| Budget Amount *help |
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2021: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2020: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2019: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Outline of Final Research Achievements |
Fluorine substitution technique is common to improve the efficacy of pharmaceutical drugs. However, efficient reaction for the synthesis of optically active organofluorine compounds remains elusive. In this study, we developed novel dianionic phase transfer catalysts in combination with cationic fluorine sources. The catalyst was found powerful for producing novel fluorinated compounds by highly enantioselective fluoro-difunctionalization of various cyclic and acyclic alkenes and dearomatizing fluorination of hydroxy arenes, which had been difficult to achieve with conventional methods.
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