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Continuum biomechanics of the whole brain circulation for the computational analysis of cerebrovascular diseases

Research Project

Project/Area Number 19H01175
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Review Section Medium-sized Section 90:Biomedical engineering and related fields
Research InstitutionOsaka University

Principal Investigator

Wada Shigeo  大阪大学, 大学院基礎工学研究科, 教授 (70240546)

Co-Investigator(Kenkyū-buntansha) 渡邉 嘉之  滋賀医科大学, 医学部, 教授 (20362733)
武石 直樹  大阪大学, 大学院基礎工学研究科, 助教 (30787669)
大谷 智仁  大阪大学, 大学院基礎工学研究科, 講師 (40778990)
伊井 仁志  東京都立大学, システムデザイン研究科, 准教授 (50513016)
石田 駿一  神戸大学, 工学研究科, 助教 (80824169)
Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥45,500,000 (Direct Cost: ¥35,000,000、Indirect Cost: ¥10,500,000)
Fiscal Year 2022: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
Fiscal Year 2021: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2020: ¥11,440,000 (Direct Cost: ¥8,800,000、Indirect Cost: ¥2,640,000)
Fiscal Year 2019: ¥15,730,000 (Direct Cost: ¥12,100,000、Indirect Cost: ¥3,630,000)
KeywordsCerebral circulation / Blood flow / Biomedical Engineering / Personalized medicine / Computational mechanics / Interstitial flow / Cerebro-spinal flow / 脳血流 / 側副血行路 / 脳脊髄液流れ / 脳微小循環 / 画像計測 / 連続体力学 / 数値シミュレーション / 脳循環 / 血流 / 物質輸送 / 脳脊髄液 / 脳血管障害 / 血流シミュレーション / 血管網構造 / 正常圧水頭症 / MRI計測 / 脳代謝 / 脳メカニクス / 全脳循環モデル / 計算力学シミュレーション
Outline of Research at the Start

臓器の形態と解剖学的構造,流体と構造の連成,構成要素の階層性や応答など,生体特有の複雑な力学的特性を考慮した連続体力学に基づいて,全脳の血液循環,脳組織の変形と細胞間質液の流動,脳神経活動に必要な酸素と代謝基質の輸送,老廃物の排出を担う脳脊髄液の循環の時空間場における物理的連立関係を数値シミュレーションにより明らかにする.これにより,正常な脳機能が維持されるための全脳循環代謝動態とそれを引き起こすメカニズムを解明し,力学的平衡状態を崩す脳出血や脳梗塞などの脳血管障害において,医用画像で観察される現象や病態を物理的側面から分析する.

Outline of Final Research Achievements

In order to understand the circulatory dynamics of blood and cerebrospinal fluid at the whole brain level, we constructed a continuum model that reproduces the morphology and anatomical structure of the cranial skeletal system, cerebral circulatory system, and cerebral parenchymal tissue system. We conducted blood flow analysis considering personal differences and collateral blood circulation, coupled analysis of blood flow and interstitial flow in cerebral microcirculation, cerebrospinal fluid flow and material transport analysis, and simulation image data analysis for intracerebral water circulation mechanism. As a result, we clarified the physical simultaneous relationship in the spatio-temporal field in the brain for blood circulation and cerebrospinal fluid circulation. In addition, using medical imaging data of patients with cerebral infarction and normal pressure hydrocephalus, we clarified the physical mechanism behind the observed pathological conditions.

Academic Significance and Societal Importance of the Research Achievements

全脳レベルの血液および脳脊髄液の循環動態を理解するために,脳の形態と解剖学的構造を忠実に再現した連続体モデルを構築し,脳血液循環および脳脊髄液循環に対して,in silicoでの観察を可能にする計算力学シミュレーションにより,脳内時空間場における物理的連立関係を明らかにすることができた.また,脳血管障害による局所的な力学的平衡状態の破綻が脳循環代謝動態に及ぼす影響を医用画像ベースで評価する計算力学解析プラットフォームを構築し,観察される病態の背後にある物理的メカニズムを明らかにした.これは,計算力学シミュレーションと医用画像データを統合した個別化医療支援技術の有効性と可能性を示すものである.

