Development of a screening method for early stage of dementia using behavioral features

• Project/Area Number: 19H01084
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Review Section: Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
• Research Institution: University of Tsukuba
• Principal Investigator: Arai Tetsuaki 筑波大学, 医学医療系, 教授 (90291145)
• Co-Investigator(Kenkyū-buntansha): 田中 喜代次 筑波大学, 体育系, 名誉教授 (50163514) ; 笹井 浩行 地方独立行政法人東京都健康長寿医療センター(東京都健康長寿医療センター研究所), 東京都健康長寿医療センター研究所, 研究員 (60733681) ; 西村 雅史 静岡大学, 情報学部, 教授 (60740363) ; 根本 清貴 筑波大学, 医学医療系, 准教授 (80550152) ; 根本 みゆき 筑波大学, 医学医療系, 講師 (80754316)
• Project Period (FY): 2019-04-01 – 2022-03-31
• Project Status: Completed (Fiscal Year 2021)
• Budget Amount: ¥45,890,000 (Direct Cost: ¥35,300,000、Indirect Cost: ¥10,590,000); Fiscal Year 2021: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000); Fiscal Year 2020: ¥13,260,000 (Direct Cost: ¥10,200,000、Indirect Cost: ¥3,060,000); Fiscal Year 2019: ¥19,370,000 (Direct Cost: ¥14,900,000、Indirect Cost: ¥4,470,000)
• Keywords: 行動特徴 / 軽度認知障害 / アルツハイマー病 / 早期スクリーニング / バイオマーカー / AI / 機械学習 / タウPET / 認知症プレクリニカル期 / スクリーニング / プレクリニカル期 / タウ / PET / MCI

Outline of Research at the Start

臨床症状のない認知症プレクリニカル期の重要性が認識されているが、患者特定には、バイオマーカーが高額・侵襲性を伴う、簡易スクリーニングの臨床検査は十分な精度がない、という課題がある。
近年、AI技術を用いた音声や歩行などの行動特徴の定量化を利用する事で、高い精度での認知症スクリーニングが可能であること、及び臨床検査と組み合わせることでその精度が更に向上することが示されている。
本研究では、この研究をプレクリニカル期に拡張し、バイオマーカーによるプレクリニカル期進行度と相関する行動特徴を同定し、日常生活及び臨床現場の双方で利用可能な非侵襲で簡便なスクリーニング手法として新規に定式化する事を目指す。

Outline of Final Research Achievements

The purpose of this study was to identify the behavioral features that correlate with various biomarkers and neuropsychological tests, and to develop a non-invasive and low-cost early screening method for dementia that can be used in both daily life and clinical settings. We constructed a screening model by using AI technology to extract and combine the features from behavioral data, including gait, speech and drawing, obtained from activities of daily living. The results showed that the cases with mild cognitive impairment and those with Alzheimer’s disease could be discriminated from healthy controls with a high accuracy of more than 90%.

Academic Significance and Societal Importance of the Research Achievements

本研究で得た、歩行、音声、描画などの行動特徴を用いたスクリーニング手法は、非侵襲的で安価な手段として、医療機関におけるAD及びMCIの早期発見に役立つだけでなく、多数例のスクリーニングが必要な疾患修飾薬等の新薬の治験の際にも力を発揮すると思われる。さらに、本手法は、地域の健康診断や介護予防教室などの専門家がいない環境においても、認知症の早期スクリーニングのツールとして利用できる可能性があり、今後の発展が期待できる。

