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Health science of circaadian clock based on life stage

Research Project

Project/Area Number 19H01089
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 59:Sports sciences, physical education, health sciences, and related fields
Research InstitutionWaseda University

Principal Investigator

SHIBATA SHIGENOBU  早稲田大学, 理工学術院, 教授 (10162629)

Co-Investigator(Kenkyū-buntansha) 金 鉉基  早稲田大学, 理工学術院, 講師(任期付) (10791874)
高橋 将記  東京工業大学, リベラルアーツ研究教育院, 准教授 (30711189)
駒田 陽子  明治薬科大学, 薬学部, 准教授 (40451380)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥45,500,000 (Direct Cost: ¥35,000,000、Indirect Cost: ¥10,500,000)
Fiscal Year 2021: ¥14,950,000 (Direct Cost: ¥11,500,000、Indirect Cost: ¥3,450,000)
Fiscal Year 2020: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000)
Fiscal Year 2019: ¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
Keywords体内時計 / 時間栄養学 / メタボリックシンドローム / 老化 / 発達 / ライフステージ / 時間運動学 / ヒト介入試験 / 高齢者 / 学童期 / 食事管理アプリ / 時計遺伝子 / ヒト / マウス / 時間栄養 / 時間運動 / 時間休養
Outline of Research at the Start

(1)体内時計の応用研究は甚だ不十分である。(2)体内時計は、日(時計遺伝子に駆動される様々な日内リズム)、週(週末に起こりうる社会的時差ボケ)、月(月経周期など)を対象とする。(3)マウス(または細胞)、ヒト観察、ヒト介入、スマホ応用の研究を実施する。(4)健康や健康寿命の延長には、食や栄養(時間栄養学)・運動(時間運動学)・睡眠(時間睡眠(休養)学)が重要であり、これらの遂行には健全な体内時計が必須である。(5)時間栄養を視点とした特定保健用食品や機能性表示食品を開発する。これらの食品の摂取タイミングの重要性を見出し(薬とは異なり、摂取時刻を表示できない)、消費者に有用な情報を提供する。

Outline of Final Research Achievements

The characteristics of the circadian rhythm by age group, that is, by life stage, are clarified in humans and mice. The life stage is divided into school children, adults and middle-aged and elderly. We investigated the importance of approaches of chrono-nutrition, chrono-exercise, and chrono-sleep on health science. The importance of regularity of feeding and sleep rhythms in the learning performance of school children and adolescents. For protection of adult obesity and hypertension, equal meal ratio of breakfast, lunch and dinner and reduction of carbohydrate at dinner, and intake of KCL through vegetables, are recommended, respectively. In addition, it was shown that more protein intake at breakfast was necessary for preventing muscle atrophy like sarcopenia in aging peoples.

Academic Significance and Societal Importance of the Research Achievements

学童期は夜のスマホ使用が夜型化の助長を起こすが、朝食時の和食摂取の習慣が改善できる可能性を示した。成人期での生活習慣リズムの不調が肥満・高血圧を引き起こすが、12時間断食や夕食の低炭水化物や昼間の野菜摂取が、それぞれ肥満や高血圧に有効であるという社会的実践を提案した。高齢者のサルコペニア予防のための朝食タンパク質摂取の有効性は、多くのタンパク質食品が開発される社会現象になっている。

Report

(5 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Comments on the Screening Results   Annual Research Report
  • Research Products

    (50 results)

All 2022 2021 2020 2019 Other

All Int'l Joint Research (2 results) Journal Article (20 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 20 results,  Open Access: 20 results) Presentation (25 results) (of which Int'l Joint Research: 1 results,  Invited: 24 results) Book (2 results) Remarks (1 results)

  • [Int'l Joint Research] NTU(南洋理工大学)(シンガポール)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] UCSI university(マレーシア)

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Polygalae Radix shortens the circadian period through activation of the CaMKII pathway.2022

    • Author(s)
      Haraguchi A, Saito K, Tahara Y, Shibata S.
    • Journal Title

      Pharm Biol.

