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Study of signaling pathways for treatment of immune/allergic diseases

Research Project

Project/Area Number 19H03364
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Review Section Basic Section 47030:Pharmaceutical hygiene and biochemistry-related
Research InstitutionHokkaido University

Principal Investigator

Matsuda Tadashi  北海道大学, 薬学研究院, 教授 (20212219)

Co-Investigator(Kenkyū-buntansha) 室本 竜太  北海道大学, 薬学研究院, 准教授 (30455597)
柏倉 淳一  北海道大学, 薬学研究院, 講師 (90373290)
鍛代 悠一  北海道大学, 薬学研究院, 助教 (90756165)
Project Period (FY) 2019-04-01 – 2022-03-31
Project Status Completed (Fiscal Year 2021)
Budget Amount *help
¥17,420,000 (Direct Cost: ¥13,400,000、Indirect Cost: ¥4,020,000)
Fiscal Year 2021: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2020: ¥5,460,000 (Direct Cost: ¥4,200,000、Indirect Cost: ¥1,260,000)
Fiscal Year 2019: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Keywordsアレルギー / 免疫疾患 / 自己免疫 / サイトカイン / 免疫応答 / 炎症 / シグナル伝達 / 免疫 / 自己免疫疾患 / 疾患制御
Outline of Research at the Start

免疫、神経等の高次生体統御系の恒常性の維持にはサイトカインの存在が不可欠であり、その異常産生やシグナル異常はアレルギー、自己免疫疾患の発症に深く関与している。申請者はこれまで免疫/アレルギー応答を担うサイトカインの機能制御に重要なSTAT3/NF-κB関連シグナルを中心に新規制御分子の同定ならびにその機能解析を行ってきた。しかしながら、それら分子群の免疫/アレルギー疾患発症への関与についての詳細は未だ明らかではない。本研究ではそれらSTAT3/NF-κB関連シグナル分子に注目し、アレルギー、免疫疾患等の疾患発症における機能と新たな疾患標的分子としての可能性を明らかにするとともに、その人為的制御法の確立を目指す。

Outline of Final Research Achievements

Cytokines control the proliferation and differentiation as well as effecter functions of immune cells to eliminate invasive pathogens; however, they sometimes involve in the onset and development of immune/allergic diseases. We identified new regulatory molecules in the cytkine signaling and analyzed their functions. Among them, we focused on STAT3 / NF-κB-related signals, which are important for controlling the function of cytokines responsible for immune / allergic responses. However, the details of the involvement of these molecules in the development of immune / allergic diseases are not yet clear. In this study, we further examined functions of these STAT3 / NF-κB-related signaling molecules and showed new mechanisms in the onset of diseases such as allergies / immune diseases.This study will provide clues toward development of novel drugs for immune/allergic diseases in the near future.

Academic Significance and Societal Importance of the Research Achievements

本研究で進めたSTAT3/NF-κB関連シグナルの研究は現在、蔓延するコロナ感染症での重症化にみられるサイトカインストームや間質性肺炎、ワクチン接種時にみられるアレルギー(即時型/遅延型)等の発症・進展の分子機序にも深く関与しており、新型コロナ重症化ならびにポストコロナにおける新たな疾患標的分子としての可能性も秘めており、本研究で焦点を当てたTyk2やSTAP-2の研究はその一助を担うものである。

Report

(4 results)
  • 2021 Annual Research Report   Final Research Report ( PDF )
  • 2020 Annual Research Report
  • 2019 Annual Research Report
  • Research Products

    (56 results)

All 2022 2021 2020 2019 Other

All Int'l Joint Research (1 results) Journal Article (20 results) (of which Int'l Joint Research: 4 results,  Peer Reviewed: 20 results,  Open Access: 14 results) Presentation (31 results) (of which Int'l Joint Research: 9 results,  Invited: 1 results) Remarks (2 results) Patent(Industrial Property Rights) (2 results) (of which Overseas: 2 results)

  • [Int'l Joint Research] Yale University School of Medicine/La Jolla Institute for Immunology/University of California San Diego(米国)

    • Related Report
      2019 Annual Research Report
  • [Journal Article] Signal-transducing adaptor protein-1 and protein-2 in hematopoiesis and diseases2022

