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Development of gamma-ray dose measurement method in a neutron/gamma-ray mixed field for BNCT

Research Project

Project/Area Number 19H02648
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 31010:Nuclear engineering-related
Research InstitutionOsaka University

Principal Investigator

Murata Isao  大阪大学, 大学院工学研究科, 教授 (30273600)

Co-Investigator(Kenkyū-buntansha) 玉置 真悟  大阪大学, 大学院工学研究科, 助教 (10823396)
日下 祐江  大阪大学, 大学院工学研究科, 技術職員 (30781314)
佐藤 文信  大阪大学, 大学院工学研究科, 教授 (40332746)
加藤 逸郎  大阪大学, 歯学部附属病院, 講師 (60314390)
吉田 茂生  東海大学, 工学部, 教授 (70174927)
宮丸 広幸  大阪公立大学, 大学院工学研究科, 教授 (80243187)
伊達道 淳  大阪大学, 大学院工学研究科, 技術専門員 (50379145)
杉本 久司  大阪大学, 工学研究科, 技術専門職員 (40379144)
Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥16,770,000 (Direct Cost: ¥12,900,000、Indirect Cost: ¥3,870,000)
Fiscal Year 2022: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2021: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2020: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2019: ¥2,860,000 (Direct Cost: ¥2,200,000、Indirect Cost: ¥660,000)
KeywordsBNCT / 中性子・ガンマ線混在場 / ガラス線量計 / フィルター / 線量 / 中性子ガンマ線混在場 / 遮へい材フィルター / ガンマ線量 / 線量計測 / 中性子とγ線の混在場 / 減速材フィルター / 混在場 / 応答関数 / 線量変換係数 / 線量評価 / 中性子/γ線混在場 / 鉛フィルター / γ線量
Outline of Research at the Start

新しいがん治療法にホウ素中性子捕捉療法(BNCT)がある。BNCTは中性子線を用いるが、患者の被曝線量の計測が難しい。本研究では、将来の普及のため、正確に被曝線量を計測・評価する手法を確立を目指す。BNCT場では、中性子によりγ線が発生するため、常に中性子とγ線の混在場になり、計測を難しくしている。本研究では、現在線量計測素子として使用されているガラス線量計と鉛フィルターを用い、混在場でも中性子とγ線の線量を、別々に正確に計測する手法の開発を目指す。本申請では、まず中性子とγ線の混在場におけるγ線の正確な線量計測法を開発する。

Outline of Final Research Achievements

We developed a gamma-ray dosimeter for boron neutron capture therapy (BNCT). In BNCT, neutrons and gamma rays are existing together in the field, so both doses must be measured separately and simultaneously. In this study, we developed a material filter for a glass dosimeter that can accurately measure high-energy gamma-rays generated by (n,γ) reactions. As a result, we succeeded in developing a filter using carbon, nickel and tungsten in a gamma-ray field. We also theoretically sought a solution to measure gamma-ray dose for the mixed field, and succeeded in finding one of the solutions using lithium. Furthermore, we have completed the design of a radiation field that reproduces the mixed field, and are currently working on producing the field. In the future, we will conduct a demonstration experiment to verify it for practical use.

Academic Significance and Societal Importance of the Research Achievements

BNCTで重要なことは、正常細胞線量を抑えることである。BNCTは中性子場に人体を設置することになり、この場合、入射する中性子だけではなく、二次的に発生するガンマ線による照射を受ける。つまり、照射中に中性子とγ線の線量を別々にその場計測する必要がある。我々は、ガラス線量計にフィルターを取り付け、2種類の線量計の差を取ることでそれぞれの線量を計測する手法を提案した。そして、10MeVまでのガンマ線を正確に計測することに成功した。BNCTの治療をすることは重要であるが、それより重要なことは、患者の被ばく量を正確に知ることである。本手法により、γ線については精度良く計測することができるようになった。

Report

(5 results)
  • 2023 Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (11 results)

All 2024 2023 2022 2021 2019

All Journal Article (2 results) (of which Peer Reviewed: 2 results) Presentation (8 results) (of which Int'l Joint Research: 6 results) Patent(Industrial Property Rights) (1 results)

  • [Journal Article] Accurate gamma-ray dose measurement up to 10 MeV by glass dosimeter with a sensitivity control filter for BNCT2024

