• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Investigating immunological and genetic basis for happiness and worker well-being: applied research in the workplace

Research Project

Project/Area Number 19H01763
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 10030:Clinical psychology-related
Research InstitutionInternational University of Health and Welfare

Principal Investigator

Nakata Akinori  国際医療福祉大学, 医学研究科, 教授 (80333384)

Co-Investigator(Kenkyū-buntansha) 井澤 修平  独立行政法人労働者健康安全機構労働安全衛生総合研究所, 産業保健研究グループ, 上席研究員 (00409757)
永田 智久  産業医科大学, 産業生態科学研究所, 准教授 (40525466)
内田 由紀子  京都大学, 人と社会の未来研究院, 教授 (60411831)
島津 明人  慶應義塾大学, 総合政策学部(藤沢), 教授 (80318724)
阿久津 聡  一橋大学, 大学院経営管理研究科, 教授 (90313436)
Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2022: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2021: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2020: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Keywords幸福感 / ポジティブ・サイコロジー / 産業保健心理学 / 遺伝子発現 / 精神神経内分泌免疫学 / 炎症マーカー / 労働者 / 健康診断 / 免疫系
Outline of Research at the Start

人の幸福感の生物学的基盤に関する研究はまだ端緒についたばかりである。我々はこれまでに、仕事への満足感、働き甲斐、良好な人間関係等の肯定的要因が炎症マーカーの抑制や細胞性免疫を増強することを報告した。また、この過程で職業要因と生活要因の相乗効果や、幸福感が免疫機能や遺伝子発現に好ましい影響を及ぼすことを突き止めた。本研究はこれまでの研究をさらに発展させ、400名規模の職域集団において、職業・生活上の幸福感・肯定要因がサイトカイン産生、遺伝子発現、爪コルチゾールにどの様に影響するか、逆にこれらの遺伝子発現やサイトカインが健康や幸福感の向上にどのように寄与するのかをコホート研究から明らかにする。

Outline of Final Research Achievements

The purpose of this study was to prospectively examine how happiness/well-being and high self-esteem are related to pro-inflammatory cytokine production, gene expression, and nail cortisol levels among workers in working populations. The main findings of the study include: 1) altruistic behavior in the workplace decreases inflammatory markers; 2) adequate sleep duration improves workers' sense of well-being; and 3) psychological safety in the workplace prevents mental health deterioration. These research results have been presented at the American Psychological Association, the Asian Pacific International Society for Psychosocial Factors in the Workplace, the Japan Society for Occupational Health, and the Japanese Psychological Association, and have been reported as original papers or are in preparation for submissions.

Academic Significance and Societal Importance of the Research Achievements

本研究は、心理学で扱う心のネガティブな側面に目を向けるのでなく、心のポジティブな側面にも目を向け、そこを強化することによってストレスに強く、幸福感の増加につながるという発展的な視点に目を向けた点に学術的意義がある。特に、幸福感や向社会的行動が体内の炎症を抑えることを示したことは、社会の健康増進の基盤となりうるという意味で、社会的意義がある。

Report

(5 results)
  • 2023 Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (47 results)

All 2024 2023 2022 2021 2020

All Journal Article (14 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 13 results,  Open Access: 13 results) Presentation (27 results) (of which Int'l Joint Research: 9 results,  Invited: 6 results) Book (6 results)

  • [Journal Article] Poor psychosocial safety climate increases teleworker vulnerability to suicidal ideation2024

    • Author(s)
      Kikunaga K, Nakata A, Tondokoro T, Dollard M.
    • Journal Title

      Journal of Occupational and Environmental Medicine

      Volume: 66 Issue: 7 Pages: e306-e311

    • DOI

      10.1097/jom.0000000000003122

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Psychological distress, Japanese teleworkers, and supervisor support during COVID-192023

    • Author(s)
      Kazuki Kikunaga, Akinori Nakata,,,Yoshihisa Fujino, Yu Igarashi
    • Journal Title

