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Elucidation of the human population history in boundary area between East Asia and Siberia based on ancient genome analysis

Research Project

Project/Area Number 19H01356
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 03060:Cultural assets study-related
Research InstitutionUniversity of the Ryukyus (2023)
Kanazawa University (2019-2022)

Principal Investigator

Sato Takehiro  琉球大学, 医学(系)研究科(研究院), 准教授 (10558026)

Project Period (FY) 2019-04-01 – 2024-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2023: ¥2,210,000 (Direct Cost: ¥1,700,000、Indirect Cost: ¥510,000)
Fiscal Year 2022: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2021: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2020: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Keywords古代ゲノム / 古人骨 / 集団遺伝学
Outline of Research at the Start

東アジアとシベリアの境界領域の東端にあたる北海道北部とサハリンでは、日本列島に由来する縄文系の文化が栄えた時期、東シベリアに起源をもつとされるオホーツク文化が栄えた 時期、そしてそれらの文化が混交した時期があることが考古学的研究により示唆されている。本研究では、古人骨のゲノム解析によって当該領域における人類集団の 変遷を解明することを目的とする。特に、シベリアに起源をもつと考えられるオホーツク文化人が在来の縄文系集団と混血していった過程をゲノムデータから明らかにするとともに、これまで一括りにされてきた「オホーツク文化人」が単一の起源をもつ集団なのかについて検証する。

Outline of Final Research Achievements

Whole-genome sequence (WGS) data of the late Okhotsk individual (NAT002) excavated from Rebun Island indicated genetic affinity with populations in the the Amur Basin. D tests and qpADm modeling suggested that NAT002 was an admixed individual between three ancestries, which were the Jomon, Kamchatka, and Amur ancestral components. The admixture dating suggested migration of Amur-related ancestry at approximately 1,600 BP, which is compatible with the archaeological evidence regarding the settlement of the Okhotsk people. Our results also imply migration of Kamchatka-related ancestry to Northern Japan at approximately 2,000 BP. In addition, WGS data of the early Okhotsk individual (NAT004) can be explained as an admixed individual between the Jomon and Kamchatka ancestries. This finding could be a direct evidence for the existence of the ancient admixed population between the Jomon and Kamchatka ancestries, which have been suggested by the NAT002 genome.

Academic Significance and Societal Importance of the Research Achievements

本研究により、従来より指摘されていた5世紀頃のアムール川下流域から北海道へのヒトの移住が裏付けられたことに加え、これまであまり指摘されてこなかった続縄文時代に相当する時期のカムチャツカ半島から北海道への移住を示唆する結果が得られた。これまで、考古学的には続縄文時代にカムチャツカ半島から北海道への移住を支持する明確な証拠は無いとされてきたが、本研究の結果は、従来の北海道考古学の研究結果について再考を促す材料のひとつとなり得る。今後、カムチャツカ半島から北海道への移住があったという前提で考古遺物を再検討すれば、考古学においても新たな発見があるかもしれない。

Report

(6 results)
  • 2023 Annual Research Report   Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (26 results)

All 2024 2023 2022 2021 2020 2019

All Journal Article (14 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 14 results,  Open Access: 13 results) Presentation (11 results) (of which Int'l Joint Research: 3 results) Book (1 results)

  • [Journal Article] Medieval genomes from eastern Mongolia share a stable genetic profile over a millennium2024

    • Author(s)
      Lee Juhyeon、Sato Takehiro、Tajima Atsushi、Amgalantugs Tsend、Tsogtbaatar Batmunkh、Nakagome Shigeki、Miyake Toshihiko、Shiraishi Noriyuki、Jeong Choongwon、Gakuhari Takashi
    • Journal Title

      Human Population Genetics and Genomics

      Volume: 4 Pages: 1-11

    • DOI

      10.47248/hpgg2404010004

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genetic Characteristics Contributing to Lipoprotein(a) Levels in the Japanese Population2023

