| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2021: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Outline of Final Research Achievements |
To exploit diverse secondary metabolites of filamentous fungi, artificial production of secondary metabolites that filamentous fungi do not normally produce is important. This study searched compounds that inhibit fungal sirtuins, which suppress the expression of secondary metabolic genes in filamentous fungi. The search yielded filamentous fungi producing this compound in the culture extracts. These contribute to developing many useful biologically active substances including medical and agricultural chemicals produced by the filamentous fungi.
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