    • Author(s)
      Ichii, Michiko; Oritani, Kenji; Toda, Jun; Hosen, Naoki; Matsuda, Tadashi; Kanakura, Yuzuru
    • Journal Title

      Experimental Hematology

      Volume: 105 Pages: 10-17

    • DOI

      10.1016/j.exphem.2021.11.002

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Current understanding of the role of tyrosine kinase 2 signaling in immune responses2022

    • Author(s)
      Ryuta Muromoto; Kenji Oritani; Tadashi Matsuda
    • Journal Title

      World Journal of Biological Chemistry

      Volume: 13 Issue: 1 Pages: 1-14

    • DOI

      10.4331/wjbc.v13.i1.1

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Possible Therapeutic Applications of Targeting STAP Proteins in Cancer2021

    • Author(s)
      Matsuda, Tadashi; Oritani, Kenji
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 44 Issue: 12 Pages: 1810-1818

    • DOI

      10.1248/bpb.b21-00672

    • NAID

      130008123608

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2021-12-01
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic Advantage of Tyk2 Inhibition for Treating Autoimmune and Chronic Inflammatory Diseases2021

    • Author(s)
      Muromoto, Ryuta; Shimoda, Kazuya; Oritani, Kenji; Matsuda, Tadashi
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 44 Issue: 11 Pages: 1585-1592

    • DOI

      10.1248/bpb.b21-00609

    • NAID

      130008110312

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2021-11-01
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] STAP-2 Adaptor Protein Regulates Multiple Steps of Immune and Inflammatory Responses2021

    • Author(s)
      Matsuda, Tadashi; Oritani, Kenji
    • Journal Title

      Biological and Pharmaceutical Bulletin

      Volume: 44 Issue: 7 Pages: 895-901

    • DOI

      10.1248/bpb.b21-00224

    • NAID

      130008060362

    • ISSN
      0918-6158, 1347-5215
    • Year and Date
      2021-07-01
    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Tyk2-mediated homeostatic control by regulating the PGE(2)-PKA-IL-10 axis2021

    • Author(s)
      Muromoto, Ryuta; Oritani, Kenji; Matsuda, Tadashi
    • Journal Title

      AIMS Allergy and Immunology

      Volume: 5 Issue: 3 Pages: 175-183

    • DOI

      10.3934/allergy.2021013

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Positive interactions between STAP-1 and BCR-ABL influence chronic myeloid leukemia cell proliferation and survival2021

    • Author(s)
      Ishiura, Marie; Kitai, Yuichi; Kashiwakura, Jun-ichi; Muromoto, Ryuta; Toda, Jun; Ichii, Michiko; Oritani, Kenji; Matsuda, Tadashi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 556 Pages: 185-191

    • DOI

      10.1016/j.bbrc.2021.03.162

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Propolis suppresses cytokine production in activated basophils and basophil-mediated skin and intestinal allergic inflammation in mice2021

    • Author(s)
      Kashiwakura Jun-ichi、Yoshihara Mari、Saitoh Kodai、Kagohashi Kota、Sasaki Yuto、Kobayashi Fuki、Inagaki Iori、Kitai Yuichi、Muromoto Ryuta、Matsuda Tadashi
    • Journal Title

      Allergology International

      Volume: 70 Issue: 3 Pages: 360-367

    • DOI

      10.1016/j.alit.2020.11.005

    • NAID

      130008064059

    • ISSN
      1323-8930, 1440-1592
    • Related Report
      2021 Annual Research Report 2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Signal-transducing adaptor protein-2 has a nonredundant role for IL-33-triggered mast cell activation2021

    • Author(s)
      Kashiwakura, Jun-ichi; Koizumi, Nao; Saitoh, Kodai; Kagohashi, Kota; Sasaki, Yuto; Kobayashi, Fuki; Kawahara, Shoya; Yamauchi, Yukie; Kitai, Yuichi; Muromoto, Ryuta; Oritani, Kenji; Matsuda, Tadashi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 572 Pages: 80-85

    • DOI

      10.1016/j.bbrc.2021.07.098

    • Related Report
      2021 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD47 promotes T-cell lymphoma metastasis by up-regulating AKAP13-mediated RhoA activation2021

    • Author(s)
      Kitai Yuichi、Ishiura Marie、Saitoh Kodai、Matsumoto Naoki、Owashi Kimiya、Yamada Shunsuke、Muromoto Ryuta、Kashiwakura Jun-ichi、Oritani Kenji、Matsuda Tadashi
    • Journal Title