Research Products

• [Journal Article] The Multicomponent Day-Care Program Prevents Volume Reduction in a Memory-Related Brain Area in Patients with Mild Cognitive Impairment (2022)
  • Author(s): Boku Youshun、Ota Miho、Nemoto Miyuki、Numata Yuriko、Kitabatake Ayako、Takahashi Takumi、Nemoto Kiyotaka、Tamura Masashi、Sekine Aya、Ide Masayuki、Kaneda Yuko、Arai Tetsuaki
  • Journal Title: Dementia and Geriatric Cognitive Disorders Volume: - Issue: 2 Pages: 1-8
  • DOI: 10.1159/000522654
  • Peer Reviewed / Open Access
• [Journal Article] Dynamic balance deficit and the neural network in Alzheimer's disease and mild cognitive impairment (2022)
  • Author(s): Ide Ryotaro、Ota Miho、Hada Yasushi、Watanabe Serina、Takahashi Takumi、Tamura Masashi、Nemoto Kiyotaka、Arai Tetsuaki
  • Journal Title: Gait & Posture Volume: 93 Pages: 252-258
  • DOI: 10.1016/j.gaitpost.2022.01.018
  • Peer Reviewed / Open Access
• [Journal Article] Relationships between the Fear of COVID-19 Scale and regional brain atrophy in mild cognitive impairment (2022)
  • Author(s): Takahashi Takumi、Ota Miho、Numata Yuriko、Kitabatake Ayako、Nemoto Kiyotaka、Tamura Masashi、Ide Masayuki、Matsuzaki Asaki、Kaneda Yuko、Arai Tetsuaki
  • Journal Title: Acta Neuropsychiatrica Volume: - Issue: 3 Pages: 1-10
  • DOI: 10.1017/neu.2022.7
  • Peer Reviewed / Open Access
• [Journal Article] Structural brain network correlations with amyloid burden in elderly individuals at risk of Alzheimer's disease (2022)
  • Author(s): Ota Miho、Numata Yuriko、Kitabatake Ayako、Tsukada Eriko、Kaneta Tomohiro、Asada Takashi、Meno Kohji、Uchida Kazuhiko、Suzuki Hideaki、Korenaga Tatsumi、Arai Tetsuaki
  • Journal Title: Psychiatry Research: Neuroimaging Volume: 319 Pages: 111415-111415
  • DOI: 10.1016/j.pscychresns.2021.111415
  • Peer Reviewed / Open Access
• [Journal Article] Automated Analysis of Drawing Process Estimates Global Cognition in Older Adults: A Preliminary International Validation on US and Japan Datasets (2022)
  • Author(s): Yasunori Yamada、Kaoru Shinkawa、Masatomo Kobayashi、Varsha D Badal、Danielle Glorioso、Ellen E Lee、Rebecca Daly、Camille Nebeker、Elizabeth W Twamley、Colin Depp、Miyuki Nemoto、Kiyotaka Nemoto、Ho-Cheol Kim、Tetsuaki Arai、Dilip V Jeste
  • Journal Title: JMIR Formative Research Volume: - Issue: 5 Pages: e37014-e37014
  • DOI: 10.2196/37014
  • Peer Reviewed / Open Access
• [Journal Article] An autopsied FTDP-17 case with MAPT IVS 10 + 14C > T mutation presenting with frontotemporal dementia (2021)
  • Author(s): Watanabe Ryohei、Kawakami Ito、Ikeuchi Takeshi、Murayama Shigeo、Arai Tetsuaki、Akiyama Haruhiko、Onaya Mitsumoto、Hasegawa Masato
  • Journal Title: eNeurologicalSci Volume: 24 Pages: 100363-100363
  • DOI: 10.1016/j.ensci.2021.100363
  • Peer Reviewed / Open Access
• [Journal Article] Differentiating Dementia with Lewy Bodies and Alzheimer's Disease by Deep Learning to Structural MRI (2021)
  • Author(s): Nemoto Kiyotaka、Sakaguchi Hiromasa、Kasai Wataru、Hotta Masatoshi、Kamei Ryotaro、Noguchi Tomoyuki、Minamimoto Ryogo、Arai Tetsuaki、Asada Takashi
