| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2022: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2021: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2020: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2019: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
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| Outline of Final Research Achievements |
Animals store various pieces of sensory information as memories, but they adapt to rapidly changing environments by actively forgetting some of those memories. We are studying the mechanism of active forgetting using the nematode C. elegans. In this study, we have revealed that forgetting is controlled by functionally changing the neural circuits after learning. Furthermore, we have demonstrated that memories can become unrecallable even if they exist in the nerve cells, through diacylglycerol. We have also revealed that the recall of these memories is regulated through neural circuits. These findings are crucial for unraveling the mechanisms of active forgetting in higher animals.
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