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Variations in the systemic coordination of human cold adaptability and effects of exercise habits

Research Project

Project/Area Number 19H03314
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 45060:Applied anthropology-related
Research InstitutionHokkaido University

Principal Investigator

Wakabayashi Hitoshi  北海道大学, 工学研究院, 准教授 (50452793)

Co-Investigator(Kenkyū-buntansha) 後藤 一成  立命館大学, スポーツ健康科学部, 教授 (60508258)
二連木 晋輔  独立行政法人国立病院機構(京都医療センター臨床研究センター), 臨床研究企画運営部, 研究員 (70741156)
斉藤 昌之  北海道大学, 獣医学研究院, 名誉教授 (80036441)
Project Period (FY) 2019-04-01 – 2023-03-31
Project Status Completed (Fiscal Year 2023)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2022: ¥1,430,000 (Direct Cost: ¥1,100,000、Indirect Cost: ¥330,000)
Fiscal Year 2021: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2020: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2019: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Keywords褐色脂肪組織 / 骨格筋 / 非震え代謝 / 震え代謝 / 寒冷適応能 / 褐色脂肪 / 寒冷適応 / 個人差 / 運動トレーニング / 主観的寒冷耐性 / 皮膚血管収縮 / 皮膚温度感受性
Outline of Research at the Start

ヒト成人の褐色脂肪組織(BAT)の活性が再検証されて以来,非震え代謝亢進に注目した研究が盛んに行われている.一方で,BATの限局性を考慮すると,骨格筋の代謝貢献,非震え代謝と震え代謝の相互補償作用や皮膚血管収縮による放熱抑制との全身的協関によって深部体温の恒常性を維持していると考えられる.
本研究では,BAT陽性者と陰性者の混在する日本人集団を対象に,体温調節機能の寒冷適応現象に見られる多様性を全身的協関の観点から検証する.さらに,寒冷環境および運動習慣が体温調節機能の適応に及ぼす相乗効果について検証する.

Outline of Final Research Achievements

This study aimed to comprehensively examine the physiological variation observed in human thermoregulatory function in cold environments from the perspective of systemic cooperation, and to examine the effects of cold exposure and exercise habits on the adaptation of thermoregulatory function. The thermoregulatory response was evaluated mainly through a mild cold exposure test in a climatic chamber. The results of this study showed that individuals with higher brown adipose tissue activity had higher non-shivering thermogenesis and also delayed the onset of shivering when the environmental temperature was lowered. These results suggested a mutually complementary functional coordination between non-shivering thermogenesis by brown fat and shivering thermogenesis by skeletal muscle, which is an interesting finding for explaining human body temperature regulation from the perspective of systemic coordination.

Academic Significance and Societal Importance of the Research Achievements

近年、栄養学や健康科学の分野で行われる褐色脂肪研究が主に軽度寒冷曝露時の非震え代謝を評価しているのに対して、ヒトの体温調節機能を総合的に検討する上では、震え代謝の評価が欠かせなかった。また、ヒトの寒冷適応研究において、褐色脂肪による産熱亢進に関する知見は十分でなく、従来の震え産熱との関係性を示す必要があった。本研究において、特に褐色脂肪組織の活性に応じた非震え代謝応答と骨格筋を発現組織とする震え代謝応答の相互補完的機能協調作用が示されたことは、全身的協関の観点からヒトの体温調節機能の寒冷適応能を説明する上で興味深い知見となった。

Report

(5 results)
  • 2023 Final Research Report ( PDF )
  • 2022 Annual Research Report
  • 2021 Annual Research Report
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (13 results)

All 2024 2022 2021 2020 2019

All Journal Article (2 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 2 results,  Open Access: 2 results) Presentation (9 results) (of which Int'l Joint Research: 4 results,  Invited: 3 results) Book (2 results)

  • [Journal Article] HUMAN BROWN ADIPOSE TISSUE AS A REGULATOR OF SYSTEMIC METABOLISM2022

    • Author(s)
      斉藤昌之、若林斉
    • Journal Title

      Japanese Journal of Physiological Anthropology

      Volume: 27 Issue: 2 Pages: 27-37

    • DOI

      10.20718/jjpa.27.2_27

    • ISSN
      1342-3215, 2432-0986
    • Year and Date
      2022-05-25
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multiorgan contribution to non-shivering and shivering thermogenesis and vascular responses during gradual cold exposure in humans2020

