Research on the development and application of metallomics methods in the field of environmental medicine

• Project/Area Number: 19H01081
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Medium-sized Section 58:Society medicine, nursing, and related fields
• Research Institution: Juntendo University
• Principal Investigator: Yokoyama Kazuhito 順天堂大学, 医学部, 客員教授 (00158370)
• Co-Investigator(Kenkyū-buntansha): 平田 岳史 東京大学, 大学院理学系研究科(理学部), 教授 (10251612) ; 藤代 瞳 徳島文理大学, 薬学部, 講師 (10389182) ; 姫野 誠一郎 昭和大学, 薬学部, 客員教授 (20181117) ; 小椋 康光 千葉大学, 大学院薬学研究院, 教授 (40292677) ; 大森 由紀 北里大学, 医学部, 助教 (30415971) ; 松川 岳久 順天堂大学, 医学部, 助教 (60453586) ; 篠原 厚子 清泉女子大学, 付置研究所, 教授 (90157850)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥47,320,000 (Direct Cost: ¥36,400,000、Indirect Cost: ¥10,920,000); Fiscal Year 2021: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000); Fiscal Year 2020: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000); Fiscal Year 2019: ¥36,790,000 (Direct Cost: ¥28,300,000、Indirect Cost: ¥8,490,000)
• Keywords: メタロミクス / 環境医学 / LA-ICP-MS / スペシエーション / ICP-MS

Outline of Research at the Start

ゲノミクス（Genomics）、プロテオミクス（Proteomics）と並ぶ、メタロミクス（Metallomics）の概念に着目し、環境医学領域におけるメタロミクス手法の開発と応用を推進する。ヒト集団を対象とする微量元素の健康影響に関する疫学研究と最新の分析手法とを統合し、各種微量元素について①複数の元素を同時に、②生体内のどこに、③どのような化学形態・同位体比で分布しているかを網羅的・総合的に明らかにする手法を確立することを目的とする。各種の測定法の開発と改良を進めるとともに、これを補完する実験研究により、各種微量元素の生体機能メカニズムの解析手法を開発する。

Outline of Final Research Achievements

The academic question of this study was how to make a breakthrough in trace element research in the field of environmental medicine. We have focused on the concept of "metallomics" and promoted the development and application of metallomics methods in the field of environmental medicine. By integrating epidemiological studies on the health effects of trace elements on human populations and the novel analytical technologies, we have been studying the establishment of a method to comprehensively and comprehensively clarify the distribution of various trace elements (1) simultaneously, (2) where in the body, and (3) in what chemical form and isotope ratio. In addition to the development and improvement of various measurement methods, we have developed methods for analyzing the biofunctional mechanisms of various trace elements through experimental research that complements these methods.

Academic Significance and Societal Importance of the Research Achievements

メタロミクスは、生物の複製・機能・代謝機構の解明に貢献できるとされる。メタロミクスの対象となる物質の総体は、メタローム（metallome）と呼ばれる。今回は、環境医学領域でのメタロミクス手法の開発と応用の推進により、微量元素研究のブレークスルーを目指してきた。環境医学領域では、各種微量元素の生体影響とそのメカニズムが重要なトピックスの一つである。しかし、これまでの研究では、単元素の解析が主体であり、臓器レベルにとどまることが多かった。本研究により、環境中の各種微量元素が生体に及ぼす影響の解明のために、さらに高次元の解析の端緒を提示できたと考える。

Research Products

• [Int'l Joint Research] ラジシャヒ大学(バングラデシュ)
• [Int'l Joint Research] テヘラン医科大学(イラン)
• [Journal Article] Imaging Analysis of Amino Acids and Sugar using a Dielectric Barrier Discharge Ionisation-Mass Spectrometer coupled with Laser Ablation Sampling Technique (2022)
  • Author(s): Hui Hsin Khoo, Haruo Shimada, Hidekazu Miyahara, Takafumi Hirata
  • Journal Title: Metallomics Research Volume: 1 Issue: 1 Pages: reg-44-reg-54
  • DOI: 10.11299/metallomicsresearch.MR202107
  • ISSN: 2436-5173
  • Year and Date: 2022-01-31
  • Peer Reviewed / Open Access
• [Journal Article] Quantitative imaging analysis of nanoparticles and dissolved forms using laser ablation-single particle-ICP-mass spectrometry (2022)
  • Author(s): Shuji Yamashita, Kumiko Ogawa, Takafumi Hirata
  • Journal Title: Metallomics Research Volume: 1 Issue: 1 Pages: reg-33-reg-43
  • DOI: 10.11299/metallomicsresearch.MR202106
  • ISSN: 2436-5173
  • Year and Date: 2022-01-06
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Size and isotopic ratio measurements of individual nanoparticles by a continuous ion-monitoring method using Faraday detectors equipped on a multi-collector-ICP-mass spectrometer (2022)
  • Author(s): Yamashita Shuji、Yamamoto Kota、Takahashi Hiroaki、Hirata Takafumi
  • Journal Title: Journal of Analytical Atomic Spectrometry Volume: 37 Issue: 1 Pages: 178-184
  • DOI: 10.1039/d1ja00312g
  • Peer Reviewed / Open Access
