| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2019: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
|
|---|
| Outline of Final Research Achievements |
Using transgenic mice for in vivo live imaging in which intestinal tuft cells detecting helminths are fluorescent-labeled, we detected responses to succinic acid, salicin, and nematode excretory/secretory product in tuft cells or their surrounding cells. When succinic acid was administered, the number of type 2 innate lymphoid cells present in intestinal lamina propria was larger in tuft cell-localized Gprc5c knockout mice than in wild-type mice, suggesting that Gprc5c may suppress type 2 innate immune response during inflammation.
|
