| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2022: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2021: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2020: ¥2,470,000 (Direct Cost: ¥1,900,000、Indirect Cost: ¥570,000)
Fiscal Year 2019: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
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| Outline of Final Research Achievements |
Clock neurons, the cells of the circadian clock that control behavioral rhythms such as sleep-wake cycles, are specific neurons located in the brain. In Drosophila melanogaster, the model organism of chronobiology, approximately 150 brain neurons have been identified as clock neurons. In this study, we have screened and identified clock neuron specific GAL4 lines that enable to manipulate those neurons for their functional analysis. Here, more than 70 new transgenic fly lines were identified or generated, and functional analysis of specific clock neurons was conducted through several international collaborations. Our study has contributed to the elucidation of the neural network of the circadian clock.
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