    • Author(s)
      Yamagami Kan、Tada Hayato、Sato Takehiro、Nomura Akihiro、Sakata Kenji、Usui Soichiro、Kawashiri Masa-aki、Tajima Atsushi、Takamura Masayuki
    • Journal Title

      Journal of Coronary Artery Disease

      Volume: 29 Issue: 4 Pages: 104-108

    • DOI

      10.7793/jcad.29.23-00015

    • ISSN
      2434-2173
    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Identification of potential disease-associated variants in idiopathic generalized epilepsy using targeted sequencing2023

    • Author(s)
      Gamirova Regina、Shagimardanova Elena、Sato Takehiro、Kannon Takayuki、Gamirova Rimma、Tajima Atsushi
    • Journal Title

      Journal of Human Genetics

      Volume: 69 Issue: 2 Pages: 59-67

    • DOI

      10.1038/s10038-023-01208-3

    • Related Report
      2023 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genetic factors associated with serum amylase in a Japanese population: combined analysis of copy-number and single-nucleotide variants2023

    • Author(s)
      Zannatun Nayema, Takehiro Sato, Takayuki Kannon, Hiromasa Tsujiguchi, Kazuyoshi Hosomichi, Hiroyuki Nakamura, Atsushi Tajima
    • Journal Title

      Journal of Human Genetics

      Volume: 68 Issue: 5 Pages: 313-319

    • DOI

      10.1038/s10038-022-01111-3

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Nutrigenetic Interaction Between Apolipoprotein C3 Polymorphism and Fat Intake in People with Nonalcoholic Fatty Liver Disease2023

    • Author(s)
      Yamamoto Reina、Takeshita Yumie、Tsujiguchi Hiromasa、Kannon Takayuki、Sato Takehiro、Hosomichi Kazuyoshi、Suzuki Keita、Kita Yuki、Tanaka Takeo、Goto Hisanori、Nakano Yujiro、Yamashita Tatsuya、Kaneko Shuichi、Tajima Atsushi、Nakamura Hiroyuki、Takamura Toshinari
    • Journal Title

      Current Developments in Nutrition

      Volume: 7 Issue: 4 Pages: 100051-100051

    • DOI

      10.1016/j.cdnut.2023.100051

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Genome-wide Survival Analysis for Macular Neovascularization Development in Central Serous Chorioretinopathy Revealed Shared Genetic Susceptibility with Polypoidal Choroidal Vasculopathy2022

    • Author(s)
      Mori Yuki、Miyake Masahiro、Hosoda Yoshikatsu、Miki Akiko、Takahashi Ayako、Muraoka Yuki、Miyata Manabu、Sato Takehiro、Tamura Hiroshi、Ooto Sotaro、Yamada Ryo、Yamashiro Kenji、Nakamura Makoto、Tajima Atsushi、Nagasaki Masao、Honda Shigeru、Tsujikawa Akitaka
    • Journal Title

      Ophthalmology

      Volume: 129 Issue: 9 Pages: 1034-1042

    • DOI

      10.1016/j.ophtha.2022.04.018

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association between serum 25-hydroxyvitamin D concentrations, CDX2 polymorphism in promoter region of vitamin D receptor gene, and chronic pain in rural Japanese residents2022

    • Author(s)
      Keita Suzuki, Hiroyuki Nakamura(19人中19番目)
    • Journal Title

      Journal of Pain Research

      Volume: 15 Pages: 1475-1485

    • DOI

      10.2147/jpr.s356630

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association between vitamin intake and chronic kidney disease according to a variant located upstream of the PTGS1 gene: A cross-sectional analysis of Shika study2022

    • Author(s)
      Kim-Oanh Pham, Hiroyuki Nakamura(21人中21番目)
    • Journal Title

      Nutrients

      Volume: 14(10) Issue: 10 Pages: 2082-2082

    • DOI

      10.3390/nu14102082

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] RHEB is a potential therapeutic target in T cell acute lymphoblastic leukemia2022

