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Mechanism of tissue interaction in human eye development.

Research Project

Project/Area Number 19H01063
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 56:Surgery related to the biological and sensory functions and related fields
Research InstitutionOsaka University

Principal Investigator

Nishida Kohji  大阪大学, 医学系研究科, 教授 (40244610)

Co-Investigator(Kenkyū-buntansha) 辻川 元一  大阪大学, 医学系研究科, 教授 (70419472)
林 竜平  大阪大学, 医学系研究科, 寄附講座教授 (70535278)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥45,500,000 (Direct Cost: ¥35,000,000、Indirect Cost: ¥10,500,000)
Fiscal Year 2021: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2020: ¥14,040,000 (Direct Cost: ¥10,800,000、Indirect Cost: ¥3,240,000)
Fiscal Year 2019: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Keywordsオルガノイド / 再生医療技術 / 順遺伝学 / 眼発生異常 / PAX6 / 器官発生 / iPS細胞 / SEAM / 疾患特異的 / 幹細胞 / SEAM法
Outline of Research at the Start

マウスなどの解析により組織発生メカニズムについては近年理解が深まったが、ヒトに
おける器官形成については未だほとんどが未知である。ヒトにおける発生系譜の異なる多くの組織が集合して形成される器官モデルが存在せず、発生期の各組織の相互作用のあり方が不明であるためである。我々はヒトiPS細胞から目に関する組織原器すべてが発生し、さらにそれが自律的に同心円状の構造を形成するSEAM法という誘導法を開発した(Nature2016)。このSEAMを用いて現在不明である器官形成時における各発生系譜の相互作用と形の形成分子メカニズムについて検討を行い、病変部位における器官構築という新たな再生医療開発につなげる。

Outline of Final Research Achievements

We had tried to elucidate the crosstalk mechanism of each tissue during human organogenesis. Specifically, we examined the mechanism by which SEAM itself is generated. In SEAM, cells and tissue primordia with different developmental genealogy are arranged concentrically.
Mutation induction by ENU (N nitrosourea) in iPS cells was performed last year to obtain many mutant strains, and then SEAM induction was performed on each of them, and 92 strains causing the abnormality were identified. These abnormalities are classified into about 5 patterns according to the phenotype, and we perform a whole-genome sequence for those that are abnormal due to poor occurrence of 2 layers and those that cause abnormalities in the shape of 3 layers.This was compared with the genomic annotations up to now, and the analysis was started in order from the one that seems to be the causative gene mutation, and the knockout form by CRSPR was analyzed for one gene and mRNAseq was performed.

Academic Significance and Societal Importance of the Research Achievements

本検討に於いてはヒトの器官形成における初めてのミュータジェネシススクリーニング系を確立したと考えている。従来に於いて、ヒトを用いた、眼のような複雑な発生過程をを持つ器官全体の発生を検討することはできなかった。本検討に於いては再生医療技術を応用することで、極めて基礎的な研究にその成果を還元できることを示したものと思われる。また、作製したライブラリーを順次解析することで人の眼の発生の機構をこれからも明らかにしていくことが期待できる

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Comments on the Screening Results   Annual Research Report
  • Research Products

    (57 results)

All 2022 2021 2020 2019

All Journal Article (34 results) (of which Int'l Joint Research: 11 results,  Peer Reviewed: 33 results,  Open Access: 20 results) Presentation (19 results) (of which Int'l Joint Research: 8 results,  Invited: 10 results) Book (1 results) Patent(Industrial Property Rights) (3 results) (of which Overseas: 2 results)

  • [Journal Article] Adiponectin accumulation in the retinal vascular endothelium and its possible role in preventing early diabetic microvascular damage2022

    • Author(s)
      Sakaue Taka-aki、Fujishima Yuya、Fukushima Yoko、Tsugawa-Shimizu Yuri、Fukuda Shiro、Kita Shunbun、Nishizawa Hitoshi、Ranscht Barbara、Nishida Kohji、Maeda Norikazu、Shimomura Iichiro
    • Journal Title

      Scientific Reports

      Volume: 12 Issue: 1 Pages: 4159-4159

    • DOI

      10.1038/s41598-022-08041-2

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Anterior chamber flare and ciliochoroidal detachment using flare photometry and anterior segment optical coherence tomography in acute lupus choroidopathy: A case report2022

