| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2022: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2021: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2020: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2019: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000)
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| Outline of Final Research Achievements |
In this study, human A2A adenosine receptor (A2AR), a G protein-coupled receptor activated by adenosine, was elucidated as the research target. We investigated the differences in dynamics upon various ligand binding and developed computational methods to predict binding affinity. We also performed state-of-the-art molecular simulations of the activated state of the A2AR bound by a ligand (NECA) and full G proteins consisting of three subunits (Gs and Go) and were able to determine dynamics differences.
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