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Involvement of hyperphosphatemia and microbiota in vascular endothelial function with in the end-stage renal diseases.

Research Project

Project/Area Number 19H01611
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 08030:Family and consumer sciences, and culture and living-related
Research InstitutionUniversity of Hyogo

Principal Investigator

SAKAUE MOTOYOSHI  兵庫県立大学, 環境人間学部, 特任教授(名誉教授) (20283913)

Co-Investigator(Kenkyū-buntansha) 伊藤 美紀子  兵庫県立大学, 環境人間学部, 教授 (50314852)
中出 麻紀子  兵庫県立大学, 環境人間学部, 准教授 (80508185)
田中 更沙  兵庫県立大学, 環境人間学部, 助教 (90733387)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2021: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
Fiscal Year 2020: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2019: ¥11,310,000 (Direct Cost: ¥8,700,000、Indirect Cost: ¥2,610,000)
Keywords慢性腎臓病 / 高リン血症 / リンスパイク / 血管石灰化 / 腸内細菌叢 / 末期腎不全 / 血管内皮機能 / 栄養療法 / 血管内皮障害
Outline of Research at the Start

末期腎不全患者でみられる高リン血症は血管機能障害と血管石灰化を引き起こし、患者の生
命予後を大きく低下させるので、リンの摂取制限は重要である。しかし、食品添加物に含まれる無機リンの摂取が多くなっている現代の生活環境において、リンの管理の確実な実行は困難である。本研究では高リン食摂取後の一過性高リン血症の血管機能や炎症、腸内環境への影響を解析する。腎機能低下モデル動物に高リン食を付加し、その影響とメカニズム解明する。さらに水溶性食物繊維を用いた予防方法を検討する。次に、実際の臨床現場で患者で血管機能障害を予防し、生活の質(QOL)の維持・増進のための栄養療法の開発をめざす。

Outline of Final Research Achievements

The effect of hyperphosphatemia on vascular function was analyzed in this study. Alternative administration of high and low phosphorus diets to renal failure model rats caused transient hyperphosphatemia, and vascular calcification to the same extent as rats fed a high phosphorus diet. Co-administration of dietary fiber with the diet suppressed plasma phosphorus concentration. Analysis of the intestinal flora revealed that administration of water-soluble dietary fiber significantly reduced bacteria involved in urinary toxin production, clarifying the molecular mechanism mediated by the intestinal flora.
The effect of water-soluble dietary fiber was also verified in hemodialysis patients. Ingestion of water-soluble dietary fiber (15 g/day) for 2 weeks significantly reduced concentrations of blood urea nitrogen and urinary toxins such as phenyl sulfate. Amount of bifidobacteria in the intestinal flora was significantly increased.

Academic Significance and Societal Importance of the Research Achievements

我が国の透析患者の最大の死因である心血管疾患の発症には高リン血症が大きく関わっている。血液透析患者の食生活でも加工食品の摂取が増加しており、加工食品には吸収率の高い無機リンが多く含まれている。本研究では無機リンの多い食事によって生じる一過性の高リン血症に注目し、血管機能と血管石灰化への影響を解析した。ここに本研究の学術的意義がある。
本研究ではラットで明らかにした結果を透析患者においても検討した。血液透析患者に水溶性食物繊維を摂取させると血中尿素窒素濃度と血中尿毒素物質が減少することが実証でき、血液透析現場での応用が期待できる。ここに社会的意義がある。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (48 results)

All 2022 2021 2020 2019

All Journal Article (16 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 16 results,  Open Access: 9 results) Presentation (28 results) (of which Int'l Joint Research: 11 results,  Invited: 1 results) Book (4 results)

  • [Journal Article] Self-determined intake of folic acid, calcium, and iron in pre-pregnant women2021

    • Author(s)
      黒川 浩美、黒川 通典、伊藤 美紀子
    • Journal Title

      Trace Nutrients Research

      Volume: 38 Issue: 0 Pages: 58-65

    • DOI

      10.51029/jtnrs.38.0_58

    • NAID

      130008162781

    • ISSN
      1346-2334, 2436-6617
    • Year and Date
      2021-12-15
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Association of a well-balanced diet with lifestyle, knowledge, health consciousness, and health status among female university students2021