• [Journal Article] Improvement of spatial resolution of elemental imaging using laser ablation-ICP-mass spectrometry (2022)
  • Author(s): Tanaka Eisei、Matsukawa Takehisa、Kuroki Yasuo、Suzuki Minoru、Yokoyama Kazuhito、Hirata Takafumi
  • Journal Title: Analytical Sciences Volume: 38 Issue: 4 Pages: 695-702
  • DOI: 10.1007/s44211-022-00085-8
  • Peer Reviewed / Open Access
• [Journal Article] A new gain calibration protocol for Faraday amplifiers equipped with a 10¹³ Ω resistor (2022)
  • Author(s): Asanuma Hisashi、Yamamoto Kota、Kemuyama Yuta、Hirata Takafumi
  • Journal Title: Journal of Analytical Atomic Spectrometry Volume: 00 Issue: 5 Pages: 1-7
  • DOI: 10.1039/d1ja00351h
  • Peer Reviewed
• [Journal Article] 飛行時間型 ICP-MS による微粒子の個別分析法の開発 (2022)
  • Author(s): 栗原かのこ，堀 越 洸，中里 雅樹，高橋 宏明，平田 岳史
  • Journal Title: 分析化学 Volume: 71 Pages: 277-282
  • Peer Reviewed / Open Access
• [Journal Article] Band 3/anion exchanger 1/solute carrier family 4 member 1 expression as determinant of cellular sensitivity to selenite exposure (2022)
  • Author(s): Fukumoto Yasunori、Matsuhashi Kemmu、Tanaka Yu-ki、Suzuki Noriyuki、Ogra Yasumitsu
  • Journal Title: Biochemistry and Biophysics Reports Volume: 29 Pages: 101223-101223
  • DOI: 10.1016/j.bbrep.2022.101223
  • Peer Reviewed / Open Access
• [Journal Article] 総説）カルコゲン元素及びニクトゲン元素のメチル化代謝 (2022)
  • Author(s): 小椋康光、福本泰典
  • Journal Title: 細胞 Volume: 54 Pages: 31-34
• [Journal Article] Manganese transport in mammals by zinc transporter family proteins, ZNT and ZIP (2022)
  • Author(s): Fujishiro Hitomi、Kambe Taiho
  • Journal Title: Journal of Pharmacological Sciences Volume: 148 Issue: 1 Pages: 125-133
  • DOI: 10.1016/j.jphs.2021.10.011
  • Peer Reviewed / Open Access
• [Journal Article] Elevated serum periostin levels among arsenic-exposed individuals and their associations with the features of asthma (2022)
  • Author(s): Tony Selim Reza、Haque Nazmul、Siddique Abu Eabrahim、Khatun Moriom、Rahman Mizanur、Islam Zohurul、Islam Md Shofikul、Islam Jahidul、Hossain Shakhawoat、Hoque Md Ashraful、Saud Zahangir Alam、Sumi Daigo、Wahed Abdus S.、Barchowsky Aaron、Himeno Seiichiro、Hossain Khaled
  • Journal Title: Chemosphere Volume: 298 Pages: 134277-134277
  • DOI: 10.1016/j.chemosphere.2022.134277
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Development of a Continuous Sampling Technique Based on Laser Ablation in Liquid (CLAL) for the Realtime-elemental Analysis of Solid Materials Using an ICP-MS (2021)
  • Author(s): 平田岳史
  • Journal Title: BUNSEKI KAGAKU Volume: 70 Issue: 12 Pages: 729-735
  • DOI: 10.2116/bunsekikagaku.70.729
  • NAID: 130008162162
  • ISSN: 0525-1931
  • Year and Date: 2021-12-05
  • Peer Reviewed / Open Access
• [Journal Article] Non-malignant diseases associated with environmental arsenic exposure in Taiwan, Chile, and Bangladesh (2021)
  • Author(s): Himeno, S., Hossain, K
  • Journal Title: Metallomics Research Volume: 1 Issue: 1 Pages: rev-31-rev-46
  • DOI: 10.11299/metallomicsresearch.MR202109
  • NAID: 130008159231
  • ISSN: 2436-5173
  • Year and Date: 2021-12-01
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Size Analysis of Small Metal Nanoparticles Using Single Particle ICP Mass Spectrometry (2021)
  • Author(s): YAMASHITA Shuji、NAKAZATO Masaki、HIRATA Takafumi
  • Journal Title: Analytical Sciences Volume: 37 Issue: 11 Pages: 1637-1640
  • DOI: 10.2116/analsci.21N014
  • NAID: 130008114755
  • ISSN: 0910-6340, 1348-2246
  • Year and Date: 2021-11-10
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Structural analysis of chemically synthesized selenophosphate, a donor for selenocysteine biosynthesis (2021)
  • Author(s): N. Suzuki, M. Verdugo, T. Hatakeyama and Y. Ogra
  • Journal Title: Metallomics Research Volume: 1 Issue: 1 Pages: reg-20-reg-25
  • DOI: 10.11299/metallomicsresearch.MR202103
  • ISSN: 2436-5173
  • Year and Date: 2021-10-15
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Roles of Gut Microflora in Selenium Metabolism of Host Animals (2021)
  • Author(s): 小椋康光、髙橋一聡
  • Journal Title: YAKUGAKU ZASSHI Volume: 141 Issue: 5 Pages: 689-693
  • DOI: 10.1248/yakushi.20-00243-4
  • NAID: 130008032750
  • ISSN: 0031-6903, 1347-5231
  • Year and Date: 2021-05-01
