| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2021: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2020: ¥4,680,000 (Direct Cost: ¥3,600,000、Indirect Cost: ¥1,080,000)
Fiscal Year 2019: ¥7,800,000 (Direct Cost: ¥6,000,000、Indirect Cost: ¥1,800,000)
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| Outline of Final Research Achievements |
Tissue-resident macrophages are a highly heterogeneous population performing specialized functions that are essential for the maintenance of tissue homeostasis. In this study, we focused on the transcription factors that are uniquely expressed in specific tissue-resident macrophage subsets, and determined whether these transcription factors function as master regulators controlling tissue-specific functions of macrophages. We found that the expression of some of these transcription factors exhibits variation among macrophages present in the same tissue environments. Additionally, we observed the fluctuation of the expression of the transcription factors results in the difference in the global gene expression pattern between tissue macrophages.
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