu、Shirasaki Tomoaki、Katsukura Nobuhiro、Hibiya Shuji、Kirimura Susumu、Negi Mariko、Okamoto Ryuichi、Matsumoto Yuka、Nakamura Tetsuya、Watanabe Mamoru、Tsuchiya Kiichiro
    • Journal Title

      Journal of Crohn's and Colitis

      Volume: 15 Issue: 9 Pages: 1558

    • DOI

      10.1093/ecco-jcc/jjab032

    • URL

      https://localhost/en/publications/e3f94db8-6569-4d0c-ab84-c3c9e646147c

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Deep Neural Network Accurately Predicts Prognosis of Ulcerative Colitis Using Endoscopic Images2021

    • Author(s)
      Kento Takenaka, Kazuo Ohtsuka, Toshimitsu Fujii, Shiori Oshima, Ryuichi Okamoto, Mamoru Watanabe
    • Journal Title

      Gastroenterology

      Volume: 160 Issue: 6 Pages: 2175-2177

    • DOI

      10.1053/j.gastro.2021.01.210

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Intraepithelial Lymphocytes Suppress Intestinal Tumor Growth by Cell-to-Cell Contact via CD103/E-Cadherin Signal.2021

    • Author(s)
      Ryo Morikawa, Yasuhiro Nemoto, Yuki Yonemoto, Shohei Tanaka, Yuria Takei, Shigeru Oshima, Takashi Nagaishi, Kiichiro Tsuchiya, Kengo Nozaki , Tomohiro Mizutani, Tetsuya Nakamura, Mamoru Watanabe, Ryuichi Okamoto.
    • Journal Title

      Cell Mol Gastroenterol Hepatol.

      Volume: 11 Issue: 5 Pages: 1483-1503

    • DOI

      10.1016/j.jcmgh.2021.01.014

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Notch and TNF-α signaling promote cytoplasmic accumulation of OLFM4 in intestinal epithelium cells and exhibit a cell protective role in the inflamed mucosa of IBD patients2021

    • Author(s)
      Kuno Reiko、Ito Go、Kawamoto Ami、Hiraguri Yui、Sugihara Hady Yuki、Takeoka Sayaka、Nagata Sayaka、Takahashi Junichi、Tsuchiya Mao、Anzai Sho、Mizutani Tomohiro、Shimizu Hiromichi、Yui Shiro、Oshima Shigeru、Tsuchiya Kiichiro、Watanabe Mamoru、Okamoto Ryuichi
    • Journal Title

      Biochemistry and Biophysics Reports

      Volume: 25 Pages: 100906-100906

    • DOI

      10.1016/j.bbrep.2020.100906

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Intestinal cancer in patients with Crohn's disease: A systematic review and meta-analysis2021

    • Author(s)
      Motoi Uchino, Hiroki Ikeuchi, Keisuke Hata, Tomohiro Minagawa, Yuki Horio, Ryuichi Kuwahara, Shiro Nakamura, Kenji Watanabe, Masayuki Saruta, Toshimitsu Fujii, Taku Kobayashi, Ken Sugimoto, Fumihito Hirai, Motohiro Esaki, Sakiko Hiraoka, Katsuyoshi Matsuoka, Shinichiro Shinzaki, Minoru Matsuura, Nagamu Inoue, et al
    • Journal Title

      J Gastroenterol Hepatol

      Volume: 36 Issue: 2 Pages: 329-336

    • DOI

      10.1111/jgh.15229

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional analysis of isoflavones using patient-derived human colonic organoids2021

    • Author(s)
      Tsuchiya Mao、Ito Go、Hama Minami、Nagata Sayaka、Kawamoto Ami、Suzuki Kohei、Shimizu Hiromichi、Anzai Sho、Takahashi Junichi、Kuno Reiko、Takeoka Sayaka、Hiraguri Yui、Sugihara Hady Yuki、Mizutani Tomohiro、Yui Shiro、Oshima Shigeru、Tsuchiya Kiichiro、Watanabe Mamoru、Okamoto Ryuichi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 542 Pages: 40-47

    • DOI

      10.1016/j.bbrc.2021.01.021

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Week 2 Symptomatic Response with Vedolizumab as a Predictive Factor in Japanese Anti-TNFα-Naive Patients with Ulcerative Colitis: A post hoc Analysis of a Randomized, Placebo-Controlled Phase 3 Trial2021