      Journal of Occupational and Environmental Medicine

      Volume: 65 Issue: 2 Pages: e68-e73

    • DOI

      10.1097/jom.0000000000002756

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Changes in work/sleep patterns due to the COVID-19 pandemic are associated with psychological distress among Japanese workers2023

    • Author(s)
      Tondokoro T, Nakata A, Tateishi S, Mafune K, Tsuji M, Ando H, Odagami K, Matsugaki R, Fujino Y.
    • Journal Title

      Frontiers in Psychology

      Volume: 14 Pages: 1133498-1133498

    • DOI

      10.3389/fpsyg.2023.1133498

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Insufficient workplace infection control and unhealthy lifestyle behaviors are related to poor self-rated health during the COVID-19 Pandemic.2023

    • Author(s)
      Inoue, Y. Nakata, A. Tateishi, S. Mafune, K. Tsuji, M. Ogami, A. Odagami, K. Matsugaki, R. Fujino, Y; CORoNa Work Project.
    • Journal Title

      Journal of Occupational and Environmental Medicine

      Volume: 65

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Occupational safety and health of flexible work style2022

    • Author(s)
      Go Muto, Akinori Nakata, Dong-Uk Park, Kazuhito Yokoyama
    • Journal Title

      Industrial Health

      Volume: 60 Issue: 4 Pages: 293-294

    • DOI

      10.2486/indhealth.60_400

    • ISSN
      0019-8366, 1880-8026
    • Year and Date
      2022-06-09
    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Burnout and poor perceived health in flexible working time in Japanese employees: the role of self-endangering behavior in relation to workaholism, work engagement, and job stressors2022

    • Author(s)
      YOKOYAMA Kazuhito、NAKATA Akinori、KANNARI Yuto、NICKEL Frank、DECI Nicole、KRAUSE Andreas、DETTMERS Jan
    • Journal Title

      Industrial Health

      Volume: 60 Issue: 4 Pages: 295-306

    • DOI

      10.2486/indhealth.2022-0063

    • ISSN
      0019-8366, 1880-8026
    • Year and Date
      2022-05-25
    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Perspectives on collaboration between physicians and nurse practitioners in Japan: A cross-sectional study2022

    • Author(s)
      Mari Igarashi, Ryuichi Ohta, Akinori Nakata, Yasuo Kurita, Yuta Mitobe, Miho Hayakawa, Tsutomu Yamazaki, Harumi Gomi
    • Journal Title

      Nursing reports (Pavia, Italy)

      Volume: 12 Issue: 4 Pages: 894-903

    • DOI

      10.3390/nursrep12040086

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Development of the Japanese Version of the Self-Endangering Work Behavior (J-SEWB) Scale2022

    • Author(s)
      YOKOYAMA KAZUHITO、NAKATA AKINORI、KANNARI YUTO、NICKEL FRANK、DECI NICOLE、KRAUSE ANDREAS、DETTMERS JAN
    • Journal Title

      Juntendo Medical Journal

      Volume: 68 Issue: 3 Pages: 242-250

    • DOI

      10.14789/jmj.JMJ21-0039-OA

    • ISSN
      2187-9737, 2188-2126
    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Use of the Naphthoquinone YM155 (Sepantronium Bromide) in the treatment of cancer: A systematic review and meta-synthesis2022

    • Author(s)
      Dariimaa Ganbat, Bat-Erdene Jugder, Lkhamaa Ganbat, Miki Tomoeda, Erdenetsogt Dungubat, Ambaga Miyegombo, Gantsetseg Garmaa, Yoshihisa Takahashi, Ryuji Fukuzawa, Ichiro Mori, Takayuki Shiomi, Akinori Nakata,Yasuhiko Tomita
    • Journal Title

      Oncologie

      Volume: 24 Issue: 2 Pages: 195-225

    • DOI

      10.32604/oncologie.2022.022299

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Giving social support at work may reduce inflammation on employees themselves: a participatory workplace intervention study among Japanese hospital nurses2021

