Elucidation of intestinal tuft cell-expressed receptor function in type 2 innate immunity and its application to food science
| Project/Area Number |
19H02915
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Review Section |
Basic Section 38050:Food sciences-related
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| Research Institution | Meiji University |
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Principal Investigator |
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| Project Period (FY) |
2019-04-01 – 2022-03-31
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| Project Status |
Completed (Fiscal Year 2021)
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| Budget Amount *help |
¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
Fiscal Year 2021: ¥1,560,000 (Direct Cost: ¥1,200,000、Indirect Cost: ¥360,000)
Fiscal Year 2020: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2019: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
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| Keywords | 受容体 / 消化管 / 代謝 / 免疫 / 遺伝子破壊マウス / 刷子細胞 / 生体イメージング / 2型自然免疫 / 遺伝子欠損マウス |
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| Outline of Research at the Start |
小腸刷子細胞は、アレルギー性疾患や寄生虫感染に対する2型免疫応答の始動において、センサーとして重要な働きをする。本研究では、小腸刷子細胞の頂端部に局在することを研究代表者自らが発見したオーファン受容体Xの生理機能を解明し、アレルギー性疾患や肥満・糖尿病の予防や治療に繋げることを目的とする。
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| Outline of Final Research Achievements |
Using transgenic mice for in vivo live imaging in which intestinal tuft cells detecting helminths are fluorescent-labeled, we detected responses to succinic acid, salicin, and nematode excretory/secretory product in tuft cells or their surrounding cells. When succinic acid was administered, the number of type 2 innate lymphoid cells present in intestinal lamina propria was larger in tuft cell-localized Gprc5c knockout mice than in wild-type mice, suggesting that Gprc5c may suppress type 2 innate immune response during inflammation.
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| Academic Significance and Societal Importance of the Research Achievements |
本研究より、刷子細胞頂端部に局在するオーファン受容体Gprc5cが、炎症時において2型自然免疫応答を抑制すると示唆されたことから、今後、Gprc5cのリガンドやその活性を調節する化合物を同定することによって、アレルギー性疾患や肥満・糖尿病の予防や治療に繋がることが期待される。
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Report
(4 results)
Research Products
(15 results)
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[Journal Article] Early origin of sweet perception in the songbird radiation2021
Author(s)
Toda Yasuka、Ko Meng-Ching、Liang Qiaoyi、Miller Eliot T.、Rico-Guevara Alejandro、Nakagita Tomoya、Sakakibara Ayano、Uemura Kana、Sackton Timothy、Hayakawa Takashi、Sin Simon Yung Wa、Ishimaru Yoshiro、Misaka Takumi、Oteiza Pablo、Crall James、Edwards Scott V.、Buttemer William、Matsumura Shuichi、Baldwin Maude W.
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Journal Title
Science
Volume: 373
Issue: 6551
Pages: 226-231
DOI
Related Report
Peer Reviewed / Open Access / Int'l Joint Research
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[Journal Article] TMC4 is a novel chloride channel involved in high-concentration salt taste sensation2021
Author(s)
Kasahara Y, Narukawa M, Ishimaru Y, Kanda S, Umatani C, Takayama Y, Tominaga M, Oka Y, Kondo K, Kondo T, Takeuchi A, Misaka T, Abe K, Asakura T.
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Journal Title
J Physiol Sci
Volume: 71
Issue: 1
Pages: 23-23
DOI
Related Report
Peer Reviewed / Open Access
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