  • Peer Reviewed / Open Access
• [Journal Article] Roles of Zinc Transporters That Control the Essentiality and Toxicity of Manganese and Cadmium (2021)
  • Author(s): Himeno Seiichiro、Fujishiro Hitomi
  • Journal Title: YAKUGAKU ZASSHI Volume: 141 Issue: 5 Pages: 695-703
  • DOI: 10.1248/yakushi.20-00243-5
  • NAID: 130008032754
  • ISSN: 0031-6903, 1347-5231
  • Year and Date: 2021-05-01
  • Peer Reviewed / Open Access
• [Journal Article] In situ isotopic analysis of uranium using a new data acquisition protocol for 10^13 ohm Faraday amplifiers (2021)
  • Author(s): Yamamoto Kota、Asanuma Hisashi、Takahashi Hiroaki、Hirata Takafumi
  • Journal Title: Journal of Analytical Atomic Spectrometry Volume: 36 Issue: 3 Pages: 668-675
  • DOI: 10.1039/d0ja00498g
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Formation Mechanism and Toxicological Significance of Biogenic Mercury Selenide Nanoparticles in Human Hepatoma HepG2 Cells (2021)
  • Author(s): Y. Tanaka, H. Usuzawa, M. Yoshida, K. Kumagai, K. Kobayashi, S. Matsuyama, T. Inoue, A. Matsunaga, M. Shimura, J. Ruiz Encinar, J.M. Costa-Fernandez, Y. Fukumoto, N. Suzuki and Y. Ogra
  • Journal Title: Chemical Research in Toxicology Volume: 34 Issue: 12 Pages: 2471-2484
  • DOI: 10.1021/acs.chemrestox.1c00231
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Distributions of mercury and selenium in rats ingesting mercury selenide nanoparticles (2021)
  • Author(s): K. Takahashi, J. Ruiz Encinar, J.M. Costa Fernandez and Y. Ogra
  • Journal Title: Ecotoxicology and Environmental Safety Volume: 226 Pages: 112867-112867
  • DOI: 10.1016/j.ecoenv.2021.112867
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Comparison of quantification of selenocyanate and thiocyanate in cultured mammalian cells between HPLC-fluorescence detector and HPLC-inductively coupled plasma mass spectrometer (2021)
  • Author(s): Hongprasit Aphinan、Okamoto Yusuke、Toida Toshihiko、Ogra Yasumitsu
  • Journal Title: Journal of Chromatography B Volume: 1181 Pages: 122924-122924
  • DOI: 10.1016/j.jchromb.2021.122924
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Determination of spatial mercury concentration by laser ablation-inductively coupled plasma mass spectrometry (2021)
  • Author(s): M. Iwase, Y. Tanaka, N. Suzuki and Y. Ogra
  • Journal Title: The Journal of Toxicological Sciences Volume: 46 Issue: 5 Pages: 193-198
  • DOI: 10.2131/jts.46.193
  • NAID: 130008033305
  • ISSN: 0388-1350, 1880-3989
  • Peer Reviewed / Open Access
• [Journal Article] 総説）化学形態分析から解き明かすセレンの代謝機構 (2021)
  • Author(s): 小椋康光
  • Journal Title: 金属 Volume: 91 Pages: 729-734
  • Peer Reviewed
• [Journal Article] Comparisons of segment-specific toxicity of platinum-based agents and cadmium using S1, S2, and S3 cells derived from mouse kidney proximal tubules (2021)
  • Author(s): Fujishiro Hitomi、Taguchi Hiroki、Hamao Satoko、Sumi Daigo、Himeno Seiichiro
  • Journal Title: Toxicology in Vitro Volume: 75 Pages: 105179-105179
  • DOI: 10.1016/j.tiv.2021.105179
  • Peer Reviewed / Open Access
• [Journal Article] Single-Cell Imaging for Studies of Renal Uranium Transport and Intracellular Behavior (2021)
  • Author(s): S. Homma-Takeda, H. Fujishiro, I. Tanaka, H. Yakumaru, K. Ayama, A. Uehara, M. Oikawa, S. Himeno, H. Ishihara
  • Journal Title: Minerals Volume: 11 Issue: 2 Pages: 191-191
  • DOI: 10.3390/min11020191
  • Peer Reviewed / Open Access
• [Journal Article] T helper 2-driven immune dysfunction in chronic arsenic-exposed individuals and its link to the features of allergic asthma (2021)
  • Author(s): Rahman, A., Islam, M. S., Tony, S. R., Siddique, A. E., Mondal, V., Hosen, Z., Islam, Z., Hossain, M. I., Rahman, M., Anjum, A., Paul, S. K., Hossen, F., Sarker, M. K., Hossain, S., Salam, K. A., Haque, A., Hoque, M. A., Saud, Z. A., Xin, L., Sumi, D., Himeno, S., Hossain K
  • Journal Title: Toxicology and Applied Pharmacology Volume: 420 Pages: 115532-115532
  • DOI: 10.1016/j.taap.2021.115532
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Horror of three synergistic factors in THA: high mechanical stress, dissimilar metals, low elasticity stem: a case report (2021)
