| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2023: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2022: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2021: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2020: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2019: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
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| Outline of Final Research Achievements |
Multicellular organisms have an ability to maintain and regenerate their body parts over long periods of time, but many aspects of this mechanism remain unknown. In this study, using the zebrafish caudal fin model, we performed an analysis focusing on the important steps of tissue regeneration processes, and obtained the following results. (1) PI3 kinase signaling is required for macrophage recruitment in the injury response. (2) For transcriptional response of genes, signals via two transcription factor binding sites are simultaneously activated. (3) Mesenchymal cells, which produce and regenerate bone and cartilage, take different lineages during development and maintain throughout life. (4) Self-renewal of skin basal stem cells and keratinocyte differentiation are induced by injury to basal cells and keratinocytes, respectively. The above results greatly contributed to the understanding of the regeneration process.
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