    • Author(s)
      Fujimoto Satoko、Wakabayashi Taku、Maruyama Kazuichi、Hara Chikako、Oguro-Igashira Eri、Nishide Masayuki、Sakaguchi Hirokazu、Kumanogoh Atsushi、Nishida Kohji
    • Journal Title

      American Journal of Ophthalmology Case Reports

      Volume: 25 Pages: 101314-101314

    • DOI

      10.1016/j.ajoc.2022.101314

    • Related Report
      2021 Annual Research Report
  • [Journal Article] PAX6-positive microglia evolve locally in hiPSC-derived ocular organoids2022

    • Author(s)
      Shiraki Nobuhiko、Maruyama Kazuichi、Hayashi Ryuhei、Oguchi Akiko、Murakawa Yasuhiro、Katayama Tomohiko、Takigawa Toru、Sakimoto Susumu、Quantock Andrew J.、Tsujikawa Motokazu、Nishida Kohji
    • Journal Title

      Stem Cell Reports

      Volume: 17 Issue: 2 Pages: 221-230

    • DOI

      10.1016/j.stemcr.2021.12.009

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Early Three-Dimensional Intrableb Structural Changes in Primary-Open Angle Glaucoma and Exfoliation Glaucoma After Ex-PRESS Surgery2022

    • Author(s)
      Sugimoto Ikki、Usui Shinichi、Okazaki Tomoyuki、Kawashima Rumi、Miki Atsuya、Kawasaki Ryo、Matsushita Kenji、Nishida Kohji
    • Journal Title

      Translational Vision Science & Technology

      Volume: 11 Issue: 2 Pages: 32-32

    • DOI

      10.1167/tvst.11.2.32

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Relationship between vitreoretinal lymphoma and the site of lymphoma development in the central nervous system2021

    • Author(s)
      Maruyama Kazuichi、Iwahashi Chiharu、Hashida Noriyasu、Ohguro Nobuyuki、Nishida Kohji
    • Journal Title

      Japanese Journal of Ophthalmology

      Volume: 66 Issue: 2 Pages: 142-150

    • DOI

      10.1007/s10384-021-00891-z

    • NAID

      210000181892

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Severe Ocular Complications Associated With Wearing of Contact Lens in Japan2021

    • Author(s)
      Shigeyasu Chika、Yamada Masakazu、Fukuda Masahiko、Koh Shizuka、Suzuki Takashi、Toshida Hiroshi、Oie Yoshinori、Nejima Ryohei、Eguchi Hiroshi、Kawasaki Ryo、Nishida Kohji、for the Research Group of Severe Contact Lens-associated Ocular Complications
    • Journal Title

      Eye & Contact Lens

      Volume: 48 Issue: 2 Pages: 63-68

    • DOI

      10.1097/icl.0000000000000870

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between choriocapillaris flow deficit and choroidal neovascularization activity in eyes with myopic choroidal neovascularization2021

    • Author(s)
      Uematsu Sato、Sakaguchi Hirokazu、Sayanagi Kaori、Ikuno Yasushi、Yokoyama Ayako、Asai Tomoko、Fukushima Yoko、Hara Chikako、Sakimoto Susumu、Nishida Kohji
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 21947-21947

    • DOI

      10.1038/s41598-021-01557-z

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human iPS cells engender corneal epithelial stem cells with holoclone-forming capabilities2021

    • Author(s)
      Watanabe Shinya、Hayashi Ryuhei、Sasamoto Yuzuru、Tsujikawa Motokazu、Ksander Bruce R.、Frank Markus H.、Quantock Andrew J.、Frank Natasha Y.、Nishida Kohji
    • Journal Title

      iScience

      Volume: 24 Issue: 6 Pages: 102688-102688

    • DOI

      10.1016/j.isci.2021.102688

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The generation of fluorometholone nanocrystal eye drops, their metabolization to dihydrofluorometholone and penetration into rabbit eyes2021

    • Author(s)
      Baba Koichi、Hashida Noriyasu、Tujikawa Motokazu、Quantock Andrew J.、Nishida Kohji
    • Journal Title

      International Journal of Pharmaceutics

      Volume: 592 Pages: 120067-120067

    • DOI

      10.1016/j.ijpharm.2020.120067

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Fourier Analysis on Regular and Irregular Astigmatism of Anterior and Posterior Corneal Surfaces in Fuchs Endothelial Corneal Dystrophy2021

