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Roles of cell proliferation and differentiation in the acquisition of uterine receptivity

Research Project

Project/Area Number 19H03144
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 42040:Laboratory animal science-related
Research InstitutionThe University of Tokyo

Principal Investigator

Hirota Yasushi  東京大学, 医学部附属病院, 准教授 (40598653)

Co-Investigator(Kenkyū-buntansha) 清水 良子  慶應義塾大学, 医学部(信濃町), 講師 (30348643)
原口 広史  東京大学, 医学部附属病院, 届出研究員 (50804506)
金谷 真由子  東京大学, 医学部附属病院, 届出研究員 (60748862)
松尾 光徳  東京大学, 医学部附属病院, 特任臨床医 (00823618)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2021: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2020: ¥5,590,000 (Direct Cost: ¥4,300,000、Indirect Cost: ¥1,290,000)
Fiscal Year 2019: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Keywords胚着床 / 子宮内膜 / 細胞増殖能 / プロゲステロン受容体 / STAT3 / 網膜芽細胞腫遺伝子 / 子宮内膜上皮 / 胚浸潤 / 着床 / 細胞周期 / ネクロトーシス / プロゲステロン / TNFα / 細胞外基質 / ヒストン修飾 / ポリコーム複合体 / 細胞増殖 / RB / ネクロプトーシス / LIF / マウスモデル / 胚接着 / 管腔上皮 / RB遺伝子
Outline of Research at the Start

過去の知見から子宮の細胞増殖・分化は子宮の胚受容能の指標と考えることができるが、着床に機能的に関与するかどうかは不明である。その科学的理解が着床のしくみの解明や着床障害・不育症(習慣流産)の治療へつながる可能性があるため、本研究では、子宮内膜細胞の分化・増殖機構に着目し、子宮の細胞増殖能を調節しているRB(Retinoblastoma)遺伝子を欠損したマウスモデルを用いて、着床における上皮・間質細胞の分化・増殖の機構と、着床障害における細胞分化障害の機構を明らかにする。

Outline of Final Research Achievements

The process of embryo implantation consists of three steps: embryo pairing, embryo attachment, and embryo invasion. Cell proliferation of the endometrial epithelium is suppressed during embryo apposition, but the mechanism and the physiological significance remain unclear. Using mouse models, we found that suppression of cell proliferation in the endometrial epithelium during the embryo implantation is regulated by progesterone receptor signaling in the endometrial epithelium, STAT3 signaling in the endometrial stroma, and the cell cycle regulator RB in the endometrial stroma. We also found that the inhibited cell proliferation of the endometrial epithelium governs embryo invasion. Furthermore, we found that the cell proliferation of the human peri-implantation endometrial epithelium is not suppressed in the women with recurrent implantation failure but in the fertile women.

Academic Significance and Societal Importance of the Research Achievements

胚移植の反復不成功で定義される着床不全は有効な診断・治療法がほとんど提案されておらず、子宮内でおこる着床は未だブラックボックスのままであり、着床不全の診断・治療法の確立が生殖医療の残された大きな課題であった。本研究では、マウスモデルを用いて着床不全の機序を新たに明らかにし、機序の解明に基づく新規の診断・治療法への応用のための科学的基盤を確立できた。またヒト着床期子宮内膜において細胞増殖能評価がヒトにおける着床能の予測方法として臨床応用できる可能性を示すことができた。

Report

(4 results)
  • 2022 Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (57 results)

All 2022 2021 2020 2019 2018 Other

All Int'l Joint Research (1 results) Journal Article (43 results) (of which Int'l Joint Research: 11 results,  Peer Reviewed: 34 results,  Open Access: 24 results) Presentation (12 results) (of which Invited: 10 results) Remarks (1 results)

  • [Int'l Joint Research] シンシナティ小児病院(米国)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] A gene network of uterine luminal epithelium organizes mouse blastocyst implantation2022