Report

(6 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Comments on the Screening Results   Annual Research Report
  • Research Products

    (59 results)

All 2023 2022 2021 2020 2019 Other

All Journal Article (14 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 12 results,  Open Access: 6 results) Presentation (40 results) (of which Int'l Joint Research: 13 results,  Invited: 18 results) Book (1 results) Remarks (4 results)

  • [Journal Article] A concept on velocity estimation from magnetic resonance velocity images based on variational optimal boundary control2022

    • Author(s)
      OTANI Tomohiro、YAMASHITA Hiroshi、IWATA Kazuma、ILIK Selin Yavuz、YAMADA Shigeki、WATANABE Yoshiyuki、WADA Shigeo
    • Journal Title

      Journal of Biomechanical Science and Engineering

      Volume: 17 Issue: 3 Pages: 22-00050-22-00050

    • DOI

      10.1299/jbse.22-00050

    • ISSN
      1880-9863
    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Numerical study on the extent of flow regulation by collateral circulation of cerebral arteries2022

    • Author(s)
      NISHIMURA Nozomi、YAMASHITA Hiroshi、OTANI Tomohiro、WADA Shigeo
    • Journal Title

      The Proceedings of the JSME Conference on Frontiers in Bioengineering

      Volume: 2022.32 Issue: 0 Pages: 2C23

    • DOI

      10.1299/jsmebiofro.2022.32.2C23

    • ISSN
      2424-2810
    • Related Report
      2022 Annual Research Report
  • [Journal Article] Numerical analysis of pulse wave of cerebral arteries in patients with thoracic aortic stent placement2022

    • Author(s)
      LI Jialong、TAKEISHI Naoki、TANAKA Hisashi、WADA Shigeo
    • Journal Title

      The Proceedings of the JSME Conference on Frontiers in Bioengineering

      Volume: 2022.32 Issue: 0 Pages: 2C18

    • DOI

      10.1299/jsmebiofro.2022.32.2C18

    • ISSN
      2424-2810
    • Related Report
      2022 Annual Research Report
  • [Journal Article] Inertial migration of red blood cells under a Newtonian fluid in a circular channel2022

    • Author(s)
      Takeishi Naoki、Yamashita Hiroshi、Omori Toshihiro、Yokoyama Naoto、Wada Shigeo、Sugihara-Seki Masako
    • Journal Title

      Journal of Fluid Mechanics

      Volume: 952 Pages: 952-952

    • DOI

      10.1017/jfm.2022.936

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] On the Impact of Left Upper Lobectomy on the Left Atrial Hemodynamics2022

    • Author(s)
      Otani Tomohiro、Yoshida Takuya、Yi Wentao、Endo Shunsuke、Wada Shigeo
    • Journal Title

      Frontiers in Physiology

      Volume: 13 Pages: 830436-830436

    • DOI

      10.3389/fphys.2022.830436

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A subject‐specific assessment of measurement errors and their correction in cerebrospinal fluid velocity maps using 4D flow MRI2021

    • Author(s)
      Yavuz Ilik Selin、Otani Tomohiro、Yamada Shigeki、Watanabe Yoshiyuki、Wada Shigeo
    • Journal Title

      Magnetic Resonance in Medicine

      Volume: 87 Issue: 5 Pages: 2412-2423

    • DOI

      10.1002/mrm.29111

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Cerebrospinal fluid flow driven by arterial pulsations in axisymmetric perivascular spaces: analogy with Taylor’s swimming sheet2021

    • Author(s)
      Yokoyama Naoto、Takeishi Naoki、Wada Shigeo
    • Journal Title

      Journal of Theoretical Biology

      Volume: in press Pages: 110709-110709

    • DOI

      10.1016/j.jtbi.2021.110709

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Axial and Nonaxial Migration of Red Blood Cells in a Microtube2021

    • Author(s)
      Takeishi Naoki、Yamashita Hiroshi、Omori Toshihiro、Yokoyama Naoto、Sugihara-Seki Masako
    • Journal Title

      Micromachines

      Volume: 12 Issue: 10 Pages: 1162-1162

    • DOI

      10.3390/mi12101162

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of a mesoscopic framework spanning nanoscale protofibril dynamics to macro-scale fibrin clot formation2021

    • Author(s)
      Takeishi Naoki、Shigematsu Taiki、Enosaki Ryogo、Ishida Shunichi、Ii Satoshi、Wada Shigeo
    • Journal Title

      Journal of The Royal Society Interface

      Volume: 18 Issue: 184 Pages: 20210554-20210554

    • DOI

      10.1098/rsif.2021.0554

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modeling of endovascular coiling for cerebral aneurysms: Effects of friction on coil mechanical behaviors2020