      International Immunology

      Volume: - Issue: 5 Pages: 273-280

    • DOI

      10.1093/intimm/dxab002

    • NAID

      120007181805

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Graft-versus-host disease develops in mice transplanted with lymphocyte-depleted bone marrow cells from signal-transducing adaptor protein-2 transgenic mice2021

    • Author(s)
      Saito H, Ichii M, Toda J, Kitai Y, Muromoto R, Kashiwakura JI, Saitoh K, Tanimura A, Yokota T, Shibayama H, Matsuda T, Oritani K, Kanakura Y, Hosen N.
    • Journal Title

      Biochem Biophys Res Commun .

      Volume: 537 Pages: 118-124

    • DOI

      10.1016/j.bbrc.2020.12.080

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Signal-transducing adaptor protein-2 delays recovery of B lineage lymphocytes during hematopoietic stress2020

    • Author(s)
      Ichii Michiko、Oritani Kenji、Toda Jun、Saito Hideaki、Shi Henyun、Shibayama Hirohiko、Motooka Daisuke、Kitai Yuichi、Muromoto Ryuta、Kashiwakura Jun-ichi、Saitoh Kodai、Okuzaki Daisuke、Matsuda Tadashi、Kanakura Yuzuru
    • Journal Title

      Haematologica

      Volume: in press Issue: 2 Pages: 225573-225573

    • DOI

      10.3324/haematol.2019.225573

    • Related Report
      2021 Annual Research Report 2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Expression of signal-transducing adaptor protein-1 attenuates experimental autoimmune hepatitis via down-regulating activation and homeostasis of invariant natural killer T cells2020

    • Author(s)
      Kashiwakura Jun-ichi、Saitoh Kodai、Ihara Takeru、Sasaki Yuto、Kagohashi Kota、Enohara Shiyo、Morioka Yuka、Watarai Hiroshi、Muromoto Ryuta、Kitai Yuichi、Iwabuchi Kazuya、Oritani Kenji、Matsuda Tadashi
    • Journal Title

      PLOS ONE

      Volume: 15 Issue: 11 Pages: e0241440-e0241440

    • DOI

      10.1371/journal.pone.0241440

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Signal-transducing adapter protein-1 is required for maintenance of leukemic stem cells in CML.2020

    • Author(s)
      Toda J, Ichii M, Oritani K, Shibayama H, Tanimura A, Saito H, Yokota T, Motooka D, Okuzaki D, Kitai Y, Muromoto R, Kashiwakura JI, Matsuda T, Hosen N, Kanakura Y.
    • Journal Title

      Oncogene

      Volume: 39 Issue: 34 Pages: 5601-5615

    • DOI

      10.1038/s41388-020-01387-9

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Synthesis of Resolvin E3, a Proresolving Lipid Mediator, and Its Deoxy Derivatives: Identification of 18-Deoxy-resolvin E3 as a Potent Anti-Inflammatory Agent2020

    • Author(s)
      Fukuda Hayato、Ikeda Hiroyuki、Muromoto Ryuta、Hirashima Koki、Ishimura Kohei、Fujiwara Koichi、Aoki-Saito Haruka、Hisada Takeshi、Watanabe Mizuki、Ishihara Jun、Matsuda Tadashi、Shuto Satoshi
    • Journal Title

      The Journal of Organic Chemistry

      Volume: 85 Issue: 21 Pages: 14190-14200

    • DOI

      10.1021/acs.joc.0c01701

    • NAID

      120007168587

    • Related Report
      2020 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] The mechanism of Tyk2 deficiency-induced immunosuppression in mice involves robust IL-10 production in macrophages2020

    • Author(s)
      Hirashima Koki、Muromoto Ryuta、Minoguchi Hiroya、Matsumoto Tomohiro、Kitai Yuichi、Kashiwakura Jun-ichi、Shimoda Kazuya、Oritani Kenji、Matsuda Tadashi
    • Journal Title

      Cytokine

      Volume: 130 Pages: 155077-155077

    • DOI

      10.1016/j.cyto.2020.155077

    • NAID

      120007097398

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dimethyl fumarate dampens IL-17-ACT1-TBK1 axis-mediated phosphorylation of Regnase-1 and suppresses IL-17-induced IκB-ζ expression2020