    • Author(s)
      F. Kamisaki, T. Inoue, K. Tomiyoshi, M. Matsuki, K. Aoki, S. Kusaka, S. Tamaki, F. Sato, I. Murata
    • Journal Title

      Applied Radiation and Isotopes

      Volume: 209 Pages: 111299-111299

    • DOI

      10.1016/j.apradiso.2024.111299

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Response control of RPLGD for gamma-ray dose measurement using lead filters for BNCT2023

    • Author(s)
      K. Tochitani, K. Tomiyoshi, T. Inoue, F. Kamisaki, M. Matsuki, K. Hiramatsu, K. Aoki, S. Kusaka, S. Tamaki, F. Sato, I. Murata
    • Journal Title

      Applied Radiation and Isotopes

      Volume: 199 Pages: 110897-110897

    • DOI

      10.1016/j.apradiso.2023.110897

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed
  • [Presentation] Development of n-γ mixed fields based on a D-D neutron source for validation of material-filtered RPLGD for BNCT2023

    • Author(s)
      Zixu Xu*, Kazuma Aoki, Shingo Tamaki, Sachie Kusaka, and Isao Murata Graduate School of Engineering, Osaka University, Osaka, Japan
    • Organizer
      THE 11TH INTERNATIONAL SYMPOSIUM ON RADIATION SAFETY AND DETECTION TECHNOLOGY
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Gamma-Ray Dosimeter Development Using Radio-Photoluminescence Glass Dosimeter (RPLGD) in Neutron/Gamma-Ray Mixed Field for BNCT -Control of the response of RPLGD with a shielding filter-2022

    • Author(s)
      Masaya Matsuki, Fumiaki Kamisaki, Zixu Xu, Shingo Tamaki, Sachie Kusaka, Fuminobu Sato, Isao Murata
    • Organizer
      Young Researchers’ BNCT Meeting 2022
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Characterization of various types of n-γ mixed fields based on a D-D neutron source2022

    • Author(s)
      Zixu Xu, Masaya Matsuki, Kazuma Aoki, Shingo Tamaki, Sachie Kusaka, and Isao Murata
    • Organizer
      2022 Symposium on Nucl. Data
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Development of n-γ mixed fields based on a D-D neutron source for validation of material-filtered RPLGD for BNCT2022

    • Author(s)
      Zixu Xua, Masaya Matsukia, Kazuma Aokib, Shingo Tamakia, Sachie Kusakaa, Isao Murata
    • Organizer
      37th Radiation Detector and Its Use
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] γ-Ray Dose Measurement Using Radio-Photoluminescence Glass Dosimeter (RPLGD) in Neutron/γ-Ray Mixed Field for BNCT ~Examination of the response of RPLGD in low-energy region~2021

    • Author(s)
      富吉 晃太郎
    • Organizer
      19th Int. Cong. Neutron Capture Therapy
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 複数材料フィルターで覆ったガラス線量計を用いた中性子・ガンマ線混在場における ガンマ線量測定法の開発2021

    • Author(s)
      神先 史晃
    • Organizer
      第17回日本中性子捕捉療法学会学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] BNCTのための蛍光ガラス線量計を用いた中性子/γ線混在場におけるγ線の測定 ~低エネルギーγ線源を用いた検証実験~2021

    • Author(s)
      富吉 晃太郎
    • Organizer
      第17回日本中性子捕捉療法学会学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Development of Gamma-ray Dosimeter Using Radio-Photoluminescence Glass Dosimeter and Gamma-ray Filter in A Neutron/Gamma-ray Mixed Field for BNCT2019

    • Author(s)
      Tokiya Inoue, Koki Tochitani, Shingo Tamaki, Sachie Kusaka, Fuminobu Sato, Isao Murata
    • Organizer
      10th Young Researchers BNCT Meeting
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Patent(Industrial Property Rights)] 放射線の線量計測方法および線量計測装置2019

    • Inventor(s)
      Isao Murata
    • Industrial Property Rights Holder
      Isao Murata
    • Industrial Property Rights Type
      特許
    • Industrial Property Number
      2019-174457
    • Filing Date
      2019
    • Related Report
      2019 Annual Research Report

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Published: 2019-04-18   Modified: 2025-01-30  

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