    • Author(s)
      Oie Yoshinori、Yasukura Yuichi、Nishida Nozomi、Koh Shizuka、Kawasaki Ryo、Maeda Naoyuki、Jhanji Vishal、Nishida Kohji
    • Journal Title

      American Journal of Ophthalmology

      Volume: 223 Pages: 33-41

    • DOI

      10.1016/j.ajo.2020.09.045

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Efficacy and safety of 5-fluorouracil in infrared monitor guided bleb revision2021

    • Author(s)
      Kawashima Rumi、Matsushita Kenji、Kawasaki Ryo、Nishida Kohji
    • Journal Title

      BMC Ophthalmology

      Volume: 21 Issue: 1 Pages: 75-82

    • DOI

      10.1186/s12886-021-01843-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Chondroitin Sulfate as a Potential Modulator of the Stem Cell Niche in Cornea.2021

    • Author(s)
      Ashworth S, Harrington J, Hammond G.M., Bains K.K, Koudouna E, Hayes A. J., Ralphs J.R., Regini J.W., Young R.D, Hayashi R, Nishida K.
    • Journal Title

      Front. Cell Dev. Biol.

      Volume: 12 Pages: 12-12

    • DOI

      10.3389/fcell.2020.567358

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Generation of functional conjunctival epithelium, including goblet cells, from human iPSCs.2021

    • Author(s)
      Nomi K, Hayashi R, Ishikawa Y, Kobayashi Y, Katayama T, Quantock AJ, and Nishida K
    • Journal Title

      Cell Rep.

      Volume: 34 Issue: 5 Pages: 108715-108715

    • DOI

      10.1016/j.celrep.2021.108715

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Rubicon regulates A2E-induced autophagy impairment in the retinal pigment epithelium implicated in the pathology of age-related macular degeneration2021

    • Author(s)
      Ando Satoru、Hashida Noriyasu、Yamashita Daisuke、Kawabata Tsuyoshi、Asao Kazunobu、Kawasaki Satoshi、Sakurai Kazushi、Yoshimori Tamotsu、Nishida Kohji
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 551 Pages: 148-154

    • DOI

      10.1016/j.bbrc.2021.02.148

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CTLA-2 Alpha Is a Potent Inhibitor of Angiogenesis in Murine Ocular Tissue2021

    • Author(s)
      Maruyama Kazuichi、Yoneda Kazuhito、Sugita Sunao、Yamamoto Yoshimi、Koike Masato、Peters Christoph、Uchiyama Yasuo、Nishida Kohji
    • Journal Title

      Antioxidants

      Volume: 10 Issue: 3 Pages: 456-456

    • DOI

      10.3390/antiox10030456

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] HLA-Matched Allogeneic iPS Cells-Derived RPE Transplantation for Macular Degeneration2020

    • Author(s)
      Sugita Sunaoら他32名
    • Journal Title

      Journal of Clinical Medicine

      Volume: 9 Issue: 7 Pages: 2217-2217

    • DOI

      10.3390/jcm9072217

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of the CAV1‐CAV2 locus with normal tension glaucoma in Chinese and Japanese2020

    • Author(s)
      Lu Shi Yao、Rong Shi Song、Wu Zhenggen、Huang Chukai、Matsushita Kenji、Ng Tsz Kin、Leung Christopher K.S.、Kawashima Rumi、Usui Shinichi、Tam Pancy O.S.、Tsujikawa Motokazu、Young Alvin L.、Zhang Mingzhi、Wiggs Janey L.、Nishida Kohji、Tham Clement C.、Pang Chi Pui、Chen Li Jia
    • Journal Title

      Clinical & Experimental Ophthalmology

      Volume: in press Issue: 5 Pages: 1-8

    • DOI

      10.1111/ceo.13744

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ocular Surface Ectoderm Instigated by WNT inhibition and BMP4.2020

    • Author(s)
      Kobayashi Y, Hayashi R, Shibata S, Quantock AJ, Nishida K.
    • Journal Title

      Stem Cell Res.