      Volume: 60 Issue: 1 Pages: 689-698

    • DOI

      10.1080/13880209.2022.2048863

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Evening rather than morning increased physical activity alters the microbiota in mice and is associated with increased body temperature and sympathetic nervous system activation.2022

    • Author(s)
      Sasaki H, Miyakawa H, Watanabe A, Tamura K, Shiga K, Lyu Y, Ichikawa N, Fu Y, Hayashi K, Imamura M, Shibata S.
    • Journal Title

      Biochim Biophys Acta Mol Basis Dis

      Volume: 1868 Issue: 6 Pages: 166373-166373

    • DOI

      10.1016/j.bbadis.2022.166373

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Association Between Na, K, and Lipid Intake in Each Meal and Blood Pressure.2022

    • Author(s)
      Momoko Imamura, Hiroyuki Sasaki, Takae Shinto, Yu Tahara, Saneyuki Makino, Mai Kuwahara, Ayako Tada, Nanako Abe, Mikiko Michie, Shigenobu Shibata
    • Journal Title

      Frontiers in nutrition

      Volume: 9 Pages: 853118-853118

    • DOI

      10.3389/fnut.2022.853118

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Solid-State Fermented Okara with Aspergillus spp. Improves Lipid Metabolism and High-Fat Diet Induced Obesity2022

    • Author(s)
      Ichikawa N, Ng LS, Makino S, Goh LL, Lim YJ, Ferdinandus, Sasaki H, Shibata S, Lee CK.
    • Journal Title

      Metabolites

      Volume: 12 Issue: 3 Pages: 198-198

    • DOI

      10.3390/metabo12030198

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Wheel-running facilitates phase advances in locomotor and peripheral circadian rhythm in social jet lag model mice.2022

    • Author(s)
      Oneda S, Cao S, Haraguchi A, Sasaki H, Shibata S
    • Journal Title

      Front Physiol.

      Volume: 16 Pages: 821199-821199

    • DOI

      10.3389/fphys.2022.821199

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Analysis of conductive olfactory dysfunction using computational fluid dynamics2022

    • Author(s)
      Asama Y, Furutani A, Fujioka M , Ozawa H, Takei S , Shibata S, Ogawa K
    • Journal Title

      PLoS One

      Volume: 17 Issue: 1 Pages: 139-147

    • DOI

      10.1371/journal.pone.0262579

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Cold Exposure during the Active Phase Affects the Short-Chain Fatty Acid Production of Mice in a Time-Specific Manner2021

    • Author(s)
      Ichikawa N, Sasaki H, Lyu Y, Furuhashi S, Watabe A, Imamura M, Hayashi K, Shibata S.
    • Journal Title

      Metabolites

      Volume: 12 Issue: 1 Pages: 20-20

    • DOI

      10.3390/metabo12010020

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Supplementation of protein at breakfast rather than at dinner and lunch is effective on skeletal muscle mass in older adults2021

    • Author(s)
      Hyeon-Ki Kim, Hanako Chijiki, Mayuko Fukazawa, Jin Okubo, Mamiho Ozaki, Takuya Nanba, Seiichirou Higashi, Miho Shioyama, Masaki Takahashi, Takashi Nakaoka, Shigenobu Shibata
    • Journal Title

      Frontiers in Nutrition

      Volume: 8 Pages: 797004-797004

    • DOI

      10.3389/fnut.2021.797004

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between Irregular Meal Timing and the Mental Health of Japanese Workers2021

    • Author(s)
      Yu Tahara, Saneyuki Makino, Takahiko Suiko, Yuki Nagamori, Takao Iwai, Megumi Aono, shigenobu shibata
    • Journal Title

      Nutrients

      Volume: 13 Issue: 8 Pages: 2775-2775

    • DOI

      10.3390/nu13082775

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distribution of dietary protein intake in daily meals influences skeletal muscle hypertrophy via the muscle clock2021

    • Author(s)
      Aoyama Shinya、Kim Hyeon-Ki、Hirooka Rina、Tanaka Mizuho、Shimoda Takeru、Chijiki Hanako、Kojima Shuichi、Sasaki Keisuke、Takahashi Kengo、Makino Saneyuki、Takizawa Miku、Takahashi Masaki、Tahara Yu、Shimba Shigeki、Shinohara Kazuyuki、Shibata Shigenobu
    • Journal Title

      Cell Reports

      Volume: 36 Issue: 1 Pages: 109336-109336

    • DOI

      10.1016/j.celrep.2021.109336

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Relationship between the Lunar Phase, Menstrual Cycle Onset and Subjective Sleep Quality among Women of Reproductive Age.2021

    • Author(s)
      Komada Y, Sato M, Ikeda Y, Kami A, Masuda C, Shibata S
    • Journal Title

      Int J Environ Res Public Health.

