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Creation of air-water interface-modified region for drug separation and design of sustainable water-based reaction and separation engineering

Research Project

Project/Area Number 19H02752
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 34030:Green sustainable chemistry and environmental chemistry-related
Research InstitutionKitami Institute of Technology

Principal Investigator

Saitoh Tohru  北見工業大学, 工学部, 教授 (40186945)

Co-Investigator(Kenkyū-buntansha) 林 英男  地方独立行政法人東京都立産業技術研究センター, 事業化支援本部技術開発支援部計測分析技術グループ, 上席研究員 (10385536)
近藤 寛子  北見工業大学, 工学部, 助教 (60700028)
安田 啓司  名古屋大学, 工学研究科, 准教授 (80293645)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2021: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2020: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2019: ¥8,970,000 (Direct Cost: ¥6,900,000、Indirect Cost: ¥2,070,000)
Keywords気液界面 / 薬物 / 分離 / 疎水相互作用 / 低環境負荷 / 水溶液 / 気泡 / 塩基性色素 / 塩基性薬物 / 排水処理 / 迅速精製 / 医療排水 / 染色排水 / 反応分離工学 / 低環境負荷プロセス / グリーン化学 / 色素 / 精製技術 / 薬物分離 / 水系反応 / フローテーション / 分子動力学 / ゼータ電位 / 汚染物質除去 / 反応工学 / 水系合成化学
Outline of Research at the Start

気液界面の溶媒特性を微量の混和性溶媒や塩により制御し、水中薬物の強力かつ選択的な捕捉場を生成させる方法論を得る。
① 界面修飾型薬物捕捉場の分光学・計算化学的溶媒特性評価と制御方法の確立
② 薬物含有医療・産業排水の高効率・低環境負荷型処理技術の開発
③ 薬物の迅速分離精製技術および分解・反応技術の開発
④ マイクロバブル技術による気液界面の高密度化と反応・分離効率の向上
からなる研究を実施し、薬物捕捉場を利用する分離や反応の基礎学術を確立し、薬物含有排水処理、薬物の分離精製、薬物の低環境負荷分解、薬物の水系合成化学を含む持続可能(高効率・低環境負荷)な水系反応分離工学を開拓する。

Outline of Final Research Achievements

Alcohol-modified air bubble flotation was designed as a simple, efficient, and eco-friendly method for the rapid separation of dyes and pharmaceuticals. The method was conducted by adding a small amount of alcohol to water in a cylindrical glass vessel with a sintered glass filter at the bottom followed by feeding air to generate air bubbles. Basic dyes and pharmaceuticals in water were enriched to temporarily generated foam on the surface of water and therefore removed from water. The separation efficiency increased with increasing alcohol concentration and carbon number in the order: ethanol < 2-propanol < 1-butanol), being attributed to the decrease in the size of air bubble, which in turn increases the surface area of air-water interface for the adsorption of the dyes. Hydrophobic interactions are a predominant factor for the adsorption on the air-water interface. The applicability was successfully demonstrated by using environmental water and synthesized dyeing wastewater.

Academic Significance and Societal Importance of the Research Achievements

薬物の分離のために様々な吸着材が開発されているが、薬物に対する選択性の他、吸着材の製造や再生・廃棄に伴う環境負荷が課題となっている。本研究では、薬物や気液界面に吸着する現象に着目し、空気(気泡)を吸着材として用いる分離技術の可能性が明らかになった。さらに、いくつかの化合物の分解反応が促進される現象も発見され、極めて環境負荷の小さい水系分離工学の基礎を開拓した。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (46 results)

All 2022 2021 2020 2019

All Journal Article (12 results) (of which Peer Reviewed: 10 results,  Open Access: 3 results) Presentation (34 results) (of which Int'l Joint Research: 12 results,  Invited: 4 results)

  • [Journal Article] Enrichment of amino acids from its aqueous solution by ultrasonic atomization and ultrafine bubbles2022

    • Author(s)
      Keiji Yasuda, Koji Hamada, and Yoshiyuki Asakura
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 61 Issue: SG Pages: SG1009-SG1009

    • DOI

      10.35848/1347-4065/ac43e5

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Frequency and power dependence of ultrasonic degassing2022