    • Author(s)
      Otani Tomohiro、Wada Shigeo、Tanaka Masao
    • Journal Title

      International Journal of Mechanical Sciences

      Volume: 166 Pages: 105206-105206

    • DOI

      10.1016/j.ijmecsci.2019.105206

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Computational modeling of braided-stent deployment for interpreting the mechanism of stent flattening2020

    • Author(s)
      Shiozaki Shunya、Otani Tomohiro、Fujimura Soichiro、Takao Hiroyuki、Wada Shigeo
    • Journal Title

      International Journal for Numerical Methods in Biomedical Engineering

      Volume: online first Issue: 12 Pages: 1-14

    • DOI

      10.1002/cnm.3335

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multiscale modeling of human cerebrovasculature: A hybrid approach using image-based geometry and a mathematical algorithm2020

    • Author(s)
      Ii Satoshi、Kitade Hiroki、Ishida Shunichi、Imai Yohsuke、Watanabe Yoshiyuki、Wada Shigeo
    • Journal Title

      PLOS Computational Biology

      Volume: 16 Issue: 6 Pages: e1007943-e1007943

    • DOI

      10.1371/journal.pcbi.1007943

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hemorheology in dilute, semi-dilute, and dense suspensions of red blood cells2019

    • Author(s)
      N. Takeishi, M.E. Rosti, Y. Imai, S. Wada, L. Brandt
    • Journal Title

      Journal of Fluid Mechanics

      Volume: 872 Pages: 818-848

    • DOI

      10.1017/jfm.2019.393

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Deformation of a red blood cell in a narrow rectangular microchannel.2019

    • Author(s)
      Naoki Takeishi, Hiroaki Ito, Makoto Kaneko, Shigeo Wada.
    • Journal Title

      Micromachines

      Volume: 10 Issue: 3 Pages: 199-199

    • DOI

      10.3390/mi10030199

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] シミュレーション科学に基づく個別化医療支援: AI技術の活用と課題2023

    • Author(s)
      和田成生
    • Organizer
      シンポジウム「富岳百景」
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Realistic Simulation in Computational Biomechanics: Connection Between Theoretical Analysis and Real Phenomenon2022

    • Author(s)
      Shigeo Wada
    • Organizer
      The 9th World Congress of Biomechanics
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 胸部大動脈ステント留置・バイパス接続による流路変更に伴う頸部血管系の脈波伝ぱを考慮しチア血流動態解析2022

    • Author(s)
      李佳龍,武石直樹,田中壽,和田成生
    • Organizer
      日本機械学会第32回バイオフロンティア講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 皮質動脈網における側副血行路の血流調整能に関する数値解析2022

    • Author(s)
      西村望,山下博士,大谷智仁,和田成生
    • Organizer
      日本機械学会 第32回バイオフロンティア講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Computational modeling of large-scale cerebral blood circulation by a hybridized approach using physics models and measurement data2022

    • Author(s)
      伊井仁志
    • Organizer
      第7回理論応用力学シンポジウム
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 振動流下における赤血球濃厚懸濁液の数値解析2021

    • Author(s)
      武石直樹, Marco E Rosti, 横山直人, 和田成生, Luca Brandt
    • Organizer
      日本流体力学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Numerical analysis of the inertial migration of the red blood cell in a channel2021

    • Author(s)
      Naoki Takeishi, Hiroshi Yamashita, Naoto Yokoyama, Masako Sugihara-Seki, Shigeo Wada
    • Organizer
      The 2nd Joint Meeting of The European Society for Clinical Hemorheology and Microcirculation
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Stability of a red blood cell in a narrow rectangular microchannel2021

    • Author(s)
      Naoki Takeishi, Hiroaki Ito, Shigeo Wada
    • Organizer
      25th International Congress of Theoretical and Applied Mechanics
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Suspension rheology of red blood cells under oscillatory shear flow2021

    • Author(s)
      Naoki Takeishi, Marco E Rosti, Naoto Yokoyama, Shigeo Wada, Luca Brandt
    • Organizer
      The 2nd Joint Meeting of The European Society for Clinical Hemorheology and Microcirculation
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Correction of eddy-current based phase offset errors in cerebrospinal fluid flow measurement: four-dimensional flow magnetic resonance imaging2021

    • Author(s)
      SY. Ilik, T. Otani, S. Yamada, Y. Watanabe, S. Wada
    • Organizer
      The 11th Asian-Pacific Biomechanics
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development on a computational framework to express patient-specific intracranial cerebrospinal fluid flow based on phase-contrast magnetic resonance images2021