  • Author(s): Ishii Seiya、Homma Yasuhiro、Matsukawa Takehisa、Baba Tomonori、Kubota Ayano、Yokoyama Kazuhito、Kaneko Kazuo、Ishijima Muneaki
  • Journal Title: Arthroplasty Volume: 3 Issue: 1 Pages: 1-7
  • DOI: 10.1186/s42836-021-00091-7
  • Peer Reviewed / Open Access
• [Journal Article] An Investigation of the Wild Rat Crown Incisor as an Indicator of Lead (Pb) Exposure Using Inductively Couple Plasma Mass Spectrometry (ICP-MS) and Laser Ablation ICP-MS (2021)
  • Author(s): Kataba Andrew、Nakayama Shouta M. M.、Nakata Hokuto、Toyomaki Haruya、Yohannes Yared B.、Yabe John、Muzandu Kaampwe、Zyambo Golden、Kubota Ayano、Matsukawa Takehisa、Yokoyama Kazuhito、Ikenaka Yoshinori、Ishizuka Mayumi
  • Journal Title: International Journal of Environmental Research and Public Health Volume: 18 Issue: 2 Pages: 767-767
  • DOI: 10.3390/ijerph18020767
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Analysis of lead distribution in avian organs by LA-ICP-MS: Study of experimentally lead-exposed ducks and kites (2021)
  • Author(s): Torimoto Ryouta、Ishii Chihiro、Sato Hiroshi、Saito Keisuke、Watanabe Yukiko、Ogasawara Kohei、Kubota Ayano、Matsukawa Takehisa、Yokoyama Kazuhito、Kobayashi Atsushi、Kimura Takashi、Nakayama Shouta M.M.、Ikenaka Yoshinori、Ishizuka Mayumi
  • Journal Title: Environmental Pollution Volume: 283 Pages: 117086-117086
  • DOI: 10.1016/j.envpol.2021.117086
  • Peer Reviewed / Open Access
• [Journal Article] Prenatal blood levels of some toxic metals and the risk of spontaneous abortion (2021)
  • Author(s): Vigeh Mohsen、Yunesian Masud、Matsukawa Takehise、Shamsipour Mansour、Jeddi Maryam Zare、Rastkari Noushin、Hassanvand Mohammad Sadegh、Shariat Mamak、Kashani Homa、Pirjani Reihaneh、Effatpanah Mohammad、Shirazi Mahboobeh、Shariatpanahi Ghazal、Ohtani Katsumi、Yokoyama Kazuhito
  • Journal Title: Journal of Environmental Health Science and Engineering Volume: 19 Issue: 1 Pages: 357-363
  • DOI: 10.1007/s40201-020-00608-3
  • Peer Reviewed / Int'l Joint Research
• [Journal Article] Uranium&-lead isotopic analysis from transient signals using high-time resolution-multiple collector-ICP-MS (HTR-MC-ICP-MS) (2021)
  • Author(s): Hirata Takafumi、Niki Sota、Yamashita Shuji、Asanuma Hisashi、Iwano Hideki
  • Journal Title: Journal of Analytical Atomic Spectrometry Volume: 36 Issue: 1 Pages: 70-74
  • DOI: 10.1039/d0ja00363h
  • NAID: 130007977149
  • Peer Reviewed / Open Access
• [Journal Article] Analytical Capability of High-Time Resolution-Multiple Collector-Inductively Coupled Plasma-Mass Spectrometry for the Elemental and Isotopic Analysis of Metal Nanoparticles (2020)
  • Author(s): Hirata Takafumi、Yamashita Shuji、Ishida Mirai、Suzuki Toshihiro
  • Journal Title: Mass Spectrometry Volume: 9 Issue: 1 Pages: A0085-A0085
  • DOI: 10.5702/massspectrometry.A0085
  • NAID: 130007854034
  • ISSN: 2186-5116, 2187-137X
  • Year and Date: 2020-06-10
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Single-dose toxicity study by intra-arterial injection of 10BSH entrapped water-in-oil-in-water emulsion for boron neutron capture therapy to hepatocellular carcinoma (2020)
  • Author(s): H. Yanagie, M. Yanagawa, T. Higuchi, N. Dewi, Y. Nonaka, A. Shinohara, T. Matsukawa, K. Yokoyama, M. Suzuki, S. Masunaga, Y. Sakurai, H. Tanaka, K. Ono, H. Yamauchi, M. Ono, J. Nakajima, S. Higashi, H. Takahashi
  • Journal Title: Applied Radiation and Isotopes Volume: 163 Pages: 109202-109202
  • DOI: 10.1016/j.apradiso.2020.109202
  • Peer Reviewed / Open Access
• [Journal Article] Production of a Urinary Selenium Metabolite, Trimethylselenonium, by Thiopurine S-Methyltransferase and Indolethylamine N-Methyltransferase (2020)
  • Author(s): Yasunori Fukumoto, Hirotaka Yamada, Kemmu Matsuhashi, Wakaba Okada, Yu-ki Tanaka, Noriyuki Suzuki, and Yasumitsu Ogra
  • Journal Title: Chemical Research in Toxicology Volume: 33 Issue: 9 Pages: 2467-2474
  • DOI: 10.1021/acs.chemrestox.0c00254
  • Peer Reviewed / Open Access
• [Journal Article] Elucidation of tellurium biogenic nanoparticles in garlic, Allium sativum, by inductively coupled plasma-mass spectrometry. (2020)
  • Author(s): Y. Tanaka, S. Takada, K. Kumagai, K. Kobayashi, A. Hokura and Y Ogra
  • Journal Title: J. Trace Elem. Med. Biol. Volume: - Pages: 126628-126628