    • Author(s)
      Yoshiyuki Asakura and Keiji Yasuda
    • Journal Title

      Ultrasonics Sonochemistry

      Volume: 82 Pages: 1058901-8

    • DOI

      10.1016/j.ultsonch.2021.105890

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 超音波照射によるウルトラファインバブルの発生と消滅2022

    • Author(s)
      安田啓司, 朝倉義幸
    • Journal Title

      混相流

      Volume: 36 Pages: 12-19

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Purification of Rhodamine B by alcohol-modified air bubble flotation2021

    • Author(s)
      Kodama Koki, Oiwa Mako, Saitoh Tohru
    • Journal Title

      Bulletin of the Chemical Society of Japan

      Volume: 94 Issue: 4 Pages: 1210-1214

    • DOI

      10.1246/bcsj.20200395

    • NAID

      130008037359

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sonochemical green technology using active bubbles: Degradation of organic substances in water2021

    • Author(s)
      Keiji Yasuda
    • Journal Title

      Current Opinion in Green and Sustainable Chemistry

      Volume: 27 Pages: 1004111-1004116

    • DOI

      10.1016/j.cogsc.2020.100411

    • NAID

      120007169530

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Sorption of Antibiotics, Pharmaceuticals, and Personal Care Products in Water on Didodecyldimethylammonium Bromide-Montmorillonite Organoclay2020

    • Author(s)
      Mako Oiwa, Kaho Yamaguchi, Takayoshi Shibayama, Tai-Ying Chiou, Tohru Saitoh
    • Journal Title

      JOURNAL OF CHEMICAL ENGINEERING OF JAPAN

      Volume: 53 Issue: 10 Pages: 608-615

    • DOI

      10.1252/jcej.19we239

    • NAID

      130007928019

    • ISSN
      0021-9592, 1881-1299
    • Year and Date
      2020-10-20
    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rapid sorption of fenitrothion on didodecyldimethylammonium bromidemontmorillonite organoclay followed by the degradation into less toxic 3-methyl-4-nitrophenolate2020

    • Author(s)
      Mako Oiwa, Kaho Yamaguchi, Hideo Hayashi, Tohru Saitoh
    • Journal Title

      Journal of Environmental Chemical Engineering

      Volume: 8 Issue: 5 Pages: 104000-104000

    • DOI

      10.1016/j.jece.2020.104000

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of ultrafine bubbles on ethanol enrichment using ultrasonic atomization2020

    • Author(s)
      Keiji Yasuda, Yumi Nohara, Yoshiyuki Asakura
    • Journal Title

      Japanese Journal of Applied Physics

      Volume: 59 Issue: SK Pages: SKKD09-SKKD09

    • DOI

      10.35848/1347-4065/ab83d9

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ウルトラファインバブルの安定性2020

    • Author(s)
      安田啓司
    • Journal Title

      化学工学

      Volume: 54 Pages: 644-644

    • Related Report
      2020 Annual Research Report
  • [Journal Article] PyDISH: database and analysis tools for heme porphyrin distortion in heme proteins2020

    • Author(s)
      Kondo Hiroko X、Kanematsu Yusuke、Masumoto Gen、Takano Yu
    • Journal Title

      Database

      Volume: 2020

    • DOI

      10.1093/database/baaa066

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Rapid sorption of fenitrothion on didodecyldimethylammonium bromide-montmollironite organoclay followed by the degradation into less toxic 3-methyl-4-nitrophenolate2020

    • Author(s)
      Oiwa Mako, Koho Yamaguchi, Hideo Hayashi, Tohru Saitoh
    • Journal Title

      Journal of Environmental Chemical Engineering

      Volume: -

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hydrogen bond donors and acceptors are generally depolarized in ホア窶辛elices as revealed by a molecular tailoring approach2019

    • Author(s)
      *H. X. Kondo, A. Kusaka, C. K. Kitakawa, J. Onari, S. Yamanaka, H. Nakamura, *Y. Takano
    • Journal Title

      Journal of Computational Chemistry

      Volume: 40 Issue: 23 Pages: 2043-2052

    • DOI

      10.1002/jcc.25859

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] ウルトラファインバブルの超音波プロセスへの応用2022

    • Author(s)
      安田啓司
    • Organizer
      化学工学会関東支部 第70回最近の化学工学講習会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 気液界面修飾型薬物捕捉場の創成と持続可能な排水処理技術および物質精製技術への適用2021