    • Author(s)
      Wakabayashi Hitoshi、Matsumoto Kentaro、Kobori Yusuke、Ebara Tasuku、Matsushita Mami、Kameya Toshimitsu、Maeda Takafumi、Saito Masayuki
    • Journal Title

      European Journal of Applied Physiology

      Volume: 120 Issue: 12 Pages: 2737-2747

    • DOI

      10.1007/s00421-020-04496-1

    • NAID

      120007173919

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] Physiological adaptation to the cold environment2022

    • Author(s)
      Hitoshi Wakabayashi
    • Organizer
      The 2nd International Mini-Symposium on Environmental Ergonomics and Physiological Anthropology in the Thermal Environment
    • Related Report
      2022 Annual Research Report 2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Relationship between human brown adipose tissue activity and thermogenesis induced by menthol skin application2022

    • Author(s)
      Tomomi Fujimoto, Aiko Miura, Juno Kita, Mami Matsushita, Takafumi Maeda, Toshimitsu Kameya, Masayuki Saito, Hitoshi Wakabayashi.
    • Organizer
      International Conference on Environmental Ergonomics
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 主観的寒冷耐性の個人差と解剖学的特性の関係2022

    • Author(s)
      渡邊優,若林斉,亀谷俊満,松下真美,米代武司,斉藤昌之.
    • Organizer
      第24回日本体力医学会北海道地方会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 温熱的中立環境におけるメンソール溶液塗布による代謝亢進と褐色脂肪組織活性の関係2021

    • Author(s)
      若林斉,三浦愛子,北樹乃,藤本知臣,前田享史,亀谷俊満,松下真美,斉藤昌之.
    • Organizer
      第76回日本体力医学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Variation in human brown adipose tissue activity and cold-induced thermogenesis2021

    • Author(s)
      Hitoshi Wakabayashi
    • Organizer
      Virtual Environmental Ergonomics
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Innovation of healthy mild cold environment for sedentary workers2019

    • Author(s)
      Hitoshi Wakabayashi
    • Organizer
      14th International Congress of Physiological Anthropology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Verification of tissue temperature in supraclavicular fossa for evaluating brown adipose tissue activity2019

    • Author(s)
      Yusuke Kobori, Kentaro Matsumoto, Hitoshi Wakabayashi, Mami Matsushita, Toshimitsu Kameya, Takafumi Maeda, Masayuki Saito.
    • Organizer
      14th International Congress of Physiological Anthropology
    • Related Report
      2019 Annual Research Report
  • [Presentation] Multiple organs coordination for non-shivering and shivering thermogenesis and vasomotor control in cold environment2019

    • Author(s)
      Kentaro Matsumoto, Yusuke Kobori, Hitoshi Wakabayashi, Toshimitsu Kameya, Mami Matsushita, Takafumi Maeda, Masayuki Saito.
    • Organizer
      14th International Congress of Physiological Anthropology
    • Related Report
      2019 Annual Research Report
  • [Presentation] Human brown adipose tissue and skeletal muscle contribution for resting, non-shivering and shivering thermogenesis during gradual cold exposure2019

    • Author(s)
      Hitoshi Wakabayashi, Kentaro Matsumoto, Yusuke Kobori, Mami Matsushita, Toshimitsu Kameya, Takafumi Maeda, Masayuki Saito.
    • Organizer
      18th International Conference on Environmental Ergonomics
    • Related Report
      2019 Annual Research Report
  • [Book] 褐色脂肪組織の研究動向と応用, 第1章 褐色脂肪組織の熱産生と健康, 褐色脂肪組織と骨格筋の機能協調による体温調節,2024

    • Author(s)
      若林斉
    • Publisher
      シーエムシー出版
    • Related Report
      2022 Annual Research Report
  • [Book] The Thermal Environment: From Viewpoints of Physiological Anthropology and Environmental Ergonomics, Yutaka Tochihara (ed), Chapter 5 Physiological Responses and Performance in the Cold Environment2024

    • Author(s)
      Hitoshi Wakabayashi
    • Publisher
      Springer Nature
    • Related Report
      2022 Annual Research Report

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Published: 2019-04-18   Modified: 2025-01-30  

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