    • Author(s)
      Aikawa Shizu、Hirota Yasushi、Fukui Yamato、Ishizawa Chihiro、IIda Rei、Kaku Tetsuaki、Hirata Tomoyuki、Akaeda Shun、Hiraoka Takehiro、Matsuo Mitsunori、Osuga Yutaka
    • Journal Title

      Reproductive Medicine and Biology

      Volume: 21 Issue: 1

    • DOI

      10.1002/rmb2.12435

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Constant Activation of STAT3 Contributes to the Development of Adenomyosis in Females2022

    • Author(s)
      Hiraoka Takehiro、Hirota Yasushi、Aikawa Shizu、Iida Rei、Ishizawa Chihiro、Kaku Tetsuaki、Hirata Tomoyuki、Fukui Yamato、Akaeda Shun、Matsuo Mitsunori、Shimizu-Hirota Ryoko、Takeda Norihiko、Osuga Yutaka
    • Journal Title

      Endocrinology

      Volume: 163 Issue: 5

    • DOI

      10.1210/endocr/bqac044

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 特集 少子化時代における就労女性の不妊治療 器質性疾患 子宮筋腫・子宮内膜ポリープ・子宮内膜症・子宮腺筋症の取り扱い2021

    • Author(s)
      石沢 千尋、廣田 泰
    • Journal Title

      産科と婦人科

      Volume: 88 Issue: 12 Pages: 1451-1456

    • DOI

      10.34433/J00525.2022034119

    • ISSN
      0386-9792
    • Year and Date
      2021-12-01
    • Related Report
      2021 Annual Research Report
  • [Journal Article] 特集 最新知識の理解に役立つ 産婦人科医療の変遷と展望 生殖医療 3.着床検査2021

    • Author(s)
      赤枝 俊、廣田 泰
    • Journal Title

      産婦人科の実際

      Volume: 70 Issue: 10 Pages: 1077-1082

    • DOI

      10.18888/sp.0000001873

    • ISSN
      0558-4728
    • Year and Date
      2021-10-01
    • Related Report
      2021 Annual Research Report
  • [Journal Article] 特集  ゲノム時代の生殖内分泌学 ゲノムと子宮腺筋症2021

    • Author(s)
      福井 大和、廣田 泰
    • Journal Title

      HORMONE FRONTIER IN GYNECOLOGY

      Volume: 28 Issue: 2 Pages: 21-25

    • DOI

      10.34449/J0015.28.02_0021-0025

    • ISSN
      1340-220X
    • Year and Date
      2021-06-01
    • Related Report
      2021 Annual Research Report
  • [Journal Article] Retinoblastoma protein promotes uterine epithelial cell cycle arrest and necroptosis for embryo invasion2021

    • Author(s)
      Akaeda Shun、Hirota Yasushi、Fukui Yamato、Aikawa Shizu、Shimizu‐Hirota Ryoko、Kaku Tetsuaki、Gebril Mona、Hirata Tomoyuki、Hiraoka Takehiro、Matsuo Mitsunori、Haraguchi Hirofumi、Saito‐Kanatani Mayuko、Takeda Norihiko、Fujii Tomoyuki、Osuga Yutaka
    • Journal Title

      EMBO reports

      Volume: 22 Issue: 2

    • DOI

      10.15252/embr.202050927

    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Uterine Epithelial LIF Receptors Contribute to Implantation Chamber Formation in Blastocyst Attachment2021

    • Author(s)
      Fukui Yamato、Hirota Yasushi、Saito-Fujita Tomoko、Aikawa Shizu、Hiraoka Takehiro、Kaku Tetsuaki、Hirata Tomoyuki、Akaeda Shun、Matsuo Mitsunori、Shimizu-Hirota Ryoko、Takeda Norihiko、Ikawa Masahito、Osuga Yutaka
    • Journal Title