    • Author(s)
      Ohgakiuchi Yui、Saino Yuka、Muromoto Ryuta、Komori Yuki、Sato Ami、Hirashima Koki、Kitai Yuichi、Kashiwakura Jun-ichi、Oritani Kenji、Matsuda Tadashi
    • Journal Title

      Biochemical and Biophysical Research Communications

      Volume: 521 Issue: 4 Pages: 957-963

    • DOI

      10.1016/j.bbrc.2019.11.036

    • NAID

      120007097378

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The basophil‐IL‐4‐mast cell axis is required for food allergy2019

    • Author(s)
      Kashiwakura Jun‐Ichi、Ando Tomoaki、Karasuyama Hajime、Kubo Masato、Matsumoto Kenji、Matsuda Tadashi、Kawakami Toshiaki
    • Journal Title

      Allergy

      Volume: 74 Issue: 10 Pages: 1992-1996

    • DOI

      10.1111/all.13834

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] IκB-ζ Expression Requires Both TYK2/STAT3 Activity and IL-17-Regulated mRNA Stabilization2019

    • Author(s)
      Muromoto Ryuta、Tawa Keisuke、Ohgakiuchi Yui、Sato Ami、Saino Yuka、Hirashima Koki、Minoguchi Hiroya、Kitai Yuichi、Kashiwakura Jun-ichi、Shimoda Kazuya、Oritani Kenji、Matsuda Tadashi
    • Journal Title

      ImmunoHorizons

      Volume: 3 Issue: 5 Pages: 172-185

    • DOI

      10.4049/immunohorizons.1900023

    • NAID

      120007097377

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] STAP-2 positively regulates FcεRI-mediated basophil activation and basophil-dependent allergic inflammatory reactions2019

    • Author(s)
      Kashiwakura Jun-ichi、Yamashita Shinsuke、Yoshihara Mari、Inui Kyosuke、Saitoh Kodai、Sekine Yuichi、Muromoto Ryuta、Kitai Yuichi、Oritani Kenji、Matsuda Tadashi
    • Journal Title

      International Immunology

      Volume: 31 Issue: 5 Pages: 349-356

    • DOI

      10.1093/intimm/dxz013

    • Related Report
      2019 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Presentation] ベンゾ[a]ピレンはAhR依存的にRegnase-1発現を抑制しIL-17応答を増強する2022

    • Author(s)
      成家康太、室本竜太、松田正
    • Organizer
      日本薬学会第142年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] STAP-2によるB細胞活性化制御機構の解明2022

    • Author(s)
      河原生知、稲垣伊織、織谷健司、柏倉淳一、松田正
    • Organizer
      日本薬学会第142年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ベンゾトリアゾール系UV吸収剤によるAhR活性化を介した制御性T細胞の誘導2022

    • Author(s)
      窪田篤人、寺崎将、室本竜太、高田秀重、小島弘幸
    • Organizer
      第28回日本免疫毒性学会学術年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] アレルギー炎症反応とSTAPファミリーアダプタータンパク質2022

    • Author(s)
      柏倉淳一
    • Organizer
      第8回総合アレルギー講習会
    • Related Report
      2021 Annual Research Report
    • Invited
  • [Presentation] サイトカインシグナル伝達系の解明と疾患治療への応用2022

    • Author(s)
      松田 正
    • Organizer
      日本薬学会第142年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 肺がん細胞におけるIκB-ζ発現に対するB[a]Pの影響の解析2021

    • Author(s)
      成家康太、斎野由佳、室本竜太、松田正
    • Organizer
      日本薬学会北海道支部第148回例会
    • Related Report
      2021 Annual Research Report
  • [Presentation] 突発性肺繊維症病態形成に対するアダブター分子STAP-2の機能解析2021

    • Author(s)
      小林風輝、織谷健司、柏倉淳一、松田正
    • Organizer
      日本薬学会北海道支部第148回例会
    • Related Report
      2021 Annual Research Report
  • [Presentation] STAP-2によるB細胞活性化制御機構の解明2021

    • Author(s)
      河原生知、稲垣伊織、織谷健司、柏倉淳一、松田正
    • Organizer
      日本薬学会北海道支部第148回例会
    • Related Report
      2021 Annual Research Report
  • [Presentation] ベンゾ[a]ピレンはAhRを介してRegnase-1発現を抑制しIL-17応答を増強する2021

