| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2022: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2021: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥3,900,000 (Direct Cost: ¥3,000,000、Indirect Cost: ¥900,000)
Fiscal Year 2019: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
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| Outline of Final Research Achievements |
Sensory neurons are responsible for tactile perception. But other than the PIEZO1 receptor, the molecular mechanism of tactile perception in vivo remains largely unclear. In this study, we employed zebrafish sensory motor system into tactile research and utilized zebrafish mutants with abnormal tactile sensation. We identified a number of genes required for tactile perception and clarified their roles in tactile reception. For example, we found that PIGK, one of the subunits of GPI transamidase enzyme, which is required for the biosynthesis of GPI-anchored proteins, contributes to tactile perception by regulating the axonal localization of voltage-gated sodium channels in primary sensory neurons. We also found that a variant of the PIGK gene caused neurodevelopmental disorders in humans.
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