      Endocrinology

      Volume: 162 Issue: 11

    • DOI

      10.1210/endocr/bqab169

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Uterine Receptivity is Reflected by LIF Expression in the Cervix2021

    • Author(s)
      Fukui Yamato、Hirota Yasushi、Aikawa Shizu、Ishizawa Chihiro、Iida Rei、Kaku Tetsuaki、Hirata Tomoyuki、Akaeda Shun、Hiraoka Takehiro、Matsuo Mitsunori、Osuga Yutaka
    • Journal Title

      Reproductive Sciences

      Volume: 29 Issue: 5 Pages: 1457-1462

    • DOI

      10.1007/s43032-021-00816-8

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 子宮内フローラと不妊症2021

    • Author(s)
      赤枝 俊、廣田泰
    • Journal Title

      医学のあゆみ

      Volume: 278 Pages: 679-683

    • Related Report
      2021 Annual Research Report
  • [Journal Article] CD206+?macrophage is an accelerator of endometriotic-like lesion via promoting angiogenesis in the endometriosis mouse model2021

    • Author(s)
      Ono Yosuke、Yoshino Osamu、Hiraoka Takehiro、Sato Erina、Furue Akiko、Nawaz Allah、Hatta Hideki、Fukushi Yoshiyuki、Wada Shinichiro、Tobe Kazuyuki、Hirota Yasushi、Osuga Yutaka、Unno Nobuya、Saito Shigeru
    • Journal Title

      Scientific Reports

      Volume: 11 Issue: 1 Pages: 853-853

    • DOI

      10.1038/s41598-020-79578-3

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Induction of aryl hydrocarbon receptor in granulosa cells by endoplasmic reticulum stress contributes to pathology of polycystic ovary syndrome2021

    • Author(s)
      Kunitomi C, Harada M, Kusamoto A, Azhary JM, Nose E, Koike H, Xu Z, Urata Y, Takahashi N, Wada-Hiraike O, Hirota Y, Koga K, Fujii T, Osuga Y.
    • Journal Title

      Mol Hum Reprod.

      Volume: 27 Issue: 3 Pages: 234-234

    • DOI

      10.1093/molehr/gaab003

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Use of selective PGE2 receptor antagonists on human endometriotic stromal cells and peritoneal macrophages2021

    • Author(s)
      Makabe Tomoko、Koga Kaori、Nagabukuro Hiroshi、Asada Mari、Satake Erina、Taguchi Ayumi、Takeuchi Arisa、Miyashita Mariko、Harada Miyuki、Hirata Tetsuya、Hirota Yasushi、Wada-Hiraike Osamu、Fujii Tomoyuki、Osuga Yutaka
    • Journal Title

      Molecular Human Reproduction

      Volume: 27 Issue: 1 Pages: 234-234

    • DOI

      10.1093/molehr/gaaa077

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Int'l Joint Research
  • [Journal Article] Automated system for diagnosing endometrial cancer by adopting deeplearning technology in hysteroscopy2021

    • Author(s)
      Takahashi Y, Sone K, Noda K, Yoshida K, Toyohara Y, Kato K, Inoue F, Kukita A, Taguchi A, Nishida H, Miyamoto Y, Tanikawa M, Tsuruga T, Iriyama T, Nagasaka K, Matsumoto Y, Hirota Y, Hiraike-Wada O, Oda K, Maruyama M, Osuga Y, Fujii T.
    • Journal Title

      PLoS One

      Volume: 16 Issue: 3 March 2021 Pages: 1-13

    • DOI

      10.1371/journal.pone.0248526

    • URL

      https://pure.teikyo.jp/en/publications/dbe27659-34db-4d66-acf7-896cfbfd6d0d

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] KRAS mutations in uterine endometrium are associated with gravidity and parity.2020

    • Author(s)
      Inoue, S., Yoshida, E., Fukui, Y., Ueno, T., Kawazu, M., Takeyama, R., Ikemura, M., Osuga, Y., Terao, Y., Hirota, Y., Mano, H.
    • Journal Title