    • Author(s)
      室本 竜太, 成家 康太, 斎野 由佳, 松田 正
    • Organizer
      第28回日本免疫毒性学会学術年会
    • Related Report
      2021 Annual Research Report
  • [Presentation] A neddylation inhibitor Pevonedistat inactivates Regnase-1 via MALT1-mediated cleavage2021

    • Author(s)
      Yuki Komori, Ryuta Muromoto and Tadashi Matsuda
    • Organizer
      The 50th Annual Meeting of The Japanese Society for immunology
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] New strategy of STAP-2-based suppression of TCR-mediated T cell activation and autoimmune encephalomyelitis2021

    • Author(s)
      Yuto Sasaki, Jun-ichi kashiwakura, Kenji oritani, Tadashi Matsuda
    • Organizer
      The 50th Annual Meeting of The Japanese Society for immunology
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] STAP-1 is involved in TCR-mediated T cell activation and pathogenesis of multiple sclerosis.2021

    • Author(s)
      Kota Kagohashi, Jun-ichi Kashiwakura, Kenji Oritani, Tadashi Matsuda
    • Organizer
      The 50th Annual Meeting of The Japanese Society for immunology
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] STAP-2 negatively regulates B cell receptor-mediated B cell activation and allergic rhinitis.2021

    • Author(s)
      Shoya Kawahara, Jun-ichi Kashiwakura, Kenji Oritani, Tadashi Matsuda
    • Organizer
      The 50th Annual Meeting of The Japanese Society for immunology
    • Related Report
      2021 Annual Research Report
    • Int'l Joint Research
  • [Presentation] IκB-ζ遺伝子転写調節におけるSTAT1の役割2021

    • Author(s)
      室本 竜太、佐藤亜美、松田 正
    • Organizer
      日本薬学会第141年会(広島)
    • Related Report
      2020 Annual Research Report
  • [Presentation] 自己免疫性肝炎発症におけるSTAP-1の役割の解析2021

    • Author(s)
      柏倉 淳一、佐々木 悠斗、篭橋 広太、松田 正
    • Organizer
      日本薬学会第141年会
    • Related Report
      2020 Annual Research Report
  • [Presentation] 肺線維化におけるアダブター分子STAP-2 の機能解析2020

    • Author(s)
      小林風輝、齋藤浩大、柏倉淳一、松田正
    • Organizer
      日本薬学会北海道支部第147回例会
    • Related Report
      2020 Annual Research Report
  • [Presentation] TCR依存的T細胞活性化におけるSTAP-1変異体の機能解析2020

    • Author(s)
      篭橋広太、齋藤浩大、柏倉淳一、松田正
    • Organizer
      日本薬学会北海道支部第147回例会
    • Related Report
      2020 Annual Research Report
  • [Presentation] NKT細胞活性化及び自己免疫性炎制御機構に対する STAP-1 の機能解析2020

    • Author(s)
      佐々木悠斗、齋藤浩大、柏倉淳一、松田正
    • Organizer
      日本薬学会北海道支部第147回例会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Signal transducing adaptor protein (STAP)-2 accelerates graft-versus-host-disease.2020

    • Author(s)
      Hideaki Saito,Michiko Ichii,Jun Toda,Yuichi Kitai,Ryuta Muromoto,Junichi Kashiwakura,Kodai Saitoh,Takafumi Yokota,Hirohiko Shibayama,Tadashi Matsuda,Kenji Oritani,Yuzuru Kanakura,Naoki Hosen.
    • Organizer
      第82回日本血液学会学術集会・総会
    • Related Report
      2020 Annual Research Report
  • [Presentation] Signal-Transducing Adaptor Protein-1 (STAP-1) is Required for Maintenance of Leukemic Stem Cells in Chronic Myeloid Leukemia2019

    • Author(s)
      Toda J, Ichii M, Shibayama H, Saito H, Matsuda T, Oritani K, Kanakura Y
    • Organizer
      The 10th JSH International Symposium
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] T細胞活性化シグナル制御におけるSTAP-1の機能解析2019

    • Author(s)
      篭橋広太、齋藤浩大、柏倉淳一、松田正
    • Organizer
      日本薬学会北海道支部第146回例会
    • Related Report
      2019 Annual Research Report
  • [Presentation] STAP-1による自己免疫性肝炎発症機構の解析2019