    • Author(s)
      齋藤 徹, 児玉 康輝, 大岩真子
    • Organizer
      第81回分析化学討論会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 気泡を用いる薬物の迅速かつ選択的な分離技術の開発2021

    • Author(s)
      児玉 康輝, 山崎広夢, 大岩真子, 齋藤 徹
    • Organizer
      日本分析化学会第70年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 気泡を分離媒体とするクロロキンの迅速精製技術2021

    • Author(s)
      児玉 康輝, 大岩真子, 齋藤 徹
    • Organizer
      化学工学会第52回秋季大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] オルガノクレーを用いる水中汚染物質の拡散防止法2021

    • Author(s)
      大岩真子, NGO Thi Thu Thao, 齋藤 徹
    • Organizer
      化学工学会第52回秋季大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] アルコール修飾気泡分離によるキサンテン色素の迅速分離2021

    • Author(s)
      山崎 広夢, 児玉 康輝, 大岩 真子, 齋藤 徹
    • Organizer
      CSJ化学フェスタ2021
    • Related Report
      2021 Annual Research Report
  • [Presentation] Sorption and degradation of pesticides using organoclay2021

    • Author(s)
      NGO Thi Thu Thao, OIWA Mako, SAITOH Tohru
    • Organizer
      CSJ化学フェスタ2021
    • Related Report
      2021 Annual Research Report
  • [Presentation] Rapid purification of Rhodamine B by alcohol-modified air bubble flotation2021

    • Author(s)
      Koki Kodama, Mako Oiwa, Tohru Saitoh
    • Organizer
      The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem 2021)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Organoclay sorption method for diffusion control of organic pollutants2021

    • Author(s)
      Mako Oiwa, Koki Kodama, Tohru Saitoh
    • Organizer
      The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem 2021)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Use of air-water interfaces for efficient and sustainable separation of pharmaceuticals and dyes in water2021

    • Author(s)
      Tohru Saitoh, Mako Oiwa, Koki Kodama
    • Organizer
      The 2021 International Chemical Congress of Pacific Basin Societies (Pacifichem 2021)
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Effect of ultrafine bubbles on enrichment of amino acid in aqueous solution by ultrasonic atomization2021

    • Author(s)
      Keiji Yasuda, Koji Hamada and Yoshiyuki Asakura
    • Organizer
      42th Symposium on Ultrasonic Electronics
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 超音波によるウルトラファインバブルの濃度制御2021

    • Author(s)
      安田啓司, 朝倉義幸
    • Organizer
      化学工学会第52回秋季大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] フローテーションによる水中塩基性薬物および色素の迅速分離2020

    • Author(s)
      齋藤 徹, 大岩真子, 児玉康揮, 大谷祐介
    • Organizer
      第80回分析化学討論会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 塩基性色素分離の界面活性剤無添加フローテーションにおけるアルコール添加の効果2020

    • Author(s)
      大岩真子, 金子広樹, 澤井亮佑 Lyu Xioye, 児玉康輝, 齋藤 徹
    • Organizer
      第80回分析化学討論会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 気泡浮上分離システムの設計と色素分離への応用2020

    • Author(s)
      齋藤 徹, 児玉康揮, 大岩真子
    • Organizer
      日本分析化学会第69年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] オルガノクレーを用いる有機汚染物質の拡散防止技術2020

    • Author(s)
      齋藤 徹, 大岩真子
    • Organizer
      化学工学会第51回秋季大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 気泡を用いる染色排水の迅速処理と分子動力学シミュレーションによる機構解明の試み2020

    • Author(s)
      大岩真子, 児玉康揮, 齋藤 徹
    • Organizer
      化学工学会第51回秋季大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 超音波霧化による水溶液中のフェニルアラニンの濃縮2020

    • Author(s)
      濱田幸治、朝倉義幸、安田啓司
    • Organizer
      第29回ソノケミストリー討論会
    • Related Report
      2020 Annual Research Report
  • [Presentation] ファインバブルの特徴と応用2020

    • Author(s)
      安田啓司
    • Organizer
      日本油化学会東海支部令和2年度油化学講演会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Rapid removal of basic dyes in water based on the sorption onto air- water interfaces2020

