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Plastic mechanisms of functional domains in the mouse brain that underlie odor-guided motivation behaviors

Research Project

Project/Area Number 19H03341
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 46030:Function of nervous system-related
Research InstitutionKochi University

Principal Investigator

Yamaguchi Masahiro  高知大学, 教育研究部医療学系基礎医学部門, 教授 (60313102)

Co-Investigator(Kenkyū-buntansha) 谷口 睦男  高知大学, 教育研究部医療学系基礎医学部門, 准教授 (10304677)
村田 芳博  高知大学, 教育研究部医療学系基礎医学部門, 助教 (40377031)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥16,640,000 (Direct Cost: ¥12,800,000、Indirect Cost: ¥3,840,000)
Fiscal Year 2021: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywords嗅覚 / モチベーション / 行動学習 / シナプス可塑性 / 神経調節因子 / 連合学習 / 嗅結節 / 局所電場電位 / モチベーション行動 / シナプス入力
Outline of Research at the Start

研究代表者は、マウスの「嗅結節」に匂い学習による誘引行動の際に活性化するドメインと、忌避行動の際に活性化するドメインが個別に存在することを明らかにした。この機能ドメイン活性化機構を明らかにするためには、学習によって強化されるシナプス入力を同定し、シナプス強化に関わる神経調節機構を解明する必要がある。本研究では、食べ物の匂いに対する誘引行動学習を題材に、匂いが特定の嗅結節機能ドメインの活性化をひきおこす神経分子機構を、「強化されるシナプス入力」の同定および「神経調節因子」の役割から解明する。本研究の成果は、嗅覚の関与が想定される摂食異常などの病態の理解と治療法の開発に資することが期待される。

Outline of Final Research Achievements

Odor information can be linked to attractive or aversive behavior based on the odor experience and learning processes. However, plastic mechanisms of olfactory neural circuit for this odor learning is not well understood. We have recently revealed specific olfactory regions of mouse brain which participate in the attractive or aversive odor learning. Here we have discovered that synaptic inputs to the specific regions are plastically modulated in a region-specific manner depending on the odor learning, and that neuromodulators act on the regions and regulate odor behaviors. These results will facilitate the understanding of basic mechanisms of learning-dependent synaptic plasticity and contribute to our healthful life by appropriately utilizing and controlling our odor experience and learning.

Academic Significance and Societal Importance of the Research Achievements

嗅覚は生物の生命維持や種の繁栄に関わる極めて重要な感覚であり、私たちの記憶や感情にも直結している。本研究によって、嗅覚行動が経験・学習によって変化し、また様々な調節因子によって調節される神経機構を明らかにすることは、行動制御の神経機構の基礎的理解を深め、更には私たちの匂い記憶や匂いの感情を適切に扱うことにより、心身ともに健康な生活を送ることに貢献できると考えられる。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (52 results)

All 2022 2021 2020 2019

All Journal Article (5 results) (of which Int'l Joint Research: 2 results,  Peer Reviewed: 5 results,  Open Access: 5 results) Presentation (45 results) (of which Int'l Joint Research: 4 results) Book (2 results)

  • [Journal Article] Dysfunction of the proteoglycan Tsukushi causes hydrocephalus through altered neurogenesis in the subventricular zone in mice2021

    • Author(s)
      Ito Naofumi、(24/28)
    • Journal Title

      Science Translational Medicine

      Volume: 13 Issue: 587 Pages: 7896-7896

    • DOI

      10.1126/scitranslmed.aay7896

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Expression of feeding-related neuromodulatory signalling molecules in the mouse central olfactory system.2020

    • Author(s)
      Nogi Y, Ahasan MM, Murata Y, Taniguchi M, Sha MFR, Ijichi C and Yamaguchi M
    • Journal Title

      Scientific reports

      Volume: 10 Issue: 1

    • DOI

      10.1038/s41598-020-57605-7

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Olfactory Stimulation with Japanese Soy Sauce Improves Upper Limb Performance.2019

    • Author(s)
      Yano Y, Murata Y, Taniguchi M, Okutani F, Yamaguchi M, and Kaba H
    • Journal Title

      Occupational Therapy International

      Volume: 2019 Pages: 1-4

    • DOI

      10.1155/2019/2748721

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] GABAergic neurons in the olfactory cortex projecting to the lateral hypothalamus in mice2019

    • Author(s)
      Murata K, Kinoshita T, Fukazawa Y, Kobayashi K, Kobayashi K, Miyamichi K, Okuno H, Bito H, Sakurai Y, Yamaguchi M, Mori K, Manabe H
    • Journal Title

      Sci Rep

      Volume: 9 Issue: 1 Pages: 7132-7132

    • DOI

      10.1038/s41598-019-43580-1

    • NAID

      120006862679

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Opposing roles of dopamine receptor D1- and D2-expressing neurons of the anteromedial olfactory tubercle in acquisition of place preference2019

    • Author(s)
      Koshi Murata, Tomoki Kinoshita, Yugo Fukazawa, Kenta Kobayashi, Akihiro Yamanaka, Takatoshi Hikida, Hiroyuki Manabe, and Masahiro Yamaguchi
    • Journal Title

      Frontiers in Behavioral Neuroscience

      Volume: 13 Pages: 50-50

    • DOI

      10.3389/fnbeh.2019.00050

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Presentation] 経験によって匂いの好き嫌いを学習するマウスの嗅覚神経機構2022

    • Author(s)
      山口正洋
    • Organizer
      第95回日本薬理学会年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] The role of appetite-stimulating signaling molecules in the olfactory cortical region in the odor-induced feeding behavior in mice2022

    • Author(s)
      Md Monjurul Ahasan, Yoshihiro Murata, Mutsuo Taniguchi, Masahiro Yamaguchi
    • Organizer
      第99回日本生理学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Olfactory learning-dependent plasticity of neuronal connection from piriform cortex to olfactory tubercle in mice2022

    • Author(s)
      Md Fazley Rabbi Sha, Yuriko Koga, Yoshihiro Murata, Mutsuo Taniguchi, Masahiro Yamaguchi
    • Organizer
      第99回日本生理学会大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 嗅球新生ニューロンのシナプス選別を制御するシナプス入力機構2022

    • Author(s)
      山口正洋、横井和子、新沼真洋
    • Organizer
      第18回成体脳ニューロン新生懇談会
    • Related Report
      2021 Annual Research Report
  • [Presentation] The role of appetite-stimulating signaling molecules in the olfactory behavior in mice.2021

    • Author(s)
      Md Monjurul Ahasan, Yoshihiro Murata, Mutsuo Taniguchi, Masahiro Yamaguchi
    • Organizer
      第44回日本神経科学大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Activation mechanism of the olfactory tubercle in the odor-guided attractive behavior learning in mice.2021

    • Author(s)
      Md Fazley Rabbi Sha, Yuriko Koga, Yoshihiro Murata, Mutsuo Taniguchi, Masahiro Yamaguchi
    • Organizer
      第44回日本神経科学大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Vasopressin suppresses the GABAergic transmission in the mouse accessory olfactory bulb through inhibition of voltage-activated Ca2+ conductance on the granule cells.2021

    • Author(s)
      谷口睦男, 村田芳博, 山口正洋, 椛秀人
    • Organizer
      第44回日本神経科学大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 匂いに対する誘引行動の代謝シグナルによる調節機構2021

    • Author(s)
      モハメッド・モンジュルル・アハサン, 村田芳博, 谷口睦男, 山口正洋
    • Organizer
      第6回食欲・食嗜好研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 匂いの行動学習を担う嗅皮質の神経回路可塑性機構2021

    • Author(s)
      モハメッド・ファズレイ・ラッビ・シャ, 古賀有里子, 村田芳博, 谷口睦男, 山口正洋
    • Organizer
      第6回食欲・食嗜好研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 本学医学科学生の辛味検知閾値と受容体遺伝子多型2021

    • Author(s)
      村田芳博, 柴野究, 山口正洋, 奥谷文乃
    • Organizer
      第6回食欲・食嗜好研究会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Control of reciprocal synaptic transmission by vasopressin V1a receptors in the mouse accessory olfactory bulb: modulation of voltage-activated Ca2+ currents in the granule cells.2021

    • Author(s)
      谷口睦男, 村田芳博, 山口正洋, 椛秀人
    • Organizer
      日本味と匂学会第55回大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Taste strips法を用いた辛味の検知閾値測定:本学医学生を対象とした一例2021

    • Author(s)
      村田芳博, 柴野究, 山口正洋, 奥谷文乃
    • Organizer
      日本味と匂学会第55回大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] The role of appetite-regulating signals in the olfactory cortical region in odor-guided feeding behavior in mice.2021

    • Author(s)
      Md Monjurul Ahasan, Yoshihiro Murata, Mutsuo Taniguchi, Masahiro Yamaguchi
    • Organizer
      日本味と匂学会第55回大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Olfactory learning-dependent plasticity of neuronal connection from piriform cortex to olfactory tubercle in mice.2021

    • Author(s)
      Md Fazley Rabbi Sha, Yuriko Koga, Yoshihiro Murata, Mutsuo Taniguchi, Masahiro Yamaguchi
    • Organizer
      日本味と匂学会第55回大会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Role of appetite-regulating molecules in the olfactory cortical region in the odor-induced feeding behavior in mice.2021

    • Author(s)
      Md Monjurul Ahasan, Yoshihiro Murata, Mutsuo Taniguchi, Masahiro Yamaguchi
    • Organizer
      第73回日本生理学会中国四国地方会
    • Related Report
      2021 Annual Research Report
  • [Presentation] Olfactory learning-dependent plasticity of neuronal connection from piriform cortex to olfactory tubercle in mice.2021

    • Author(s)
      Md Fazley Rabbi Sha, Yuriko Koga, Yoshihiro Murata, Mutsuo Taniguchi, Masahiro Yamaguchi
    • Organizer
      第73回日本生理学会中国四国地方会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 食行動における嗅覚と代謝シグナルの協調機構2021

    • Author(s)
      山口正洋
    • Organizer
      第7回ケモビ研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] マウス副嗅球相反性シナプス伝達におけるバソプレシンV1a受容体の役割2021

    • Author(s)
      谷口睦男
    • Organizer
      第7回ケモビ研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 母親を通してのみ受け継がれるミトコンドリアペプチドが系統特異的化学感覚シグナルとして機能する2021

    • Author(s)
      藤田博子、村田芳博、谷口睦男、山口正洋、椛秀人
    • Organizer
      第7回ケモビ研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Suppression of the GABAergic transmission in the mouse accessory olfactory bulb by the vasopressin receptor through inhibition of voltage-activated Ca currents2021

    • Author(s)
      谷口睦男、村田芳博、山口正洋、椛秀人
    • Organizer
      第98回日本生理学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 匂い学習による嗅球新生ニューロンの組み込み制御機構2021

    • Author(s)
      山口正洋
    • Organizer
      第98回日本生理学会大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Role of feeding-related neuromodulatory signal molecules in the olfactory appetitive behavior in mice.2020

    • Author(s)
      Ahasan MM, Murata Y, Taniguchi M, Yamaguchi M.
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] A role for vasopressin in dendrodendritic inhibition in the mouse accessory olfactory bulb: effects on the voltage-activated Ca currents recorded from granule cells.2020

    • Author(s)
      谷口睦男、村田芳博、山口正洋、椛秀人
    • Organizer
      第43回日本神経科学大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Detection thresholds to capsaicin and genotyping analysis of receptor gene in humans.2020

    • Author(s)
      Murata Y, Shibano K, Yamaguchi M, Okutani F.
    • Organizer
      The 18th International Symposium on Olfaction and Taste
    • Related Report
      2020 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 匂いに基づく摂食行動の神経調節性シグナルによる調節機構2020

    • Author(s)
      モハメッド・モンジュルル・アハサン、村田芳博、谷口睦男、山口正洋
    • Organizer
      第5回食欲・食嗜好の分子・神経基盤研究会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 匂いの行動学習に関わる嗅球-嗅皮質の可塑性機構2020

    • Author(s)
      山口正洋
    • Organizer
      日本味と匂学会第54回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Role of neuromodulatory signals in the odor-guided feeding behavior in mice.2020

    • Author(s)
      Ahasan MM, Murata Y, Taniguchi M, Yamaguchi M.
    • Organizer
      日本味と匂学会第54回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 神経性食思不振症モデルマウスの行動と脳活動性の解析2020

    • Author(s)
      西山典寛、山口正洋
    • Organizer
      日本味と匂学会第54回大会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 化学感覚情報処理におけるバソプレシンの作用---- V1a受容体を介したマウス副嗅球相反性シナプス電流に対する抑制効果2020

    • Author(s)
      谷口睦男、村田芳博、山口正洋、椛秀人
    • Organizer
      第72回日本生理学会中国四国地方会
    • Related Report
      2020 Annual Research Report
  • [Presentation] The role of appetite-stimulating signaling molecules in the anteromedial olfactory tubercle in the odor-induced feeding behavior in mice.2020

    • Author(s)
      Ahasan MM, Murata Y, Taniguchi M, Yamaguchi M.
    • Organizer
      第72回日本生理学会中国四国地方会
    • Related Report
      2020 Annual Research Report
  • [Presentation] フェロモン情報処理におけるバソプレシンの役割…V1a受容体を介したマウス副嗅球樹状突起間抑制性シナプス伝達における抑制作用2020

    • Author(s)
      谷口睦男、村田芳博、山口正洋、椛秀人
    • Organizer
      第20回KMS research meeting
    • Related Report
      2020 Annual Research Report
  • [Presentation] A role for vasopressin in reciprocal current in the mouse accessory olfactory bulb: effects on the granule-to-mitral dendrodendritic GABAergic transmission.2019

    • Author(s)
      谷口睦男、村田芳博、山口正洋、椛秀人
    • Organizer
      第42回日本神経科学大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 食行動を誘導する匂いは上肢運動機能を変化させる2019

    • Author(s)
      箭野豊、山本学、門田真治、椛秀人、宮田剛、山口正洋
    • Organizer
      第4回食欲・食嗜好の分子・神経基盤研究会
    • Related Report
      2019 Annual Research Report
  • [Presentation] マウス新生仔の離乳行動における嗅結節の役割2019

    • Author(s)
      山口正洋、築田靖崇
    • Organizer
      日本味と匂学会第53回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] マウス副嗅球樹状突起間抑制性シナプス伝達のバゾプレッシンによる制御: GABAに対する僧帽細胞応答の修飾2019

    • Author(s)
      谷口睦男、村田芳博、山口正洋、椛秀人
    • Organizer
      日本味と匂学会第53回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Expression of feeding-related neuromodulatory signaling molecules in the central olfactory system of mice2019

    • Author(s)
      Ahasan MM, Nogi Y, Murata Y, Taniguchi M, Ijichi C, Yamaguchi M
    • Organizer
      日本味と匂学会第53回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 上肢運動機能向上を目的とした食べ物の匂いの効果2019

    • Author(s)
      箭野豊、村田芳博、谷口睦男、奥谷文乃、椛秀人、宮田剛、山口正洋
    • Organizer
      日本味と匂学会第53回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 匂いによる誘引行動学習に関わる嗅結節の活性化メカニズムの検討2019

    • Author(s)
      古賀有里子、横井和子、山口正洋
    • Organizer
      日本味と匂学会第53回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 本学医学生の口腔内カプサイシン閾値と辛味受容体遺伝子の多型解析2019

    • Author(s)
      柴野究、村田芳博、山口正洋、奥谷文乃
    • Organizer
      日本味と匂学会第53回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 神経性食思不振症モデルマウスの行動と脳活動性の解析2019

    • Author(s)
      西山典寛、宮本和泉、山口正洋
    • Organizer
      日本味と匂学会第53回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 嗅球新生ニューロンの組み込みに関わるシナプス入力の検討2019

    • Author(s)
      横井和子、古賀有里子、山口正洋
    • Organizer
      日本味と匂学会第53回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Oral capsaicin thresholds and genotyping analyses of capsaicin receptor gene TRPV1 in humans2019

    • Author(s)
      Murata Y, Shibano K, Yamaguchi M, Okutani F
    • Organizer
      日本比較生理生化学会第41回大会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Pheromonal memory for sustaining pregnancy in the female mouse2019

    • Author(s)
      Murata Y, Taniguchi M, Ota E, Yamaguchi M, Kaba H
    • Organizer
      he 10th International Congress of Comparative Physiology and Biochemistry (ICCPB2019)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Feeding-related neuromodulator expression and the role of appetite regulating signals on olfactory feeding behavior in mice2019

    • Author(s)
      Ahasan MM, Nogi Y, Murata Y, Taniguchi M, Ijichi C, Yamaguchi M
    • Organizer
      The 18th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Pereception (ISMNTOP)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Role of olfactory tubercle in the weaning process of neonatal mice2019

    • Author(s)
      Yamaguchi M, Chikuda Y
    • Organizer
      The 18th International Symposium on Molecular and Neural Mechanisms of Taste and Olfactory Pereception (ISMNTOP)
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Book] 食と嗅覚:食べ物の匂いの検知から食行動まで 実験医学特集号「食と栄養のサイエンス」2021

    • Author(s)
      山口正洋
    • Total Pages
      12
    • Publisher
      羊土社
    • Related Report
      2020 Annual Research Report
  • [Book] 匂い・フェロモンの受容と嗅覚行動の神経機構2021

    • Author(s)
      山口正洋
    • Total Pages
      5
    • Publisher
      ファルマシア
    • Related Report
      2020 Annual Research Report

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Published: 2019-04-18   Modified: 2023-01-30  

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