| Budget Amount *help |
¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Fiscal Year 2022: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2021: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2020: ¥2,340,000 (Direct Cost: ¥1,800,000、Indirect Cost: ¥540,000)
Fiscal Year 2019: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
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| Outline of Final Research Achievements |
Microbial cells exist all across the natural world. However, it is uncommon that those cells are exposed to nutrient-rich environments to support their exponential growth. In this study, we aimed to understand how microbial cells would change their physiological conditions from stationary phase to death phase. We decided to use Escherichia coli as a model organism for this purpose and evaluated physiological conditions at a single cell level. It was shown that some of dead cells, which lost their ability to proliferate even when nutrients were replenished, were able to maintain cell-membrane homeostasis and cellular energy status at a level comparable to that of living cells.
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