      Cell Death Disease

      Volume: 11 Issue: 5 Pages: 347-347

    • DOI

      10.1038/s41419-020-2559-0

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] PAX8: A Highly Sensitive Marker for the Glands in Extragenital Endometriosis2020

    • Author(s)
      Arakawa Tomoko、Fukuda Shinya、Hirata Tetsuya、Neriishi Kazuaki、Wang Yu、Takeuchi Arisa、Saeki Ai、Harada Miyuki、Hirota Yasushi、Matsumoto Takashi、Koga Kaori、Wada-Hiraike Osamu、Kurihara Masatoshi、Fujii Tomoyuki、Osuga Yutaka
    • Journal Title

      Reproductive Sciences

      Volume: 27 Issue: 8 Pages: 1580-1586

    • DOI

      10.1007/s43032-020-00186-7

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] IFITM1 is a Novel, Highly Sensitive Marker for Endometriotic Stromal Cells in Ovarian and Extragenital Endometriosis2020

    • Author(s)
      Sun Hui、Fukuda Shinya、Hirata Tetsuya、Arakawa Tomoko、Ma Suke、Neriishi Kazuaki、Wang Yu、Takeuchi Arisa、Saeki Ai、Harada Miyuki、Hirota Yasushi、Matsumoto Takashi、Koga Kaori、Wada-Hiraike Osamu、Kurihara Masatoshi、Fujii Tomoyuki、Osuga Yutaka
    • Journal Title

      Reproductive Sciences

      Volume: 27 Issue: 8 Pages: 1595-1601

    • DOI

      10.1007/s43032-020-00189-4

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Acquired contractile ability in human endometrial stromal cells by passive loading of cyclic tensile stretch2020

    • Author(s)
      Kim Jeonghyun、Ushida Takashi、Montagne Kevin、Hirota Yasushi、Yoshino Osamu、Hiraoka Takehiro、Osuga Yutaka、Furuakwa Katsuko S.
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 9014-9014

    • DOI

      10.1038/s41598-020-65884-3

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Prolapse of a pedunculated uterine leiomyoma through the cervix during GnRH antagonist treatment: Case report and literature review2020

    • Author(s)
      Ishizawa Chihiro、Hirota Yasushi、Urata Yoko、Morishima Kaoru、Fujii Tomoyuki、Osuga Yutaka
    • Journal Title

      Journal of Obstetrics and Gynaecology Research

      Volume: 46 Issue: 12 Pages: 2679-2683

    • DOI

      10.1111/jog.14479

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A case of hemorrhagic shock occurred during dienogest therapy for uterine adenomyosis2020

    • Author(s)
      Takamura Masashi、Koga Kaori、Harada Miyuki、Hirota Yasushi、Fujii Tomoyuki、Osuga Yutaka
    • Journal Title

      Journal of Obstetrics and Gynaecology Research

      Volume: 46 Issue: 12 Pages: 2696-2700

    • DOI

      10.1111/jog.14519

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Uterine Epithelial Progesterone Receptor Governs Uterine Receptivity Through Epithelial Cell Differentiation2020

    • Author(s)
      Gebril Mona、Hirota Yasushi、Aikawa Shizu、Fukui Yamato、Kaku Tetsuaki、Matsuo Mitsunori、Hirata Tomoyuki、Akaeda Shun、Hiraoka Takehiro、Shimizu-Hirota Ryoko、Takeda Norihiko、Taha Tamer、Balah Osama Al、Elnoury Mohamed Amr H、Fujii Tomoyuki、Osuga Yutaka
    • Journal Title

      Endocrinology

      Volume: 161 Issue: 12 Pages: 12-12

    • DOI

      10.1210/endocr/bqaa195

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] CD206+ M2-like Macrophages are Essential for Successful Implantation.2020

    • Author(s)
      Ono Y, Yoshino O, Ushijima A, Hiraoka T, Fukui Y, Nawaz A, Hirota Y, Wada S, Tobe K, Nakashima A, Osuga Y and Saito S.
    • Journal Title

      Front Immunol.