    • Author(s)
      Masakazu Nagahori, Kenji Watanabe, Satoshi Motoya, Haruhiko Ogata, Takanori Kanai, Toshiyuki Matsui, Yasuo Suzuki, Philippe Pinton, Lyann Ursos, Shigeru Sakamoto, Mitsuhiro Shikamura, Tetsuharu Hori, Jovelle Fernandez, Toshifumi Hibi, Mamoru Watanabe
    • Journal Title

      Digestion

      Volume: 15 Issue: 5 Pages: 1-11

    • DOI

      10.1159/000512235

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Nickel ions attenuate autophagy flux and induce transglutaminase 2 (TG2) mediated post-translational modification of SQSTM1/p62.2020

    • Author(s)
      Emi Aonuma, Akiko Tamura, Hiroki Matsuda, Takehito Asakawa, Yuriko Sakamaki, Kana Otsubo, Yoichi Nibe, Michio Onizawa, Yasuhiro Nemoto, Takashi Nagaishi, Kiichiro Tsuchiya, Tetsuya Nakamura, Motohiro Uo, Mamoru Watanabe, Ryuichi Okamoto, Shigeru Oshima.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 542 Pages: 17-23

    • DOI

      10.1016/j.bbrc.2021.01.023

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CEACAM1 specifically suppresses B cell receptor signaling-mediated activation..2020

    • Author(s)
      Naoya Tsugawa, Daiki Yamada, Taro Watabe, Michio Onizawa, Shuang Wang, Yasuhiro Nemoto, Shigeru Oshima, Takeshi Tsubata, Takahiro Adachi, Yohei Kawano, Mamoru Watanabe, Richard S. Blumberg, Ryuichi Okamoto, Takashi Nagaishi.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 535 Pages: 99-105

    • DOI

      10.1016/j.bbrc.2020.11.126

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Intestinal phenotype is maintained by Atoh1 in the cancer region of intraductal papillary mucinous neoplasm2020

    • Author(s)
      Katsukura Nobuhiro、Watanabe Sho、Shirasaki Tomoaki、Hibiya Shuji、Kano Yoshihito、Akahoshi Keiichi、Tanabe Minoru、Kirimura Susumu、Akashi Takumi、Kitagawa Masanobu、Okamoto Ryuichi、Watanabe Mamoru、Tsuchiya Kiichiro
    • Journal Title

      Cancer Science

      Volume: 112 Issue: 2 Pages: 932

    • DOI

      10.1111/cas.14755

    • URL

      https://localhost/en/publications/0b846b2e-755c-4577-9e18-e680b9f2f8f9

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High b-value computed diffusion-weighted imaging for differentiating bowel inflammation in Crohn's disease2020

    • Author(s)
      Yoshio Kitazume, Junichi Tsuchiya, Kento Takenaka, Kazuo Ohtsuka, Koichiro Kimura, Ryosuke Watanabe, Tomoyuki Fujioka, Toshimitsu Fujii, Mamoru Watanabe, Ukihide Tateisi
    • Journal Title

      Eur J Radiol

      Volume: 133 Pages: 109362-109362

    • DOI

      10.1016/j.ejrad.2020.109362

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TGF-β promotes fetal gene expression and cell migration velocity in a wound repair model of untransformed intestinal epithelial cells2020

    • Author(s)
      Anzai Sho、Kawamoto Ami、Nagata Sayaka、Takahashi Junichi、Kawai Mao、Kuno Reiko、Kobayashi Sakurako、Watanabe Satoshi、Suzuki Kohei、Shimizu Hiromichi、Hiraguri Yui、Takeoka Sayaka、Sugihara Hady Yuki、Yui Shiro、Oshima Shigeru、Watanabe Mamoru、Okamoto Ryuichi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 524 Issue: 3 Pages: 533-541

    • DOI

      10.1016/j.bbrc.2020.01.108

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Receptor-Interacting Protein Kinase 3 (RIPK3) inhibits autophagic flux during necroptosis in intestinal epithelial cells.2020

    • Author(s)
      Otsubo K, Maeyashiki C, Nibe Y, Tamura A, Aonuma E, Matsuda H, Kobayashi M, Onizawa M, Nemoto Y, Nagaishi T, Okamoto R, Tsuchiya K, Nakamura T, Torii S, Itakura E, Watanabe M, Oshima S.
    • Journal Title

      FEBS letters

      Volume: 594 Issue: 10 Pages: 1586-1595

    • DOI

      10.1002/1873-3468.13748

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Organoid-based regenerative medicine for inflammatory bowel diasease.2020

    • Author(s)
      Okamoto R, Shimizu H, Suzuki K, Kawamoto A, Takahashi J, Kawai M, Nagata S, Hiraguri Y, Takeoka S, Sugihara HY, Yui S, Watanabe M
    • Journal Title

      Regen Ther.

