• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Neural circuit underlying flexible behavior in animals

Research Project

Project/Area Number 19H01769
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 10040:Experimental psychology-related
Research InstitutionOsaka University

Principal Investigator

Ozawa Takaaki  大阪大学, 蛋白質研究所, 助教 (90625352)

Co-Investigator(Kenkyū-buntansha) 兎田 幸司  慶應義塾大学, 文学部(三田), 助教 (60794948)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2021: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2020: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2019: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Keywords予測 / 報酬 / 罰 / 時間 / 嫌悪 / 行動の柔軟性 / 神経回路 / 神経
Outline of Research at the Start

予測や期待とその柔軟な制御はヒトとをヒトたらしめている重要な能力である。本研究は,情動に関連する事柄を空間や時間情報を手がかりに予測し,その予測を状況に応じて切り替える際に働く心理学的・神経科学的メカニズムを明らかにする。本研究では,予測・期待の獲得とその柔軟な制御を一連のダイナミックな学習・認知過程と捉え,様々な課題を遂行中の被験体において神経細胞の活動を測定,あるいは操作することで,学習・認知に関する心理学的メカニズムがどのような神経メカニズムによって実装されているのかを包括的に検討する。

Outline of Final Research Achievements

We investigated the psychophysiological and neuronal mechanisms underlying the regulation of the flexible expectations for the future reward or punishment. As a result, we revealed the involvement of dopaminergic mechanisms in the expectation for both reward and punishment. Furthermore, we found that the pupil reaction is a potential physiological measurement of a time-based reward expectation and that the limbic circuit is a key neural mechanism in the regulation of time perception.

Academic Significance and Societal Importance of the Research Achievements

予測や期待とその柔軟な制御はヒトをヒトたらしめている重要な能力である。本研究は、この認知機能を司る神経メカニズムの一端を明らかにした点で、心理学・神経科学的に重要な意義を持つ。また、本研究で新たに明らかにされた神経メカニズムは、様々な認知機能障害に対する薬物治療の開発・発展に貢献する。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (51 results)

All 2021 2020 2019

All Journal Article (8 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 8 results,  Open Access: 6 results) Presentation (42 results) (of which Int'l Joint Research: 11 results,  Invited: 4 results) Book (1 results)

  • [Journal Article] Functional organization of the midbrain periaqueductal gray for regulating aversive memory formation2021

    • Author(s)
      Yeh Li-Feng, Ozawa Takaaki, Johansen Joshua P.
    • Journal Title

      Molecular Brain

      Volume: 14 Issue: 1 Pages: 136-136

    • DOI

      10.1186/s13041-021-00844-0

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Effects of Importin α1/KPNA1 deletion and adolescent social isolation stress on psychiatric disorder-associated behaviors in mice2021

    • Author(s)
      Sakurai Koki, Itou Taichi, Morita Makiko, Kasahara Emiko, Moriyama Tetsuji, Macpherson Tom, Ozawa Takaaki, Miyamoto Yoichi, Yoneda Yoshihiro, Sekiyama Atsuo, Oka Masahiro, Hikida Takatoshi
    • Journal Title

      PLOS ONE

      Volume: 16 Issue: 11 Pages: e0258364-e0258364

    • DOI

      10.1371/journal.pone.0258364

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Pharmacologically induced N‐methyl‐D‐aspartate receptor hypofunction impairs goal‐directed food seeking in rats2021

    • Author(s)
      Ozawa Takaaki、Itokazu Tatsumi、Ichitani Yukio、Yamada Kazuo
    • Journal Title

      Neuropsychopharmacology Reports

      Volume: 41 Issue: 4 Pages: 526-531

    • DOI

      10.1002/npr2.12209

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Long-term associative memory in rats: Effects of familiarization period in object-place-context recognition test2021

    • Author(s)
      Shimoda Shota、Ozawa Takaaki、Ichitani Yukio、Yamada Kazuo
    • Journal Title

      PLoS ONE

      Volume: 16 Issue: 7 Pages: e0254570-e0254570

    • DOI

      10.1371/journal.pone.0254570

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] An Introduction to Optogenetics: Novel Tools for Physiological Psychology Research2020

    • Author(s)
      OZAWA Takaaki
    • Journal Title

      Japanese Journal of Physiological Psychology and Psychophysiology

      Volume: 38 Issue: 1 Pages: 48-58

    • DOI

      10.5674/jjppp.2004si

    • NAID

      130008000325

    • ISSN
      0289-2405, 2185-551X
    • Year and Date
      2020-04-30
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dysregulation of the Synaptic Cytoskeleton in the PFC Drives Neural Circuit Pathology, Leading to Social Dysfunction2020

    • Author(s)
      Kim Il Hwan, Kim Namsoo, Kim Sunwhi, Toda Koji, Catavero Christina M., Courtland Jamie L., Yin Henry H., Soderling Scott H.
    • Journal Title

      Cell Reports

      Volume: 32 Issue: 4 Pages: 107965-107965

    • DOI

      10.1016/j.celrep.2020.107965

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] D-Cycloserine reverses scopolamine-induced object and place memory deficits in a spontaneous recognition paradigm in rats2019

    • Author(s)
      Ozawa Takaaki、Yamada Kazuo、Ichitani Yukio
    • Journal Title

      Pharmacology Biochemistry and Behavior

      Volume: 187 Pages: 172798-172798

    • DOI

      10.1016/j.pbb.2019.172798

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Neural circuits in goal-directed and habitual behavior: Implications for circuit dysfunction in obsessive-compulsive disorder.2019

    • Author(s)
      Simmler LD, Ozawa T.
    • Journal Title

      Neurochemistry International

      Volume: 129 Pages: 104464-104464

    • DOI

      10.1016/j.neuint.2019.104464

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Presentation] 脳内イメージングによる 多様なドーパミン神経伝達の解析2021

    • Author(s)
      小澤貴明
    • Organizer
      大阪大学蛋白質研究所セミナー「多様なドーパミン神経伝達から脳を探る」
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Pharmacologically-induced N-methyl-D-aspartate receptor hypofunction impairs goal-directed food seeking in rats.2021

    • Author(s)
      Takaaki Ozawa, Tatsumi Itokazu, Yukio Ichitani, Kazuo Yamada
    • Organizer
      日本動物心理学会 第81回大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Analysis of prefrontal dopamine release dynamics during reward expectation in mice.2021

    • Author(s)
      Yuma Matsumoto, Tomohiro Shibata, Moe Nakamura, Macpherson Tom, Takatoshi Hikida, Takaaki Ozawa
    • Organizer
      日本動物心理学会 第81回大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] うま味成分が持つ塩味嗜好性増強効果における脳内報酬系の役割2021

    • Author(s)
      柴田智弘, 米丸ひなの, 松本悠真, 中村萌, 岩本涼太郎, 尾山賀信, 櫻井 航輝, Macpherson Tom, 疋田貴俊, 小澤貴明
    • Organizer
      日本味と匂学会 第55回大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Dopaminergic circuit controls salt and umami seeking behavior.2021

    • Author(s)
      Takaaki Ozawa
    • Organizer
      日本味と匂学会 第55回大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] インポーチンα3欠損マウスのアルコール関連行動解析2021

    • Author(s)
      青峰 良淳, 櫻井 航輝, Macpherson Tom, 小澤 貴明, 宮本 洋一, 米田 悦啓, 岡 正啓, 疋田 貴俊
    • Organizer
      第44回日本神経科学大会,CJK第1回国際会議
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マウスの報酬予測行動における線条体ドーパミン放出動態の解析2021

    • Author(s)
      柴田 智弘, 小澤 貴明, 中村 萌, Macpherson Tom, 疋田 貴俊
    • Organizer
      第44回日本神経科学大会,CJK第1回国際会議
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 空間性の文脈記憶の想起における脳梁膨大部後部皮質の役割2021

    • Author(s)
      下田 翔太, 小澤 貴明, 山田 一夫
    • Organizer
      第44回日本神経科学大会,CJK第1回国際会議
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 社会的孤立ストレスによるImportin α1/KPNA1ノックアウトマウスに見られる行動異常の増悪2021

    • Author(s)
      櫻井 航輝, 伊藤 大一, 森田 真規子, Macpherson Tom, 小澤 貴明, 宮本 洋一, 米田 悦啓, 岡 正啓, 疋田 貴俊
    • Organizer
      第44回日本神経科学大会,CJK第1回国際会議
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 聴覚性恐怖条件づけにおける線条体ドーパミン放出動態の解析2021

    • Author(s)
      中村 萌, 小澤 貴明, 柴田 智弘, Macpherson Tom, 疋田 貴俊
    • Organizer
      第44回日本神経科学大会,CJK第1回国際会議
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Importin α1/KPNA1ノックアウトマウスに見られる社会的孤立ストレスへの感受性増加2021

    • Author(s)
      櫻井 航輝, 伊藤 大一, 森田 真規子, Macpherson Tom, 小澤 貴明, 宮本 洋一, 米田 悦啓, 岡 正啓, 疋田 貴俊
    • Organizer
      第51回 日本神経精神薬理学会年会
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 22q11.2欠失症候群モデルマウスにおける脳内モノアミン量の解析2021

    • Author(s)
      米丸ひなの, 小澤貴明, 櫻井航輝, 志茂優斗, 青峰良淳, 谷垣健二, 疋田貴俊
    • Organizer
      第51回 日本神経精神薬理学会年会
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effects of optogenetic manipulations of GABAergic neurons in the lateral septum on the performance in open-field, real-time conditioned place preference, and delay conditioning tasks in mice.2021

    • Author(s)
      Hirakata, H., Yatagai, S., Yamada, K., Tamura, R., Nasukawa, D., Niki, Y., Ujihara, Y., & Toda, K.
    • Organizer
      日本動物心理学会第81回大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Kaneko, S., Niki, Y., Yamada, K. & Toda, K. Effects of the nicotinic acetylcholine receptor antagonist on the performance of temporal conditioning in mice.2021

    • Author(s)
      Kaneko, S., Niki, Y., Yamada, K. & Toda, K.
    • Organizer
      日本動物心理学会第81回大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Differential effects of oxytocin antagonist on social hierarchy and social interaction.2021

    • Author(s)
      Nasukawa, D., Tamura, R. Hirakata, H., Yatagai, S. & Toda, K.
    • Organizer
      日本動物心理学会第81回大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Modulation of the pupillary response in mice during the temporal conditioning task.2021

    • Author(s)
      Niki, Y., Ujihara, Y., Yatagai, S., Yamada, K. & Toda, K.
    • Organizer
      日本動物心理学会第81回大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Effects of oxytocin antagonist on ultrasonic vocalization and social interaction in mice.2021

    • Author(s)
      Tamura, R., Nasukawa, D., Ujihara, Y., Tanaka, M. & Toda, K.
    • Organizer
      日本動物心理学会第81回大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Curiosity-driven computational model explains extinction bursts.2021

    • Author(s)
      Yamada, K., Matsui, H. & Toda, K.
    • Organizer
      日本動物心理学会第81回大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Auditory perception elicited by the infrared neural stimulation of cochlear nerves in Mongolian gerbils.2021

    • Author(s)
      Miku Uenaka, Yuta Tamai, Yuki Ito, Koji Toda, Shizuko Hiryu, & Kohta I. Kobayasi.
    • Organizer
      Society for Neuroscience 2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Pupil dynamics reflect temporal prediction in mice.2021

    • Author(s)
      Niki, Y., Ujihara, Y., Yatagai, S., Yamada, K. & Toda, K.
    • Organizer
      第44回日本神経科学大会,CJK第1回国際会議
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Habit formation as structural change in behavioral network.2021

    • Author(s)
      Yamada, K. & Toda, K.
    • Organizer
      第44回日本神経科学大会,CJK第1回国際会議
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] マウスにおける塩味とうま味の相乗作用2020

    • Author(s)
      小澤貴明
    • Organizer
      第5回 食欲・食嗜好の分子・神経基盤研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] うま味物質の持つ塩味嗜好性増強効果-マウスにおける検討-2020

    • Author(s)
      柴田智弘,疋田貴俊,小澤貴明
    • Organizer
      日本味と匂学会 第54回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 恐怖条件づけの消去におけるアデノシン受容体阻害薬の影響2020

    • Author(s)
      加瀬田 晃大,小澤 貴明,一谷 幸男,山田 一夫
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] うま味物質の持つ塩味嗜好性増強効果における脳内報酬系の関与2020

    • Author(s)
      小澤 貴明,疋田 貴俊
    • Organizer
      大阪大学蛋白質研究所セミナー「食行動の脳内基盤と分子機構」
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Effects of systemic oxytocin manipulations on social hierarchy in mice.2020

    • Author(s)
      Nasukawa, D., Ujihara, Y., Yamada, K., Yatagai, S. & Toda, K.
    • Organizer
      日本動物心理学会第80回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Conditioned licking suppression in head-fixed mice.2020

    • Author(s)
      Niki, Y., Ujihara, Y., Yamada, K., Yatagai, S. & Toda, K.
    • Organizer
      日本動物心理学会第80回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Reversal learning in head-fixed mice.2020

    • Author(s)
      Toda K., Yamamoto K., Yamada, K., Niki, Y., Nasukawa, D., Yatagai, S. & Ujihara, Y.
    • Organizer
      日本動物心理学会第80回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Effects of pharmacological manipulations of dopamine receptors on learning and memory in head-fixed mice.2020

    • Author(s)
      Yamada, K., Ujihara, Y. & Toda, K.
    • Organizer
      日本動物心理学会第80回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Effects of optogenetic manipulations of GABAergic neurons in the hippocampus on interval timing in head-fixed mice.2020

    • Author(s)
      Yatagai, S., Ujihara, Y., Niki, Y., Yamada, K., Sakurai, K. & Toda, K.
    • Organizer
      日本動物心理学会第80回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Let there be sound: auditory perception evoked by trans-tympanic laser stimulation in Mongolian gerbils.2020

    • Author(s)
      Uenaka, M., Tamai, Y., Ito, Y., Toda, K., Hiryu, S. & Kobayasi, KI.
    • Organizer
      日本動物心理学会第80回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Effects of pharmacological manipulations on interval timing in head-fixed mice.2020

    • Author(s)
      Ujihara, Y., Yatagai, S., Niki, Y., Yamada, K. & Toda, K.
    • Organizer
      日本動物心理学会第80回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Developing new auditory prosthesis: auditory perception evoked by trans-tympanic laser stimulation in Mongolian gerbil.2020

    • Author(s)
      Uenaka, M., Tamai, Y., Ito, Y., Toda, K., Hiryu, S. & Kobayasi, KI.
    • Organizer
      日本比較生理生化学会第42回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Does laser irradiation of auditory nerves create auditory perception.2020

    • Author(s)
      Tamai, Y., Uenaka, M., Ito, Y., Toda, K., Furuyama, T., Hiryu, S. & Kobayasi, KI.
    • Organizer
      日本神経科学学会第43回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Neural mechanism of time perception.2020

    • Author(s)
      Toda, K., Yatagai, S., Yamada, K., Yamamoto, K., Sakurai, K., Meck, WH. & Yin, HH.
    • Organizer
      日本生理学会第97回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 恐怖学習を制御するネガティブフィードバック神経回路2019

    • Author(s)
      小澤貴明
    • Organizer
      蛋白研セミナー「精神疾患の分子・回路病態研究の最前線」
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 学習の速さと記憶促進薬の効果には個体差がある ―空間記憶の記銘におけるラットの個体差とD-Cycloserineの効果―2019

    • Author(s)
      下田 翔太,五十嵐 優香,小澤 貴明,山田 一夫,一谷 幸男
    • Organizer
      日本心理学会第83回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Caffeine facilitates fear extinction in rats2019

    • Author(s)
      Kodai Kaseda, Takaaki Ozawa, Yukio Ichitani, Kazuo Yamada
    • Organizer
      動物心理学会第79回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] The effects of serotonergic lesion of dorsal raphe nucleus (DRN) and median raphe necleus (MRN) on fear extinction in rats2019

    • Author(s)
      S. NAKAZAWA, T. OZAWA, Y. ICHITANI, K. YAMADA
    • Organizer
      Neuroscinece 2019, Annual meeting of Society for Neuroscinece
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neural correlates of interval timing in head-fixed mice2019

    • Author(s)
      Saya Yatagai, Kota Yamada, Kohei Yamamoto, Katsuyasu Sakurai, Koji Toda
    • Organizer
      動物心理学会第79回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Laser induced auditory perception in Mongolian gerbil (Meriones unguiculatus)2019

    • Author(s)
      Tamai, Y., Uenaka, M., Ito, Y., Furuyama, T., Horinouchi, K., Murashima, N., Mithimoto, I., Toda, K., Hiryu, S. & Kobayasi, KI
    • Organizer
      日本比較生理生化学会第41回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Understanding the properties of learning by extracting behavioral elements with machine learning in mice.2019

    • Author(s)
      Yamada, K. & Toda, K.
    • Organizer
      日本動物心理学会第79回大会
    • Related Report
      2019 Annual Research Report
  • [Book] もっとよくわかる!食と栄養のサイエンス2021

    • Author(s)
      佐々木 努
    • Total Pages
      215
    • Publisher
      羊土社
    • ISBN
      9784758122092
    • Related Report
      2020 Annual Research Report

URL: 

Published: 2019-04-18   Modified: 2023-01-30  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi