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Systems biology for DNA cis-elements in circadian clockwork

Research Project

Project/Area Number 19H03175
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 43030:Functional biochemistry-related
Research InstitutionTokyo Metropolitan Institute of Medical Science (2020-2022)
The University of Tokyo (2019)

Principal Investigator

YOSHITANE Hikari  公益財団法人東京都医学総合研究所, 基礎医科学研究分野, 副参事研究員 (70569920)

Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2022)
Budget Amount *help
¥17,160,000 (Direct Cost: ¥13,200,000、Indirect Cost: ¥3,960,000)
Fiscal Year 2022: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Keywords概日時計 / DNAシスエレメント / CRISPR-Cas9 / システムバイオロジー / 転写ネットワーク / ゲノム編集 / 転写制御 / 体内時計
Outline of Research at the Start

1日周期で繰り返す生理機能リズムは、生物が地球環境の24時間サイクルに適応して獲得した生体システムであり、このリズムを生み出す機構は概日時計と呼ばれる。哺乳類では、さまざまな組織において特徴的な遺伝子にリズム性が見られ、約43%もの遺伝子は全身のどこかの臓器においてリズミックに発現していることが報告された。そのため、体内時計の破綻は、高血圧、発癌、免疫異常、代謝異常、白内障、高次脳機能障害、など様々な疾病の発症リスクを増大させる。本研究では、時計シス配列に着目したゲノム編集技術を大規模に展開し、24時間周期の時計振動の仕組みと、そこからの時計機能出力に不可欠な転写制御を同定する。

Outline of Final Research Achievements

The E-box-mediated core feedback loop is interlocked with the RRE-mediated feedback loop, but biological significance of the RRE-mediated loop has been elusive. In this study, we established mutant cells and mice deficient for rhythmic transcription of Bmal1 gene by deleting its upstream RRE elements and hence disrupted the RRE-mediated feedback loop. We observed apparently normal circadian rhythms in the mutant cells and mice, but a combination of mathematical modeling and experiments revealed that the circadian period and amplitude of the mutants were more susceptible to disturbance of CRY1 protein rhythm. Our findings demonstrate that the RRE-mediated feedback regulation of Bmal1 underpins the E-box-mediated rhythm in cooperation with CRY1-dependent posttranslational regulation of BMAL1 protein, thereby conferring the perturbation-resistant oscillation and chronologically-organized output of the circadian clock.

Academic Significance and Societal Importance of the Research Achievements

遺伝子そのものではなく、その転写制御配列をゲノム編集することにより、その転写制御の重要性を示すことができる、ということを証明した。Bmal1遺伝子は、遺伝子の欠損により時計振動は停止するが、その転写リズムを一定にしても時計振動は停止しなかった。このような研究戦略は、転写リズムを持つ遺伝子に対してのみならず、概日時計分野に限らず広い研究分野に対して、遺伝子そのものではなく、遺伝子の転写制御の意義を評価する上で、効果的であると期待される。

Report

(5 results)
  • 2022 Annual Research Report   Final Research Report ( PDF )
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (98 results)

All 2023 2022 2021 2020 2019 Other

All Int'l Joint Research (10 results) Journal Article (14 results) (of which Int'l Joint Research: 5 results,  Peer Reviewed: 12 results,  Open Access: 12 results) Presentation (73 results) (of which Int'l Joint Research: 15 results,  Invited: 22 results) Remarks (1 results)

  • [Int'l Joint Research] KAIST(韓国)

    • Related Report
      2022 Annual Research Report
  • [Int'l Joint Research] Duke Univ. Medical center(シンガポール)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] KAIST(韓国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] UCSD/UT South westernou(米国)

    • Related Report
      2021 Annual Research Report
  • [Int'l Joint Research] Duke Univ. Medical center(シンガポール)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] KAIST(韓国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] UCSD/UT South western(米国)

    • Related Report
      2020 Annual Research Report
  • [Int'l Joint Research] Duke University Medical Center,(シンガポール)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] KAIST(韓国)

    • Related Report
      2019 Annual Research Report
  • [Int'l Joint Research] UCSD/UT South western(米国)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Rhythmic transcription of Bmal1 stabilizes the circadian timekeeping system in mammals2022

    • Author(s)
      Abe Yasuko O.、Yoshitane Hikari、Kim Dae Wook、Kawakami Satoshi、Koebis Michinori、Nakao Kazuki、Aiba Atsu、Kim Jae Kyoung、Fukada Yoshitaka
    • Journal Title

      Nature Communications

      Volume: 13 Issue: 1 Pages: 4652-4652

    • DOI

      10.1038/s41467-022-32326-9

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Lint‐O cooperates with L(3)mbt in target gene suppression to maintain homeostasis in fly ovary and brain2022

    • Author(s)
      Yamamoto‐Matsuda Hitomi、Miyoshi Keita、Moritoh Mai、Yoshitane Hikari、Fukada Yoshitaka、Saito Kuniaki、Yamanaka Soichiro、Siomi Mikiko C
    • Journal Title

      EMBO reports

      Volume: 23 Issue: 10

    • DOI

      10.15252/embr.202153813

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Adiponectin Regulates the Circadian Rhythm of Glucose and lipid metabolism2022

    • Author(s)
      Wada T, Yamamoto Y, Takasughi Y, Ishii H, Uchiyama T, Saithoh K, Suzuki M, Uchiyama M, Yoshitane H, Fukada Y, Shimba S
    • Journal Title

      Journal of Endoclinology

      Volume: 254 Issue: 2 Pages: 121-133

    • DOI

      10.1530/joe-22-0006

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Molecular encoding and synaptic decoding of context during salt chemotaxis in C. elegans2022

    • Author(s)
      Hiroki Shingo、Yoshitane Hikari、Mitsui Hinako、Sato Hirofumi、Umatani Chie、Kanda Shinji、Fukada Yoshitaka、Iino Yuichi
    • Journal Title

      Nature Communications

      Volume: 13 Issue: 1 Pages: 2928-2928

    • DOI

      10.1038/s41467-022-30279-7

    • Related Report
      2022 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Diurnal shift of mouse activity by the deficiency of an ageing-related gene <i>Lmna</i>2022

    • Author(s)
      Kawakami Satoshi、Yoshitane Hikari、Morimura Taiki、Kimura Wataru、Fukada Yoshitaka
    • Journal Title

      The Journal of Biochemistry

      Volume: - Issue: 5 Pages: 509-518

    • DOI

      10.1093/jb/mvac015

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] mTOR-AKT Signaling in Cellular Clock Resetting Triggered by Osmotic Stress.2022

    • Author(s)
      Yoshitane H, Imamura K, Okubo T, Otobe Y, Kawakami S, Ito S, Takumi T, Hattori K, Naguro I, Ichijo H, Fukada Y
    • Journal Title

      Antioxid Redox Signal

      Volume: in press Issue: 10-12 Pages: 631-646

    • DOI

      10.1089/ars.2021.0059

    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Rhythmic transcription of Bmal1 stabilizes the circadian timekeeping system in mammals2022

    • Author(s)
      Yasuko O. Abe, Hikari Yoshitane, Dae Wook Kim, Michinori Koebis, Kazuki Nakao, Atsu Aiba, Jae Kyoung Kim and Yoshitaka Fukada
    • Journal Title

      Nature Communications

      Volume: -

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Post-transcriptional repression of circadian component CLOCK regulates cancer-stemness in murine breast cancer cells2021

    • Author(s)
      Ogino Takashi、Matsunaga Naoya、Tanaka Takahiro、Tanihara Tomohito、Terajima Hideki、Yoshitane Hikari、Fukada Yoshitaka、Tsuruta Akito、Koyanagi Satoru、Ohdo Shigehiro
    • Journal Title

      eLife

      Volume: 10

    • DOI

      10.7554/elife.66155

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Attenuated SIRT1 activity leads to PER2 cytoplasmic localization and dampens the amplitude of Bmal1 promoter-driven circadian oscillation2021

    • Author(s)
      Ashimori Atsushige、Nakahata Yasukazu、Sato Toshiya、Fukamizu Yuichiro、Matsui Takaaki、Shinohara Kazuyuki、Bessho Yasumasa
    • Journal Title

      Frontiers in Neuroscience

      Volume: - Pages: 647589-647589

    • DOI

      10.3389/fnins.2021.647589

    • NAID

      120007168842

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Circadian Phosphorylation of CLOCK and BMAL12021

    • Author(s)
      Yoshitane Hikari、Fukada Yoshitaka
    • Journal Title

      Methods Mol. Biol.

      Volume: 2130 Pages: 195-203

    • DOI

      10.1007/978-1-0716-0381-9_15

    • ISBN
      9781071603802, 9781071603819
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mutation of PER2 phosphodegron perturbs the circadian phosphoswitch2020

    • Author(s)
      Shusaku Masuda, Rajesh Narasimamurthy, Hikari Yoshitane, Jae Kyoung Kim, Yoshitaka Fukada and David M. Virshup
    • Journal Title

      Proc. Natl. Acad. Sci. USA.

      Volume: 117 Issue: 20 Pages: 10888-10896

    • DOI

      10.1073/pnas.2000266117

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Posttranscriptional and posttranslational regulation of rhythmic components in circadian clockwork of mice2019

    • Author(s)
      吉種 光
    • Journal Title

      生化学

      Volume: 91 Issue: 6 Pages: 753-762

    • DOI

      10.14952/SEIKAGAKU.2019.910753

    • NAID

      40022117184

    • ISSN
      0037-1017
    • Year and Date
      2019-12-25
    • Related Report
      2019 Annual Research Report
    • Open Access
  • [Journal Article] Functional D-box sequences reset the circadian clock and drive mRNA rhythms.2019

    • Author(s)
      Hikari Yoshitane, Yoshimasa Asano, Aya Sagami, Seinosuke Sakai, Yutaka Suzuki, Hitoshi Okamura, Wataru Iwasaki, Haruka Ozaki, and Yoshitaka Fukada
    • Journal Title

      Communications Biology

      Volume: 2 Issue: 1 Pages: 300-300

    • DOI

      10.1038/s42003-019-0522-3

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Mutation of a PER2 phosphodegron perturbs the circadian phosphoswitch2019

    • Author(s)
      Shusaku Masuda, Rajesh Narasimamurthy, Hikari Yoshitane, Jae Kyoung Kim, Yoshitaka Fukada, and David M. Virshup
    • Journal Title

      BioRxiv

      Volume: 2019.12.16. Pages: 876615-876615

    • DOI

      10.1101/2019.12.16.876615

    • Related Report
      2019 Annual Research Report
    • Open Access / Int'l Joint Research
  • [Presentation] 時間タンパク質学: 時計タンパク質の相互作用リズムと翻訳後修飾コード2023

    • Author(s)
      吉種光
    • Organizer
      第12回 都医学研シンポジウム
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 時計老化: 加齢に基づく老化現象の分子メカニズム2023

    • Author(s)
      吉種光
    • Organizer
      日本生理学会 第100回 記念大会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Circadian quartz: Implication for protein oscillator in mammalian circadian clockwork2022

    • Author(s)
      Hikari Yoshitane
    • Organizer
      Sapporo Symposium on Biological Rhythm
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Rhythmic transcription of Bmal1 stabilizes the circadian timekeeping system in mammals2022

    • Author(s)
      Hikari Yoshitane, Yasuko O. Abe, Dae W. Kim, Jae K. Kim and Yoshitaka Fukada
    • Organizer
      ヨーロッパ時間生物学会EBRS 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Circadian rhythm of protein-protein interactions and post-translational modifications in the clock protein complex2022

    • Author(s)
      Yuta Otobe, Michinori Koebis, Atsu Aiba, Yoshitaka Fukada and Hikari Yoshitane
    • Organizer
      ヨーロッパ時間生物学会EBRS 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] molecular basis for mammalian circadian clock oscillation2022

    • Author(s)
      Yuta Otobe, Shunsuke Ito, Michinori Koebis, Atsu Aiba, Yoshitaka Fukada and Hikari Yoshitane
    • Organizer
      米国時間生物学会SRBR 2022
    • Related Report
      2022 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 概日時計クオーツ:真核生物でもタンパク質振動子が自律振動する可能性2022

    • Author(s)
      吉種光
    • Organizer
      第29回 日本時間生物学会学術大会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 線虫C.elegansにおいてROR/NHR-23の標的遺伝子の転写リズムは発生から概日性の時間スケールへと周波数変調する2022

    • Author(s)
      廣木進吾、飯野雄一、吉種光
    • Organizer
      第29回 日本時間生物学会学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 時間タンパク質学:時計タンパク質の相互作用リズムと翻訳後修飾コード2022