    • Author(s)
      中出 麻紀子、岩城 なつ美、中村 優花、黒谷 佳代
    • Journal Title

      Japanese Journal of Health Education and Promotion

      Volume: 29 Issue: 1 Pages: 51-60

    • DOI

      10.11260/kenkokyoiku.29.51

    • NAID

      130007996232

    • ISSN
      1340-2560, 1884-5053
    • Year and Date
      2021-02-28
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Elevation of the serotonin-derived quinone, tryptamine-4,5-dione, in the intestine of ICR mice with dextran sulfate-induced colitis2021

    • Author(s)
      Suga Naoko、Murakami Akira、Arimitsu Hideyuki、Shiogama Kazuya、Tanaka Sarasa、Ito Mikiko、Kato Yoji
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 69 Issue: 1 Pages: 61-67

    • DOI

      10.3164/jcbn.20-161

    • NAID

      130008060399

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The Relationship between Eating Behavior and a Japanese Well-Balanced Diet among Young Adults Aged 20‐39 Years2021

    • Author(s)
      Nakade Makiko、Kibayashi Etsuko、Morooka Ayumi
    • Journal Title

      Nippon Eiyo Shokuryo Gakkaishi

      Volume: 74 Issue: 5 Pages: 265-271

    • DOI

      10.4327/jsnfs.74.265

    • NAID

      130008105685

    • ISSN
      0287-3516, 1883-2849
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] SLC37A2, a phosphorus-related molecule, increases in smooth muscle cells in the calcified aorta2021

    • Author(s)
      Tani Mariko、Tanaka Sarasa、Oeda Chihiro、Azumi Yuichi、Kawamura Hiromi、Sakaue Motoyoshi、Ito Mikiko
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 68 Issue: 1 Pages: 23-31

    • DOI

      10.3164/jcbn.19-114

    • NAID

      130007965281

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dietary Habits and Health Awareness in Regular Eaters of Well-balanced Breakfasts (Consisting of <i>Shushoku</i>, <i>Shusai</i>, and <i>Fukusai</i>)2020

    • Author(s)
      木林悦子、中出麻紀子、諸岡歩.
    • Journal Title

      The Japanese Journal of Nutrition and Dietetics

      Volume: 78 Issue: 6 Pages: 243-253

    • DOI

      10.5264/eiyogakuzashi.78.243

    • NAID

      130007975665

    • ISSN
      0021-5147, 1883-7921
    • Year and Date
      2020-12-01
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of repetitive diet-induced fluctuations in plasma phosphorus on vascular calcification and inflammation in rats with early-stage chronic kidney disease2020

    • Author(s)
      Tani Mariko、Tanaka Sarasa、Takamiya Kana、Sakaue Motoyoshi、Ito Mikiko
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 66 Issue: 2 Pages: 139-145

    • DOI

      10.3164/jcbn.19-93

    • NAID

      130007804503

    • ISSN
      0912-0009, 1880-5086
    • Year and Date
      2020-03-01
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] High-fat diets provoke phosphorus absorption from the small intestine in rats.2020

    • Author(s)
      Kawamoto K, Sakuma M, Tanaka S, Masuda M, Nakao-Muraoka M, Niida Y, Nakamatsu Y, Ito M, Taketani Y, Arai H.
    • Journal Title

      Nutrition

      Volume: 72 Pages: 110694-110694

    • DOI

      10.1016/j.nut.2019.110694

    • NAID

      120006939630

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of dietary fiber on vascular calcification by repetitive diet-induced fluctuations in plasma phosphorus in early-stage chronic kidney disease rats2020

    • Author(s)
      Tani Mariko、Tanaka Sarasa、Takamiya Kana、Kato Yoji、Harata Gaku、He Fang、Sakaue Motoyoshi、Ito Mikiko
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: 67 Issue: 3 Pages: 283-289

    • DOI

      10.3164/jcbn.20-46

    • NAID

      130007934161

    • ISSN
      0912-0009, 1880-5086
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 朝食時における家族との共食状況と成人の朝食欠食との関連2020

