| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2021: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2020: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2019: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Outline of Final Research Achievements |
The skeletal muscle is an important organ not only for locomotion activity but also for whole-body metabolism. The age-associated skeletal muscle atrophy sarcopenia is a major risk factor that causes disability for the elderly. Its prevention is the most critical challenge for extending healthy life expectancy. In this study, we investigated a role of the mevalonate pathway and its metabolites in the regulation of skeletal muscle homeostasis using human iPS cell-derived myocytes. This study revealed that the mevalonate pathway plays diverse important roles in skeletal muscle homeostasis, including protein homeostasis and transcriptional regulation.
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