    • Author(s)
      吉種光
    • Organizer
      第95回 日本生化学会大会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 時計遺伝子Bmal1のリズミックな転写制御を介した概日時計振動の安定化機構2022

    • Author(s)
      阿部泰子、吉種光、Dae Wook Kim、川上聖司、古戎道典、中尾和貴、饗場篤、 Jae Kyoung Kim, 深田吉孝
    • Organizer
      第95回 日本生化学会大会
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 時計タンパク質の相互作用リズムと翻訳後修飾コード2022

    • Author(s)
      乙部優太、伊藤舜喬、安藤涼音、古戎道典、饗場篤、深田吉孝、吉種光
    • Organizer
      第95回 日本生化学会大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 「時」を生み出す分子メカニズム2022

    • Author(s)
      吉種光
    • Organizer
      千葉大学 生化学特論 第18回生化セミナー
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 「時」をビックデータとシステムバイオロジーで理解する2022

    • Author(s)
      吉種光
    • Organizer
      東京大学 生物科学セミナー
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Molecular mechanism of circadian clockwork2022

    • Author(s)
      Hikari Yoshitane
    • Organizer
      The University of Tokyo, Advanced photon life sciences
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] 「時」を生み出す分子メカニズム2022

    • Author(s)
      吉種光
    • Organizer
      東京都立大学 生命科学教室セミナー
    • Related Report
      2022 Annual Research Report
    • Invited
  • [Presentation] Molecular studies on circadian phosphorylation rhythms of CLOCK2022

    • Author(s)
      倉林伸博、乙部優太、吉種光
    • Organizer
      第29回 日本時間生物学会学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 哺乳類培養細胞を用いた時計の位相同調メカニズムの解析2022

    • Author(s)
      加藤雪、吉種光
    • Organizer
      第29回 日本時間生物学会学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 高度に同期した時計タンパク質の複合体形成リズムとリン酸化スイッチ2022

    • Author(s)
      乙部優太、古戎道典、饗場篤、深田吉孝、吉種光
    • Organizer
      第29回 日本時間生物学会学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 時計遺伝子欠損細胞の機能回復実験から迫る時計タンパク質翻訳後修飾の役割2022

    • Author(s)
      伊藤舜喬、乙部優太、深田吉孝、吉種光
    • Organizer
      第29回 日本時間生物学会学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 加齢に伴い概日リズムの出力が破綻する分子基盤の解明2022

    • Author(s)
      森村太貴、川上聖司、深田吉孝、吉種光
    • Organizer
      第29回 日本時間生物学会学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] Molecular studies on circadian phosphorylation rhythms of CLOCK2022

    • Author(s)
      浅野吉政、酒井誠之介、尾崎遼、鈴木穣、岩崎渉、吉種光、深田吉孝
    • Organizer
      第29回 日本時間生物学会学術大会
    • Related Report
      2022 Annual Research Report
  • [Presentation] The changes in protein-protein interaction of RNA binding proteins during poly(I:C)-transfection2022

    • Author(s)
      Yoshimasa Asano, Koji Onomoto, Mitsutoshi Yoneyama, Yuta Otobe, Hikari Yoshitane, Kumiko Ui-Tei
    • Organizer
      第45回 日本分子生物学会年会
    • Related Report
      2022 Annual Research Report
  • [Presentation] 時間タンパク質学: 時計タンパク質の相互作用リズムと翻訳後修飾コード2022

    • Author(s)
      吉種光
    • Organizer
      時間タンパク質学キックオフシンポジウム
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 「時」を生み出す分子メカニズム2021

    • Author(s)
      吉種光
    • Organizer
      東京大学 第1383回生物科学セミナー
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] がん研究におけるHybrid研究者の役割2021

    • Author(s)
      吉種光
    • Organizer
      第80回 日本癌学会学術大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 時間タンパク質学:時計タンパク質の相互作用リズムと翻訳後修飾コード2021

    • Author(s)
      吉種光
    • Organizer
      第2回時間タンパク質学領域会議
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] Clock Aging: Molecular basis for age-related functional decline2021

    • Author(s)
      吉種光
    • Organizer
      第94回日本生化学会大会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] あなたは何時に実験しましたか?~概日時計の基礎から応用まで~2021

    • Author(s)
      吉種光
    • Organizer
      第 78回 Scienc-ome
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 「時」を生み出すタンパク質複合体の相互作用と翻訳後修飾リズム2021