    • Author(s)
      中出 麻紀子、木林 悦子、諸岡 歩
    • Journal Title

      日本健康教育学会誌

      Volume: 28 Pages: 198-206

    • NAID

      130007894790

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] SLC37A2, a phosphorus-related molecule, increases in smooth muscle cells in the calcified aorta.2020

    • Author(s)
      Tani Mariko, Tanaka Sarasa, Oeda Chihiro, Azumi Yuichi, Kawamura Hiromi, Sakaue Motoyoshi, Ito Mikiko.
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: -

    • NAID

      130007965281

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of dietary fiber on vascular calcification by repetitive diet-induced fluctuations in plasma phosphorus in early-stage chronic kidney disease rats2020

    • Author(s)
      Tani Mariko, Tanaka Sarasa, Takamiya Kana, Kato Yoji, Harata Gaku, He Fang, Sakaue Motoyoshi, Ito Mikiko
    • Journal Title

      Journal of Clinical Biochemistry and Nutrition

      Volume: -

    • NAID

      130007934161

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 外来維持血液透析患者の細胞外水分比と塩味味覚閾値との関係について2019

    • Author(s)
      市橋きくみ、坂上元祥
    • Journal Title

      日本病態栄養学会誌

      Volume: 22 Pages: 259-266

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The ellagitannin trimer rugosin G inhibits recombinant human histidine decarboxylase2019

    • Author(s)
      Nitta Yoko、Ito Hideyuki、Komori Hirohumi、Ueno Hiroshi、Takeshima Daiki、Ito Mikiko、Sakaue Motoyoshi、Kikuzaki Hiroe
    • Journal Title

      Bioscience, Biotechnology, and Biochemistry

      Volume: 印刷中 Issue: 7 Pages: 1315-1318

    • DOI

      10.1080/09168451.2019.1606695

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Fish and meat intakes and prevalence of anemia among the Japanese elderly.2019

    • Author(s)
      Imai Eri、Nakade Makiko
    • Journal Title

      Asia Pacific Journal of Clinical Nutrition

      Volume: 28 Pages: 276-284

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of the putative PKC phosphorylation sites of the type IIc sodium-dependent phosphate transporter in parathyroid hormone regulation.2019

    • Author(s)
      Fujii T, Segawa H, Hanazaki A, Nishiguchi S, Minoshima S, Ohi A, Tominaga R, Sasaki S, Tanifuji K, Koike M, Arima Y, Shiozaki Y, Kaneko I, Ito M, Tatsumi S, Miyamoto KI
    • Journal Title

      Clin Exp Nephrol.

      Volume: in press Issue: 7 Pages: 898-907

    • DOI

      10.1007/s10157-019-01725-6

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 透析患者における尿毒素物質に着目した水溶性食物繊維摂取の影響2022

    • Author(s)
      田中更沙、井貫雅子、橋本渚、安部綾、小関誠、坂上元祥、伊藤美紀子
    • Organizer
      第24・25回日本病態栄養学会年次学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 軽度リフィーディングシンドロームモデル動物における栄養投与方法の違いが代謝変動に及ぼす影響2021

    • Author(s)
      田中 更沙、博多 涼、多田 恭歌、守本 彩乃、橋本 渚、坂上 元祥、伊藤 美紀
    • Organizer
      第75回日本栄養・食糧学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 慢性腎臓病早期における食事誘発性リンスパイクへの水溶性食物繊維の効果2021

    • Author(s)
      2田中更沙、谷真理子、坂上元祥、伊藤美紀子
    • Organizer
      第9回日本腎栄養代謝研究会学術集会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Nutrient intake from university cafeteria lunches―A comparison between students who are health-conscious and those who are not.2021

    • Author(s)
      Nakade M, Nakamura Y, Iwaki N
    • Organizer
      nternational Congress of dietetics 2020
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of a nudge intervention for increasing vegetable intake among university students in a university cafeteria.2021