      Volume: 11 Pages: 557184-557184

    • DOI

      10.3389/fimmu.2020.557184

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Niclosamide suppresses macrophage-induced inflammation in endometriosis†2020

    • Author(s)
      Sekulovski Nikola、Whorton Allison E、Tanaka Tomoki、Hirota Yasushi、Shi Mingxin、MacLean James A、de Mola Julio Ricardo Loret、Groesch Kathleen、Diaz-Sylvester Paula、Wilson Teresa、Hayashi Kanako
    • Journal Title

      Biol Reprod

      Volume: in press Issue: 5 Pages: 1011-1019

    • DOI

      10.1093/biolre/ioaa010

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The effects of tokishakuyakusan, a traditional Japanese medicine (kampo), ferulic acid and paeoniflorin, on human endometriotic stromal cells and peritoneal macrophages2020

    • Author(s)
      Takeuchi Arisa、Koga Kaori、Tokita Yohei、Matsumoto Takashi、Satake Erina、Taguchi Ayumi、Makabe Tomoko、Miyashita Mariko、Takamura Masashi、Harada Miyuki、Hirata Tetsuya、Hirota Yasushi、Wada-Hiraike Osamu、Fujii Tomoyuki、Osuga Yutaka
    • Journal Title

      J Reprod Immunol

      Volume: 139 Pages: 103104-103104

    • DOI

      10.1016/j.jri.2020.103104

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential roles of uterine epithelial and stromal STAT3 coordinate uterine receptivity and embryo attachment2020

    • Author(s)
      Hiraoka Takehiro、Hirota Yasushi、Fukui Yamato、Gebril Mona、Kaku Tetsuaki、Aikawa Shizu、Hirata Tomoyuki、Akaeda Shun、Matsuo Mitsunori、Haraguchi Hirofumi、Saito-Kanatani Mayuko、Shimizu-Hirota Ryoko、Takeda Norihiko、Yoshino Osamu、Fujii Tomoyuki、Osuga Yutaka
    • Journal Title

      Scientific Reports

      Volume: 10 Issue: 1 Pages: 15523-15523

    • DOI

      10.1038/s41598-020-72640-0

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dienogest suppresses cellular proliferation status of endometrial polyps and acts differently depending on the morphological type2020

    • Author(s)
      Inaba Kei、Wada-Hiraike Osamu、Harada Miyuki、Hirota Yasushi、Koga Kaori、Fujii Tomoyuki、Osuga Yutaka
    • Journal Title

      Women's Health

      Volume: 16 Pages: 174550652095200-174550652095200

    • DOI

      10.1177/1745506520952003

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 【子宮腺筋症と不妊症および妊娠予後】子宮腺筋症の薬物療法と手術療法2020

    • Author(s)
      廣田泰
    • Journal Title

      日本産科婦人科学会雑誌

      Volume: 72 Pages: 591-595

    • Related Report
      2020 Annual Research Report
  • [Journal Article] 【いま、脂質がおもしろい~若手研究者による最新の脂質研究~】臨床 脂肪酸代謝物による子宮機能の制御2020

    • Author(s)
      松尾光徳、廣田泰
    • Journal Title

      The Lipid

      Volume: 31 Pages: 21-27

    • Related Report
      2020 Annual Research Report
  • [Journal Article] 【着床を考える】着床研究の最前線2020

    • Author(s)
      平岡毅大、廣田泰
    • Journal Title

      産科と婦人科

      Volume: 87 Pages: 1247-1252

    • Related Report
      2020 Annual Research Report
  • [Journal Article] 【内膜を極めるI-内膜の機能と着床をめぐる最近の話題-】着床の分子メカニズム2020