    • Author(s)
      Pham Loc Thi、Peng Hui、Ueno Masaya、Kohno Susumu、Kasada Atuso、Hosomichi Kazuyoshi、Sato Takehiro、Kurayoshi Kenta、Kobayashi Masahiko、Tadokoro Yuko、Kasahara Atsuko、Shoulkamy Mahmoud I.、Xiao Bo、Worley Paul F.、Takahashi Chiaki、Tajima Atsushi、Hirao Atsushi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 621 Pages: 74-79

    • DOI

      10.1016/j.bbrc.2022.06.089

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The Role of Polygenic Susceptibility on Air Pollution-Associated Asthma between German and Japanese Elderly Women2022

    • Author(s)
      Sara Kress, Akinori Hara, Claudia Wigmann, Takehiro Sato, Keita Suzuki, Kim-Oanh Pham, Qi Zhao, Ashtyn Areal, Atsushi Tajima, Holger Schwender, Hiroyuki Nakamura, Tamara Schikowski
    • Journal Title

      International Journal of Environmental Research and Public Health

      Volume: 19(16) Issue: 16 Pages: 9869-9869

    • DOI

      10.3390/ijerph19169869

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Whole-Genome Sequencing of a 900-Year-Old Human Skeleton Supports Two Past Migration Events from the Russian Far East to Northern Japan2021

    • Author(s)
      Sato Takehiro、Adachi Noboru、Kimura Ryosuke、Hosomichi Kazuyoshi、Yoneda Minoru、Oota Hiroki、Tajima Atsushi、Toyoda Atsushi、Kanzawa-Kiriyama Hideaki、Matsumae Hiromi、Koganebuchi Kae、Shimizu Kentaro K、Shinoda Ken-ichi、Hanihara Tsunehiko、Weber Andrzej、Kato Hirofumi、Ishida Hajime
    • Journal Title

      Genome Biology and Evolution

      Volume: 13 Issue: 9 Pages: 192-192

    • DOI

      10.1093/gbe/evab192

    • NAID

      120007170565

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Exploring correlations in genetic and cultural variation across language families in Northeast Asia.2021

    • Author(s)
      H. Matsumaea*, P. Ranacher*, P. E. Savage*, D. E. Blasig, T. E. Curriej, K. Kognebuchi, N. Nishidal, T. Sato, H. Tanabe, A. Tajima, S. Browno, M. Stoneking, K. K. Shimizua, H. Oota*, and B. Bickel*
    • Journal Title

      Science Advances

      Volume: 7(34) Issue: 34 Pages: 9223-9223

    • DOI

      10.1126/sciadv.abd9223

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Ancient Jomon genome sequence analysis sheds light on migration patterns of early East Asian populations2020

    • Author(s)
      Gakuhari T. ,Yoneda M. et.al.
    • Journal Title

      Communications Biology

      Volume: 3 Issue: 1 Pages: 1-40

    • DOI

      10.1038/s42003-020-01162-2

    • NAID

      120007168801

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Genome-wide association study of semen volume, sperm concentration, testis size, and plasma inhibin B levels2020

    • Author(s)
      Sato Youichi、Tajima Atsushi、Kiguchi Misaki、Kogusuri Suzu、Fujii Aki、Sato Takehiro、Nozawa Shiari、Yoshiike Miki、Mieno Makiko、Kojo Kosuke、Uchida Masahiro、Tsuchiya Haruki、Yamasaki Kazumitu、Imoto Issei、Iwamoto Teruaki
    • Journal Title

      Journal of Human Genetics

      Volume: 65 Issue: 8 Pages: 683-691

    • DOI

      10.1038/s10038-020-0757-3

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 礼文島浜中2遺跡出土オホーツク文化前期人骨のゲノム解析2024

    • Author(s)
      佐藤丈寛 、久保大輔 、木村亮介 、米田穣 、加藤博文
    • Organizer
      第129回日本解剖学会総会・全国学術集会
    • Related Report
      2023 Annual Research Report
  • [Presentation] The role of polygenic susceptibility on air pollution-associated asthma between Caucasian and Asian elderly women2022

