| Budget Amount *help |
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2022: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2021: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2020: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
Fiscal Year 2019: ¥7,150,000 (Direct Cost: ¥5,500,000、Indirect Cost: ¥1,650,000)
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| Outline of Final Research Achievements |
This research aims to develop chemical catalysts that simplify the chemical synthesis of proteins. Specifically, we aimed to develop a catalyst that simultaneously activates a peptide C-terminal thioester and a peptide N-terminus and ligates them. As a result, we succeeded in finding catalysts that activate the C-terminus and the N-terminus respectively, but were unable to fuse them into a single catalyst while maintaining their activity. Based on the knowledge obtained in this study, we will focus on developing N-terminal activating catalysts that can coexist with C-terminal activating catalysts, in order to develop catalysts that will revolutionize and simplify protein chemical synthesis.
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