      Volume: 13 Pages: 1-6

    • DOI

      10.1016/j.reth.2019.11.004

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] CD8αα+ T cells show amoeboid shape and frequent morphological change in?vitro, and localize to small intestinal intraepithelial region in?vivo2020

    • Author(s)
      Takei Yuria、Nemoto Yasuhiro、Morikawa Ryo、Tanaka Shohei、Oshima Shigeru、Nagaishi Takashi、Okamoto Ryuichi、Tsuchiya Kiichiro、Nakamura Tetsuya、Watanabe Mamoru
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 523 Issue: 2 Pages: 328-335

    • DOI

      10.1016/j.bbrc.2019.12.021

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High-fat diet-derived free fatty acids impair the intestinal immune system and increase sensitivity to intestinal epithelial damage2020

    • Author(s)
      Tanaka Shohei、Nemoto Yasuhiro、Takei Yuria、Morikawa Ryo、Oshima Shigeru、Nagaishi Takashi、Okamoto Ryuichi、Tsuchiya Kiichiro、Nakamura Tetsuya、Stutte Susanne、Watanabe Mamoru
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 522 Issue: 4 Pages: 971-977

    • DOI

      10.1016/j.bbrc.2019.11.158

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Small Bowel Healing Detected by Endoscopy in Patients With Crohn’s Disease After Treatment With Antibodies Against Tumor Necrosis Factor2019

    • Author(s)
      Takenaka Kento、Fujii Toshimitsu、Suzuki Kohei、Shimizu Hiromichi、Motobayashi Maiko、Hibiya Shuji、Saito Eiko、Nagahori Masakazu、Watanabe Mamoru、Ohtsuka Kazuo
    • Journal Title

      Clinical Gastroenterology and Hepatology

      Volume: inpress Issue: 7 Pages: 1545-1552

    • DOI

      10.1016/j.cgh.2019.08.024

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] TP53 mutation by CRISPR system enhances the malignant potential of colon cancer.2019

    • Author(s)
      Watanabe S, Tsuchiya K, Nishimura R, Shirasaki T, Katsukura N, Hibiya S, Okamoto R, Nakamura T, Watanabe M
    • Journal Title

      Mol Cancer Res.

      Volume: in press Issue: 7 Pages: 1459-1467

    • DOI

      10.1158/1541-7786.mcr-18-1195

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 特別講演:腸からヒト全身を繙く新しい時代の到来2021

    • Author(s)
      渡辺 守
    • Organizer
      第76回日本大腸肛門病学会学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Machine learning to synthesize endoscopy findings in ulcerative colitis2021

    • Author(s)
      Mamoru Watanabe
    • Organizer
      IOBD Satellite Meeting
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 基調講演:再生医療研究・応用を目指す次世代の消化器臨床医へ2021

    • Author(s)
      渡辺 守
    • Organizer
      JDDW2021(第63回日本消化器病学会大会)
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 特別講演:IBD診療における温故知新2021

    • Author(s)
      渡辺 守
    • Organizer
      第39回日本大腸検査学会総会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] AJM300, an Oral Antagonist of α4-Integrin, as induction therapy for patients with Moderately Active Ulcerative Colitis: A Phase 3, randomized, double-blind, placebo-controlled induction study.2021

    • Author(s)
      Mamoru Watanabe, Katsuyoshi Matsuoka, Toshihide Ohmori, Koichi Nakajima, Tetsuya Ishida ,Yoh Ishiguro, Kazunari Kanke, Kiyonori Kobayashi, Fumihito Hirai, Kenji Watanabe, Toshifumi Hibi
    • Organizer
      ECCO2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 本邦におけるIBD治療の変遷とIBD研究班2021

    • Author(s)
      渡辺 守
    • Organizer
      25周年記念web講演会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 招待講演:再生医療おける内視鏡の役割2021

    • Author(s)
      渡辺 守
    • Organizer
      第101回日本消化器内視鏡学会総会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 次世代オルガノイド医療2021