    • Author(s)
      Nakade M, Matsushita M, Fukui R, Nakamura K, Fujishiro M
    • Organizer
      Society for nutrition education and behavior annual conference 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 現在の主食・主菜・副菜を組み合わせた食事と学童期の食習慣、食環境、食体験との関連2021

    • Author(s)
      中出麻紀子、中村こころ、福井涼太、松下眞子、藤城美穂
    • Organizer
      第68回日本栄養改善学会学術総会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Dietary intake of patients with type 2 diabetes was adversely affected by the psychological burden related to diabetes and its treatment.2020

    • Author(s)
      Muneishi M, Ozasa R, Fujimoto C, Kihara N, Sakaue M
    • Organizer
      ESPEN 2020 (欧州臨床栄養・代謝学会)Virtual Congress
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Dietary awareness, eating attitudes, and phosphorus intake in hemodialysis patients with protein-energy wasting (PEW).2020

    • Author(s)
      Fujimoto C, Kaji Y, Muneishi M, Kamimura K, Sakaue M
    • Organizer
      ESPEN 2020 (欧州臨床栄養・代謝学会)Virtual Congress
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Association of nutrient intakes with physical activity in patients on chronic hemodialysis.2020

    • Author(s)
      Inuki M, Fujimoto C, Muneishi M, Sakaue M
    • Organizer
      ESPEN 2020 (欧州臨床栄養・代謝学会)Virtual Congress
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 2型糖尿病外来通院患者における糖尿病治療に関する心理的負担度と食物摂取量の関連2020

    • Author(s)
      酒井亜月1、小笹里歩、田中久美、井野隆弘、坂上元祥
    • Organizer
      第57回日本糖尿病学会近畿地方会(Web ポスター発表)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 生活習慣病を有する高齢女性患者のフレイルと食習慣・運動習慣の関係2020

    • Author(s)
      竹林希歩、森倉美月、田中久美、井野隆弘、坂上元祥
    • Organizer
      第31回日本老年医学会近畿地方会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 軽度リフィーディングの肝臓における網羅的代謝変動解析2020

    • Author(s)
      田中更沙、緒方茉衣、博多涼、谷真理子、坂上元祥、伊藤美紀子
    • Organizer
      第74回日本栄養・食糧学会大会(誌上開催)
    • Related Report
      2020 Annual Research Report
  • [Presentation] リフィーディングシンドロームモデル動物における栄養投与法が代謝変動に及ぼす影響2020

    • Author(s)
      田中更沙、博多涼、多田恭歌、藤川晴奈、坂上元祥、伊藤美紀子
    • Organizer
      第59回 日本栄養・食糧学会 近畿支部大会(Web 開催)
    • Related Report
      2020 Annual Research Report
  • [Presentation] Association of a healthy dietary habit with dietary practices for lifestyle disease prevention and with health awareness.2020

    • Author(s)
      Kibayashi E, Nakade M, Morooka A
    • Organizer
      Society for nutrition education and behavior annual conference 2020(Web 開催)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 20、30歳代成人における主食・主菜・副菜の揃った食事と関連する食習慣2020

    • Author(s)
      中出麻紀子,木林悦子,諸岡歩
    • Organizer
      第67回日本栄養改善学会学術総会(誌上発表)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 大学生における昼食時の料理選択と食事に対する意識との関連2020

    • Author(s)
      中出麻紀子
    • Organizer
      第79回日本公衆衛生学会総会(Web 発表)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 外来維持血液透析患者の細胞外水分比と塩味味覚閾値 との関係について2020

    • Author(s)
      市橋きくみ 、坂上元祥
    • Organizer
      第23回日本病態栄養学会年次学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] リフィーディング時におけるインスリン分泌能にリンが及ぼす影響2020

    • Author(s)
      田中更沙、本玉紗友香、尾田桃子、河村弘美、谷真理子、坂上元祥、伊藤美紀子
    • Organizer
      第23回日本病態栄養学会年次学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] The relation between dietary phosphorus-protein ratio and nutritional status in hemodialysis patients.2019

    • Author(s)
      Uda Kaede, Inoue Aina, Miyamae Natsumi, Ozasa Riho, Furusato Maho, Sakaue Motoyoshi
    • Organizer
      PENSA( Parenteral and Enteral Nutrition Society of Asia) 2019 Congress
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 生活習慣病で外来通院する患者に おける食習慣・運動習慣とフレイルの 関係について2019