    • Author(s)
      TONDOKORO Tsukumi、NAKATA Akinori、OTSUKA Yasumasa、YANAGIHARA Nobuyuki、ANAN Ayumi、KODAMA Hiromi、SATOH Noriaki
    • Journal Title

      Industrial Health

      Volume: 60 Issue: 3 Pages: 266-275

    • DOI

      10.2486/indhealth.2021-0096

    • NAID

      130008107799

    • ISSN
      0019-8366, 1880-8026
    • Year and Date
      2021-10-25
    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Association of self-rated health with inflammatory markers among nursing home employees2021

    • Author(s)
      井上 由貴子, 中田 光紀, 栗岡 住子, 永田 智久, 森 晃爾
    • Journal Title

      SANGYO EISEIGAKU ZASSHI

      Volume: 63 Issue: 4 Pages: 117-128

    • DOI

      10.1539/sangyoeisei.2020-020-B

    • NAID

      130008067430

    • ISSN
      1341-0725, 1349-533X
    • Year and Date
      2021-07-20
    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Effects of participatory workplace improvement program on stress-related biomarkers and self-reported stress among university hospital nurses: a preliminary study2021

    • Author(s)
      Tondokoro T, Nakata A, Otsuka Y, Yanagihara N, Anan A, Kodama H, Satoh N.
    • Journal Title

      Industrial Health

      Volume: 59 Issue: 2 Pages: 128-141

    • DOI

      10.2486/indhealth.2020-0176

    • NAID

      130008002331

    • ISSN
      0019-8366, 1880-8026
    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Psychosocial impact of COVID-19 for general workers2020

    • Author(s)
      Shimazu Akihito、Nakata Akinori、Nagata Tomohisa、Arakawa Yutaka、Kuroda Sachiko、Inamizu Nobuyuki、Yamamoto Isamu
    • Journal Title

      Journal of Occupational Health

      Volume: 62 Issue: 1 Pages: n/a

    • DOI

      10.1002/1348-9585.12132

    • NAID

      130007879992

    • ISSN
      1341-9145, 1348-9585
    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 生産性向上と健康増進の両立を可能にするガイドラインの作成2020

    • Author(s)
      中田 光紀, 梶木繁之
    • Journal Title

      産業精神保健

      Volume: 28 Pages: 22-29

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
  • [Presentation] Good sleep may improve work engagement among workers in Japanese small and medium-sized enterprises.2023

    • Author(s)
      Tondokoro T, Nakata A, Kikunaga K, Inoue Y, Yamakawa S.
    • Organizer
      17th International Congress of Behavioral Medicine
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of a workplace improvement intervention program during the COVID-19 Pandemic for managerial-level hospital nurses.2023

    • Author(s)
      Tondokoro, T., Nakata, A., Hashimoto, K., Izawa, S., Kikunaga, K.
    • Organizer
      Joint Congress of the International Commission on Occupational Health-Work Organization and Psychosocial Factors & Asia Pacific Academy of Psychosocial Factors at Work 2023
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The role of psychosocial safety climate in relation to depressive symptoms, self-reported and actual antidepressant usage.2023

    • Author(s)
      Afsharian, A., Dollard, M.F., Nakata, A., Glozier, N., Crispin, C.
    • Organizer
      Joint Congress of the International Commission on Occupational Health-Work Organization and Psychosocial Factors & Asia Pacific Academy of Psychosocial Factors at Work 2023
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Balance of work-sleep hours on psychological status in Japan.2023

    • Author(s)
      Tondokoro, T., Nakata, A.
    • Organizer
      Joint Congress of the International Commission on Occupational Health-Work Organization and Psychosocial Factors & Asia Pacific Academy of Psychosocial Factors at Work 2023
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Psychosocial safety climate as a preventive factor from a decrease in social support among teleworkers in Japan.2023

    • Author(s)
      Kikunaga, K., Nakata, A., Tondokoro, T.
    • Organizer
      Joint Congress of the International Commission on Occupational Health-Work Organization and Psychosocial Factors & Asia Pacific Academy of Psychosocial Factors at Work 2023
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Are workers in workplaces with increased psychosocial safety climate healthier? - A preliminary analysis among Japanese workers in small- and medium-sized businesses -.2023