      Volume: 46 Pages: 101868-101868

    • DOI

      10.1016/j.scr.2020.101868

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Cell jamming, stratification and p63 expression in cultivated human corneal epithelial cell sheets2020

    • Author(s)
      Baba Koichi、Sasaki Kei、Morita Mio、Tanaka Tomoyo、Teranishi Yosuke、Ogasawara Takahiro、Oie Yoshinori、Kusumi Izumi、Inoie Masukazu、Hata Ken-ichiro、Quantock Andrew J.、Kino-oka Masahiro、Nishida Kohji
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 1-1

    • DOI

      10.1038/s41598-020-64394-6

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation of knockout rabbits with X-linked severe combined immunodeficiency (X-SCID) using CRISPR/Cas92020

    • Author(s)
      Hashikawa Yoshiko、Hayashi Ryuhei、Tajima Masaru、Okubo Toru、Azuma Shohei、Kuwamura Mitsuru、Takai Naofumi、Osada Yasuyuki、Kunihiro Yayoi、Mashimo Tomoji、Nishida Kohji
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 9957-9957

    • DOI

      10.1038/s41598-020-66780-6

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel mutation identified in Leber congenital amaurosis - a case report2020

    • Author(s)
      Sato Shigeru、Morimoto Takeshi、Tanaka Sayaka、Hotta Kikuko、Fujikado Takashi、Tsujikawa Motokazu、Nishida Kohji
    • Journal Title

      BMC Ophthalmology

      Volume: 20 Issue: 1 Pages: 313-313

    • DOI

      10.1186/s12886-020-01577-9

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Complete Visual Recovery From Severe Outer Retinitis After Tonsillitis2020

    • Author(s)
      Kawashima Rumi、Matsushita Kenji、Hashida Noriyasu、Kuniyoshi Kazuki、Fujikado Takashi、Nishida Kohji
    • Journal Title

      Journal of Neuro-Ophthalmology

      Volume: Publish Ahead of Print Issue: 4 Pages: 1-1

    • DOI

      10.1097/wno.0000000000001073

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Corneal Opacity Induced by Light in a Mouse Model of Gelatinous Drop-Like Corneal Dystrophy2020

    • Author(s)
      Nagahara Y, Tsujikawa M, Koto R, Uesugi K, Sato S, Kawasaki S, Maruyama K, Nishida K.
    • Journal Title

      The American Journal of Pathology

      Volume: 190 Issue: 12 Pages: 2330-2342

    • DOI

      10.1016/j.ajpath.2020.08.017

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Structural En Face OCT Angiography Image of Avulsed Retinal Vessels and Vitreal Neovascularization2020

    • Author(s)
      Ito Jun、Hara Chikako、Nishida Kohji
    • Journal Title

      Ophthalmology Retina

      Volume: 4 Issue: 12 Pages: 1157-1157

    • DOI

      10.1016/j.oret.2020.05.010

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Anterior segment optical coherence tomography and in vivo confocal microscopy in cases of mucopolysaccharidosis2020

    • Author(s)
      Matoba Ayumi、Oie Yoshinori、Tanibuchi Honami、Winegarner Andrew、Nishida Kohji
    • Journal Title

      American Journal of Ophthalmology Case Reports

      Volume: 19 Pages: 100728-100728

    • DOI

      10.1016/j.ajoc.2020.100728

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cell-Type-Specific Adhesiveness and Proliferation Propensity on Laminin Isoforms Enable Purification of iPSC-Derived Corneal Epithelium.2020

    • Author(s)
      Shibata S, Hayashi R, Kudo Y, Okubo T, Imaizumi T, Katayama T, Ishikawa Y, Kobayashi Y, Toga J, Taniguchi Y, Honma Y, Sekiguchi K, Nishida K.
    • Journal Title

      Stem Cell Reports.

      Volume: 14(4) Issue: 4 Pages: 663-676

    • DOI

      10.1016/j.stemcr.2020.02.008

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Comparison of composite and segmental methods for acquiring optical axial length with swept-source optical coherence tomography2020

    • Author(s)
      Goto So、Maeda Naoyuki、Noda Toru、Ohnuma Kazuhiko、Koh Shizuka、Iehisa Ikko、Nishida Kohji
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 4474-4474

    • DOI

      10.1038/s41598-020-61391-7

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation and validation of a PITX2-EGFP reporter line of human induced pluripotent stem cells enables isolation of periocular mesenchymal cells.2020

    • Author(s)
      Okubo T, Hayashi R, Shibata S, Kudo Y, Ishikawa Y, Inoue S, Kobayashi Y, Honda A, Honma Y, Kawasaki S, Nishida K.
    • Journal Title

      J Biol Chem.