  • Journal Title: Journal of Neuroimaging Volume: - Issue: 3 Pages: 579-587
  • DOI: 10.1111/jon.12835
  • Peer Reviewed / Open Access
• [Journal Article] Using Speech Data From Interactions With a Voice Assistant to Predict the Risk of Future Accidents for Older Drivers: Prospective Cohort Study (2021)
  • Author(s): Yamada Yasunori、Shinkawa Kaoru、Kobayashi Masatomo、Takagi Hironobu、Nemoto Miyuki、Nemoto Kiyotaka、Arai Tetsuaki
  • Journal Title: Journal of Medical Internet Research Volume: 23 Issue: 4 Pages: e27667-e27667
  • DOI: 10.2196/27667
  • Peer Reviewed / Open Access
• [Journal Article] Automatic Assessment of Loneliness in Older Adults Using Speech Analysis on Responses to Daily Life Questions (2021)
  • Author(s): Yamada Yasunori、Shinkawa Kaoru、Nemoto Miyuki、Arai Tetsuaki
  • Journal Title: Frontiers in Psychiatry Volume: 12
  • DOI: 10.3389/fpsyt.2021.712251
  • Peer Reviewed / Open Access
• [Journal Article] Combining Multimodal Behavioral Data of Gait, Speech, and Drawing for Classification of Alzheimer’s Disease and Mild Cognitive Impairment (2021)
  • Author(s): Yamada Yasunori、Shinkawa Kaoru、Kobayashi Masatomo、Vittorio Caggiano Vittorio、Nemoto Miyuki、Nemoto Kiyotaka、Arai Tetsuaki
  • Journal Title: Journal of Alzheimer's Disease Volume: 84 Issue: 1 Pages: 315-327
  • DOI: 10.3233/jad-210684
  • Peer Reviewed
• [Journal Article] Tablet-Based Automatic Assessment for Early Detection of Alzheimer's Disease Using Speech Responses to Daily Life Questions (2021)
  • Author(s): Yamada Yasunori、Shinkawa Kaoru、Kobayashi Masatomo、Nishimura Masafumi、Nemoto Miyuki、Tsukada Eriko、Ota Miho、Nemoto Kiyotaka、Arai Tetsuaki
  • Journal Title: Frontiers in Digital Health Volume: 3
  • DOI: 10.3389/fdgth.2021.653904
  • Peer Reviewed
• [Journal Article] Effects of Age-Related Cognitive Decline on Elderly User Interactions with Voice-Based Dialogue Systems (2019)
  • Author(s): Kobayashi Masatomo、Kosugi Akihiro、Takagi Hironobu、Nemoto Miyuki、Nemoto Kiyotaka、Arai Tetsuaki、Yamada Yasunori
  • Journal Title: Human-Computer Interaction Volume: 11749 Pages: 53-74
  • DOI: 10.1007/978-3-030-29390-1_4
  • ISBN: 9783030293895, 9783030293901
  • Peer Reviewed
• [Journal Article] Multimodal Behavior Analysis Towards Detecting Mild Cognitive Impairment: Preliminary Results on Gait and Speech (2019)
  • Author(s): Kaoru Shinkawa, Akihiro Kosugi, Masafumi Nishimura, Miyuki Nemoto, Kiyotaka Nemoto, Tomoko Takeuchi, Yuriko Numata, Ryohei Watanabe, Eriko Tsukada, Miho Ota, Shinji Higashi, Tetsuaki Arai, Yasunori Yamada
  • Journal Title: Stud Health Technol Inform Volume: 264 Pages: 343-347
  • Peer Reviewed
• [Journal Article] Handwriting Features of Multiple Drawing Tests for Early Detection of Alzheimer's Disease: A Preliminary Result. (2019)
  • Author(s): Tatsuya Ishikawa, Miyuki Nemoto, Kiyotaka Nemoto, Tomoko Takeuchi, Yuriko Numata, Ryohei Watanabe, Eriko Tsukada, Miho Ota, Shinji Higashi, Tetsuaki Arai, Yasunori Yamada