    • Author(s)
      赤枝俊、廣田泰
    • Journal Title

      産婦人科の実際

      Volume: 69 Pages: 1037-1042

    • Related Report
      2020 Annual Research Report
  • [Journal Article] 【着床環境の改善はどこまで可能か?-エキスパートに聞く最新研究と具体的対処法】同期不全の臨床 プロゲステロンが着床に果たす役割とメカニズム2020

    • Author(s)
      廣田泰
    • Journal Title

      臨床婦人科産科

      Volume: 74 Pages: 1211-1216

    • Related Report
      2020 Annual Research Report
  • [Journal Article] Mdm2-p53-SF1 pathway in ovarian granulosa cells directs ovulation and fertilization by conditioning oocyte quality2019

    • Author(s)
      Haraguchi Hirofumi、Hirota Yasushi、Saito-Fujita Tomoko、Tanaka Tomoki、Shimizu-Hirota Ryoko、Harada Miyuki、Akaeda Shun、Hiraoka Takehiro、Matsuo Mitsunori、Matsumoto Leona、Hirata Tetsuya、Koga Kaori、Wada-Hiraike Osamu、Fujii Tomoyuki、Osuga Yutaka
    • Journal Title

      The FASEB Journal

      Volume: 33 Issue: 2 Pages: 2610-2620

    • DOI

      10.1096/fj.201801401r

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Uterine adenomyosis is an oligoclonal disorder associated with KRAS mutations2019

    • Author(s)
      Inoue Satoshi、Hirota Yasushi、Ueno Toshihide、十人省略、Tanaka Yosuke、Sakata Seiji、Takeuchi Kengo、Muraoka Ayako、Osuka Satoko、Saito Tsuyoshi、Oda Katsutoshi、Osuga Yutaka、Terao Yasuhisa、Kawazu Masahito、Mano Hiroyuki
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 1-13

    • DOI

      10.1038/s41467-019-13708-y

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Uterine receptivity, embryo attachment, and embryo invasion: Multistep processes in embryo implantation2019

    • Author(s)
      Fukui Yamato、Hirota Yasushi、Matsuo Mitsunori、Gebril Mona、Akaeda Shun、Hiraoka Takehiro、Osuga Yutaka
    • Journal Title

      Reproductive Medicine and Biology

      Volume: 18 Issue: 3 Pages: 234-240

    • DOI

      10.1002/rmb2.12280

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Progesterone governs endometrial proliferation-differentiation switching and blastocyst implantation2019

    • Author(s)
      Hirota Yasushi
    • Journal Title

      Endocrine Journal

      Volume: 66 Issue: 3 Pages: 199-206

    • DOI

      10.1507/endocrj.EJ18-0431

    • NAID

      130007626244

    • ISSN
      0918-8959, 1348-4540
    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endothelial Cells in the Decidual Bed Are Potential Therapeutic Targets for Preterm Birth Prevention2019

    • Author(s)
      Deng Wenbo、Yuan Jia、Cha Jeeyeon、Sun Xiaofei、Bartos Amanda、Yagita Hideo、Hirota Yasushi、Dey Sudhansu K.
    • Journal Title

      Cell Rep

      Volume: 27 Issue: 6 Pages: 1755-1768.e4

    • DOI

      10.1016/j.celrep.2019.04.049

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Endometriosis Triggers Excessive Activation of Primordial Follicles via PI3K-PTEN-Akt-Foxo3 Pathway2019

    • Author(s)
      Takeuchi Arisa、Koga Kaori、Satake Erina、Makabe Tomoko、Taguchi Ayumi、Miyashita Mariko、Takamura Masashi、Harada Miyuki、Hirata Tetsuya、Hirota Yasushi、Yoshino Osamu、Wada-Hiraike Osamu、Fujii Tomoyuki、Osuga Yutaka
    • Journal Title

