| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2021: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2020: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2019: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
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| Outline of Final Research Achievements |
Several types of fluorescent probes that can realize imaging of the whole brain of living mice without killing the mice have been developed. Specifically, developed probes exhibited both high water-solubility which is required for administering a living body simply by dissolving in water and salient multiphoton excitation efficiencies and intense luminescence in the wavelength range of 650 to 1300 nm with high efficiencies, which is highly accessible to the deepest parts of the living organ. By using the developed probes, non-invasive imaging of the whole brain of a living mouse was realized for the first time.
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