Neural circuit underlying flexible behavior in animals
| Project/Area Number |
19H01769
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 10040:Experimental psychology-related
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| Research Institution | Osaka University |
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Principal Investigator |
Ozawa Takaaki 大阪大学, 蛋白質研究所, 助教 (90625352)
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| Co-Investigator(Kenkyū-buntansha) |
兎田 幸司 慶應義塾大学, 文学部(三田), 助教 (60794948)
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2021: ¥2,080,000 (Direct Cost: ¥1,600,000、Indirect Cost: ¥480,000)
Fiscal Year 2020: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2019: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
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| Keywords | 予測 / 報酬 / 罰 / 時間 / 嫌悪 / 行動の柔軟性 / 神経回路 / 神経 |
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| Outline of Research at the Start |
予測や期待とその柔軟な制御はヒトとをヒトたらしめている重要な能力である。本研究は，情動に関連する事柄を空間や時間情報を手がかりに予測し，その予測を状況に応じて切り替える際に働く心理学的・神経科学的メカニズムを明らかにする。本研究では，予測・期待の獲得とその柔軟な制御を一連のダイナミックな学習・認知過程と捉え，様々な課題を遂行中の被験体において神経細胞の活動を測定，あるいは操作することで，学習・認知に関する心理学的メカニズムがどのような神経メカニズムによって実装されているのかを包括的に検討する。
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| Outline of Final Research Achievements |
We investigated the psychophysiological and neuronal mechanisms underlying the regulation of the flexible expectations for the future reward or punishment. As a result, we revealed the involvement of dopaminergic mechanisms in the expectation for both reward and punishment. Furthermore, we found that the pupil reaction is a potential physiological measurement of a time-based reward expectation and that the limbic circuit is a key neural mechanism in the regulation of time perception.
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| Academic Significance and Societal Importance of the Research Achievements |
予測や期待とその柔軟な制御はヒトをヒトたらしめている重要な能力である。本研究は、この認知機能を司る神経メカニズムの一端を明らかにした点で、心理学・神経科学的に重要な意義を持つ。また、本研究で新たに明らかにされた神経メカニズムは、様々な認知機能障害に対する薬物治療の開発・発展に貢献する。
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Report
(4 results)
Research Products
(51 results)
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[Journal Article] Effects of Importin α1/KPNA1 deletion and adolescent social isolation stress on psychiatric disorder-associated behaviors in mice2021
Author(s)
Sakurai Koki, Itou Taichi, Morita Makiko, Kasahara Emiko, Moriyama Tetsuji, Macpherson Tom, Ozawa Takaaki, Miyamoto Yoichi, Yoneda Yoshihiro, Sekiyama Atsuo, Oka Masahiro, Hikida Takatoshi
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Journal Title
PLOS ONE
Volume: 16
Issue: 11
Pages: e0258364-e0258364
DOI
Related Report
Peer Reviewed / Open Access
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[Presentation] Effects of optogenetic manipulations of GABAergic neurons in the lateral septum on the performance in open-field, real-time conditioned place preference, and delay conditioning tasks in mice.2021
Author(s)
Hirakata, H., Yatagai, S., Yamada, K., Tamura, R., Nasukawa, D., Niki, Y., Ujihara, Y., & Toda, K.
Organizer
日本動物心理学会第81回大会
Related Report
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[Presentation] Kaneko, S., Niki, Y., Yamada, K. & Toda, K. Effects of the nicotinic acetylcholine receptor antagonist on the performance of temporal conditioning in mice.2021
Author(s)
Kaneko, S., Niki, Y., Yamada, K. & Toda, K.
Organizer
日本動物心理学会第81回大会
Related Report
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[Presentation] Reversal learning in head-fixed mice.2020
Author(s)
Toda K., Yamamoto K., Yamada, K., Niki, Y., Nasukawa, D., Yatagai, S. & Ujihara, Y.
Organizer
日本動物心理学会第80回大会
Related Report
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[Presentation] Effects of optogenetic manipulations of GABAergic neurons in the hippocampus on interval timing in head-fixed mice.2020
Author(s)
Yatagai, S., Ujihara, Y., Niki, Y., Yamada, K., Sakurai, K. & Toda, K.
Organizer
日本動物心理学会第80回大会
Related Report
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[Presentation] Let there be sound: auditory perception evoked by trans-tympanic laser stimulation in Mongolian gerbils.2020
Author(s)
Uenaka, M., Tamai, Y., Ito, Y., Toda, K., Hiryu, S. & Kobayasi, KI.
Organizer
日本動物心理学会第80回大会
Related Report
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[Presentation] Developing new auditory prosthesis: auditory perception evoked by trans-tympanic laser stimulation in Mongolian gerbil.2020
Author(s)
Uenaka, M., Tamai, Y., Ito, Y., Toda, K., Hiryu, S. & Kobayasi, KI.
Organizer
日本比較生理生化学会第42回大会
Related Report
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[Presentation] Does laser irradiation of auditory nerves create auditory perception.2020
Author(s)
Tamai, Y., Uenaka, M., Ito, Y., Toda, K., Furuyama, T., Hiryu, S. & Kobayasi, KI.
Organizer
日本神経科学学会第43回大会
Related Report
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[Presentation] Neural mechanism of time perception.2020
Author(s)
Toda, K., Yatagai, S., Yamada, K., Yamamoto, K., Sakurai, K., Meck, WH. & Yin, HH.
Organizer
日本生理学会第97回大会
Related Report
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[Presentation] Laser induced auditory perception in Mongolian gerbil (Meriones unguiculatus)2019
Author(s)
Tamai, Y., Uenaka, M., Ito, Y., Furuyama, T., Horinouchi, K., Murashima, N., Mithimoto, I., Toda, K., Hiryu, S. & Kobayasi, KI
Organizer
日本比較生理生化学会第41回大会
Related Report
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