      Volume: 18 Issue: 6 Pages: 3245-3245

    • DOI

      10.3390/ijerph18063245

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Psychological state during pregnancy is associated with sleep quality: preliminary findings from MY-CARE cohort study2021

    • Author(s)
      Teoh AN, Kaur S, Mohd Shukri NH, Shafie SR, Ahmad Bustami N, Takahashi M, Lim PJ, Shibata S
    • Journal Title

      Chronobiol Int.

      Volume: 28 Issue: 7 Pages: 1-12

    • DOI

      10.1080/07420528.2021.1902338

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Screen time duration and timing: effects on obesity, physical activity, dry eyes, and learning ability in elementary school children.2021

    • Author(s)
      Mineshita Y, Kim HK, Chijiki H, Nanba T, Shinto T, Furuhashi S, Oneda S, Kuwahara M, Suwama A, Shibata S
    • Journal Title

      BMC Public Health.

      Volume: 21 Issue: 1 Pages: 422-422

    • DOI

      10.1186/s12889-021-10484-7

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of the Intake of a Snack Containing Dietary Fiber on Postprandial Glucose Levels2020

    • Author(s)
      Kim HK, Nanba T, Ozaki M, Chijiki H, Takahashi M, Fukazawa M, Okubo J, Shibata S.
    • Journal Title

      Foods

      Volume: 9 Issue: 10 Pages: 1500-1500

    • DOI

      10.3390/foods9101500

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Ingestion of Helianthus tuberosus at Breakfast Rather Than at Dinner is More Effective for Suppressing Glucose Levels and Improving the Intestinal Microbiota in Older Adults2020

    • Author(s)
      Kim Hyeon-Ki、Chijiki Hanako、Nanba Takuya、Ozaki Mamiho、Sasaki Hiroyuki、Takahashi Masaki、Shibata Shigenobu
    • Journal Title

      Nutrients

      Volume: 12 Issue: 10 Pages: 3035-3035

    • DOI

      10.3390/nu12103035

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Time-of-Day-Dependent Physiological Responses to Meal and Exercise2020

    • Author(s)
      Aoyama Shinya、Shibata Shigenobu
    • Journal Title

      Frontiers in Nutrition

      Volume: 7 Pages: 18-28

    • DOI

      10.3389/fnut.2020.00018

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effect of Dose and Timing of Burdock (Arctium lappa) Root Intake on Intestinal Microbiota of Mice2020

    • Author(s)
      Watanabe Aya、Sasaki Hiroyuki、Miyakawa Hiroki、Nakayama Yuki、Lyu Yijin、Shibata Shigenobu
    • Journal Title

      Microorganisms

      Volume: 8 Issue: 2 Pages: 220-220

    • DOI

      10.3390/microorganisms8020220

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mice Microbiota Composition Changes by Inulin Feeding with a Long Fasting Period under a Two-Meals-Per-Day Schedule2019

    • Author(s)
      Sasaki、Miyakawa、Watanabe、Nakayama、Lyu、Hama、Shibata
    • Journal Title

      Nutrients

      Volume: 11 Issue: 11 Pages: 2802-2802

    • DOI

      10.3390/nu11112802

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Timing Effects of Soy Protein Intake on Mice Gut Microbiota2019

    • Author(s)
      Tamura Konomi、Sasaki Hiroyuki、Shiga Kazuto、Miyakawa Hiroki、Shibata Shigenobu
    • Journal Title

      Nutrients

      Volume: 12 Issue: 1 Pages: 87-87

    • DOI

      10.3390/nu12010087

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Correlation among clock gene expression rhythms, sleep quality, and meal conditions in delayed sleep-wake phase disorder and night eating syndrome.2019

    • Author(s)
      Haraguchi A, Komada Y, Inoue Y, Shibata S.
    • Journal Title

      Choronobiology International

      Volume: 未定 Issue: 6 Pages: 1-14

    • DOI

      10.1080/07420528.2019.1585366

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 体内時計の基礎から応用研究2022

    • Author(s)
      柴田重信
    • Organizer
      第99回日本生理学会大会 教育講演
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 高齢者におけるたんぱく質摂取量をどう考えるか2022

    • Author(s)
      柴田重信
    • Organizer
      第24・25回日本病態栄養学会年次学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 時間栄養学をふまえた食生活の実践~いつ食べるとどう体に作用するか~2022

    • Author(s)
      柴田重信
    • Organizer
      江戸川区 令和3年度栄養士・管理栄養士のためのスキルアップ講習会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 体内時計の仕組みを理解し時間栄養学を学ぶ~最新の栄養学を学び、保健指導や栄養指導等に役立てよう~2022

    • Author(s)
      柴田重信
    • Organizer
      令和3年度健康づくり事業推進指導者育成研修
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 時間栄養学の視点から2022

    • Author(s)
      柴田重信
    • Organizer
      日本栄養改善学会東北支部市民講座
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] いつ食べる?時間栄養学に学ぶ賢い食べ方2022

    • Author(s)
      柴田重信
    • Organizer
      板橋区健康づくり21計画
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 体内時計と栄養や運動との相互作用を視点とした肥満・糖尿病研究2022

    • Author(s)
      柴田重信
    • Organizer
      第51回川越糖尿病談話会 特別講演
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 機能性食品と時間栄養学2021

    • Author(s)
      柴田重信
    • Organizer
      第19回日本機能性食品医用学会 総会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 個別化栄養学による体内時計と健康を考える2021

    • Author(s)
      柴田重信、田原優
    • Organizer
      第28回時間生物学会学術大会 南視点の時間生物学 シンポジウム
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 時間運動学と時間栄養学2021

    • Author(s)
      柴田重信
    • Organizer
      第31回日本呼吸ケア・リハビリテーション学会学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 朝食時の分岐鎖アミノ酸摂取による筋肉量の増加には体内時計が関わっている2021

    • Author(s)
      柴田重信
    • Organizer
      コロナ禍克服の鍵となるヘルステック&フードテックの新しい波
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 時間栄養学と健康科学・代謝障害2021

    • Author(s)
      柴田重信
    • Organizer
      Toranomon Nephrology Forum 2021
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 食べる時間でこんなに変わる時間栄養学入門2021

    • Author(s)
      柴田重信
    • Organizer
      令和3年度千葉県栄養改善大会  健康づくり食生活講演会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 健康科学に寄与する生体リズムの仕組みにおける時間栄養学2021

    • Author(s)
      柴田重信
    • Organizer
      第17回高尿酸血症・メタボリックシンドロームリサーチフォーラム
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 動物実験における時間栄養学の考え方と応用2021

    • Author(s)
      柴田重信
    • Organizer
      第68回日本実験動物学会総会 シンポジウム2
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 体内時計を応用した時間軸の研究科学2020

    • Author(s)
      柴田重信
    • Organizer
      第7回 日本腎臓研究会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 時間栄養学の内分泌・代謝学への応用2020

    • Author(s)
      柴田重信
    • Organizer
      第38回 小児内分泌代謝研究会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 感染症と体内時計2020

    • Author(s)
      柴田重信
    • Organizer
      食育健康サミット2020 日本医師会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 時間栄養学の内分泌・代謝学への応用2020

    • Author(s)
      柴田重信
    • Organizer
      第18回世田谷ENDOフォーラム
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 時間栄養学からみえるも2020

    • Author(s)
      重信
    • Organizer
      第63回 日本糖尿病学会年次学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 時間生物学の基礎知識2019

    • Author(s)
      柴田重信
    • Organizer
      第74回 日本体力医学会大会」
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 体内時計リセットのための朝日と朝ご飯の重要性2019

    • Author(s)
      柴田重信
    • Organizer
      第57回全国大学保健管理協会関東甲信越地方部会研究集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 時間栄養学~マウスからヒトへ2019

    • Author(s)
      柴田重信
    • Organizer
      第41回日本臨床栄養学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 時間栄養学で健康増進2019

    • Author(s)
      柴田重信
    • Organizer
      福島市医師会 介護予防講習会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Timing effect of intake of inulin and inulin containing food/ vegetables on the continuous blood glucose level, fecal short chain fatty acids and microbiota in mice and humans2019

    • Author(s)
      Shigenobu Shibata
    • Organizer
      XVI Congress of the European Biological Rhythms Society
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Book] 食べる時間でこんなに変わる 時間栄養学入門2021

    • Author(s)
      柴田重信
    • Total Pages
      264
    • Publisher
      講談社
    • ISBN
      9784065238752
    • Related Report
      2021 Annual Research Report
  • [Book] 時間栄養学2020

    • Author(s)
      柴田 重信
    • Total Pages
      256
    • Publisher
      化学同人
    • ISBN
      9784759820362
    • Related Report
      2020 Annual Research Report
  • [Remarks] 柴田研究室

    • URL

      https://www.waseda-shibatas.com/

    • Related Report
      2019 Annual Research Report

URL: 

Published: 2019-04-18   Modified: 2023-01-30  

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