    • Author(s)
      Inoue, Y., Nakata, A., Tondokoro, TS., Kikunaga, K.
    • Organizer
      Joint Congress of the International Commission on Occupational Health-Work Organization and Psychosocial Factors & Asia Pacific Academy of Psychosocial Factors at Work 2023
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Is mistimed eating associated with subjective fatigue symptoms? A cross-sectional study of 74,997 workers in Japan.2023

    • Author(s)
      Nakata, A., Nagata, T., Otsuka, Y., Inoue, Y.
    • Organizer
      Joint Congress of the International Commission on Occupational Health-Work Organization and Psychosocial Factors & Asia Pacific Academy of Psychosocial Factors at Work 2023
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Why do the Japanese work excessive hours? Meaningful work perspective2023

    • Author(s)
      Nakata, A.
    • Organizer
      Joint Congress of the International Commission on Occupational Health-Work Organization and Psychosocial Factors & Asia Pacific Academy of Psychosocial Factors at Work 2023
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Mistimed eating behaviors and suicidal ideation among the working population: A cross-sectional study of 75,449 Japanese workers.2023

    • Author(s)
      Nakata, A., Otsuka, Y., Nagata, T., Inoue, Y., Tondokoro, T., Kikunaga, K., Yamakawa, S.
    • Organizer
      Work, Stress, and Health: 2023
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ウィズ/ポストコロナ時代のポジティブメンタルヘルス:「朗働」に向けた学際的アプローチ 労働者の睡眠支援2022

    • Author(s)
      中田光紀
    • Organizer
      第29回日本産業精神保健学会
    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Invited
  • [Presentation] これからの職場のメンタルヘルス ~労働観の転換と朗働の実現~ 朗働を目指した働き方と眠り方2022

    • Author(s)
      中田光紀
    • Organizer
      日本心理学会第86回大会
    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Invited
  • [Presentation] 論文執筆が進まない貴方へ朗報!行動医学論文の書き方教えます!2022

    • Author(s)
      中田光紀
    • Organizer
      第29回日本行動医学会学術総会
    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Invited
  • [Presentation] 心理社会的支援と仕事と家庭生活の両立 中小企業勤務者を対象としたインターネット調査 男女別、職場・家庭の支援別解析2022

    • Author(s)
      頓所つく実、中田光紀、井上由貴子、菊永一輝、山川誠司、並木連太郎
    • Organizer
      第30回日本産業ストレス学会
    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
  • [Presentation] 看護師の健康管理対策を目的としたリラクセーション法の生理学的評価 ―自律神経バランスを中心に―2022

    • Author(s)
      児玉裕美、辻慶子、遠藤淑美、岡田なぎさ、松井聡子、中田光紀
    • Organizer
      第38回日本ストレス学会
    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
  • [Presentation] 被服製造労働者の爪内のコルチゾール値による仕事のストレス評価2022

    • Author(s)
      川﨑幹子、中田光紀、井澤修平
    • Organizer
      第38回日本ストレス学会
    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
  • [Presentation] 中小企業に勤務する成人におけるヘルスリテラシーと運動に関する健康行動の関連2022

    • Author(s)
      並木連太郎、中田光紀、頓所つく実、山川誠司、菊永一輝、井上由貴子
    • Organizer
      第38回日本ストレス学会
    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
  • [Presentation] Desired job characteristics and their relationships with mental health: A preliminary study2022

    • Author(s)
      Kikunaga K, Nakata A, Yamakawa S, Tondokoro T, Inoue Y, Namiki R.
    • Organizer
      第38回日本ストレス学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Differences in association between probable primary headache and psychosocial support at work among male and female Japanese employees at a food manufacturing company2022

    • Author(s)
      Tondokoro T, Nakata A, Inoue Y, Kikunaga K, Yamakawa S.
    • Organizer
      第38回日本ストレス学会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Desired job characteristics and their relationships with mental health: A preliminary study2022