      Volume: 295 Issue: 11 Pages: 3456-3465

    • DOI

      10.1074/jbc.ra119.010713

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A novel mutation in gelatinous drop-like corneal dystrophy and functional analysis2019

    • Author(s)
      Nagahara Yukiko、Tsujikawa Motokazu、Takigawa Toru、Xu Peng、Kai Chifune、Kawasaki Satoshi、Nakatsukasa Mina、Inatomi Tsutomu、Kinoshita Shigeru、Nishida Kohji
    • Journal Title

      Human Genome Variation

      Volume: 6 Issue: 1 Pages: 6-33

    • DOI

      10.1038/s41439-019-0060-z

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Eleven-year follow-up of a Japanese retinitis pigmentosa patient with an HK1 gene mutation.2019

    • Author(s)
      Sato S, Morimoto T, Hotta K, Fujikado T, Nishida K
    • Journal Title

      Ophthalmic Genet.

      Volume: 40 Issue: 5 Pages: 466-469

    • DOI

      10.1080/13816810.2019.1678179

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] KLF4 prevents epithelial to mesenchymal transition in human corneal epithelial cells via endogenous TGF-β2 suppression2019

    • Author(s)
      Fujimoto Satoko、Hayashi Ryuhei、Hara Susumu、Sasamoto Yuzuru、Harrington Jodie、Tsujikawa Motokazu、Nishida Kohji
    • Journal Title

      Regenerative Therapy

      Volume: 11 Pages: 249-257

    • DOI

      10.1016/j.reth.2019.08.003

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Homeostasis of SLC4A11 protein is mediated by endoplasmic reticulum-associated degradation2019

    • Author(s)
      Hara Susumu、Tsujikawa Motokazu、Kawasaki Satoshi、Nishida Kohji
    • Journal Title

      Experimental Eye Research

      Volume: 188 Pages: 107782-107782

    • DOI

      10.1016/j.exer.2019.107782

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The secretome of adipose-derived mesenchymal stem cells attenuates epithelial-mesenchymal transition in human corneal epithelium.2019

    • Author(s)
      Shibata S, Hayashi R, Okubo T, Kudo Y, Baba K, Honma Y, Nishida K.
    • Journal Title

      Regen Ther.

      Volume: Jul 2:11 Pages: 114-122

    • DOI

      10.1016/j.reth.2019.06.005

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification and application of p75 neurotrophin receptor-expressing human trabecular meshwork progenitor cells2019

    • Author(s)
      Hara Susumu、Tsujikawa Motokazu、Nishida Kohji
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 514 Issue: 3 Pages: 580-585

    • DOI

      10.1016/j.bbrc.2019.04.178

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] Development of stem cell-based therapy for limbal stem cell deficiency -from tissue stem cell to iPS cel2021

    • Author(s)
      K. Nishida
    • Organizer
      The 7th Asia Cornea Society Biennial Scientific Meeting, 2021/4/29
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of iPS cell-based therapy for limbal stem cell deficiency2021

    • Author(s)
      K. Nishida
    • Organizer
      The 7th Asia Cornea Society Biennial Scientific Meeting, 2021/4/29
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] iPS細胞を用いた角膜再生医療2021

    • Author(s)
      西田幸二
    • Organizer
      第122回日本耳鼻咽喉科学会総会・学術講演会, 2021/5/14
    • Related Report
      2021 Annual Research Report
  • [Presentation] Induced Pluripotent Stem Cell-Derived Limbal Stem Cells2021

    • Author(s)
      K. Nishida
    • Organizer
      AAO 2021 American Academy of Ophthalmology Annual Meeting
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] アカデミアから見た再生医療産業化の現状と課題,2021

    • Author(s)
      西田幸二
    • Organizer
      第21回日本再生医療学会, 2022/3/18
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] iPS細胞を使った再生治療臨床応用の最前線2020

    • Author(s)
      西田幸二
    • Organizer
      第41回 日本炎症・再生医学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 角膜疾患に対する医療パラダイムチェンジ2020

    • Author(s)
      西田幸二
    • Organizer
      第74回日本臨床眼科学会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] iPS細胞の臨床応用-現状と未来-2020

    • Author(s)
      西田幸二
    • Organizer
      第50回日本臨床神経生理学会学術大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] iPS細胞を用いた角膜再生医療の実用化に向けて2020

