| Budget Amount *help |
¥17,290,000 (Direct Cost: ¥13,300,000、Indirect Cost: ¥3,990,000)
Fiscal Year 2022: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2021: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2020: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2019: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
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| Outline of Final Research Achievements |
We developed correlated light and electron microscopy (CLEM) with combination of in vivo imaging using two photon microscopy and large volume electron microscopy using automated tape collecting ultramicrotome (ATUM) to analyze the cortical neural microcircuit changes that occured in the M1 cortex for seed reaching task motor learning task using with forelimb. During the learning task, we observed that the secondary motor cortex (M2) → M1 neural pathway plays an important role in “motor learning” while the acquired “motor memory” is transferred to the thalamus → M1 neural pathway, indicating that neural circuit remodeling has been occurred in M1 cortex. We concluded that “synaptic connections for learning” helps in formation and maturation of “synaptic connections for memory” for the skill learning.
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