| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2023: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2022: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2021: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2020: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2019: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
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| Outline of Final Research Achievements |
Functional and structural analyses of the biosynthetic enzymes involved in the production of aminoglycoside antibiotics and related natural products containing (amino)cyclitols such as kanamycin, istamycin, and butirosin, have been conducted. As a result, the biosynthetic reaction mechanism of kanamycin A, a representative compound among aminoglycoside antibiotics, has been elucidated. Furthermore, through the functional and structural analyses of other biosynthetic enzymes, unique modification enzymes for sugar moieties in biosynthetic intermediates and enzymes responsible for the unique cyclitol formation have been identified.
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