    • Author(s)
      Kazuki KIKUNAGA, Akinori NAKATA, Seiji YAMAKAWA, Tsukumi TONDOKORO, Yukiko INOUE, Rentaro NAMIKI
    • Organizer
      第38回日本ストレス学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Differences in association between probable primary headache and psychosocial support at work among male and female Japanese employees at a food manufacturing company2022

    • Author(s)
      Tsukumi TONDOKORO, Akinori NAKATA, Yukiko INOUE, Kazuki KIKUNAGA, Seiji YAMAKAWA
    • Organizer
      第38回日本ストレス学会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 社会的時差ボケとメタボリックシンドロームの関連(シンポジウム)2020

    • Author(s)
      柴崎貴通,中田光紀
    • Organizer
      第27回日本行動医学会学術総会
    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
    • Invited
  • [Presentation] Work, Happiness, and Health ~今、直面している危機をどう乗り越えるか2020

    • Author(s)
      中田光紀
    • Organizer
      第27回日本行動医学会学術総会(大会長講演)
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 被服製造労働者の爪コルチゾール値と努力報酬不均衡モデルとの関連2020

    • Author(s)
      川﨑幹子,中田光紀,井澤修平,頓所つく実,井上由貴子
    • Organizer
      第27回日本行動医学会学術総会
    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
  • [Presentation] Does giving social support at work decrease inflammation? -Changes in blood inflammatory markers after the participatory workplace improvement program among hospital nurses2020

    • Author(s)
      Tondokoro T, Nakata A, Otsuka Y, Yanagihara N, Anan A, Kodama H, Satoh N.
    • Organizer
      第27回日本行動医学会学術総会
    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
  • [Presentation] 企業従業員における主観的健康感と風邪罹患・病欠日数の関連2020

    • Author(s)
      井上由貴子,中田光紀,永田智久,頓所つく実 ,阿久津聡,勝村史昭
    • Organizer
      第27回日本行動医学会学術総会
    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
  • [Presentation] 主観的健康感の経年変化は炎症マーカーInterleukin (IL)-6 の上昇を予見する2020

    • Author(s)
      井上由貴子,中田光紀,栗岡住子,永田智久,森晃爾
    • Organizer
      第38回産業医科大学学会
    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
  • [Presentation] Work, Happiness, and Health ~今、直面している危機をどう乗り越えるか~2020

    • Author(s)
      中田光紀
    • Organizer
      第27回日本行動医学会学術総会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Book] 職場のポジティブメンタルヘルス42024

    • Author(s)
      島津明人
    • Total Pages
      195
    • Publisher
      誠信書房
    • ISBN
      9784414802139
    • Related Report
      2022 Annual Research Report
  • [Book] 疫学の事典2023

    • Author(s)
      日本疫学会、三浦 克之、玉腰 暁子、尾島 俊之
    • Total Pages
      576
    • Publisher
      朝倉書店
    • ISBN
      9784254310979
    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
  • [Book] 職場のポジティブメンタルヘルス3 いきいきと働くための睡眠のとり2020

    • Author(s)
      中田光紀
    • Publisher
      誠信書房
    • Related Report
      2020 Annual Research Report
  • [Book] 職場のポジティブメンタルヘルス3 海外出張していないのに時差ぼけ!?―社会的時差ぼけの健康影響2020

    • Author(s)
      中田光紀
    • Publisher
      誠信書房
    • Related Report
      2020 Annual Research Report
  • [Book] 職場のポジティブメンタルヘルス3 いきいきと働くための睡眠のとり方2020

    • Author(s)
      中田光紀
    • Publisher
      誠信書房
    • Related Report
      2019 Annual Research Report
  • [Book] 職場のポジティブメンタルヘルス3 海外出張していないのに時差ぼけ!?―社会的時差ぼけの健康影響ー2020

    • Author(s)
      中田光紀
    • Publisher
      誠信書房
    • Related Report
      2019 Annual Research Report

URL: 

Published: 2019-04-18   Modified: 2025-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi