| Budget Amount *help |
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2023: ¥2,730,000 (Direct Cost: ¥2,100,000、Indirect Cost: ¥630,000)
Fiscal Year 2022: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2021: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2020: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2019: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
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| Outline of Final Research Achievements |
This research project proposes a new microspectroscopy method to analyze the surface and internal nanostructures of DDS (Drug Delivery System) microparticles and their pharmacological properties. We developed a novel nonlinear confocal laser microscope using a vectorial polarization interference system in combination with light-wave mixing optics, and proposed a super-resolution imaging method for spectroscopic measurement of the surface and internal nanostructures of DDS microparticles in storage solutions and matrices. We were able to suggest future possibilities for label-free microscopic measurement techniques for DDS microparticles under test. In addition, we evaluated the uniformity of the microscope in the nanospatial region using nano-rulers, which are standardized samples of microparticles, and succeeded in generating uniform images with almost no aberrations of the detection system.
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