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Functional coordination within social brain networks for processing others' actions

Research Project

Project/Area Number 19H03344
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 46030:Function of nervous system-related
Research InstitutionNational Institute for Physiological Sciences

Principal Investigator

Isoda Masaki  生理学研究所, システム脳科学研究領域, 教授 (90466029)

Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2021: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2020: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2019: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywords社会脳 / 他者 / 自己 / 動作
Outline of Research at the Start

自己を他者とつなぐ脳の高次機能である社会的認知機能は、どの脳領域および脳領域を結ぶ神経路の、どのような仕組みによって実現されるのであろうか。本研究では、社会的認知機能として重要な「他者の動作情報処理」に焦点を絞り、その機能を担うと考えられてきた2つの神経システムの機能連関の解明を目指す。対面する2頭の実験動物が互いに相手の動作情報を参照し、それに基づいて自己の行動を決定する際の神経活動を計測して解析するとともに、ウイルスベクターを用いた神経路選択的な活動操作をおこなって、2つの神経システム間の機能連関を因果的に検証する。

Outline of Final Research Achievements

The actions of others provide an important window into their unobservable states of minds. To investigate the neural mechanisms underlying the monitoring of others’ actions, we performed neurophysiological experiments using macaques. We found that the ventral premotor cortex (PMv) and the medial prefrontal cortex (MPFC) contain neurons that fired in response to others’ actions. Analysis of local field potentials that were recorded simultaneously from the two regions revealed increased coherence during others’ actions. Furthermore, selective blockade of the PMv-to-MPFC pathway impaired the monitoring of others’ actions and the selection of one’s own actions. Thus, functional coordination between the PMv and MPFC plays a critical role in social action monitoring and decision making.

Academic Significance and Societal Importance of the Research Achievements

自閉スペクトラム症などの神経発達障害では、他者の動作への関心が低下したり、他者の心を推測することが困難となったりすることが報告されている。さらに、同症では腹側運動前野や内側前頭前野の応答が、定型発達者とは異なることも報告されている。本研究の成果は、自閉スペクトラム症の脳特性の理解において重要な知見を提供する。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (32 results)

All 2021 2020 2019

All Journal Article (12 results) (of which Int'l Joint Research: 1 results,  Peer Reviewed: 7 results,  Open Access: 6 results) Presentation (20 results) (of which Int'l Joint Research: 7 results,  Invited: 8 results)

  • [Journal Article] 社会的文脈での意思決定とその神経機構2021

    • Author(s)
      磯田昌岐
    • Journal Title

      Clinical Neuroscience

      Volume: 39 Pages: 943-946

    • Related Report
      2021 Annual Research Report
  • [Journal Article] The role of the medial prefrontal cortex in moderating neural representations of self and other in primates2021

    • Author(s)
      Isoda M
    • Journal Title

      Annual Review of Neuroscience

      Volume: 44 Issue: 1 Pages: 295-313

    • DOI

      10.1146/annurev-neuro-101420-011820

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Live agent preference and social action monitoring in the macaque mid-superior temporal sulcus region2021

    • Author(s)
      Ninomiya T, Noritake A, Isoda M
    • Journal Title

      Proceedings of the National Academy of Sciences of the United States of America

      Volume: 118(44) Issue: 44

    • DOI

      10.1073/pnas.2109653118

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] 意思決定と行動選択-Overview2021

    • Author(s)
      伊佐正、磯田昌岐、南本敬史
    • Journal Title

      Clinical Neuroscience

      Volume: 39 Pages: 934-936

    • Related Report
      2021 Annual Research Report
  • [Journal Article] 自閉症スペクトラム症の霊長類モデル2021

    • Author(s)
      磯田昌岐
    • Journal Title

      Clinical Neuroscience

      Volume: 40 Pages: 345-349

    • Related Report
      2021 Annual Research Report
  • [Journal Article] Subcortical encoding of agent-relevant associative signals for adaptive social behavior in the macaque2021

    • Author(s)
      Noritake A, Ninomiya T, Isoda M
    • Journal Title

      Neurosci Biobehav Rev

      Volume: 125 Pages: 78-87

    • DOI

      10.1016/j.neubiorev.2021.02.018

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] A causal role for frontal cortico-cortical coordination in social action monitoring2020

    • Author(s)
      Ninomiya T, Noritake A, Kinoshita K, Isoda M
    • Journal Title

      Nat Commun

      Volume: 11 Issue: 1 Pages: 5233-5233

    • DOI

      10.1038/s41467-020-19026-y

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Socially relative reward valutaion in the primate brain2020

    • Author(s)
      Isoda M
    • Journal Title

      Curr Opin Neurobiol

      Volume: 68 Pages: 15-12

    • DOI

      10.1016/j.conb.2020.11.008

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Representation of distinct reward variables for self and other in primate lateral hypothalamus.2020

    • Author(s)
      Noritake A, Ninomiya T, Isoda M.
    • Journal Title

      Proc Natl Acad Sci U S A.