    • Author(s)
      Mako Oiwa, Tohru Saitoh
    • Organizer
      International Chemical Engineering Symposia 2020
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 界面活性剤無添加フローテーションによる低環境負荷染色排水処理2020

    • Author(s)
      児玉 康輝, Lyu Xiaoye, 澤井 亮佑, 木谷 優輝, 大岩 真子, 齋藤 徹
    • Organizer
      化学工学会第85年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Organoclay sorption method for diffusion control of fenitrothion to aquatic environment2019

    • Author(s)
      Mako Oiwa, Tohru Saitoh
    • Organizer
      第28回環境化学討論会(国際発表部門)
    • Related Report
      2019 Annual Research Report
  • [Presentation] Bifunctional property of organoclay for the sorption and degradation of fenitrothion in water2019

    • Author(s)
      Mako Oiwa, Tohru Saitoh
    • Organizer
      Europian Congress and Exhibition on Advanced Material and Processes EUROMAT2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Modified air bubbles as highly selective and sustainable adsorbents for cationic dyes in water2019

    • Author(s)
      Tohru Saitoh, Lyu Xiaoye, Mako Oiwa
    • Organizer
      Europian Congress and Exhibition on Advanced Material and Processes EUROMAT2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Coagulation-flotation for the rapid removal of fluoroquinolone antibiotics from wastewater2019

    • Author(s)
      Koki Kodata, Kota Tsutsui, Mako Oiwa, Tohru Saitoh
    • Organizer
      18th Asian Pacific Confederation of Chemical Engineering Congress (APCChE 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Alcohol-modified air bubble flotation for dye wastewater treatment2019

    • Author(s)
      Lyu Xiaoye, Mako Oiwa, Tohru Saitoh
    • Organizer
      18th Asian Pacific Confederation of Chemical Engineering Congress (APCChE 2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Negative Fragmentation Approachを用いたタンパク質の二次構造における相互作用エネルギーの解析2019

    • Author(s)
      近藤寛子,草鹿あゆみ,中村春木,鷹野優
    • Organizer
      日本コンピュータ化学会2019秋季年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Hydrogen bond donors and acceptors are generally depolarized in α-helices as revealed by a molecular tailoring approach2019

    • Author(s)
      Hiroko X. Kondo, Ayumi Kusaka, Haruki Nakamura, Yu Takano
    • Organizer
      第19回日本蛋白質科学会年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ヘムの構造歪みに着目した統計解析・電子状態計算による構造機能相関の解明とデータベースの構築2019

    • Author(s)
      近藤 寛子,兼松 佑典,藤井 理則,石井 学,舛本 現,今田 康博,吉田 孝,鷹野 優
    • Organizer
      第46回生体分子科学討論会
    • Related Report
      2019 Annual Research Report
  • [Presentation] ウルトラファインバブルの発生と消滅に及ぼす超音波周波数の影響2019

    • Author(s)
      安田啓司
    • Organizer
      分離技術会年会2019
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Size-controlled Synthesis of Gold Nanoparticles Using Pulsed Wave and Ultrafine Bubbles2019

    • Author(s)
      Keiji Yasuda, Tomofumi Sato, Yoshiyuki Asakura
    • Organizer
      4th Asia-Oceania Sonochemical Society Conference
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Ultrafine Bubble Generation and Elimination by Ultrasound2019

    • Author(s)
      Keiji Yasuda, Hodaka Matushima, Yoshiyuki Asakura
    • Organizer
      The 18th Asian Pacific Confederation of Chemical Engineering Congress
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Effect of Ultrafine Bubbles on Ethanol Enrichment from Aqueous Solution by Ultrasonic Atomization2019

    • Author(s)
      Keiji Yasuda, Yumi Nohara, Yoshiyuki Asakura
    • Organizer
      40th Symposium on Ultrasonic Electronics
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 金ナノ粒子の粒子径とコロイドの安定性に及ぼすウルトラファインバブルの影響2019

    • Author(s)
      平手快斗, 佐藤智史, 朝倉義幸, 高橋史樹, 金継業, 安田啓司
    • Organizer
      第28回ソノケミストリー討論会
    • Related Report
      2019 Annual Research Report

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Published: 2019-04-18   Modified: 2023-01-30  

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