    • Author(s)
      小笹里歩、森倉美月、田中久美、井野隆弘、坂上元祥
    • Organizer
      第56回日本糖尿病学会近畿地方会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Effects of diet-induced repetitive spikes in plasma phosphorus on vascular calcifications in rats with mild kidney dysfunction.2019

    • Author(s)
      Tani Mariko, Takamiya Kana, Tanaka Sarasa, Sakaue Motoyoshi, Ito Mikiko
    • Organizer
      41th European Society for Clinical Nutrition and Metabolism Congress
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of soluble dietary fiber on plasma phosphorus and endothelial function.2019

    • Author(s)
      Tanaka Sarasa, Tani Mariko, Kawamura Hiromi, Sakaue Shiori, Matsui Mayu, Ishitani Midori, Sakaue Motoyoshi, Ito Mikiko.
    • Organizer
      The 7th International Conference on Food Factors
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 軽度リフィーディングシンドロームにおけるリン・糖代謝への影響2019

    • Author(s)
      田中更沙、本玉紗友香、尾田桃子、 河村弘美、井元夢乃、浦田侑里、谷真理子、坂上元祥、伊藤美紀子
    • Organizer
      第73回 日本栄養・食糧学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 食餌による一過性血中リン濃度上昇の反復が血管へ及ぼす影響2019

    • Author(s)
      谷 真理子、田中更沙、高宮佳奈、坂上元祥、伊藤美紀子
    • Organizer
      第7回 日本腎栄養代謝研究会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Association between dietary practices for lifestyle disease prevention and breakfast habits.2019

    • Author(s)
      Kibayashi Etsuko, Nakade Makiko, Nobuki Yukiko, Yamawaki Natsumi, Morooka Ayumi
    • Organizer
      Society for nutrition education and behavior annual conference 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Vegetable intake at breakfast and associated factors among young adults in Japan.2019

    • Author(s)
      Nakade Makiko, Shiozawa Yuhya, Aiba Naomi.
    • Organizer
      The 13th Asian Congress of Nutrition
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 朝食時における家族との共食の状況と朝食欠食との関連2019

    • Author(s)
      中出麻紀子、木林悦子、信木由紀子、山脇奈津実、諸岡歩.
    • Organizer
      第66回日本栄養改善学会学術総会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 「生活困窮世帯およびその子どもへの健康支援のあり方」12-4:生活困窮世帯の子どもに対する支援活動:国内の取り組み状況とその課題2019

    • Author(s)
      新杉知沙、中出麻紀子、黒谷佳代
    • Organizer
      第78回日本公衆衛生学会学術総会
    • Related Report
      2019 Annual Research Report
    • Invited
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    • Author(s)
      坂上 元祥(田中 明、藤岡 由夫 編)
    • Total Pages
      320
    • Publisher
      羊土社
    • ISBN
      9784758113670
    • Related Report
      2021 Annual Research Report
  • [Book] 生活習慣病:糖尿病とメタボリックシンドローム、図説作業療法技術ガイド(第4版)2021

    • Author(s)
      坂上元祥、谷口 洋
    • Total Pages
      1384
    • Publisher
      文光堂
    • ISBN
      9784830645891
    • Related Report
      2020 Annual Research Report
  • [Book] 公衆栄養学 第3章栄養政策2020

    • Author(s)
      中出麻紀子、編集:荒牧礼子、今井絵理
    • Total Pages
      192
    • Publisher
      化学同人
    • ISBN
      9784759819038
    • Related Report
      2019 Annual Research Report
  • [Book] 公衆栄養学(改訂第7版)国民健康・栄養調査2020

    • Author(s)
      瀧本秀美、中出麻紀子、今井絵理、編集:吉池信男、林宏一
    • Total Pages
      318
    • Publisher
      南江堂
    • ISBN
      9784524225279
    • Related Report
      2019 Annual Research Report

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Published: 2019-04-18   Modified: 2023-01-30  

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