      The Journal of Clinical Endocrinology & Metabolism

      Volume: 104 Issue: 11 Pages: 5547-5554

    • DOI

      10.1210/jc.2019-00281

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Macrophage hypoxia signaling regulates cardiac fibrosis via Oncostatin M.2019

    • Author(s)
      Abe H, Takeda N, Isagawa T, Semba H, Nishimura S, Morioka MS, Nakagama Y, Sato T, Soma K, Koyama K, Wake M, Katoh M, Asagiri M, Neugent ML, Kim JW, Stockmann C, Yonezawa T, Inuzuka R, Hirota Y, Maemura K, Yamashita T, Otsu K, Manabe I, Nagai R, Komuro I.
    • Journal Title

      Nature Communications

      Volume: 10 Issue: 1 Pages: 2824-2833

    • DOI

      10.1038/s41467-019-10859-w

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] A survey of public attitudes toward uterus transplantation, surrogacy, and adoption in Japan2019

    • Author(s)
      Nakazawa Akari、Hirata Tetsuya、Arakawa Tomoko、Nagashima Natsuki、Fukuda Shinya、Neriishi Kazuaki、Harada Miyuki、Hirota Yasushi、Koga Kaori、Wada-Hiraike Osamu、Koizumi Yoshio、Fujii Tomoyuki、Irahara Minoru、Osuga Yutaka
    • Journal Title

      PLOS ONE

      Volume: 14 Issue: 10 Pages: 0223571-0223571

    • DOI

      10.1371/journal.pone.0223571

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Accumulation of advanced glycation end products in follicles is associated with poor oocyte developmental competence2019

    • Author(s)
      Takahashi Nozomi、Harada Miyuki、Azhary Jerilee M K、Kunitomi Chisato、Nose Emi、Terao Hiromi、Koike Hiroshi、Wada-Hiraike Osamu、Hirata Tetsuya、Hirota Yasushi、Koga Kaori、Fujii Tomoyuki、Osuga Yutaka
    • Journal Title

      Molecular Human Reproduction

      Volume: 25 Issue: 11 Pages: 684-694

    • DOI

      10.1093/molehr/gaz050

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Placental expression of lysophosphatidic acid receptors in normal pregnancy and preeclampsia2019

    • Author(s)
      Fujii Tatsuya、Nagamatsu Takeshi、Schust Danny J.、Ichikawa Mayuko、Kumasawa Keiichi、Yabe Shinichiro、Iriyama Takayuki、Hirota Yasushi、Osuga Yutaka、Aoki Junken、Yatomi Yutaka、Fujii Tomoyuki
    • Journal Title

      American Journal of Reproductive Immunology

      Volume: 82 Issue: 5

    • DOI

      10.1111/aji.13176

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Activation of Nrf2/Keap1 pathway by oral Dimethylfumarate administration alleviates oxidative stress and age-associated infertility might be delayed in the mouse ovary2019

    • Author(s)
      Akino Nana、Wada-Hiraike Osamu、Isono Wataru、Terao Hiromi、Honjo Harunori、Miyamoto Yuichiro、Tanikawa Michihiro、Sone Kenbun、Hirano Mana、Harada Miyuki、Hirata Tetsuya、Hirota Yasushi、Koga Kaori、Oda Katsutoshi、Fujii Tomoyuki、Osuga Yutaka
    • Journal Title

      Reproductive Biology and Endocrinology

      Volume: 17 Issue: 1 Pages: 2323-2323

    • DOI

      10.1186/s12958-019-0466-y

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Endoplasmic Reticulum Stress Activated by Androgen Enhances Apoptosis of Granulosa Cells via Induction of Death Receptor 5 in PCOS2018