    • Author(s)
      S. Maeda, T. Otani, S. Yamada, Y. Watanabe, SY Ilik, N. Takeishi, S. Wada
    • Organizer
      Summer Biomechanics, Bioengineering and Biotransport Conference
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 脳微小血管構造の数理モデリング 微小循環系に対する血液の非ニュートン性の影響2021

    • Author(s)
      尼子大,大谷智仁,武石直樹,和田成生
    • Organizer
      日本機械学会第34回計算力学講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] MRI計測に基づく正常圧水頭症患者の脳脊髄液流れの数値シミュレーション2021

    • Author(s)
      前田修作,Selin Yavuz Ilik,大谷智仁,武石直樹,和田成生
    • Organizer
      日本機械学会 第33回バイオエンジニアリング講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 脳血流をコンピュータで解く:数値計算で、今なにができるか2021

    • Author(s)
      大谷智仁
    • Organizer
      第39回日本小児心身医学会学術集会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Computational modeling in intracranial fluid dynamics: cerebrospinal and interstitial fluids2021

    • Author(s)
      T. Otani, S. Maeda, S. Yamada, Y. Wadatabe, SY. Ilik, N. Takeishi, S. Wada
    • Organizer
      第60回日本生体医工学会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 毛細血管周囲の脳間質流れの数値流体解析2021

    • Author(s)
      岡谷拓実,正本和人,伊井仁志
    • Organizer
      第32回バイオフロンティア講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 流体・多孔質体連成流れの統一計算モデルを用いた毛細血管周囲の脳間質流れの三次元モデリング2021

    • Author(s)
      岡谷拓実,正本和人,伊井仁志
    • Organizer
      日本流体力学会年会2021
    • Related Report
      2021 Annual Research Report
  • [Presentation] 脳循環システムの数理モデリングと数値解析技法2021

    • Author(s)
      伊井仁志
    • Organizer
      第60回日本生体医工学会大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 計測データを活用した生体力学現象のデータ同化逆解析シミュレーション2021

    • Author(s)
      伊井仁志
    • Organizer
      混相流レクチャーシリーズ46
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] メカニクスを通じて理解する生体現象:個別化医療支援へ向けたシミュレーション科学2021

    • Author(s)
      和田成生
    • Organizer
      MMDSセミナー「生体工学と数学の接点を求めて」
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Computational Biomechanics: Simulation approach from theoretical analysis to clinical support2021

    • Author(s)
      Shigeo Wada
    • Organizer
      The 11th Asian-Pasific Conference on Biomechanics
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 医療と工学をつなぐ生体力学シミュレーション: 現象の理解から個別化医療支援まで2021

    • Author(s)
      和田成生
    • Organizer
      第62回日本脈管学会総会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] メカニクスを通じて理解する生体現象:個別化医療支援へ向けたシミュレーション科学2021

    • Author(s)
      和田成生
    • Organizer
      日本顎口腔機能学会 第65回学術大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Development on a computational framework to express patient-specific intracranial cerebrospinal fluid flow based on phase-contrast magnetic resonance images2021

    • Author(s)
      S. Maeda, T. Otani, S. Yamada, Y. Watanabe, I. Selin, N. Takeishi, S. Wada
    • Organizer
      Summer Biomechanics, Bioengineering and Biotransport Conference (SB3C)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 位相コントラストMRI計測に基づく正常圧水頭症における頭蓋内脳脊髄液動態の解析2021

    • Author(s)
      前田 修作、大谷 智仁、Yavuz Ilik Selin、山田 茂樹、渡邊 嘉之、武石 直樹、和田 成生
    • Organizer
      日本機械学会関西支部96期定時総会講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 側副血行路を持つ脳血液循環の数理モデリング2021

    • Author(s)
      西村 望、尼子 大、山下 博士、大谷 智仁、武石 直樹、和田 成生
    • Organizer
      日本機械学会関西学生会2020年度学生卒業研究発表講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 脳微小循環網の構造が脳皮質内物質輸送に及ぼす影響2020

    • Author(s)
      尼子大,武石直樹,和田成生
    • Organizer
      日本機械学会関西学生会2019年度学生卒業研究発表講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 全脳間質液流動の全容解明に向けた計算力学モデルの構築と解析2020

    • Author(s)
      前田修作,北出宏紀,武石直樹,和田成生
    • Organizer
      日本機械学会関西学生会2019年度学生卒業研究発表講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ヒト脳室系における脳脊髄液流れの駆動メカニズム:数値流体力学シミュレーションによる検討2020