  • DOI: 10.1016/j.jtemb.2020.126628
  • Peer Reviewed / Open Access
• [Journal Article] Quantitative elemental analysis of a single cell using inductively coupled plasma-mass spectrometry in fast time-resolved analysis mode (2020)
  • Author(s): Yu-ki Tanaka, Risako Iida, Shohei Takada, Tetsuo Kubota, Michiko Yamanaka, Naoki Sugiyama, Yolande Abdelnour and Yasumitsu Ogra
  • Journal Title: ChemBioChem Volume: 21 Issue: 22 Pages: 3266-3272
  • DOI: 10.1002/cbic.202000358
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Effect of gut microflora on nutritional availability of selenium (2020)
  • Author(s): Takahashi Kazuaki、Suzuki Noriyuki、Ogra Yasumitsu
  • Journal Title: Food Chemistry Volume: 319 Pages: 126537-126537
  • DOI: 10.1016/j.foodchem.2020.126537
  • Peer Reviewed / Open Access
• [Journal Article] Role of Metallothionein in Transcriptional Regulation by Metal-Responsive Element-Binding Transcription Factor 1 (2020)
  • Author(s): Tanaka Yu-ki、Futami Yoshiaki、Fukumoto Yasunori、Suzuki Noriyuki、Ogra Yasumitsu
  • Journal Title: BPB Reports Volume: 3 Issue: 1 Pages: 22-27
  • DOI: 10.1248/bpbreports.3.1_22
  • NAID: 130007944892
  • ISSN: 2434-432X
  • Peer Reviewed / Open Access
• [Journal Article] Identification of the biliary selenium metabolite and the biological significance of selenium enterohepatic circulation (2020)
  • Author(s): Takahashi Kazuaki、Ogra Yasumitsu
  • Journal Title: Metallomics Volume: 12 Issue: 2 Pages: 241-248
  • DOI: 10.1039/c9mt00274j
  • Peer Reviewed / Open Access
• [Journal Article] In Vitro Evaluation of the Effects of Cadmium on Endocytic Uptakes of Proteins into Cultured Proximal Tubule Epithelial Cells (2020)
  • Author(s): Fujishiro Hitomi、Yamamoto Hazuki、Otera Nobuki、Oka Nanae、Jinno Mei、Himeno Seiichiro
  • Journal Title: Toxics Volume: 8 Issue: 2 Pages: 24-24
  • DOI: 10.3390/toxics8020024
  • Peer Reviewed / Open Access
• [Journal Article] Arsenic exposure-related hyperglycemia is linked to insulin resistance with concomitant reduction of skeletal muscle mass (2020)
  • Author(s): Mondal Victor、Hosen Zubaer、Hossen Faruk、Siddique Abu Eabrahim、Tony Selim Reza、Islam Zohurul、Islam Md. Shofikul、Hossain Shakhawoat、Islam Khairul、Sarker Md. Khalequzzaman、Hasibuzzaman M.M.、Liu Ling-Zhi、Jiang Bing-Hua、Hoque Md Mominul、Saud Zahangir Alam、Xin Lian、Himeno Seiichiro、Hossain Khaled
  • Journal Title: Environment International Volume: 143 Pages: 105890-105890
  • DOI: 10.1016/j.envint.2020.105890
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Bioimaging of Pb and STIM1 in mice liver, kidney and brain using Laser Ablation Inductively Coupled Plasma Mass Spectrometry (LA-ICP-MS) and immunohistochemistry (2020)
  • Author(s): Togao Masao、Nakayama Shouta M.M.、Ikenaka Yoshinori、Mizukawa Hazuki、Makino Yoshiki、Kubota Ayano、Matsukawa Takehisa、Yokoyama Kazuhito、Hirata Takafumi、Ishizuka Mayumi
  • Journal Title: Chemosphere Volume: 238 Pages: 124581-124581
  • DOI: 10.1016/j.chemosphere.2019.124581
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Elemental and Isotope Ratio Analysis of Single Nanoparticles Using a Multiple Collector ICP-MS (2019)
  • Author(s): 平田岳史、山下修司、鈴木敏弘、石田未来
  • Journal Title: BUNSEKI KAGAKU Volume: 68 Issue: 2 Pages: 81-88
  • DOI: 10.2116/bunsekikagaku.68.81
  • NAID: 130007607784
  • ISSN: 0525-1931
  • Year and Date: 2019-02-05
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] Development of an Imaging Method for Nanoparticles by a Laser Ablation ICP-MS (2019)
  • Author(s): 山下修司、鈴木敏弘、平田岳史
  • Journal Title: BUNSEKI KAGAKU Volume: 68 Issue: 1 Pages: 1-7
  • DOI: 10.2116/bunsekikagaku.68.1
  • NAID: 130007590776
  • ISSN: 0525-1931
  • Year and Date: 2019-01-05
  • Peer Reviewed / Open Access / Int'l Joint Research
• [Journal Article] レーザーアブレーションICP 質量分析法 による元素およびナノ粒子のイメージング (2019)
  • Author(s): 平田岳史， 槇納好岐， 山下修司
  • Journal Title: ぶんせき Volume: 8 Pages: 334-341
• [Journal Article] Quantitative Bio-imaging of Gadolinium-157 in Tissues Through Laser-ablation ICP-MS for Neutron Capture Therapy (2019)
  • Author(s): Kubota A., Matsukawa T., Yanagie H., Yanagawa M., Hirata T., Shinohara A., Yokoyama K.