      Volume: 117(10) Issue: 10 Pages: 5516-5524

    • DOI

      10.1073/pnas.1917156117

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Multiple neuronal circuits for variable object?action choices based on short- and long-term memories2019

    • Author(s)
      Hikosaka Okihide、Yasuda Masaharu、Nakamura Kae、Isoda Masaki、Kim Hyoung F.、Terao Yasuo、Amita Hidetoshi、Maeda Kazutaka
    • Journal Title

      Proceedings of the National Academy of Sciences

      Volume: 116 Issue: 52 Pages: 26313-26320

    • DOI

      10.1073/pnas.1902283116

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] 社会行動2019

    • Author(s)
      植松明子、二宮太平、磯田昌岐
    • Journal Title

      Clinical Neuroscience

      Volume: 38(2) Pages: 161-164

    • Related Report
      2019 Annual Research Report
  • [Journal Article] 他者の報酬が気になる神経機構2019

    • Author(s)
      則武厚、二宮太平、磯田昌岐
    • Journal Title

      Clinical Neuroscience

      Volume: 38(2) Pages: 378-380

    • Related Report
      2019 Annual Research Report
  • [Presentation] Roles for medial prefrontal cortex and dopaminergic midbrain nuclei in social reward monitoring and valuation2021

    • Author(s)
      Isoda M
    • Organizer
      Special symposium of Experimental Psychology Society
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] 社会的意思決定の神経基盤:自閉的行動との関わり2021

    • Author(s)
      磯田昌岐
    • Organizer
      第44回日本神経科学大会
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] 社会的コンテキストにおけるマカクザルの運動リズム同調2021

    • Author(s)
      戸松彩花、磯田昌岐
    • Organizer
      第44回日本神経科学大会
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Action and reward in the primate social brain2021

    • Author(s)
      Isoda M
    • Organizer
      JANUBET Primate Neurobiology School
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] 顔の本物らしさと視線への扁桃体ニューロンの応答特性2021

    • Author(s)
      新居桂陽、二宮太平、磯田昌岐
    • Organizer
      第11回名古屋大学医学系研究科・生理学研究所合同シンポジウム
    • Related Report
      2021 Annual Research Report
  • [Presentation] Neurons in the macaque amygdala encode face animacy and self-relevant gaze shift2021

    • Author(s)
      Arai K, Isoda M, Ninomiya T
    • Organizer
      SfN2021
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neuronal responses to real and artificial faces in the macaque amygdala2021

    • Author(s)
      新居桂陽, 二宮太平, 磯田昌岐
    • Organizer
      第2回CIBoGリトリート(第13回NAGOYAグローバルリトリート)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 霊長類動物をモデルとして社会性の神経機構を探る2021

    • Author(s)
      磯田昌岐
    • Organizer
      文部科学省共同利用・共同研究拠点/大学共同利用機関連携シンポジウム
    • Related Report
      2020 Annual Research Report
  • [Presentation] 腹側運動前野と内側前頭前野の機能連関から自閉スペクトラム症を考える2020

    • Author(s)
      磯田昌岐
    • Organizer
      生理学研究所研究会「社会性の創発・発達、その多様な軌跡」
    • Related Report
      2020 Annual Research Report
  • [Presentation] Neuronal responses to real and artificial faces in the macaque amygdala2020

    • Author(s)
      新居桂陽, 二宮太平, 磯田昌岐
    • Organizer
      Life Science Retreat 2020
    • Related Report
      2020 Annual Research Report
  • [Presentation] 脳内の自己ニューロンと他者ニューロンから自閉スペクトラム症を考える2020

    • Author(s)
      磯田昌岐
    • Organizer
      講義:発達障害に「似て非なる」大人たち
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] マカクザルをモデルとして高次脳機能のゲノム基盤と神経基盤を明らかにする 実験的アプローチ2020

    • Author(s)
      磯田昌岐
    • Organizer
      第9回日本マーモセット研究会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] Developing a systems neuroscience of self and others using macaques2020

    • Author(s)
      Isoda M
    • Organizer
      チュラロンコン大学・京都大学・生理研合同シンポジウム
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] マカクザルを用いた社会的認知機能の生理学的理解2019

    • Author(s)
      磯田昌岐
    • Organizer
      第42回日本神経科学学会
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] マカクザルのミラーシステムおよびメンタライジングシステムにおける自他行動モニタリング中の神経活動およびその相互作用2019

    • Author(s)
      二宮太平、則武厚、磯田昌岐
    • Organizer
      第42回日本神経科学学会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Neural basis of social reward monitoring and valuation2019

    • Author(s)
      Isoda M
    • Organizer
      7th International Symposium on Motivational and Cognitive Control
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Social reward signals in cortico-subcortical networks of the macaque2019

    • Author(s)
      則武厚、二宮太平、磯田昌岐
    • Organizer
      生理学研究所研究会:視覚・認知脳機能研究の先端
    • Related Report
      2019 Annual Research Report
  • [Presentation] Social reward monitoring and valuation in corticosubcortical networks of the macaque2019

    • Author(s)
      則武厚、二宮太平、磯田昌岐
    • Organizer
      The 9th Okazaki / Tuebingen / Beijing Joint Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] ニホンザルを用いた社会脳研究2019

    • Author(s)
      磯田昌岐
    • Organizer
      第42回日本分子生物学会のNBRPシンポジウム
    • Related Report
      2019 Annual Research Report
    • Invited
  • [Presentation] 報酬の主観的価値を生みだす神経メカニズム2019

    • Author(s)
      則武厚、二宮太平、磯田昌岐
    • Organizer
      次世代脳プロジェクト 冬のシンポジウム2019
    • Related Report
      2019 Annual Research Report

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Published: 2019-04-18   Modified: 2023-01-30  

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