| Budget Amount *help |
¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
Fiscal Year 2022: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2021: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2019: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
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| Outline of Final Research Achievements |
This study aimed to comprehend the molecular mechanisms of how the various metamorphic events are coordinated in a single body of the ascidian Ciona. Ciona metamorphosis is initiated by the neurotransmitter GABA. GABA signaling uses G-proteins as the downstream factor and induces cAMP accumulation for starting metamorphosis. Ciona larvae sense the mechanical stimulus generated by adhesion for starting metamorphosis. We characterized the TRP channel gene for this sensing. GnRH is involved in initiating metamorphic events such as tail regression. D-serine is a signaling molecule downstream of the neuropeptide signaling. During metamorphosis, Ciona develops adult organs through cell proliferation. TPO, the enzyme synthesizing thyroid hormone in vertebrates, is responsible for this process. TPO is expressed in the mesenchyme in addition to the thyroid gland homologous organ. Both organs regulate cell proliferation during metamorphosis, suggesting the role of TPO in non-thyroid organs.
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