    • Author(s)
      吉種光、乙部優太、深田吉孝
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] circadian quartz & clock aging2021

    • Author(s)
      吉種光
    • Organizer
      令和3年度 機能低下領域 PRIME会議
    • Related Report
      2021 Annual Research Report
  • [Presentation] Molecular Encoding and Synaptic Decoding of Memory of Chemical Concentration in C. elegans2021

    • Author(s)
      Shingo Hiroki, Hikari Yoshitane, Yoshitaka Fukada, Masahiro Tomioka, Muneki Ikeda, Ikue Mori, and Yuichi Iino
    • Organizer
      22nd International C. elegans Conference
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Clock aging: a molecular basis for age-related physiological dysfunction2021

    • Author(s)
      Hikari Yoshitane, Satoshi Kawakami, Rina Nunokawa, Yutaka Suzuki, and Yoshitaka Fukada
    • Organizer
      National Academy of Medicine (NAM) Healthy Longevity Global Innovator Summit
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 時計タンパク質複合体の相互作用マップと翻訳後修飾リズム2021

    • Author(s)
      乙部優太、古戎道典、饗場篤、深田吉孝、吉種光
    • Organizer
      第94回日本生化学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Clock aging: a molecular basis for age-related physiological dysfunction2021

    • Author(s)
      Satoshi Kawakami, Rina Nunokawa, Yutaka Suzuki, Yoshitaka Fukada, and Hikari Yoshitane
    • Organizer
      第28回日本時間生物学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Bmal1の転写リズムを介した概日時計振動の安定化機構2021

    • Author(s)
      Yasuko O. Abe, Hikari Yoshitane, Dae Wook Kim, Michinori Koebis, Kazuki Nakao, Atsu Aiba, Jae Kyoung Kim, and Yoshitaka Fukada
    • Organizer
      第28回日本時間生物学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 時計タンパク質複合体の相互作用マップと翻訳後修飾リズム2021

    • Author(s)
      乙部優太、古戎道典、饗場篤、深田吉孝、吉種光
    • Organizer
      第28回日本時間生物学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Rhythmic transcription of Bmal1 stabilizes the circadian timekeeping system in mammals2021

    • Author(s)
      今井圭子、吉種光、三輪久美子、深田吉孝、近藤孝男
    • Organizer
      第28回日本時間生物学会学術大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Chronocode: molecular basis for mammalian circadian clock oscillation2021

    • Author(s)
      Yuta. Otobe, Shunsuke. Ito, Michinori Koebis, Atsu Aiba, Yoshitaka Fukada and Hikari Yoshitane
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 脳腫瘍抑制因子L(3)mbtによるpiRNA因子群の転写制御機構の解明2021

    • Author(s)
      山本瞳、山中総一郎、盛藤舞、吉種光、深田吉孝、塩見美喜子
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ナルディライジンによる核内受容体ROR/REV-ERB活性調節機構の解明2021

    • Author(s)
      平岡義範、古市真唯、村瀬満政、久米典昭、吉種光、深田吉孝、池田正明、_英一郎
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 大腸菌増殖の誘導期におけるATP依存性プロテアーゼの関与2021

    • Author(s)
      保科真樹、吉村美歩、吉種光、山本兼由
    • Organizer
      第44回日本分子生物学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 時を刻む時計タンパク質複合体の相互作用マップと翻訳後修飾コード2020

    • Author(s)
      吉種光
    • Organizer
      第93回日本生化学会大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 時を刻む時計タンパク質複合体の相互作用マップと翻訳後修飾コード2020

    • Author(s)
      吉種光、深田吉孝
    • Organizer
      第27回日本時間生物学会学術大会
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Circadian quartz and clock aging2020

    • Author(s)
      Hikari Yoshitane
    • Organizer
      東京都医学総合研究所 医学研セミナー
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] 祝10周年生物リズム若手研究者の集い2020

    • Author(s)
      吉種光
    • Organizer
      生物リズム若手研究者の集い2020
    • Related Report
      2020 Annual Research Report
    • Invited
  • [Presentation] Rhythmic transcription of_Bmal1_stabilizes the robust circadian oscillation2020

    • Author(s)
      Yasuko O. Abe, Hikari Yoshitane, Michinori Koebis, Atsu Aiba, Yoshitaka Fukada
    • Organizer
      日本比較生理生化学会第42回山形大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Clock Aging: A Molecular Basis for Age-Related Physiological Dysfunction2020