  • Journal Title: Juntendo Medical Journal Volume: 65 Issue: 5 Pages: 461-467
  • DOI: 10.14789/jmj.2019.65.JMJ19-OA12
  • NAID: 130007752696
  • ISSN: 2187-9737, 2188-2126
  • Peer Reviewed / Open Access
• [Journal Article] Segment-specific and direction-dependent transport of cadmium and manganese in immortalized S1, S2, and S3 cells derived from mouse kidney proximal tubules (2019)
  • Author(s): Fujishiro Hitomi、Hamao Satoko、Isawa Misaki、Himeno Seiichiro
  • Journal Title: The Journal of Toxicological Sciences Volume: 44 Issue: 9 Pages: 611-619
  • DOI: 10.2131/jts.44.611
  • NAID: 130007700742
  • ISSN: 0388-1350, 1880-3989
  • Peer Reviewed / Open Access
• [Journal Article] Gene expression profiles of immortalized S1, S2, and S3 cells derived from each segment of mouse kidney proximal tubules (2019)
  • Author(s): Fujishiro Hitomi、Himeno Seiichiro
  • Journal Title: Fundamental Toxicological Sciences Volume: 6 Issue: 4 Pages: 117-123
  • DOI: 10.2131/fts.6.117
  • NAID: 130007649488
  • ISSN: 2189-115X
  • Peer Reviewed / Open Access
• [Journal Article] Toxicometallomics of Cadmium, Manganese and Arsenic with Special Reference to the Roles of Metal Transporters (2019)
  • Author(s): Himeno Seiichiro、Sumi Daigo、Fujishiro Hitomi
  • Journal Title: Toxicological Research Volume: 35 Issue: 4 Pages: 311-317
  • DOI: 10.5487/tr.2019.35.4.311
  • Peer Reviewed / Open Access
• [Presentation] レーザーアブレーション（LA）ーICP質量分析法を用いた超高感度元素分析 (2022)
  • Author(s): 平田岳史
  • Organizer: 4.一般社団法人ニューガラスフォーラム 2021年度第2回ガラス科学技術／評価技術合同研究会
  • Invited
• [Presentation] 質量分析法を用いたハイブリッド・イメージング法の開発 (2022)
  • Author(s): 平田岳史
  • Organizer: 2回レドックスR&D戦略委員会 春のシンポジウム
  • Invited
• [Presentation] 腎臓におけるカドミウム動態解析とその毒性発現機構 (2022)
  • Author(s): 高岡理奈、藤代瞳、松本可南子、久保田章乃、松川岳久、横山和仁、竹内久美子、姫野誠一郎、角大悟
  • Organizer: 日本薬学会第142年会
• [Presentation] ヒト腎臓近位尿細管由来不死化細胞を用いた再吸収障害機構の検討 (2022)
  • Author(s): 藤川真美、増富由姫、藤代瞳、姫野誠一郎、角大悟
  • Organizer: 日本薬学会第142年会
• [Presentation] シスプラチン曝露による近位尿細管S3領域の毒性発現機構の検討 (2022)
  • Author(s): 田口央基、藤代瞳、姫野誠一郎、角大悟
  • Organizer: 日本薬学会第142年会
• [Presentation] 低濃度鉛曝露による離乳後の仔ラットの注意力低下と海馬中D,L-セリンへの影響 (2022)
  • Author(s): 大森由紀, 上窪裕二, 関根正恵, 杉谷善信, 松川岳久, 小林桃子, 武藤剛, 横山和仁, 角田正史, 片根真澄, 齋藤康昭, 宮本哲也, 加藤くみ子, 本間浩, 堀口兵剛
  • Organizer: 第92回日本衛生学会学術総会
• [Presentation] メタロミクス研究に向けたイメージング分析技術開発 (2021)
  • Author(s): 平田岳史
  • Organizer: 新学術領域研究「生命金属科学」
  • Invited
• [Presentation] レーザー質量分析計が切り拓く地質学研究の新展開 (2021)
  • Author(s): 平田岳史
  • Organizer: 日本地質学会第128回学術大会
  • Invited
• [Presentation] レーザーアブレーション;プラズマイオン源質量分析法による 超高感度イメージング (2021)
  • Author(s): 平田岳史
  • Organizer: 日本医用マススペクトル学会
  • Invited
• [Presentation] シスプラチンの近位尿細管領域特異的毒性発現とその機序の検討 (2021)
  • Author(s): 藤代瞳，田口央基、姫野誠一郎、上原章寛、武田志乃、角大悟
  • Organizer: 第48回日本毒性学会学術年会
  • Invited
• [Presentation] バングラデシュのヒ素汚染地での喘息発症に関与するTh2サイトカイン、エオタキシン、ペリオスチン (2021)
  • Author(s): 姫野誠一郎、角 大悟、野原恵子、Khaled Hossain
  • Organizer: 第28回日本免疫毒性学会学術年会
• [Presentation] カドミウムメタロチオネイン投与による近位尿細管障害の解析 (2021)
  • Author(s): 藤代 瞳、高岡 理奈、姫野 誠一郎、角 大悟
  • Organizer: フォーラム2021：衛生薬学・環境トキシコロジー
• [Presentation] 近位尿細管S3領域のシスプラチンによる不可逆毒性発現機構の解析 (2021)