    • Author(s)
      Azhary Jerilee M K、Harada Miyuki、Takahashi Nozomi、Nose Emi、Kunitomi Chisato、Koike Hiroshi、Hirata Tetsuya、Hirota Yasushi、Koga Kaori、Wada-Hiraike Osamu、Fujii Tomoyuki、Osuga Yutaka
    • Journal Title

      Endocrinology

      Volume: 160 Issue: 1 Pages: 119-132

    • DOI

      10.1210/en.2018-00675

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression of Nerve Injury-Induced Protein1 (Ninj1) in Endometriosis2018

    • Author(s)
      Miyashita Mariko、Koga Kaori、Takeuchi Arisa、Makabe Tomoko、Taguchi Ayumi、Urata Yoko、Izumi Gentaro、Takamura Masashi、Harada Miyuki、Hirata Tetsuya、Hirota Yasushi、Wada-Hiraike Osamu、Yoshino Osamu、Fujii Tomoyuki、Osuga Yutaka
    • Journal Title

      Reproductive Sciences

      Volume: in press Issue: 8 Pages: 368-375

    • DOI

      10.1177/1933719118806395

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] 子宮腺筋症合併不妊への対応2021

    • Author(s)
      廣田泰
    • Organizer
      第58回東北生殖医学会学術講演会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 子宮内膜上皮のleukemia inhibitory factor受容体は子宮管腔構造変化を介してマウスの胚接着を制御する2021

    • Author(s)
      福井大和、廣田泰、平岡毅大、賀来哲明、平田知之、赤枝俊、松尾光徳、大須賀穣
    • Organizer
      第66回日本生殖医学会学術講演会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 子宮内膜症と反復着床障害~cine MRI 検査を通して~2021

    • Author(s)
      福井大和、廣田泰、賀来哲明、平田知之、飯田麗、石沢千尋、赤枝俊、平岡毅大、松尾光徳、大須賀穣
    • Organizer
      第66回日本生殖医学会学術講演会・シンポジウム
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Cox-1・Cox-2による胚着床機構の解明2021

    • Author(s)
      藍川志津、廣田泰、赤枝俊、松尾光徳、賀来哲明、福井大和、大須賀穣
    • Organizer
      第94回日本生化学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 着床障害の診断・治療とその発症機序2020

    • Author(s)
      廣田泰
    • Organizer
      第93回日本内分泌学会学術総会・教育講演
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 今改めて生殖外科を考える 子宮腺筋症に対する生殖外科手術の意義2020

    • Author(s)
      廣田泰
    • Organizer
      第65回日本生殖医学会学術講演会・シンポジウム
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 反復着床不全をどう克服するか? プロゲステロンによる子宮内膜増殖能と着床の制御機構2020

    • Author(s)
      赤枝俊、廣田泰、大須賀穣
    • Organizer
      第65回日本生殖医学会学術講演会・シンポジウム
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 妊孕能温存を考慮した 子宮内膜症の低侵襲手術を考える2020

    • Author(s)
      廣田泰
    • Organizer
      第35回日本女性医学学会学術集会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 月経困難症の外来管理と病診連携2020

    • Author(s)
      廣田泰
    • Organizer
      東京産婦人科医会城西南ブロック 子宮内膜症研究会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 子宮内膜による胚の接着・浸潤の調節2019

    • Author(s)
      廣田泰
    • Organizer
      第15回日本A-PART学術講演会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 内分泌調節による子宮への受精卵の接着・浸潤2019

    • Author(s)
      廣田泰
    • Organizer
      第37回内分泌代謝学サマーセミナー
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 子宮への着床胚の浸潤に関わる機能的脂質2019

    • Author(s)
      廣田泰
    • Organizer
      第92回日本生化学学会大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Remarks] 【プレスリリース】子宮内膜上皮の細胞増殖の持続が着床障害を起こす

    • URL

      https://www.h.u-tokyo.ac.jp/press/20210105-2.html

    • Related Report
      2020 Annual Research Report

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Published: 2019-04-18   Modified: 2024-01-30  

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