    • Author(s)
      Hikari Yoshitane , Satoshi Kawakami, Rina Nunokawa, Yutaka Suzuki and Yoshitaka Fukada
    • Organizer
      Society for Research on Biological Rhythms Meeting (SRBR 2020)
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A molecular basis for disruption of circadian rhythm during aging2020

    • Author(s)
      Satoshi Kawakami, Hikari Yoshitane, and Yoshitaka Fukada
    • Organizer
      第27回日本時間生物学会学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 哺乳類概日時計におけるBmal1のリズミックな転写制御の生理的意義2020

    • Author(s)
      Yasuko O. Abe, Hikari Yoshitane, Michinori Koebis, Atsu Aiba, and Yoshitaka Fukada
    • Organizer
      第27回日本時間生物学会学術大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Comprehensive identification of DBP / E4BP4 binding motifs2019

    • Author(s)
      浅野 吉政、吉種 光、 佐上 彩、 酒井 誠之介、 鈴木 穣、 岡村 均、 岩崎 渉、 尾崎 遥、 深田 吉孝
    • Organizer
      第19回東京大学生命科学シンポジウム
    • Related Report
      2019 Annual Research Report
  • [Presentation] Roles of FBXL21-mediated Ubiquitination of CRY protein2019

    • Author(s)
      Hikari Yoshitane, Kaori Nobe, Masaki Motomiya, Arisa Hirano, Kanae Yumimoto, Keiichi I. Nakayama, Joe Takahashi, Yoshitaka Fukada
    • Organizer
      V World Congress of Chronobiology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 時計タンパク質DBPの分解を制御するE3ユビキチンリガーゼ2019

    • Author(s)
      増田 周作、吉種 光、深田吉孝
    • Organizer
      時間生物フォーラム東京2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] Function D-box sequences and their roles in circadian clockwork2019

    • Author(s)
      浅野 吉政、吉種 光、佐上 彩、酒井 誠之介、鈴木 穣、岡村 均、岩崎 渉、尾崎 遼、深田 吉孝
    • Organizer
      時間生物フォーラム東京2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] マウス肝臓における時計タンパク質E4BP4の生理的役割2019

    • Author(s)
      酒井 誠之介、浅野 吉政、吉種 光、鈴木 穣、深田 吉孝
    • Organizer
      時間生物フォーラム東京2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] Roles of FBXL21-mediated Ubiquitination of CRY protein2019

    • Author(s)
      Hikari Yoshitane, Kaori Nobe, Masaki Motomiya, Arisa Hirano, Kanae Yumimoto, Keiichi I. Nakayama, Joe Takahashi, Yoshitaka Fukada
    • Organizer
      時間生物フォーラム東京2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] 日時計の位相と周期の変化に関わる鍵分子ASKキナーゼの上流と下流の解析2019

    • Author(s)
      大久保 毅紀、吉種 光、今村 聖路、吉田 賢人、服部 一輝、名黒 功、一條 秀憲、深田 吉孝
    • Organizer
      時間生物フォーラム東京2019
    • Related Report
      2019 Annual Research Report
  • [Presentation] Functional D-box sequences and their roles in the circadian clockwork2019

    • Author(s)
      Yoshimasa Asano, Hikari Yoshitane, Aya Sagami, Seinosuke Sakai, Yutaka Suzuki, Hitoshi Okamura, Wataru Iwasaki, Haruka Ozaki, Yoshitaka Fukada
    • Organizer
      XVI European Biological Rhythms Society Congress
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Roles of Ubiquitination of CRY protein by FBXL3 and FBXL212019

    • Author(s)
      Hikari Yoshitane, Kaori Nobe, Masaki Motomiya, Joe Takahashi, Yoshitaka Fukada
    • Organizer
      XVI European Biological Rhythms Society Congress
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Initial protein events commonly pivotal for various environments/stresses-triggered cellular clock synchronization2019

    • Author(s)
      TAMARU Teruya, KAWAMURA Genki, YOSHITANE Hikari, OZAWA Takeaki, FUKADA Yoshitaka, TAKAMATSU Ken
    • Organizer
      XVI European Biological Rhythms Society Congress
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Nardilysin is a critical component of the mammalian circadian negative feedback loop2019