    • Author(s)
      Sara Kress, Akinori Hara, Claudia Wigmann, Takehiro Sato, Keita Suzuki, Kim-Oanh Pham, Qi Zhao, Atsushi Tajima, Holger Schwender, Hiroyuki Nakamura, Tamara Schikowski
    • Organizer
      ISEE Conference
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 古代人ゲノム解析に基づく環オホーツク海地域の集団史2021

    • Author(s)
      佐藤丈寛
    • Organizer
      第75回日本人類学会大会 シンポジウム7「古代・現代人ゲノムが明らかにするヤポネシア人の歴史」
    • Related Report
      2021 Annual Research Report
  • [Presentation] 全エクソーム解析によるセルトリ細胞遺残症候群病因遺伝子の探査2020

    • Author(s)
      舛田千裕、細道一善、飯島将司、観音隆幸、 佐藤丈寛、溝上敦、田嶋敦
    • Organizer
      日本人類遺伝学会第65回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ゲノムワイド関連解析による血中inhibin B値関連遺伝子の同定と遺伝子改変マウスの解析2020

    • Author(s)
      上殿千晴、藤井亜紀、田嶋敦、佐藤丈寛、井本逸勢、佐藤陽一
    • Organizer
      日本人類遺伝学会第65回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Genome-wide analysis of the Nivkh people in the Sakhalin focused on the relationships between peopling history and linguistic diversity in Northeast Asia2020

    • Author(s)
      Hiromi Matsumae, Takehiro Sato, Chiara Baribieri, Kae Koganebuchi, Nao Nishida, Eriko Ochiai, Motoki Osawa, Tadashi Imanishi, Ryosuke Kimura, Hideyuki Tanabe, Atsushi Tajima, Hiroki Oota9 Kentaro K. Shimizu
    • Organizer
      日本進化学会第22回オンライン大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] モンゴル帝国期以前における東モンゴル遺跡出土人骨の人類遺伝学的研究2019

    • Author(s)
      佐藤丈寛、覚張隆史、田嶋敦、ツェンド・アマガラントグス、バトムンフ・ツォグトバータル、三宅俊彦、白石典之
    • Organizer
      第73回日本人類学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Genome-wide analysis on the genetic basis of human head morphology in Japanese2019

    • Author(s)
      Kyoko Yamaguchi, Kae Koganebuchi, Takehiro Sato, Takayuki Kannon, Hiromasa Tsujiguchi, Kazuyoshi Hosomichi, Atsushi Tajima, Ken Yamamoto, Hajime Ishida, Hiroyuki Nakamura, Ryosuke Kimura
    • Organizer
      Society of Molecular Biology & Evolution Annual Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 日本列島古代人のCPT1A欠損症関連遺伝子変異の分布.第73回日本人類学会大会2019

    • Author(s)
      安達 登、神澤秀明、佐藤丈寬、角田恒雄、篠田謙一
    • Organizer
      第73回日本人類学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Complex population history links to high linguistic diversity in the Pacific coast of North Asia2019

    • Author(s)
      Hiromi Matsumae, Takehiro Sato, Kae Koganebuchi, Nao Nishida, Ryosuke Kimura, Atsushi Tajima, Hiroki Oota, Kentaro K. Shimizu
    • Organizer
      Asia Pacific Conference on Human Evolution
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 言語の多様性は人類集団史を反映しているか?2019

    • Author(s)
      Hiromi Matsumae, Patrick E. Savage, Peter Ranacher, Damian E. Blasi, Thomas E. Currie, Takehiro Sato, Atsushi Tajima, Mark Stoneking, Steven Brown, Kentaro K. Shimizu, Hiroki Oota, Balthasar Bickel
    • Organizer
      日本進化学会第21回大会
    • Related Report
      2019 Annual Research Report
  • [Book] 北海道考古学の最前線2023

    • Author(s)
      高瀬克範 編
    • Total Pages
      151
    • Publisher
      雄山閣
    • ISBN
      9784639029137
    • Related Report
      2023 Annual Research Report

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Published: 2019-04-18   Modified: 2025-01-30  

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