    • Author(s)
      渡辺 守
    • Organizer
      第20回日本再生医療学会総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Clinical Application of Organoids for Tissue Regeneration.2020

    • Author(s)
      Mamoru Watanabe
    • Organizer
      KDDW2020
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] ヒト潰瘍性大腸炎モデルを用いた粘膜治癒に対する新規治療標的の同定2020

    • Author(s)
      渡辺 翔、土屋輝一郎、渡辺 守
    • Organizer
      JDDW2020
    • Related Report
      2020 Annual Research Report
  • [Presentation] 腸からヒト全身を繙く新しい時代へ2020

    • Author(s)
      渡辺 守
    • Organizer
      第58回日本小腸学会学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Organoid medicine in human GI diseases2020

    • Author(s)
      Mamoru Watanabe
    • Organizer
      EMBO EMBL SYMPOSIUM
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 炎症性腸疾患に対する上皮再生医療2020

    • Author(s)
      水谷知裕、岡本隆一、渡辺 守
    • Organizer
      第48回日本臨床免疫学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ヒト小腸オルガノイドを用いたクローン病病態解明の試み2020

    • Author(s)
      日比谷秀爾、白崎友彬、勝倉暢洋、渡辺 翔、岡本隆一、土屋輝一郎、渡辺 守
    • Organizer
      第106回日本消化器病学会総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Establishment of chronic inflammation model using human small intestinal and colonic organoids.2019

    • Author(s)
      Hibiya S, Tsuchiya K, Nishimura R, Watanabe S, Katsukura N, Shirasaki R, Okamoto R, Watanabe M
    • Organizer
      UEG Week 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of APL expression in an animal model of chronic colitis.2019

    • Author(s)
      Nagaishi T, Kojima Y, Watabe T, Tsugawa N, Yamada D, Jose N, Hosoya A, Suzuki M, Onizawa M, Watanabe M
    • Organizer
      FOCIS 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The role of ubiquitination in crosstalk of intestinal epithelial cell death and autophagic signaling was revealed by a novel polyubiquitin imaging system2019

    • Author(s)
      Otsubo K, Nibe Y, Maeyashiki C, Tamura A, Aonuma E, Matsuda H, Watanabe, M Oshima S
    • Organizer
      ICMI 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Analysis of Ileocecal Immune Response in an Animal Model of Colitis2019

    • Author(s)
      Yamada D, Nagaishi T, Watabe T, Tsugawa N, Kojima Y, Adachi T, Watanabe M
    • Organizer
      ICMI 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Focus Session: Cutting Edge Regenerative Medicine Using Stem Cells】Intestinal Epithelial Stem Cell Organoids and IBD2019

    • Author(s)
      Okamoto R, Watanabe M
    • Organizer
      ISSCR 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Stem Cells in Gut, Who are They and How They Work, What Can We Count on Them.2019

    • Author(s)
      Yui S, Watanabe M
    • Organizer
      AOCC 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] APL downregulation in an animal model of chronic colitis.2019

    • Author(s)
      Yamada D, Nagaishi T, Kojima Y, Watabe T, Tsugawa N, Jose N, Hosoya A, Suzuki M, Onizawa M, Watanabe M
    • Organizer
      AOCC 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Long-term inflammation model using human colonic organoids.2019

    • Author(s)
      Hibiya S, Tsuchiya K, Nishimura R, Shirasaki T, Watanabe S, Katsukura N, Oshima S, Okamoto R, Nakamura T, Watanabe M
    • Organizer
      AOCC 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Functional analysis of isoflavones using patient-derived intestinal organoids.2019

    • Author(s)
      Kawai M, Hama M, Nagata S, Kawamoto A, Suzuki K, Shimizu H, Anzai S, Takahashi J, Kuno R, Takeoka S, Hiraguri Y, Yui S, Okamoto R, Watanabe M
    • Organizer
      AOCC 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 【The 6th JSGE International Topic Conference Lifestyle-related Diseases in Gastroenterology】Gastrointestinal tract(role of gut microbiome and diet).2019

    • Author(s)
      Okamoto R, Kawai M, Hama M, Nagata S, Kawamoto A, Suzuki K, Shimizu H, Anzai S, Takahashi J, Kuno R, Takeoka S, Hiraguri Y, Yui S, Watanabe M
    • Organizer
      第105回 日本消化器病学会総会
    • Related Report
      2019 Annual Research Report

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Published: 2019-04-18   Modified: 2023-01-30  

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