    • Author(s)
      西田幸二
    • Organizer
      第20回 日本再生医療学会総会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] iPS細胞を用いた眼細胞分化と再生医療への応用2019

    • Author(s)
      林竜平
    • Organizer
      第123回日本眼科学会総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 眼の再生医療2019

    • Author(s)
      西田幸二
    • Organizer
      大阪府眼科医会:健康講座
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] iPS細胞を用いた角膜移植2019

    • Author(s)
      西田幸二
    • Organizer
      第23回Cornea Update Seminar Tokyo
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] iPS細胞を用いた角膜移植2019

    • Author(s)
      大家 義則, 西田 幸二
    • Organizer
      第39回日本眼薬理学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] iPS細胞を用いた角膜上皮の再生医療2019

    • Author(s)
      相馬剛至
    • Organizer
      第73回日本臨床眼科学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Novel OPA1 gene mutations in Japanese patients with optic atrophy.2019

    • Author(s)
      SHIGERU SATO, N. Hashida, T. Morimoto, K. Hotta, T. Fujikado, K. Nishida.
    • Organizer
      ARVO Annual Meeting 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of MHC conformity on corneal epithelial cell sheet transplantation in non-human primates.2019

    • Author(s)
      Yu Yoshinaga, T. Soma, R. Hayashi, S. Azuma, K. Maruyama, Y. Hashikawa. T. Katayama, N. hosen, T. Shiina, K. Ogasawara, K. Nishida.
    • Organizer
      ARVO Annual Meeting 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The phenotype of knockout mouse of tumor-associated calcium signal transducer2 as a model of gelatinous drop-like corneal dystrophy.2019

    • Author(s)
      Yukiko Nagahara, k. uesugi, P. Xu, S. Kawasaki, M. Tsujikawa, K. Nishida.
    • Organizer
      ARVO Annual Meeting 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] HLA 6 loci matched allogeneic iPS cells derived retinal pigment epithelial cells (iPSC-RPE) transplantation.2019

    • Author(s)
      Masayo Takahashi, S. Sugita, M. Mandai, Y. HIrami, S. Takagi, M. Yamamoto, N. Koide, H. Sakaguchi, K. Maruyama, K. Nishida, S. Yamanaka, Y. Kurimoto.
    • Organizer
      ARVO Annual Meeting 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] KLF4 Prevents Epithelial-to-Mesenchymal Transition in Human Corneal Epithelia via SMAD2/3 Nuclear Translocation Inhibition of the TGF-β Signaling Pathway.2019

    • Author(s)
      Satoko Fujimoto, R. Hayashi, Y. Sasamoto, S. Hara, J. Harrington, M. Tsujikawa, K. Nishida.
    • Organizer
      ARVO Annual Meeting 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Book] 【"適応&修復"のサイエンスと臨床応用の最前線】眼の適応・修復と疾患, 別冊Bio Clinica:慢性炎症と疾患2019

    • Author(s)
      西田 幸二
    • Total Pages
      4
    • Publisher
      北隆館
    • Related Report
      2019 Annual Research Report
  • [Patent(Industrial Property Rights)] "重層扁平上皮細胞の正常分化・成熟促進剤、上皮疾患治療剤及び 重層扁平上皮細胞の正常分化・成熟促進方法"2021

    • Inventor(s)
      西田幸二,林竜平,本間 陽一,大久保 徹,柴田 峻
    • Industrial Property Rights Holder
      西田幸二,林竜平,本間 陽一,大久保 徹,柴田 峻
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Related Report
      2021 Annual Research Report
  • [Patent(Industrial Property Rights)] 多能性幹細胞の分化制御方法2019

    • Inventor(s)
      西田 幸二,関口 清俊,林 竜平,柴田 峻
    • Industrial Property Rights Holder
      西田 幸二,関口 清俊,林 竜平,柴田 峻
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Acquisition Date
      2021
    • Related Report
      2021 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] 多能性幹細胞由来結膜細胞の誘導方法2019

    • Inventor(s)
      西田幸二,林竜平,能美君人
    • Industrial Property Rights Holder
      西田幸二,林竜平,能美君人
    • Industrial Property Rights Type
      特許
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report
    • Overseas

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Published: 2019-04-18   Modified: 2023-12-25  

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