  • Author(s): 田口央基、藤代瞳、姫野誠一郎、角大悟
  • Organizer: フォーラム2021：衛生薬学・環境トキシコロジー
• [Presentation] 亜鉛輸送体ZIP8の金属結合モチーフがMn輸送に及ぼす影響の解析 (2021)
  • Author(s): 藤代瞳、田口央基、神戸大朋、姫野誠一郎、角大悟
  • Organizer: 第32回日本微量元素学会学術集会
• [Presentation] シスプラチン曝露による近位尿細管S3領域の不可逆毒性発現機構の検討 (2021)
  • Author(s): 田口央基、藤代瞳、姫野誠一郎、角大悟
  • Organizer: 第60回日本薬学会・日本薬剤師会・日本病院薬剤師会中国四国支部学術大会
• [Presentation] アジアにおけるヒ素汚染と健康影響： ー実験科学者による野外調査への挑戦 (2021)
  • Author(s): 姫野誠一郎
  • Organizer: メタルバイオサイエンス研究会2021
  • Invited
• [Presentation] 近位尿細管S3領域のシスプラチンによる毒性発現機構の解析 (2021)
  • Author(s): 田口央基，藤代瞳, 姫野誠一郎，角大悟
  • Organizer: メタルバイオサイエンス研究会2021
• [Presentation] カドミウム-メタロチオネイン複合体投与腎障害モデルの検討 (2021)
  • Author(s): 石崎友香，藤代瞳，松川岳久, 横山和仁, 姫野誠一郎，角 大悟
  • Organizer: メタルバイオサイエンス研究会2021
• [Presentation] 長期カドミウム曝露によるカドミウムの分布と腎機能の経時的変化 (2021)
  • Author(s): 北村はるか，藤代瞳，松川岳久, 横山和仁, 姫野誠一郎, 角大悟
  • Organizer: メタルバイオサイエンス研究会2021
• [Presentation] 医薬品開発へのLA-ICP-MSの実践的応用 (2021)
  • Author(s): 松川岳久, 横山和仁
  • Organizer: 第8回レーザーアブレーションワークショップ-どうするどうなるLA-ICP-MS
• [Presentation] Comparison of CR-39 autoradiography and laser ablation ICP-MS imaging to assess 10B distribution of tibia bone in 10BPA-treated mice (2021)
  • Author(s): Matsukawa T., Takeno S., Iwasaki R., Suzuki M., Yokoyama, K
  • Organizer: The 19th International Congress on Neutron Capture Therapy (ICNCT 19)
  • Int'l Joint Research
• [Presentation] Tumor growth suppression by gadolinium-neutron capture therapy with intra-tumoral injection of gadolinium-liposome complex (Gd-plex) to pancreatic cancer model in vivo (2021)
  • Author(s): Yanagie Y., Yanagie H., Hou X., Yanagawa M., Matsukawa T., Kubota A., Suzuki M., Masunaga S., Sakurai Y., Tanaka H., Nashimoto M., Takahashi H
  • Organizer: The 19th International Congress on Neutron Capture Therapy (ICNCT 19)
  • Int'l Joint Research
• [Presentation] Application of intra-tumoral injection of cationic polymers mixed with Gd compounds for Neutron Capture therapy to pancreatic cancer model (2021)
  • Author(s): Yanagie H., Yanagawa M., Hou X., Yanagie Y., Matsukawa T., Kubota A., Suzuki M., Masunaga S., Sakurai Y., Tanaka H., Nashimoto M., Takahashi H.
  • Organizer: The 19th International Congress on Neutron Capture Therapy (ICNCT 19)
  • Int'l Joint Research
• [Presentation] 一般病院の腎疾患患者における高β2-ミクログロブリン尿症 (2021)
  • Author(s): 堀口兵剛, 小熊悦子, 大森由紀, 小林桃子, 松川岳久, 澤村昌人, 菊地孝哉, 伊藤圭吾, 宮島江里子, 高橋遼
  • Organizer: 第91回日本衛生学会学術総会
• [Presentation] ガドリニウム中性子捕捉療法製剤のマウスin vivoでの用量依存性に関する基礎検討 (2020)
  • Author(s): 松川岳久, 鈴木実, 久保田章乃, 篠原厚子, 横山和仁
  • Organizer: メタルバイオサイエンス研究会2020
• [Presentation] マウス悪性黒色腫骨転移モデルにおけるガドリニウム中性子捕捉療法の検討 (2020)
  • Author(s): 篠原厚子, 松川岳久, 鈴木実, 久保田章乃, 梶野一徳, 横山和仁
  • Organizer: 第36回希土類討論会
• [Presentation] LM8骨腫瘍マウスモデルにおけるGd-EDTMP中性子捕捉療法による効果の検討 (2020)
  • Author(s): 松川岳久, 鈴木実, 久保田章乃, 篠原厚子, 横山和仁
  • Organizer: 第90回日本衛生学会学術総会
• [Presentation] カドミウム－メタロチオネイン投与による腎障害モデルの再検 (2020)
  • Author(s): 藤代瞳、松本可南子、竹森千紗、松川岳久、横山和仁、姫野誠一郎
  • Organizer: 第31回日本微量元素学会学術集会
• [Presentation] Dysfunction of manganese metabolism due to mutations of zinc transporter ZIP8. (2020)
  • Author(s): Fujishiro, H.