    • Author(s)
      佐々木悠斗、齋藤浩大、柏倉淳一、松田正
    • Organizer
      日本薬学会北海道支部第146回例会
    • Related Report
      2019 Annual Research Report
  • [Presentation] IgE依存性好塩基球活性化反応におけるSTAP-2の機能解析2019

    • Author(s)
      吉原真梨、柏倉淳一、松田正
    • Organizer
      日本薬学会北海道支部第146回例会
    • Related Report
      2019 Annual Research Report
  • [Presentation] IL-17/TBK1シグナルによるIκB-ζ mRNA安定化機構の解明2019

    • Author(s)
      斎野由佳、大垣内優衣、室本竜太、松田正
    • Organizer
      日本薬学会北海道支部第146回例会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 自己免疫性肝炎病態制御におけるSTAP蛋白ファミリーの機能解析2019

    • Author(s)
      齋藤 浩大、柏倉 淳一、室本 竜太、鍛代 悠一、吉村 昭彦、織谷 健司、松田 正
    • Organizer
      第56回 日本生化学会北海道支部 支部例会
    • Related Report
      2019 Annual Research Report
  • [Presentation] STAT1 acts as a negative regulator or IκB-ζ gene transcription2019

    • Author(s)
      室本竜太、佐藤亜美、松田正
    • Organizer
      第26回日本免疫毒性学会学術年会
    • Related Report
      2019 Annual Research Report
  • [Presentation] 慢性骨髄性白血病幹細胞におけるアダプター蛋白STAP-1の役割2019

    • Author(s)
      Jun Toda, Michiko Ichii, Kenji Oritani, Hideaki Saito, Yuichi Kitai, Ryuta Muromoto, Jun-ichi Kashiwakura, Kodai Saitoh, Tadashi Matsuda, Yuzuru Kanakura
    • Organizer
      第81回日本血液学会学術集会
    • Related Report
      2019 Annual Research Report
  • [Presentation] Opposing roles of STAT1 and STAT3 in IκB-ζ gene transcription2019

    • Author(s)
      Ami Sato, Ryuta Muromoto, Tadashi Matsuda
    • Organizer
      The 48th Annual Meeting of The Japanese Society for immunology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] STAP-2 positively modulates TCR-mediated Tcell activation2019

    • Author(s)
      SAITOH Kodai, Kashiwakura Jun-ichi, YOSHIMURA Akihiko, ORITANI Kenji, MATSUDA Tadashi
    • Organizer
      The 48th Annual Meeting of The Japanese Society for immunology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Functional analysis of the adaptor protein STAP-1 in TCR-mediated T cell activation2019

    • Author(s)
      Kota Kagohashi, Kodai Saitoh,Jun-ichi Kashiwakura, Tadashi Matsuda
    • Organizer
      The 48th Annual Meeting of The Japanese Society for immunology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Presentation] The function of Signal-transducing Adaptor Protein-1( STAP-1) in autoimmune hepatitis2019

    • Author(s)
      Yuto Sasaki, Kodai Saitoh, Jun-ichi Kashiwakura, Tadashi Matsuda
    • Organizer
      The 48th Annual Meeting of The Japanese Society for immunology
    • Related Report
      2019 Annual Research Report
    • Int'l Joint Research
  • [Remarks] 北海道大学大学院薬学研究院 衛生化学研究室

    • URL

      http://www.pharm.hokudai.ac.jp/eisei/

    • Related Report
      2021 Annual Research Report
  • [Remarks] 北海道大学大学院薬学研究院衛生化学研究室

    • URL

      http://www.pharm.hokudai.ac.jp/eisei/index.php

    • Related Report
      2020 Annual Research Report 2019 Annual Research Report
  • [Patent(Industrial Property Rights)] 抗腫瘍ペプチド及びその利用2021

    • Inventor(s)
      松田 正,鍛代 悠一 ,織谷 健司
    • Industrial Property Rights Holder
      北海道大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Related Report
      2021 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] ペプチド及び医薬用組成物2021

    • Inventor(s)
      松田 正
    • Industrial Property Rights Holder
      北海道大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2021
    • Related Report
      2021 Annual Research Report
    • Overseas

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Published: 2019-04-18   Modified: 2023-01-30  

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