    • Author(s)
      前田修作,Selin Yavuz Ilik ,大谷智仁,武石直樹,和田成生
    • Organizer
      日本機械学会 第31回バイオフロンティア講演会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Modeling cerebral vasculatures for analysis of the whole cerebral circulation2019

    • Author(s)
      Hiroki KITADE, Satoshi II, Yohsuke IMAI, Shunichi ISHIDA, Shigeo WADA
    • Organizer
      Computational and Mathematical Biomedical Engineering
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Numerical analysis of dense suspension rheology of red blood cells in a shear flow2019

    • Author(s)
      Naoki Takeishi, Marco E Rosti, Yohsuke Imai, Shigeo Wada, Luca Brandt
    • Organizer
      Summer Biomechanics, Bioengineering and Biotransport Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ミクロな赤血球流動とマクロな血液の特性をつなぐための数値解析2019

    • Author(s)
      武石直樹
    • Organizer
      第1回計算粉体力学研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 大脳動脈の被験者個別モデルを用いた大規模血流解析2019

    • Author(s)
      小林維磨,石田 駿一,武石直樹,今井陽介,和田成生
    • Organizer
      日本機械学会 第32回計算力学講演会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Numerical analysis of large-scale cerebral artery blood flow using patient-specific cerebrovascular models2019

    • Author(s)
      Yuima Kobayashi, Shunichi Ishida, Naoki Takeishi, Yohsuke Imai, Shigeo Wada
    • Organizer
      The 10th Asian-Pacific Conference on Biomechanics
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A Cartesian grid method for solving blood flow in left atrium with considering prescribed moving wall boundary condition2019

    • Author(s)
      Tomohiro Otani and Shigeo Wada
    • Organizer
      10th Asian-Pacific Conference on Biomechanics
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Computational Modeling of Thrombus Formation in Patient-Specific Cerebral Aneurysms after Endovascular Coiling2019

    • Author(s)
      Shigeo Wada and Tomohiro Otani
    • Organizer
      10th International Conference on. Materials for Advanced Technologies (ICMAT)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 富岳を用いた全脳血液循環シミュレータの開発と個別化医療支援2019

    • Author(s)
      和田成生
    • Organizer
      第25回流動化・粒子プロセッシングシンポジウム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 個別化医療に向けたデータ分析とシミュレーション解析2019

    • Author(s)
      和田成生
    • Organizer
      第36回日本小児臨床アレルギー学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 個別化医療支援に向けた 生体力学シミュレーションとデータ同化2019

    • Author(s)
      和田成生
    • Organizer
      第36回日本呼吸器外科学会学術集会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 生体力学シミュレーションによる 個別化医療支援 ~生体現象の理解とリアリティーの追求~2019

    • Author(s)
      和田成生
    • Organizer
      HPCI計算科学フォーラム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Book] 医療に活かす生体医工学2021

    • Author(s)
      日本生体医工学会、平田 雅之、齋藤 充弘、紀ノ岡 正博、和田 成生、伊井 仁志、大谷 智仁、武石 直樹、橋爪 誠、大城 理、岡山 慶太、坂田 泰史、河野 喬仁、村田 正治、佐久間 一郎、篠原 一彦、江藤 正俊、小林 聡、牟田口 淳、今田 憲二郎、家入 里志、山田 耕嗣、大西 峻、山家 智之、不二門 尚、松村 泰志、野村 泰伸
    • Total Pages
      224
    • Publisher
      コロナ社
    • ISBN
      9784339072471
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
  • [Remarks] 大阪大学大学院基礎工学研究科和田研究室

    • URL

      https://sites.google.com/site/biomechwadalab/home

    • Related Report
      2022 Annual Research Report
  • [Remarks] 大阪大学大学院基礎工学研究科バイオメカニクス研究室

    • URL

      https://sites.google.com/site/biomechwadalab/

    • Related Report
      2021 Annual Research Report
  • [Remarks] 大阪大学大学院 基礎工学研究科 和田研究室

    • URL

      https://sites.google.com/site/biomechwadalab/

    • Related Report
      2020 Annual Research Report
  • [Remarks] 大阪大学大学院基礎工学研究科 和田研究室

    • URL

      https://sites.google.com/site/biomechwadalab/

    • Related Report
      2019 Annual Research Report

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Published: 2019-04-18   Modified: 2024-01-30  

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