    • Author(s)
      HIRAOKA Yoshinori, YOSHITANE Hikari, OHNO Mikiko, MORITA Yusuke, NUNOKAWA Rina, NISHI Kiyoto, KUME Noriaki, KIMURA Takeshi, FUKADA Yoshitaka, NISHI Eiichiro
    • Organizer
      XVI European Biological Rhythms Society Congress
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] MOCCS2: evaluating all DNA-binding sequences from ChIP-Seq data2019

    • Author(s)
      Yoshimasa Asano, Hikari Yoshitane, Seinosuke Sakai, Aya Sagami, Yutaka Suzuki, Hitoshi Okamura, Wataru Iwasaki, Haruka Ozaki and Yoshitaka Fukada
    • Organizer
      第8回生命医薬情報学連合大会(IIBM2019)
    • Related Report
      2019 Annual Research Report
  • [Presentation] Functional D-box sequences and their roles in the circadian clockwork2019

    • Author(s)
      浅野 吉政、 吉種 光、 佐上 彩、 酒井 誠之介、 鈴木 穣、 岡村 均、 尾崎 遼、 岩崎 渉、 深田 吉孝
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 浸透圧ストレスシグナリングによる概日時計の時刻制御2019

    • Author(s)
      吉種 光
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 概日時計におけるBmal1の転写リズムの生理的意義2019

    • Author(s)
      阿部 泰子、吉種 光、深田 吉孝
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 時計タンパク質DBPの転写活性を制御するRING型E3ユビキチンリガーゼ2019

    • Author(s)
      増田 周作、吉種 光、布川 莉奈、深田 吉孝
    • Organizer
      第92回日本生化学会大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 概日時計における Bmal1 の mRNA リズムの生理的意義2019

    • Author(s)
      阿部 泰子、吉種 光、古戎 道典、饗場 篤、深田 吉孝
    • Organizer
      第 26 回日本時間生物学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 環境ストレス適応の共通基盤となる細胞時計同期を司る初期シグナル2019

    • Author(s)
      田丸 輝也、吉種 光、河村 玄気、小澤 岳昌、深田 吉孝
    • Organizer
      第 26 回日本時間生物学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] マウス概日時計機構における PER2 Ser478 のリン酸化の役割2019

    • Author(s)
      増田 周作、Rajesh Narasimamurthy、吉種 光、深田 吉孝、David M. Virshup
    • Organizer
      第 26 回日本時間生物学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Functional D-box sequences reset the circadian clock and drive mRNA rhythms2019

    • Author(s)
      浅野 吉政、吉種 光、酒井 誠之助、佐上 彩、鈴木 穣、岡村 均、岩崎 渉、尾崎 遼、 深田 吉孝
    • Organizer
      第 26 回日本時間生物学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Roles of Ubiquitination of CRY protein by FBXL3 and FBXL212019

    • Author(s)
      Hikari Yoshitane, Kaori Nobe, Masaki Motomiya, Arisa Hirano, Kanae Yumimoto, Keiichi I. Nakayama, Joe Takahashi, Yoshitaka Fukada
    • Organizer
      第 26 回日本時間生物学会学術大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] In vivo role of the PER2 phosphoswitch in mammalian circadian clockwork2019

    • Author(s)
      Shusaku Masuda, Rajesh Narasimamurthy, Hikari Yoshitane, Yoshitaka Fukada, David M. Virshup
    • Organizer
      International Conference on Mathematical Modeling and Applications 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Functional D-box sequences and their roles in the circadian clockwork2019

    • Author(s)
      Yoshimasa Asano, Hikari Yoshitane, Aya Sagami, Seinosuke Sakai, Yutaka Suzuki, Hitoshi Okamura, Haruka Ozaki, Wataru Iwasaki, Yoshitaka Fukada
    • Organizer
      International Conference on Mathematical Modeling and Applications 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Physiological Roles of Bmal1 Expression Rhythm in the Circadian Clock Oscillation2019

    • Author(s)
      Yasuko O. Abe, Hikari Yoshitane, Michinori Koebisu, Atsu Aiba and Yoshitaka Fukada
    • Organizer
      International Conference on Mathematical Modeling and Applications 2019
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 研究室HP

    • URL

      https://www.igakuken.or.jp/circadian/index.html

    • Related Report
      2022 Annual Research Report

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Published: 2019-04-18   Modified: 2024-01-30  

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