  • Journal Title: Stud Health Technol Inform Volume: 264 Pages: 168-172
  • Peer Reviewed
• [Presentation] A Study for Detecting Mild Cognitive Impairment by Analyzing Conversations with Humanoid Robots. (2021)
  • Author(s): Kenta Yoshii, Masafumi Nishimura, Daiki Kimura, Akihiro Kosugi. Kaoru Shinkawa, Toshiro Takase, Masatomo Kobayashi, Yasunori Yamada, Miyuki Nemoto, Ryohei Watanabe, Eriko Tsukada, Miho Ota, Kiyotaka Nemonoto, Teesuaki Arai, Shinji Higashi.
  • Organizer: 2021 IEEE 3rd Global Conference on Life Sciences and Technologies
  • Int'l Joint Research
• [Presentation] 人型ロボットとの日常会話音声を用いた認知症簡易スクリーニングのための基礎的検討. (2020)
  • Author(s): 吉井謙太, 木村大毅, 小杉晋央, 新川香, 高瀬俊郎, 小林正朋, 山田康智, 根本みゆき, 渡辺亮平, 塚田恵鯉子, 太田深秀, 東晋二, 根本清貴, 新井哲明, 西村雅史.
  • Organizer: 情報処理学会研究報告
• [Presentation] 人型ロボットとの会話における軽度認知症者の発話特徴分析. (2020)
  • Author(s): 吉井謙太, 阿部元樹, 木村大毅, 小杉晋央, 新川香, 高瀬俊郎, 小林正朋, 山田康智, 根本みゆき, 渡辺亮平, 塚田恵鯉子, 太田深秀, 東晋二, 根本清貴, 新井哲明, 西村雅史.
  • Organizer: 第19回情報科学技術フォーラム(FIT2020）
• [Presentation] Multimodal Behavioral Analysis for Early Detection of Alzheimer's Disease: A Preliminary Result. (2020)
  • Author(s): Yasunori Yamada, Kaoru Shinkawa, Tatsuya Ishikawa, Masafumi Nishimura, Miyuki Nemoto, Eriko Tsukada, Miho Ota, Kiyotaka Nemoto, Tetsuaki Arai.
  • Organizer: AAIC2020
  • Int'l Joint Research
• [Presentation] Automatic Detection of Alzheimer's Disease and Mild Cognitive Impairment from Spontaneous Speech Collected during Tablet-Based Interviews: A Preliminary Result. (2020)
  • Author(s): Kaoru Shinkawa, Akihiro Kosugi, Masatomo Kobayashi, Masafumi Nishimura, Miyuki Nemoto, Eriko Tsukada, Miho Ota, Kiyotaka Nemoto, Tetsuaki Arai, Yasunori Yamada.
  • Organizer: AAIC2020
  • Int'l Joint Research
• [Presentation] Predicting Future Accident Risks of Older Drivers by Speech Data from a Voice-Based Dialogue System: A Preliminary Result. (2020)
  • Author(s): Yasunori Yamada, Kaoru Shinkawa, Akihiro Kosugi, Masatomo Kobayashi, Hironobu Takagi, Miyuki Nemoto, Kiyotaka Nemoto, Tetsuaki Arai.
  • Organizer: AHFE 2020
  • Int'l Joint Research
• [Presentation] Multimodal Behavioral Analysis for Early Detection of Alzheimer’s Disease: A Preliminary Result (2020)
  • Author(s): Yasunori Yamada, Kaoru Shinkawa, Tatsuya Ishikawa, Masafumi Nishimura, Miyuki Nemoto, Eriko Tsukada, Miho Ota, Kiyotaka Nemoto, Tetsuaki Arai
  • Organizer: Alzheimer’s Association International Conference
  • Int'l Joint Research
• [Presentation] Automatic Detection of Alzheimer’s Disease and Mild Cognitive Impairment from Spontaneous Speech Collected during Tablet-Based Interviews: A Preliminary Result (2020)
  • Author(s): Kaoru Shinkawa, Akihiro Kosugi, Masatomo Kobayashi, Masafumi Nishimura, Miyuki Nemoto, Eriko Tsukada, Miho Ota, Kiyotaka Nemoto, Tetsuaki Arai, Yasunori Yamada
  • Organizer: Alzheimer’s Association International Conference
  • Int'l Joint Research
• [Book] アルツハイマー病治療の新たなストラテジー (2022)
  • Author(s): 岩田淳・橋本衛・編、part6分著：根本みゆき、根本清貴、新井哲明
  • Total Pages: 149
  • Publisher: 先端医学社
  • ISBN: 9784865505405