  • Organizer: The Pharmaceutical Society of Korea 2020
  • Int'l Joint Research / Invited
• [Presentation] 亜鉛輸送体ZIP8の変異による全身性マンガン恒常性調節異常 (2020)
  • Author(s): 藤代瞳、神戸大朋
  • Organizer: 第93回日本生化学会大会
• [Presentation] メタロミクスの積極的な医学応用=メディカルメタロミクス= (2019)
  • Author(s): 松川岳久, 横山和仁
  • Organizer: メタルバイオサイエンス研究会2019
• [Presentation] 元素イメージングと免疫組織染色によるカドミウムの腎臓蓄積と毒性の評価 (2019)
  • Author(s): 姫野誠一郎, 角野心晴, 藤代瞳, 松川岳久, 横山和仁
  • Organizer: 第30回日本微量元素学会
• [Presentation] LA-ICP-MSを用いた腎臓中カドミウム集積部位の解析とKim-1発現部位との比較 (2019)
  • Author(s): 藤代瞳, 角野心晴, 松川岳久, 横山和仁, 姫野誠一郎
  • Organizer: 第46回日本毒性学会学術年会
• [Presentation] 定同位体組成を指標にした元素代謝評価 (2019)
  • Author(s): 田中 佑樹，小椋 康光, 高垣 裕子, 平田 岳史
  • Organizer: メタルバイオサイエンス研究会2019
• [Presentation] 世界をリードする日本のメタロミクス研究：ISM-8 (2021) に向けて (2019)
  • Author(s): 小椋康光
  • Organizer: メタルバイオサイエンス研究会2019
• [Presentation] メタロチオネインによる重金属依存性転写因子の活性調節機構の解明 (2019)
  • Author(s): 田中 佑樹，二見 叔亮，松橋 研武，福本 泰典，鈴木 紀行，小椋 康光
  • Organizer: メタルバイオサイエンス研究会2019
• [Presentation] 髙橋 一聡，小椋 康光 (2019)
  • Author(s): 消化管内におけるセレン代謝の影響とその生物学的意義の解明
  • Organizer: メタルバイオサイエンス研究会2019
• [Presentation] セレンを含有する天然物セレノネインの生理作用の検討 (2019)
  • Author(s): 栗原 菜摘，鈴木 紀行，市川 惠一，原 精一，伊藤 考太郎，小椋 康光
  • Organizer: メタルバイオサイエンス研究会2019
• [Presentation] 松橋 研武，渋川 侑果，田中 佑樹，福本 泰典，鈴木 紀行，小椋 康光 (2019)
  • Author(s): セレン糖のメチル化に関わる転移酵素の探索
  • Organizer: メタルバイオサイエンス研究会2019
• [Presentation] レーザーアブレーション ICP 質量分析法によるナノ粒子イメージング分析法の開発 (2019)
  • Author(s): 山下 修司，鈴木 敏弘，平田 岳史
  • Organizer: メタルバイオサイエンス研究会2019
• [Book] Chapter 6: Bismuth. in “Handbook on the Toxicology of Metals, Volume II. Fifth Edition” (2021)
  • Author(s): Himeno, S., Fujishiro, H., Sumi, D.
  • Total Pages: 1011
  • Publisher: Elsevier
  • ISBN: 9780128229460
• [Book] 腎臓におけるカドミウムとマンガンの輸送とその撹乱, 「生命金属ダイナミクス: 生体内における金属の挙動と制御」城 宜嗣・津本浩平（監修） (2021)
  • Author(s): 藤代瞳、姫野誠一郎
  • Total Pages: 564
  • Publisher: エヌ・ティー・エス出版
  • ISBN: 9784860437060
• [Book] 「環境化学物質および医薬品としてのヒ素化合物」 生命金属ダイナミクス: 生体内における金属の挙動と制御 城 宜嗣・津本浩平 監修 (2021)
  • Author(s): 角大悟、姫野誠一郎
  • Total Pages: 564
  • Publisher: エヌ・ティー・エス出版
  • ISBN: 9784860437060
• [Book] 生命金属ダイナミクス 生体内における金属の挙動と制御 (2021)
  • Author(s): 小椋康光（分担執筆）
  • Publisher: エヌ・ティー・エス
• [Book] 生命金属ダイナミクス：生体内における金属の挙動と制御 (2021)
  • Author(s): 藤代 瞳、姫野誠一郎（分担執筆）
  • Publisher: エヌ・ティー・エス
• [Book] ICP-質量分析法、衛生試験法・注解2020 (2020)
  • Author(s): 小椋康光（分担執筆、編集委員長）
  • Total Pages: 1
  • Publisher: 日本薬学会編、金原出版
• [Book] Essential and Toxic Trace Elements and Vitamins in Human Health (2020)
  • Author(s): Himeno, S., Fujishiro, H.
  • Publisher: Elsevier